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https://www.readbyqxmd.com/read/30108655/-in-vitro-antidiabetic-activity-and-mechanism-of-action-of-brachylaena-elliptica-thunb-dc
#1
Idowu Jonas Sagbo, Maryna van de Venter, Trevor Koekemoer, Graeme Bradley
In South Africa, the number of people suffering from diabetes is believed to be rising steadily and the current antidiabetic therapies are frequently reported to have adverse side effects. Ethnomedicinal plant use has shown promise for the development of cheaper, cost-effective antidiabetic agents with fewer side effects. The aim of this study was to investigate the antidiabetic activity and mechanism of action of aqueous leaf extract prepared from Brachylaena elliptica . The potential of the extract for cytotoxicity was evaluated using MTT assay in HepG2 cells...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30107882/ectopic-expression-of-fvwrky42-a-wrky-transcription-factor-from-the-diploid-woodland-strawberry-fragaria-vesca-enhances-resistance-to-powdery-mildew-improves-osmotic-stress-resistance-and-increases-abscisic-acid-sensitivity-in-arabidopsis
#2
Wei Wei, Meng-Yuan Cui, Yang Hu, Kuan Gao, Yin-Ge Xie, Ying Jiang, Jia-Yue Feng
WRKY transcription factors play a critical role in biotic and abiotic stress responses in plants, but very few WRKYs have been reported in strawberry plants. Here, a multiple stress-inducible gene, FvWRKY42, was isolated from the wild diploid woodland strawberry (accession Heilongjiang-3). FvWRKY42 expression was induced by treatment with powdery mildew, salt, drought, salicylic acid (SA), methyl jasmonate (MeJA), abscisic acid (ABA), and ethylene. The protein interaction network analysis showed that the FvWRKY42 protein interacts with various stress-related proteins...
October 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/30105196/chemopreventive-and-anti-breast-cancer-activity-of-compounds-isolated-from-leaves-of-abrus-precatorius-l
#3
Mohammed Shafi Sofi, M K Sateesh, Mohsin Bashir, Mohd Ashraf Ganie, Shabnum Nabi
The present study focuses on isolation and evaluation of the anti-cancer activity of compounds from the leaves of Abrus precatorius . The bioassay-directed strategy was adopted using chromatographic, gas chromatographic-mass spectrum analysis, nuclear magnetic resonance and X-ray crystallography techniques for purification and characterization of active cytotoxic compounds. Further, MDA-MB-231 breast cancer cell lines and 7,12-dimethylbenz (a) anthracene (DMBA) induced virgin female Sprague Dawley (SD) rats were used for in vitro and in vivo cytotoxicity evaluation...
August 2018: 3 Biotech
https://www.readbyqxmd.com/read/30103494/effect-of-selenium-on-the-responses-induced-by-heat-stress-in-plant-cell-cultures
#4
Massimo Malerba, Raffaella Cerana
High temperatures are a significant stress factor for plants. In fact, many biochemical reactions involved in growth and development are sensitive to temperature. In particular, heat stress (HS) represents a severe issue for plant productivity and strategies to obtain high yields under this condition are important goals in agriculture. While selenium (Se) is a nutrient for humans and animals, its role as a plant micronutrient is still questioned. Se can prevent several abiotic stresses (drought, heat, UV, salinity, heavy metals), but the action mechanisms are poorly understood...
August 11, 2018: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/30103001/fraxinellone-has-anticancer-activity-in-vivo-by-inhibiting-programmed-cell-death-ligand-1-expression-by-reducing-hypoxia-inducible-factor-1%C3%AE-and-stat3
#5
Yue Xing, Chunliu Mi, Zhe Wang, Zhi Hong Zhang, Ming Yue Li, Hong Xiang Zuo, Jing Ying Wang, Xuejun Jin, Juan Ma
Dictamnus dasycarpus is a traditional Chinese medicine that has been commonly used in the treatment of cancer. Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities. However, whether fraxinellone exerts anticancer effects and the mechanisms by which it may inhibit tumor growth remain unknown. Here, we found that fraxinellone, in a dose-dependented manner, inhibited the expression of programmed cell death ligand-1 (PD-L1), which plays a pivotal role in tumorigenesis...
August 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30100991/-prosopis-juliflora-sw-dc-induces-apoptosis-and-cell-cycle-arrest-in-triple-negative-breast-cancer-cells-in-vitro-and-in-vivo-investigations
#6
Utage Bhimashankar Gurushidhappa, Patole Milind Shivajirao, Nagvenkar Punam Vasudeo, Kamble Sonali Shankar, Gacche Rajesh Nivarti
Plant originated drugs/formulations are extensively prescribed by the physicians as a complementary therapy for treating various human ailments including cancer. In this study Prosopis juliflora leaves methanol extract was prepared and exposed to human breast cancer cell lines i.e. MDA-MB-231 and MCF-7 and human keratinocytes HaCaT as a representative of normal cells. Initially, a series of in vitro experiments like cell proliferation, migration, colony formation, cell cycle arrest and inhibition of angiogenesis...
July 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/30099383/anac087-and-anac046-control-distinct-aspects-of-programmed-cell-death-in-the-arabidopsis-columella-and-lateral-root-cap
#7
Marlies Huysmans, Rafael Andrade Buono, Noemi Skorzinski, Marta Cubria Radio, Freya De Winter, Boris Parizot, Jan Mertens, Mansour Karimi, Matyas Fendrych, Moritz K Nowack
Programmed cell death in plants occurs both during stress responses and as an integral part of regular plant development. Despite the undisputed importance of developmentally controlled cell death processes for plant growth and reproduction, we are only beginning to understand the underlying molecular genetic regulation. Exploiting the Arabidopsis root cap as a cell death model system, we identified two NAC transcription factors, the yet uncharacterized ANAC087 and the leaf-senescence regulator ANAC046, as being sufficient to activate the expression of cell death-associated genes and to induce ectopic programmed cell death...
August 10, 2018: Plant Cell
https://www.readbyqxmd.com/read/30099266/excess-lung-cancer-occurrence-in-poultry-plants-occupational-risk-factors-findings-for-oncogenic-viruses-exposure-and-other-occupational-exposures
#8
Eric S Johnson, Mohammed Faramawi, Irene P Chedjieu, Robert Delongchamp, Kyung-Mee Choi, Tianjiao Shen
Certain viruses naturally infect and cause cancer in chickens and turkeys. Humans are widely exposed. The viruses cause cancer in primates, and transform human cells in vitro, but it is not known if they cause cancer in humans, mainly because of the lack of epidemiologic evidence. We conducted cohort mortality studies of workers in poultry slaughtering/processing plants across the United States, because they have the highest human exposures. An excess of lung cancer and other deaths was recorded in the poultry workers...
July 30, 2018: Environmental Research
https://www.readbyqxmd.com/read/30098520/femtosecond-laser-pulse-assisted-photoporation-for-drug-delivery-in-chronic-myelogenous-leukemia-cells
#9
Hemanth Naick Banavath, Srinivasa Rao Allam, Stella Sravanthi Valathati, Alok Sharan, Baskaran Rajasekaran
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder occurs in the pluripotent hematopoietic stem cell. Currently, first-generation tyrosine kinase inhibitor (TKI) imatinib is the mainstay for the treatment of CML. Second generation TKI's like ponatinib, dasatinib, nilotinib, and bafetinib were treated against resistant CML. However, several CML patients develop resistance towards all existing inhibitors. Curcumin (Curcuma longa) a plant-derived natural compound is an effective bioactive component against various cancers including CML...
July 31, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/30098110/nad-p-hx-repair-deficiency-causes-central-metabolic-perturbations-in-yeast-and-human-cells
#10
Julia Becker-Kettern, Nicole Paczia, Jean-François Conrotte, Chenchen Zhu, Oliver Fiehn, Paul P Jung, Lars M Steinmetz, Carole L Linster
NADHX and NADPHX are hydrated and redox inactive forms of the NADH and NADPH cofactors, known to inhibit several dehydrogenases in vitro. A metabolite repair system that is conserved in all domains of life and that comprises the two enzymes NAD(P)HX dehydratase and NAD(P)HX epimerase, allows reconversion of both the S- and R-epimers of NADHX and NADPHX to the normal cofactors. An inherited deficiency in this system has recently been shown to cause severe neurometabolic disease in children. Although evidence for the presence of NAD(P)HX has been obtained in plant and human cells, little is known about the mechanism of formation of these derivatives in vivo and their potential effects on cell metabolism...
August 11, 2018: FEBS Journal
https://www.readbyqxmd.com/read/30097123/bioactive-compound-1-8-cineole-selectively-induces-g2-m-arrest-in-a431-cells-through-the-upregulation-of-the-p53-signaling-pathway-and-molecular-docking-studies
#11
Sowndarya Sampath, Sangeetha Subramani, Sridevi Janardhanam, Preethi Subramani, Arun Yuvaraj, Rose Chellan
BACKGROUND: Callistemon citrinus has been traditionally known for its medicinal property. Recently, our research group identified 1,8-Cineole, as one of the predominant compound present in the hexane extract (HE-C), whose leaves have potent anticancer activity. HYPOTHESIS/PURPOSE: The present study was designed to isolate 1,8-Cineole from Callistemon citrinus plant and to determine their role in anticancer effects in in vitro using skin carcinoma cells. Moreover, the molecular mechanism of apoptosis and molecular docking studies were also investigated...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30097110/grandiflorenic-acid-promotes-death-of-promastigotes-via-apoptosis-like-mechanism-and-affects-amastigotes-by-increasing-total-iron-bound-capacity
#12
Bruna Taciane da Silva Bortoleti, Manoela Daiele Gonçalves, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, João Paulo Assolini, Amanda Cristina Machado Carloto, Priscila Goes Camargo de Carvalho, Ian Lucas Alves Cardoso, Andréa Name Colado Simão, Nilton Syogo Arakawa, Idessania Nazareth Costa, Ivete Conchon-Costa, Wander Rogério Pavanelli
BACKGROUND: American tegumentary leishmaniasis (ATL) is a zoonotic disease caused by protozoa of the genus Leishmania. The high toxicity, high costs and resistance of some strains to current drugs has prompted the search for therapeutic alternatives for the management of this disease. Sphagneticola trilobata is a plant that has diterpenes as main constituents, including grandiflorenic acid (GFA) that has antiinflammatory, antiprotozoal, antibacterial and antinociceptive activity. PURPOSE: The aim of our study was to determine the effect of GFA on both the promastigotes and the amastigotes of Leishmania amazonensis...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30091410/post-translational-n-terminal-arginylation-of-protein-fragments-a-pivotal-portal-to-proteolysis
#13
Mohamed A Eldeeb, Mohamed A Ragheb
The majority of tRNA studies has focused on tRNA molecules as pivotal player in the fundamental process of protein synthesis. Mounting studies have unveiled further functions for tRNA beyond protein synthesis, including non-ribosomal amino acid transfer, and regulation of targeted proteolysis. Post-translational N-terminal arginylation of protein fragments, a non-ribosomal amino acid transfer, is one of the crucial ways by which tRNA participates in various protein degradation trajectories and influences global cellular functions...
August 8, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/30090601/cytometrical-analysis-of-the-adverse-effects-of-indican-indoxyl-indigo-and-indirubin-on-rat-thymic-lymphocytes
#14
Yurie Funakoshi, Ayako Azuma, Mizuki Ishikawa, Satoru Itsuki, Yasuaki Tamura, Kaori Kanemaru, Shogo Hirai, Yasuo Oyama
Many businesses thrive by producing health supplements from agricultural products, as exemplified by the production of functional (or health) foods using plants traditionally cultivated in rural areas. Dyes, such as indican, indigo, indoxyl, and indirubin, present in dye plants, possess antibacterial, antifungal, and antiproliferative activities. However, these effects may also lead to cytotoxicity. Thus, studies on normal mammalian cells are necessary to identify cytotoxicity and prevent adverse effects of functional foods that contain these dyes...
May 8, 2018: Toxicology Research
https://www.readbyqxmd.com/read/30087685/dna-damage-and-chromatin-conformation-changes-confer-nonhost-resistance-a-hypothesis-based-on-effects-of-anti-cancer-agents-on-plant-defense-responses
#15
Lee A Hadwiger, Kiwamu Tanaka
Over the last decades, medical research has utilized DNA altering procedures in cancer treatments with the objective of killing cells or suppressing cell proliferation. Simultaneous research related to enhancing disease resistance in plants reported that alterations in DNA can enhance defense responses. These two opposite perspectives have in common their effects on the center for gene transcription, the nuclear chromatin. A review of selected research from both anticancer- and plant defense-related research provides examples of some specific DNA altering actions: DNA helical distortion, DNA intercalation, DNA base substitution, DNA single cleavage by DNases, DNA alkylation/methylation, and DNA binding/exclusion...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30084118/metabolic-profiling-of-wheat-rachis-node-infection-by-fusarium-graminearum-decoding-deoxynivalenol-dependent-susceptibility
#16
Jakob Bönnighausen, Nicolas Schauer, Wilhelm Schäfer, Jörg Bormann
Fusarium graminearum is a filamentous ascomycete and the causal agent of Fusarium head blight on wheat that threatens food and feed production worldwide as infection reduces crop yield both quantitatively by interfering with kernel development and qualitatively by poisoning any remaining kernels with mycotoxins. In wheat, F. graminearum infects spikelets and colonizes the entire head by growing through the rachis node at the bottom of each spikelet. Without the mycotoxin deoxynivalenol (DON), the pathogen cannot penetrate the rachis node and wheat is able to resist colonization...
August 7, 2018: New Phytologist
https://www.readbyqxmd.com/read/30075446/impact-of-surface-modification-on-the-toxicity-of-zerovalent-iron-nanoparticles-in-aquatic-and-terrestrial-organisms
#17
Hakwon Yoon, Monmi Pangging, Min-Hee Jang, Yu Sik Hwang, Yoon-Seok Chang
Nanoscale zerovalent iron (nZVI)-based materials are increasingly being applied in environmental remediation, thereby lead to their exposure to aquatic and terrestrial biota. However, little is known regarding the toxic effects of surface-modified nZVI on multiple species in the ecosystem. In this study, we systematically compared the toxicities of different forms of nZVIs, such as bare nZVI, carboxymethyl cellulose (CMC)-stabilized nZVI, tetrapolyphosphate (TPP)-coated nZVI and bismuth (Bi)-doped nZVI, on a range of aquatic and terrestrial organisms, including bacteria (Escherichia coli and Bacillus subtilis), plant (Arabidopsis thaliana), water flea (Daphnia magna) and earthworm (Eisenia fetida)...
July 31, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30065765/protective-effect-of-hydroalcoholic-extracts-of-trifolium-pratense-l-on-pancreatic-%C3%AE-cell-line-rin-5f-against-cytotoxicty-of-streptozotocin
#18
Mozafar Khazaei, Mona Pazhouhi
Natural plants have traditionally been used throughout the world for their anti-diabetic effects. The aim of the present study was to investigate the protective effect of hydroalcoholic extract of Trifolium pratens L . ( T. pratense ) on streptozotocin (STZ) cytotoxicity and insulin concentration from RIN-5F pancreatic β cell line. In this study, possible cytoprotective action of T. pratense extract (using pre-treatment, simultaneous, and post-treatment schedules) against STZ (30 mM) was evaluated using MTT assay...
August 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30065745/expression-of-a-plastid-targeted-flavodoxin-decreases-chloroplast-reactive-oxygen-species-accumulation-and-delays-senescence-in-aging-tobacco-leaves
#19
Martín L Mayta, Anabella F Lodeyro, Juan J Guiamet, Vanesa B Tognetti, Michael Melzer, Mohammad R Hajirezaei, Néstor Carrillo
Leaf senescence is a concerted physiological process involving controlled degradation of cellular structures and reallocation of breakdown products to other plant organs. It is accompanied by increased production of reactive oxygen species (ROS) that are proposed to signal cell death, although both the origin and the precise role of ROS in the execution of this developmental program are still poorly understood. To investigate the contribution of chloroplast-associated ROS to natural leaf senescence, we used tobacco plants expressing a plastid-targeted flavodoxin, an electron shuttle flavoprotein present in prokaryotes and algae...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30060552/nitrogen-source-dependent-changes-in-central-sugar-metabolism-maintain-cell-wall-assembly-in-mitochondrial-complex-i-defective-frostbite1-and-secondarily-affect-programmed-cell-death
#20
Anna Podgórska, Monika Ostaszewska-Bugajska, Agata Tarnowska, Maria Burian, Klaudia Borysiuk, Per Gardeström, Bożena Szal
For optimal plant growth, carbon and nitrogen availability needs to be tightly coordinated. Mitochondrial perturbations related to a defect in complex I in the Arabidopsis thaliana frostbite1 ( fro1 ) mutant, carrying a point mutation in the 8-kD Fe-S subunit of NDUFS4 protein, alter aspects of fundamental carbon metabolism, which is manifested as stunted growth. During nitrate nutrition, fro1 plants showed a dominant sugar flux toward nitrogen assimilation and energy production, whereas cellulose integration in the cell wall was restricted...
July 28, 2018: International Journal of Molecular Sciences
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