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Mohamed M Abdel-Diam, Dalia H Samak, Yasser S El-Sayed, Lotfi Aleya, Saud Alarifi, Saad Alkahtani
The ubiquitous use of diazinon (DZN, an organophosphorus insecticide) has increased the probability of occupational, public, and the ecosystem exposure; these exposures are linked to negative health outcomes. The flavonoids curcumin (CUR) and quercetin (QUE) exert significant anti-inflammatory and antioxidant activities against toxicants, including insecticides. However, it is unclear whether their combination enhances these activities. Therefore, 40 albino rat were divided randomly into the CTR, DZN, CUR + DZN, QUE + DZN, and CUR + QUE + DZN groups, which are treated daily via gavage for 28 days...
December 8, 2018: Environmental Science and Pollution Research International
Abdelhabib Semlali, Narasimha Reddy Parine, Nouf S Al-Numair, Mikhlid Almutairi, Yousef M Hawsawi, Abdullah Al Amri, Abdulrahman M Aljebreen, Maha Arafah, Majid A Almadi, Nahla Ali Azzam, Othman Alharbi, Mohammad Saud Alanazi
Background: Inflammation is a fundamental factor that contributes to the development and progression of several types of cancer including colon cancer. Toll-like receptors ( TLRs ) and their signaling pathways have been reported to be associated with chronic inflammation and thereby induced cancer. Our aim was to investigate the expression and polymorphisms of TLR2 and their association with colon cancer. Methods: Real-time PCR and immunohistochemistry were used to investigate TLR2 gene expression and to evaluate the potential risk of predisposition to colon cancer caused by three tagging single-nucleotide polymorphisms (SNPs) on TLR2 , including rs3804100, rs4696480, and rs3804099...
2018: OncoTargets and Therapy
F Kegles, O C Madruga, E Schmoeller, L F Bragança, U S Londero, L Marins, J O Feijó, M N Corrêa, E Schmitt, F A B Del Pino
This study was designed to evaluate the response of hematological and biochemical parameters submitted to pegbovigrastim administration and postchallenge with lipopolysaccharide (LPS). In experiment 1, 20 newborn Holstein calves were divided into 2 groups: the Imrestor (Elanco Saúde Animal, São Paulo, Brazil) group (IMR, n = 10), which received a 25 μg/kg of body weight (BW) subcutaneous administration of pegbovigrastim, and the control group (CTR, n = 10), which received a subcutaneous administration of 0...
October 24, 2018: Journal of Dairy Science
Saud Alsahli, Waleed Al-Twaijri, Fuad Al Mutairi
Early onset epileptic encephalopathy (EOEE) has been used to encompass Ohtahara syndrome (early infantile epileptic encephalopathy [EIEE]), early myoclonic epilepsy, and many others. Multiple genes have been established to cause epileptic encephalopathy in the immature brain, and next-generation sequencing has accelerated the process of novel gene discovery. Many of the previously published candidate genes are still pending confirmatory reports or functional studies. Although most of the genes involved are ion channels (channelopathies), multiple other pathways have been implicated as well...
December 2018: Epilepsia Open
Isabella Vitral Pinto, Laura Augusta Barufaldi, Maryane Oliveira Campos, Deborah Carvalho Malta, Rayone Moreira Costa Veloso Souto, Mariana Gonçalves de Freitas, Cheila Marina de Lima, Marco Antonio Ratzsch de Andreazzi
OBJECTIVE: To present trends found in the last three editions of the National Adolescent Student Health Survey (Pesquisa Nacional de Saúde do Escolar - PeNSE) on violent situations experienced by Brazilian students. METHODS: Time-series study with a focus on the Brazilian state capitals, using PeNSE databases of 2009, 2012, and 2015. The indicators evaluated were: missing classes due to insecurity in the home-school route or at school; involvement in a fight with firearm or melee weapon; and physical assault by an adult of the family...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Simoni Urbano da Silva, Laura Augusta Barufaldi, Silvânia Suely Caribé de Araújo Andrade, Maria Aline Siqueira Santos, Rafael Moreira Claro
INTRODUCTION: This study aimed to analyze the association between nutritional status, body image perception, and extreme weight control behaviors among adolescents. METHODS: This is an analytical cross-sectional study conducted in Brazil based on the National Adolescent Student Health Survey (Pesquisa Nacional de Saúde do Escolar - PeNSE) of 2015, with adolescents aged 13 to 17 years. Nutritional status and body image perception were the independent variables. The two dependent variables were vomiting or laxative use and use of medicines and other formulas for weight control in the 30 days prior to data collection...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Otaviana Cardoso Chaves, Gustavo Velasquez-Melendez, Dário Alves da Silva Costa, Waleska Teixeira Caiaffa
OBJECTIVE: To estimate the association between soft drink consumption and body mass index (BMI) in eutrophic and overweight adolescents. METHODS: We used data from the National Adolescent Student Health Survey (Pesquisa Nacional de Saúde do Escolar - PeNSE) of 2009. The dependent variable (outcome) was the tertiles of BMI score (zBMI), and the main independent variable (exposure) was the consumption of sugar-sweetened soft drinks. The models included age, school type, home goods and services score, and maternal schooling as adjustment variables...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Fernanda Almeida Fettermann, Elisabeta Albertina Nietsche, Marlene Gomes Terra, Cléton Salbego, Odete Messa Torres, Tierle Kosloski Ramos
OBJECTIVE: To analyze the influences of the Vivências e Estágios na Realidade do Sistema Único de Saúde (Brazilian Unified Health System), in the training and performance of nurses. METHOD: A qualitative study was carried out with 14 nurses who participated in the VER-SUS project in Rio Grande do Sul State. The data were collected through a semi-structured interview technique. The data were analyzed, interpreted and discussed, through the technique of Content Analysis...
November 2018: Revista Brasileira de Enfermagem
Mamata Sherpa Awasthi, Kiran Raj Awasthi, Harish Singh Thapa, Bhuvan Saud, Sarita Pradhan, Roshani Agrawal Khatry
Background and Objective: Antenatal care (ANC) is one of the main components of maternal health. Utilization of safe motherhood is deprived in women who belong to low-caste groups like Dalit of Nepal. Low socioeconomic status, poor knowledge and awareness on obstetric complications, lack of decision-making autonomy, and limited health care options lead to underutilization of existing maternal health care service. The aim of this study was to ascertain the utilization of antenatal care services in terms of ANC visits with health personnel, receiving recommended period of iron tablets, consumption of antihelminthes and number of Tetanus Toxoid (TT) vaccines taken among child bearing women in Dalit community...
2018: Journal of Pregnancy
Mohammad S Masoud, Majed S Alokail, Sobhy M Yakout, Malak Nawaz K Khattak, Marwan M AlRehaili, Kaiser Wani, Nasser M Al-Daghri
Vitamin D deficiency has been shown to affect iron status via decreased calcitriol production, translating to decreased erythropoiesis. The present study aimed to determine for the first time whether vitamin D supplementation can affect iron levels among Arab adolescents. A total of 125 out of the initial 200 Saudi adolescents with vitamin D deficiency (serum 25(OH)D < 50 nmol/L) were selected from the Vitamin D-School Project of King Saud University in Riyadh, Saudi Arabia. Cluster randomization was done in schools, and students received either vitamin D tablets (1000 IU/day) ( N = 53, mean age 14...
December 2, 2018: Nutrients
Manzer H Siddiqui, Saud A Alamri, Mutahhar Y Y Al-Khaishany, Mohammed A Al-Qutami, Hayssam M Ali, Mohamed H Al-Whaibi, Mona S Al-Wahibi, Hesham F Alharby
The effects of magnesium (Mg) supplementation on the growth performance, oxidative damage, DNA damage, and photosynthetic pigment synthesis, as well as on the activity level of carbonic anhydrase (CA), ribulose-1,5-bisphosphate carboxylase (Rubisco), and antioxidant enzymes were studied in Vicia faba L. plants exposed to heat stress (HS) and non-heat-stress (non-HS) conditions. Seeds were grown in pots containing a 1:1 mixture of sand and peat, with Mg treatments. The treatments consisted of (i) 0 Mg and non-HS (ambient temperature; control); (ii) 50 mM Mg; (iii) HS (38 °C); and (iv) 50 mM Mg and HS (38 °C)...
November 2018: Saudi Journal of Biological Sciences
Mohammad M Al-Qattan, Mervat M Abd-Alwahed, Medhat K Shier
OBJECTIVE: To determine the effects of TGF&beta;1 and an anti-scar protein nAG on normal (un-injured) 3-D astrocyte cultures with special emphasis on astrocyte proliferation, and the expression of GFAP, CSPG4, S100B, and IL-6. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: King Saud University, Riyadh, Saudi Arabia, from March to September 2017. METHODOLOGY: 3-D astrocyte gels were treated differently to create one control group (control, untreated astrocytes) and five experimental groups: nAg-only (treated astrocytes with 1 nM nAG recombinant protein), TGF&beta;1-only (treated astrocytes with 10 ng/ml TGF&beta;1), TGF&beta;1+low nAg concentration, TGF&beta;1+intermediate nAg concentration, and TGF&beta;1+high nAg concentration...
December 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Deemah AlAteeq, Abdullah AlDaoud, Ahmad AlHadi, Hanoof AlKhalaf, Roumen Milev
Background: Stigma plays a powerful role in an individual's attitude towards mental illness and in their seeking psychiatric and psychological services. Assessing stigma from the perspective of people with mood disorders is important as these disorders have been ranked as major causes of disability. Objectives: To determine the extent and impact of stigma experiences in Saudi patients with depression and bipolar disorder, and to examine stigma experiences across cultures...
2018: Annals of General Psychiatry
Thamra S Alghafri, Saud Mohamed Alharthi, Yahya Al-Farsi, Abdul Hakeem Alrawahi, Elaine Bannerman, Angela M Craigie, Annie S Anderson
Objective: This study examined the impact of a multicomponent intervention to increase physical activity (PA) in adults with type 2 diabetes (T2D) in Oman. Research design and methods: This is a cluster randomized controlled trial in eight primary health centers. Participants were physically inactive, aged ≥18 years, and with no contraindication to PA. Patients attending intervention health centers (n=4) received the 'MOVEdiabetes' intervention, which consisted of personalized, individual face-to-face consultations by dietitians...
2018: BMJ Open Diabetes Research & Care
Camilla Wattrus, Jorge Zepeda, Ruth Vania Cornick, Ronaldo Zonta, Matheus Pacheco de Andrade, Lara Fairall, Daniella Georgeu-Pepper, Lauren Anderson, Tracy Eastman, Eric D Bateman, Alvaro A Cruz, Max O Bachmann, Sonia Natal, Tanya Doherty, Rafael Stelmach
Brazil's Sistema Único de Saúde, or Unified Health System policy, has delivered major improvements in health coverage and outcomes, but challenges remain, including the rise of non-communicable diseases (NCDs) and variations in quality of care across the country. Some of these challenges may be met through the adaptation and implementation of a South African primary care strategy, the Practical Approach to Care Kit (PACK). Developed by the University of Cape Town's Knowledge Translation Unit (KTU), PACK is intended for in-country adaptation by employing a mentorship model...
2018: BMJ Global Health
Rafa S Almeer, Daoud Ali, Saud Alarifi, Saad Alkahtani, Mansour Almansour
Metal nanoparticles are widely used in industry, agriculture, textiles, drugs, and so on. The adverse effect of green platinum nanoparticles on human embryonic kidney (HEK293) cells is not well established. In the current study, green platinum nanoparticles were synthesized using leaf extract of Azadirachta indica L. Green platinum nanoparticles were characterized by dynamic light scattering and transmission electron microscope. The cytotoxicity of green platinum nanoparticle was observed in HEK293 cells by applying 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) and Neutral red uptake (NRU) assays...
October 2018: Dose-response: a Publication of International Hormesis Society
Syed Rashid Habib, Saad Saud AlOtaibi, Fahad Abdulrahman Abdullatif, Ibrahim Mohammed AlAhmad
BACKGROUND: Scientific research is an important part of healthcare curricula and a vital exercise to help develop clinician's research skills. The aim of this study was to evaluate quantitatively the knowledge and attitude of undergraduate dental students towards scientific research. In addition, the study explored the reasons for lack of interest in research by the dental students. METHODS: This cross-sectional study was conducted among students of three dental schools in Riyadh...
July 2018: Journal of Ayub Medical College, Abbottabad: JAMC
Muhammad Sarwar, Muhammad Farrukh Saleem, Najeeb Ullah, Muhammad Rizwan, Shafaqat Ali, Muhammad Rizwan Shahid, Saud A Alamri, Mohammed Nasser Alyemeni, Parvaiz Ahmad
Episodes of extremely high temperature during reproductive stages of cotton crops are common in many parts of the world. Heat stress negatively influences plant growth, physiology and ultimately lint yield. This study attempts to modulate heat-induced damage to cotton crops via application of growth regulators e.g. hydrogen peroxide (H2 O2 30ppm), salicylic acid (SA 50ppm), moringa leaf extract (MLE 30 times diluted) and ascorbic acid (ASA 70ppm). Cotton plants were exposed to different thermal regimes by staggering sowing time (field) or exposing to elevated temperatures (38/24 °C and 45/30 °C) for one week during reproductive growth stages (glasshouse)...
November 20, 2018: Scientific Reports
Depeng Wang, Shah Fahad, Shah Saud, Muhammad Kamran, Aziz Khan, Mohammad Nauman Khan, Hafiz Mohkum Hammad, Wajid Nasim
Food security is confronted by major threats from crop yield stagnation and global climate change. The benefits of phenotypic plasticity across environments for given crop genotypes are thought to be imperative for high-yielding cropping systems. Given that 3D modeling is increasingly recognized for dissecting crop phenotypic plasticity, it requires an assessment of the potential benefits of architectural adaptation of super rice to different agronomic practices. In this study, we focused on a comprehensive evaluation of the phenotypic plasticity of super rice on the aspects of 3D architectural "reoptimization," photosynthetic productivity, nitrogen economy, and grain yield...
November 12, 2018: Plant Physiology and Biochemistry: PPB
Ulrik Pedersen-Bjergaard, Saud Alsifri, Ronnie Aronson, Maja Cigrovski Berković, Gagik Galstyan, Helge Gydesen, Jesper Barner Lekdorf, Bernhard Ludvik, Erik Moberg, Ambady Ramachandran, Kamlesh Khunti
AIMS: Optimal diabetes care requires clear understanding of the incidence of hypoglycaemia in real-world clinical practice. Current data on hypoglycaemia are generally limited to those reported from randomised controlled clinical trials. The Hypoglycaemia Assessment Tool (HAT) study, a non-interventional real-world study of hypoglycaemia, assessed hypoglycaemia in 27,585 people across 24 countries. The present study compared the incidence of hypoglycaemia from the HAT study with other similarly designed, large, real-world studies...
November 20, 2018: Diabetes, Obesity & Metabolism
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