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https://www.readbyqxmd.com/read/30342412/stable-perfluorocarbon-emulsions-for-the-delivery-of-halogenated-ether-anesthetics
#1
Behrouz Ashrafi, Mohammad Hossein Tootoonchi, Ryan Bardsley, Ruth Damaris Molano, Phillip Ruiz, Ernesto A Pretto, Christopher A Fraker
BACKGROUND: Research into injectable volatile anesthetics has been ongoing for approximately 40 years, with limited success, in an attempt to address the deficiencies of inhalational anesthesia. The purpose of this work was to formulate and optimize volatile anesthetic carrier emulsions based on our prior work in perfluorocarbon emulsions. METHODS: Perfluorocarbons were screened for their volatilty and emulsion stability. Optimal anesthetic emulsions were manufactured by high pressure homogenization of a select, clinically relevant perfluorocarbon, isoflurane and a surfactant-containing aqueous phase...
September 12, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30341744/interaction-of-the-hydrogen-sulfide-system-with-the-oxytocin-system-in-the-injured-mouse-heart
#2
Tamara Merz, Britta Lukaschewski, Daniela Wigger, Aileen Rupprecht, Martin Wepler, Michael Gröger, Clair Hartmann, Matthew Whiteman, Csaba Szabo, Rui Wang, Christiane Waller, Peter Radermacher, Oscar McCook
BACKGROUND: Both the hydrogen sulfide/cystathionine-γ-lyase (H2 S/CSE) and oxytocin/oxytocin receptor (OT/OTR) systems have been reported to be cardioprotective. H2 S can stimulate OT release, thereby affecting blood volume and pressure regulation. Systemic hyper-inflammation after blunt chest trauma is enhanced in cigarette smoke (CS)-exposed CSE-/- mice compared to wildtype (WT). CS increases myometrial OTR expression, but to this point, no data are available on the effects CS exposure on the cardiac OT/OTR system...
October 19, 2018: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/30341528/real-time-ultrasound-guided-spinal-anesthesia-using-a-new-paramedian-transverse-approach
#3
Yong Liu, Wei Qian, Xi-Jian Ke, Wei Mei
Ultrasound-guided spinal anesthesia is an attracting and advanced technique. We developed a new paramedian transverse approach for real-time ultrasound-guided spinal anesthesia. Using this approach, the block can be performed with the dominant hand whether in right or left lateral decubitus or sitting position. Our preliminary experience in 42 orthopedic and obstetric patients showed it could achieve high first pass success rate with acceptable procedure time. The effectiveness and safety of this approach need further investigation by comparing it with blind technique and other ultrasound-guided techniques with well-designed randomized controlled trials...
October 2018: Current medical science
https://www.readbyqxmd.com/read/30341471/laparoscopic-hepatectomy-versus-open-hepatectomy-for-the-management-of-hepatocellular-carcinoma-a-comparative-study-using-a-propensity-score-matching
#4
Xavier Untereiner, Audrey Cagniet, Riccardo Memeo, Zineb Cherkaoui, Tullio Piardi, François Severac, Didier Mutter, Reza Kianmanesh, Taiga Wakabayashi, Daniele Sommacale, Patrick Pessaux
OBJECTIVES: The aim of this study was to compare the results between laparoscopic hepatectomy and open hepatectomy in two French university hospitals, for the management of hepatocellular carcinoma (HCC) using a propensity score matching. MATERIALS AND METHODS: A patient in the laparoscopic surgery group (LA) was randomly matched with another patient in the open approach group (OA) using a 1:1 allocated ratio with the nearest estimated propensity score. Matching criteria included age, presence of comorbidities, American Society of Anesthesiologists score, and resection type (major or minor)...
October 19, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/30341448/-correction-to-drugs-for-intravenous-induction-of-anesthesia-ketamine-midazolam-and-synopsis-of-current-hypnotics
#5
E Halbeck, C Dumps, D Bolkenius
No abstract text is available yet for this article.
October 19, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/30341014/bringing-perioperative-emergency-manuals-to-your-institution-a-how-to-from-concept-to-implementation-in-10-steps
#6
Aalok V Agarwala, L Kelsey McRichards, Vanessa Rao, Vanessa Kurzweil, Sara N Goldhaber-Fiebert
BACKGROUND: Emergency manuals (EMs) are context-relevant sets of crisis checklists or cognitive aids designed to enable professional teams to deliver optimal care during critical events. Evidence from simulation and other high-risk industries have proven that use of these types of checklists can significantly improve event management and decrease omissions of key steps. However, simply printing and placing tools in operating rooms (ORs) is unlikely to be effective. How interventions are implemented influences whether clinicians actually change practice and whether patient care is affected...
October 16, 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/30340927/early-injection-laryngoplasty-after-surgery-30-cases-and-proposed-aspiration-assessment-protocol
#7
Sara Abu-Ghanem, Shannon Rudy, Sandra Deane, Shu Wei Tsai, Liang-Chun Shih, Edward J Damrose, Chih-Kwang Sung
Vocal fold movement impairment may significantly compromise postoperative recovery and quality of life of patients following thoracic or cardiothoracic surgery or prolonged intubation. The literature is limited and there is no standard screening protocol for the optimal postoperative swallowing and aspiration evaluations. We performed retrospective review of adult patients undergoing early vocal fold (VF) injection laryngoplasty for acute postoperative Vocal fold movement impairment (<30 days) that had both pre- and postinjection speech language pathologist (SLP) performed swallowing/aspiration evaluations...
October 16, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/30340926/liposomal-bupivacaine-mixture-has-similar-pain-relief-and-significantly-fewer-complications-at-less-cost-compared-with-indwelling-interscalene-catheter-in-total-elbow-arthroplasty
#8
Kirk M Thompson, Richard A Smith, Tyler J Brolin, Frederick M Azar, Thomas W Throckmorton
BACKGROUND: Postoperative pain control, short-term and long-term narcotic consumption, complication rates, and costs of indwelling interscalene catheter (ISC) were compared with a liposomal bupivacaine (LBC) mixture in patients undergoing primary total elbow arthroplasty. METHODS: Forty-four consecutive patients were identified, the first 28 with an ISC and the later 16 with intraoperative LBC injection that also included ketorolac and 0.5% bupivacaine. Medical records were reviewed for visual analog scale scores for pain, oral morphine equivalent (OME) use, complications, and facility charges...
October 16, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/30340916/impact-of-frailty-on-outcomes-after-primary-and-revision-total-hip-arthroplasty
#9
Rebecca L Johnson, Matthew P Abdel, Ryan D Frank, Alanna M Chamberlain, Elizabeth B Habermann, Carlos B Mantilla
BACKGROUND: Frailty and disability from arthritis are closely intertwined and little is known about the impact of frailty on total hip arthroplasty (THA) outcomes. We hypothesized that higher preoperative frailty is associated with more adverse events following THA. METHODS: All patients (≥50 years) undergoing unilateral primary or revision THA at a single institution from 2005 through 2016 were included. We analyzed the association of frailty (measured by a frailty deficit index) with postoperative outcomes in hospital, within 90 days, and within 1 year using multivariable logistic and Cox regression, adjusting for age...
September 25, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30340661/regional-anesthetic-techniques-for-the-thoracic-limb-and-thorax-in-small-animals-a-review-of-the-literature-and-technique-description
#10
REVIEW
D A Portela, N Verdier, P E Otero
Veterinary regional anesthesia (RA) has been rapidly increasing in popularity over the last 10 years, as evidenced by the increasing amount of literature available and the continuous development of new techniques in small animals. The introduction of new technologies such as nerve stimulation and ultrasound (which increased the objectivity and precision of the procedure) and the promising beneficial perioperative effects conferred by RA are encouraging clinicians to incorporate these techniques in their daily perioperative anesthetic and analgesic animal care...
November 2018: Veterinary Journal
https://www.readbyqxmd.com/read/30340570/oral-and-maxillofacial-surgery-in-patients-undergoing-dialysis-for-advanced-renal-disease-report-of-five-cases
#11
Yumi Mochizuki, Hiroyuki Harada, Misaki Yokokawa, Naoya Kinoshita, Kazumasa Kubota, Tomokazu Okado, Haruhisa Fukayama
BACKGROUND: Perioperativemanagement of hemodialysis patients involves many difficulties. High mortality rate and circulatory or respiratory complications in these patients were reported. However, in such reports, there is no concrete information of perioperative management in hemodialysis patients to prevent surgical complications and successful outcomes. CASE PRESENTATION: We retrospectively reviewed the cases of 5 hemodialysis patients who underwent oral surgery under general anesthesia between January 2005 and December 2017...
October 19, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/30340524/the-ultrasound-guided-selective-nerve-block-in-the-upper-arm-an-approach-of-retaining-the-motor-function-in-elbow
#12
Weijuan Zhu, Riyong Zhou, Lulu Chen, Yuanqing Chen, Lvdan Huang, Yun Xia, Thomas J Papadimos, Xuzhong Xu
BACKGROUND: Proximal brachial plexus blocks can lead to an extended period of motor paralysis and delay the return of motor function. This could influence patient satisfaction, and extend hospitalizations. The aim of the study is to compare a selective distal nerve block of the arm to a proximal axillary block, both ultrasound-guided, in terms of their motor block intensity of the elbow. Our hypothesis is that a selective nerve block of the arm would result in a different motor block of the elbow, compared to the axillary block...
October 19, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/30339687/a-prospective-observational-study-of-the-impact-of-an-electronic-questionnaire-epaq-po-on-the-duration-of-nurse-led-pre-operative-assessment-and-patient-satisfaction
#13
Sarah K Taylor, John C Andrzejowski, Matthew D Wiles, Sarah Bland, Georgina L Jones, Stephen C Radley
OBJECTIVE: Standard pre-operative assessment at our institution involves a comprehensive history and examination by a nurse practitioner. An electronic pre-operative assessment questionnaire, ePAQ-PO® (ePAQ, Sheffield, UK) has previously been developed and validated. This study aimed to determine the impact of ePAQ-PO on nurse consultation times and patient satisfaction in low-risk patients. METHODS: The duration of pre-operative assessment consultation was recorded for American Society of Anesthesiology physical classification 1 and 2 patients undergoing pre-operative assessment by an electronic questionnaire (ePAQ-PO group) and standard face-to-face assessment by a nurse practitioner (standard group)...
2018: PloS One
https://www.readbyqxmd.com/read/30339670/a-fixed-moderate-dose-combination-of-tiletamine-zolazepam-outperforms-midazolam-in-induction-of-short-term-immobilization-of-ball-pythons-python-regius
#14
Lynn J Miller, David P Fetterer, Nicole L Garza, Matthew G Lackemeyer, Ginger C Donnelly, Jesse T Steffens, Sean A Van Tongeren, Jimmy O Fiallos, Joshua L Moore, Shannon T Marko, Luis A Lugo-Roman, Greg Fedewa, Joseph L DeRisi, Jens H Kuhn, Scott J Stahl
Laboratory animals are commonly anesthetized to prevent pain and distress and to provide safe handling. Anesthesia procedures are well-developed for common laboratory mammals, but not as well established in reptiles. We assessed the performance of intramuscularly injected tiletamine (dissociative anesthetic) and zolazepam (benzodiazepine sedative) in fixed combination (2 mg/kg and 3 mg/kg) in comparison to 2 mg/kg of midazolam (benzodiazepine sedative) in ball pythons (Python regius). We measured heart and respiratory rates and quantified induction parameters (i...
2018: PloS One
https://www.readbyqxmd.com/read/30339619/maximum-recommended-dosage-of-ropivacaine-and-bupivacaine-for-pediatric-regional-anesthesia
#15
Ban C H Tsui, Karen Boretsky, Charles Berde
No abstract text is available yet for this article.
November 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/30339613/anesthesia-during-awake-breast-surgery-additional-questions
#16
Valentine Woodham, Karthick Duraisamy, Amit Pawa
No abstract text is available yet for this article.
November 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/30339595/bucket-handle-bipedicled-scalp-flaps-for-coverage-of-cranial-constructs-in-cranioplasty
#17
Chris Devulapalli, Orion Paul Mercaitis, Maria Orbe, Christopher J Salgado
Composite frontal scalp defects involving the frontal bone and full thickness scalp can pose a reconstructive challenge. Often, they necessitate the use of microsurgical free tissue transfer, which can be physiologically demanding in high-risk patients with multiple comorbidities, with exposure to prolonged general anesthesia time and increased surgical morbidity. The experience of a single surgeon was reviewed with reconstruction of composite frontal scalp wounds in 4 patients with structural framework and a bipedicled scalp advancement (ie, "bucket handle") flap, thus obviating the need for free tissue transfer...
October 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30339496/genetic-deletion-of-the-alamandine-receptor-mrgd-leads-to-dilated-cardiomyopathy-in-mice
#18
Aline Cristina Oliveira, Marcos Barrouin Melo, Daisy Motta-Santos, Antonio Ab Peluso, Fernando Souza-Neto, Rafaela F da Silva, Jonathas Fq Almeida, Giovanni Canta, Adelina M Reis, Gleisy Goncalves, Gabriela G Cerri, Danielle Coutinho, Itamar Couto Guedes de Jesus, Silvia Guatimosim, Natalia D Linhares, Natalia Alenina, Michael Bader, Maria José Campagnole-Santos, Robson A Souza Santos
We have recently described a new peptide of the renin angiotensin system, alamandine, a derivative of angiotensin-(1-7). The Mas-related G-protein coupled receptor member D (MrgD) was identified as its receptor. Although similar cardioprotective effects of alamandine to those of Ang-(1-7) have been described, the significance of this peptide in heart function is still elusive. We aimed to evaluate the functional role of the alamandine receptor, MrgD, in the heart, using MrgD-deficient mice. MrgD was localized in cardiomyocytes by immunofluorescence using confocal microscopy...
October 19, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/30339460/diabetes-mellitus-attenuates-the-pressure-response-against-hypotensive-stress-by-impairing-the-sympathetic-regulation-of-the-baroreflex-afferent-arc
#19
Kazuhiro Kamada, Keita Saku, Takeshi Tohyama, Toru Kawada, Hiroshi Mannoji, Kiyokazu Abe, Takuya Nishikawa, Genya Sunagawa, Takuya Kishi, Kenji Sunagawa, Hiroyuki Tsutsui
Patients with diabetes mellitus (DM) often show arterial pressure (AP) lability associated with cardiovascular autonomic neuropathy. Since the arterial baroreflex tightly regulates AP via sympathetic nerve activity (SNA), we investigated the systematic baroreflex function considering the control theory in DM by an open-loop analysis. We used Zucker Diabetic Fatty (ZDF)-Fatty rats as a type 2 DM model. Under general anesthesia, we isolated the carotid sinuses from systemic circulation, changed intra-carotid sinus pressure (CSP), and recorded SNA and AP responses...
October 19, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/30339204/procedural-variables-influencing-stereotactic-accuracy-and-efficiency-in-deep-brain-stimulation-surgery
#20
Zaman Mirzadeh, Tsinsue Chen, Kristina M Chapple, Margaret Lambert, John P Karis, Rohit Dhall, Francisco A Ponce
BACKGROUND: Deep brain stimulation (DBS) is well-established, evidence-based therapy for Parkinson disease, essential tremor, and primary dystonia. Clinical outcome studies have recently shown that "asleep" DBS lead placement, performed using intraoperative imaging with stereotactic accuracy as the surgical endpoint, has motor outcomes comparable to traditional "awake" DBS using microelectrode recording (MER), but with shorter case times and improved speech fluency...
October 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
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