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Plant cell death

Baohua Feng, Caixia Zhang, Tingting Chen, Xiufu Zhang, Longxing Tao, Guanfu Fu
BACKGROUND: Extremely high temperatures are becoming an increasingly severe threat to crop yields. It is well documented that salicylic acid (SA) can enhance the stress tolerance of plants; however, its effect on the reproductive organs of rice plants has not been described before. To investigate the mechanism underlying the SA-mediated alleviation of the heat stress damage to rice pollen viability, a susceptible cultivar (Changyou1) was treated with SA at the pollen mother cell (PMC) meiosis stage and then subjected to heat stress of 40 °C for 10 d until 1d before flowering...
October 19, 2018: BMC Plant Biology
Jing Jin, Hao Li, Gaonian Zhao, Su Jiang
BACKGROUND Spinal cord injury (SCI) is an injury-triggered event that is associated with permanent neurologic deficit. The deficit instigated by SCI leads to medical co-morbidity, not only affecting sensory and motor capabilities, but also having an impact on the physiological and economic condition of the patient. Against this backdrop, the present study was carried out to investigate the effect of lycopsamine, a plant-derived alkaloid in SCI rats. MATERIAL AND METHODS The traumatic SCI injury in rats was created using a force-calibrated weight-drop device...
October 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Fengqing Han, Xiaoli Zhang, Limei Yang, Mu Zhuang, Yangyong Zhang, Zhansheng Li, Zhiyuan Fang, Honghao Lv
Ogura cytoplasmic male sterility (CMS) contributes considerably to hybrid seed production in Brassica crops. To detect the key protein species and pathways involved in Ogura-CMS, we analysed the proteome of the cabbage Ogura-CMS line CMS01-20 and its corresponding maintainer line F01-20 using the isobaric tags for the relative and absolute quantitation (iTRAQ) approach. In total, 162 differential abundance protein species (DAPs) were identified between the two lines, of which 92 were down-accumulated and 70 were up-accumulated in CMS01-20...
October 15, 2018: International Journal of Molecular Sciences
Kirin Gada, Leigh D Plant
Chronic pain is a debilitating and increasingly common medical problem with few effective treatments. In addition to the direct and indirect economic burden of pain syndromes, the concomitant increase in prescriptions for narcotics has contributed to a sharp rise in deaths associated with drug misuse-the 'opioid crisis'. Together, these issues highlight the unmet clinical and social need for a new generation of safe, efficacious analgesics. The detection and transmission of pain stimuli is largely mediated by somatosensory afferent fibres of the dorsal root ganglia...
October 16, 2018: British Journal of Pharmacology
Guiyan Huang, Zhirou Liu, Biao Gu, Hong Zhao, Jinbu Jia, Guangjin Fan, Yuling Meng, Yu Du, Weixing Shan
RXLR effectors encoded by Phytophthora species play a central role in pathogen-plant interactions. Understanding the biological functions of RXLR effectors are conducive to illuminating pathogenic mechanisms and developing disease-control strategies. However, the virulence function of Phytophthora parasitica RXLR effectors is poorly understood. Here, we describe the identification of a P. parasitica RXLR effector gene, PPTG00121 (PpE4), which is highly transcribed during the early stages of infection and conserved among various Phytophthora species...
October 15, 2018: Molecular Plant Pathology
Feudjio Ndemanou Yolande, Bhattacharyya Sayantan, Ghosh Paramita, Sarkar Deblina, Mouokeu Raymond Simplice, Tume B Christopher, Murmu Nabendu
Cancer is a disease resulting from the deregulation of cell growth control, caused by an interaction between dietary, genetic, and environmental risk factors. Melanoma accounts for about 4% of cancers diagnosed; however they represent 75% of skin cancer-related deaths, with the incidence and death rates having increased globally over the past few decades. Spondias cytherea is a plant from the family Anacardiaceae. Its usage in the treatment of wounds, sores, and burns is reported from several countries, but the anticancer effects of the fruit have not yet been studied...
2018: Journal of Environmental Pathology, Toxicology and Oncology
Ching-Han Yu, Shu-Chen Chu, Shun-Fa Yang, Yih-Shou Hsieh, Chih-Yi Lee, Pei-Ni Chen
Cinnamomum cassia has been widely studied in different fields to reveal its antidiabetic, antidepressive, antiviral, anti-inflammatory, antiosteoporotic, and anticancer effects. Its antimalignant activities have been explored in lung cancer, breast cancer, colorectal cancer, and even oral cancer, but the detailed signaling mechanism and effects of this plant on animal models need to be clarified. In the current study, C. cassia extract (CCE) was used to investigate the antitumorigenesis mechanism in vitro and in vivo...
October 14, 2018: Journal of Cellular Physiology
Rochelle Tixeira, Ivan K H Poon
Programmed cell death (PCD) is a conserved phenomenon in multicellular organisms required to maintain homeostasis. Among the regulated cell death pathways, apoptosis is a well-described form of PCD in mammalian cells. One of the characteristic features of apoptosis is the change in cellular morphology, often leading to the fragmentation of the cell into smaller membrane-bound vesicles through a process called apoptotic cell disassembly. Interestingly, some of these morphological changes and cell disassembly are also noted in cells of other organisms including plants, fungi and protists while undergoing 'apoptosis-like PCD'...
October 13, 2018: Cellular and Molecular Life Sciences: CMLS
Sumira Jan, Nazia Abbas, Muhammad Ashraf, Parvaiz Ahmad
Plant leaves offer an exclusive windowpane to uncover the changes in organs, tissues, and cells as they advance towards the process of senescence and death. Drought-induced leaf senescence is an intricate process with remarkably coordinated phases of onset, progression, and completion implicated in an extensive reprogramming of gene expression. Advancing leaf senescence remobilizes nutrients to younger leaves thereby contributing to plant fitness. However, numerous mysteries remain unraveled concerning leaf senescence...
October 11, 2018: Protoplasma
Clement G Yedjou, Jennifer N Sims, Sylvianne Njiki, Nole Tsabang, Ifedayo V Ogungbe, Paul B Tchounwou
The World Health Organization (WHO) has been on front line to encourage developing countries to identify medicinal plants that are safe and easily available to patients. Traditional medicine represents the first-treatment choice for the healthcare of approximately 80% of people living in developing countries. Also, its use in the United States has increased by 38% during within the last decade of the 20th century alone. Therefore, the aim of the present study was to explore the efficacy of a medicinal plant, Vernonia amygdalina Delile (VAD), as a new targeted therapy for the management of acute promyelocytic leukemia (APL), using HL-60 cells as a test model...
August 2018: Global journal of advanced engineering technologies and sciences
Xin Wang, Huan Zhang, Lu-Yuan Shao, Xin Yan, Hui Peng, Jie-Xiu Ouyang, Shao-Bo Li
Heat shock proteins (HSPs) play essential roles in both plant growth and abiotic stress tolerance. In rice, OsHSP40 was recently reported to regulate programmed cell death (PCD) of suspension cells under high temperature. However, the expression and functions of OsHSP40 under normal growth or other abiotic stress conditions is still unknown. We reported the expression and function of a rice OsHSP40 gene under salt stress. Homologous proteins of OsHSP40 were collected from the NCBI database and constructed the neighbor-joining (NJ) phylogenetic tree...
October 8, 2018: Genes & Genomics
B Darvishi, L Farahmand, N Jalili, K Majidzadeh-A
Antibody-toxin fused agents or immunotoxins, are a newly engineered class of cytotoxic agents consisting of a bacterial or plant toxin moiety hooked up either to a monoclonal antibody or a specific growth factor. Nevertheless, acquiring a full potency in clinic is mostly restricted due to the Capillary leak syndrome (CLS), a serious immune provoked, life-threatening side effect, subsequent to the endothelial damage, resulting in fluid escape from the bloodstream into tissues including lungs, muscle and brain, developing organ failure and eventually death...
October 4, 2018: Current Molecular Medicine
Daniel Cruceriu, Ovidiu Balacescu, Elena Rakosy
A continuous challenge in cancer management is to improve treatment efficacy and to diminish its side effects. Consequently, new conventional and unconventional drugs and bioactive compounds from plants are constantly developed, characterized, and used for in vitro and in vivo models. This review focuses on the antitumor properties of Calendula officinalis, its biological and molecular effects in tumor cells and animal models, as well as its role in cancer palliative care. A systematic review of studies describing the cytotoxic role of C officinalis and its therapeutic role on cancer cells were carried out using the PubMed database...
October 5, 2018: Integrative Cancer Therapies
Mara Yone Dias Fernandes, Marta Regina Santos do Carmo, Analu Aragão Fonteles, Julliana Catharina de Sousa Neves, Ana Thaís Araújo da Silva, Juliana Fernandes Pereira, Emerson de Oliveira Ferreira, Neila Maria Rocha de Lima, Kelly Rose Tavares Neves, Geanne Matos de Andrade
The pathophysiology of ischemic stroke involves multiple events such as inflammation and oxidative stress which will lead to neuronal death and cognitive deficits. The (-)-α-bisabolol is a monocyclic sesquiterpene alcohol found in various plants and mainly in Matricaria chamomilla, which exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. The aim of this work was to investigate the neuroprotective effects of (-)-α-bisabolol in mice underwent permanent occlusion of the middle cerebral artery (pMCAO)...
October 1, 2018: European Journal of Pharmacology
Tengqian Zhang, Yulin Zhao, Yucheng Wang, Zhongyuan Liu, Caiqiu Gao
The MYB transcription factors (TFs) is a plant TF families, which involves in hormone signal transduction, and abiotic stress tolerance, etc. However, there are few studies on the MYB TFs family and its regulatory mechanism in Tamarix hispida . In this study, 14 MYB genes (named ThMYB1 - ThMYB14 ) were cloned and characterized from T. hispida . The transcription profiles of ThMYBs in T. hispida under different abiotic stress conditions were monitored using qRT-PCR. Most of studied ThMYBs were significantly downregulated and/or upregulated by salt and osmotic stress, ABA, GA3 and JA treatments in at least one organ...
2018: Frontiers in Plant Science
Andrea Amaroli, Sara Ferrando, Stefano Benedicenti
After 50 years of studies on photobiomodulation (PBM) there is still so much to investigate to understand the laser-light - non-plant cells interactions. The current scientific knowledge allows to say that the phenomena induced by PBM are based on cellular pathways that are key points of cell life. The mitochondria chromophores, also present on the bacterial membrane, the calcium channels, ion that regulates the life-and-death cellular processes, as well as the TRP-family, whose genes have been found in protozoa and suggest that its basic mechanism evolved long before the appearance of animals, seem to be elective targets in photobiomodulatory events by wavelengths from 600 nm up to 980 nm...
October 3, 2018: Photochemistry and Photobiology
Giseli Buffon, Édina Aparecida Dos Reis Blasi, Angie Geraldine Sierra Rativa, Thainá Inês Lamb, Rodrigo Gastmann, Janete Mariza Adamski, Joséli Schwambach, Felipe Klein Ricachenevsky, Angelo Schuabb Heringer, Vanildo Silveira, Mara Cristina Barbosa Lopes, Raul Antonio Sperotto
Rice is the staple food for over half of the world's population. Infestation of Schizotetranychus oryzae (Acari: Tetranychidae) causes great losses in rice productivity. To search for rice genotypes that could better tolerate S. oryzae infestation, we evaluated morphological and production parameters in Brazilian cultivars, and identified two cultivars with contrasting responses. Leaf damage during infestation was similar for all cultivars. However, infestation in Puitá INTA-CL resulted in reduction in the number of seeds per plant, percentage of full seeds, weight of 1,000 seeds, and seed length, whereas infestation in IRGA 423 increased weight of 1,000 seeds and seed length...
2018: Frontiers in Plant Science
Brunna Xavier Martins, Raul Ferraz Arruda, Gildeíde Aparecida Costa, Hassan Jerdy, Sávio Bastos de Souza, Julianna Maria Santos, William Rodrigues de Freitas, Milton Masahiko Kanashiro, Eulógio Carlos Queiroz de Carvalho, Nadir Francisca Sant'Anna, Fernanda Antunes, Raul Martinez-Zaguilan, Sennoune Souad, Anna Lvovna Okorokova-Façanha, Arnoldo Rocha Façanha
BACKGROUND: Metastatic tumor cells have acidic extracellular pH and differential electrochemical H+ gradients generated across their cell membranes by V-type H+ -ATPases. This study shows that inhibition of the V-ATPases by the plant-derived monoterpene Myrtenal results in tumor cell death and decreased metastatic dissemination in mice. METHODS: The Myrtenal anticancer toxicity was evaluated in vitro using murine (B16F0 and B16F10) and human (SkMel-5) melanoma cell lines, and in in vivo mouse metastatic dissemination model...
September 11, 2018: Biochimica et biophysica acta. General subjects
Chandana Pandey, Meetu Gupta
The toxic metalloid arsenic (As) is consumed mostly through contaminated rice. Therefore, reducing its accumulation and maintaining nutrient homeostasis in crop plants are imperative to ensure food safety. However, there is a dearth of information on the interrelationship between nutrient homeostasis and the regulatory mechanisms of arsenic-selenium (As-Se) interactive pathways responsible for stress tolerance. In the present study, experiments were conducted in hydroponically grown 12-day-old seedlings of rice (Oryza sativa L...
September 27, 2018: Journal of Plant Physiology
Dimitrios Giakoumettis, Chryssa Pourzitaki, Theofanis Vavilis, Anastasia Tsingotjidou, Anastasia Kyriakoudi, Maria Tsimidou, Marina Boziki, Antonia Sioga, Nikolaos Foroglou, Aristeidis Kritis
Crocus sativus L., a dietary herb, has been used for various diseases including cancer. This is an in vitro study investigating the antineoplastic effect of the extract of the plant against C6 glioma rat cell line. The mechanism of cellular death and the synergistic effect of the extract with the alkylating agent temozolomide (TMZ) were investigated. Cellular viability was examined in various concentrations of the extract alone or in combination with TMZ. Apoptosis was determined with flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and autophagy by western blotting of the light chain 3 (LC3)-II...
October 1, 2018: Nutrition and Cancer
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