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Fibrosis pulmonary

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https://www.readbyqxmd.com/read/30120989/tgf-%C3%AE-1-induced-smad2-3-4-activation-promotes-relm-%C3%AE-transcription-to-modulate-the-endothelium-mesenchymal-transition-in-human-endothelial-cells
#1
Yongliang Jiang, Xuanfen Zhou, Ruicheng Hu, Aiguo Dai
Endothelial-to-mesenchymal transition (EndMT), which is characterized by increased proliferation, migration and invasion of endothelial cells, increased expression of mesenchymal markers and reduced expression of endothelial markers, has been reported to be closely related to the pathogenesis of several diseases, including pulmonary fibrosis. Resistin-like molecule-β (RELM-β), also known as "found in inflammatory zone 2" (FIIZ2), plays an essential role in airway remodeling and pulmonary fibrosis; however, its role and mechanism in EndMT remain unclear...
August 15, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/30120950/meta-analysis-of-gastroesophageal-reflux-disease-and-idiopathic-pulmonary-fibrosis
#2
David Bédard Méthot, Évelyne Leblanc, Yves Lacasse
BACKGROUND: The relationship between gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF) is controversial. Current guidelines recommend that clinicians use regular antacid treatment, while 2 recent meta-analyses of antacid therapy in IPF were inconclusive. Our objective was to examine the evidence regarding the association between GERD and IPF through a systematic review and a meta-analysis, with special reference to the methodological quality of the observational studies...
August 15, 2018: Chest
https://www.readbyqxmd.com/read/30120123/dysregulated-calcium-homeostasis-in-cystic-fibrosis-neutrophils-leads-to-deficient-antimicrobial-responses
#3
Frank H Robledo-Avila, Juan de Dios Ruiz-Rosado, Kenneth L Brockman, Benjamin T Kopp, Amal O Amer, Karen McCoy, Lauren O Bakaletz, Santiago Partida-Sanchez
Cystic fibrosis (CF), one of the most common human genetic diseases worldwide, is caused by a defect in the CF transmembrane conductance regulator (CFTR). Patients with CF are highly susceptible to infections caused by opportunistic pathogens (including Burkholderia cenocepacia ), which induce excessive lung inflammation and lead to the eventual loss of pulmonary function. Abundant neutrophil recruitment into the lung is a key characteristic of bacterial infections in CF patients. In response to infection, inflammatory neutrophils release reactive oxygen species and toxic proteins, leading to aggravated lung tissue damage in patients with CF...
August 17, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30119248/inhibition-of-ep300-and-ddr1-synergistically-alleviates-pulmonary-fibrosis-in-vitro-and-in-vivo
#4
Jia Tao, Min Zhang, Zhijie Wen, Baoxue Wang, Lei Zhang, Yu Ou, Xu Tang, Xiaoping Yu, Qinglin Jiang
OBJECTIVES: Pulmonary fibrosis is strongly correlated with inflammation factors, cytokine, and collagen secretion, whereby discoidin domain receptor 1 (DDR1) signaling plays an important role. EP300 is defined as an acetyltransferase that can acetylate histone and has been broadly studied in several chronic diseases, including cancer, inflammation and fibrosis. This study aimed to investigate the relationship between p300 and DDR1 in the pathological processes of pulmonary fibrosis. MATERIALS AND METHODS: Transcriptome analysis of single cell RNA-sequencing for idiopathic pulmonary fibrosis (IPF) bronchial epithelial cells demonstrated that both DDR1 and EP300 were up-regulated and involved in the regulation of autophagy, cellular response to organonitrogen compounds, and collagen metabolic pathways, respectively...
July 30, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30119159/rising-stars-of-dpld-survival-fvc-and-exercise-desaturation-a-single-center-study
#5
Ayperi Öztürk, Oya Kayacan
Background/aim: Diffuse parenchymal lung diseases (DPLDs) comprise a broad, heterogeneous group of diseases with common functional characteristics and a common final pathway, usually leading to irreversible fibrosis. We investigated the effects of the physiological and functional parameters and of pulmonary hypertension (PH) on survival in DPLDs. Materials and methods: The study included 158 patients with DPLDs. Patient data were examined retrospectively, and survival status was obtained through phone calls...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30118374/cystic-fibrosis-respiratory-microbiota-unraveling-complexity-to-inform-clinical-practice
#6
Lindsay J Caverly, John J LiPuma
Cystic fibrosis (CF) lung disease is characterized by chronic cycles of pulmonary infection, inflammation, and mucus obstruction, beginning early in life, and eventually leading to progressive lung damage and early mortality. During the past ~15 years, culture-independent analyses of CF respiratory samples have identified diverse bacterial communities in CF airways, and relationships between respiratory microbiota and clinical outcomes. Areas covered: This article reviews recent advances in our understanding of the relationships between respiratory microbiota and CF lung disease...
August 17, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/30118349/inhibition-of-autotaxin-alleviates-inflammation-and-increases-the-expression-of-sodium-dependent-glucose-cotransporter-1-and-na-h-exchanger-3-in-samp1-fc-mice
#7
Peijian He, Abedul Haque, Songbai Lin, Fabio Cominelli, C Chris Yun
Crohn's disease (CD) is a chronic, relapsing, inflammatory disease that is often associated with malnutrition due to inflammation in the small intestine. Autotaxin (ATX) is a secreted enzyme that produces extracellular lysophosphatidic acid (LPA). Increasing evidence suggests that ATX is upregulated during inflammation and inhibition of ATX has been effective in attenuating chronic inflammatory conditions, such as arthritis and pulmonary fibrosis. This study is aimed to determine whether inhibition of ATX alleviates CD-associated inflammation and malnutrition by using SAMP1/Fc mice, a model of CD-like ileitis...
August 17, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/30117783/a-potential-biomarker-for-predicting-the-risk-of-radiation-induced-fibrosis-in-the-lung
#8
Angela M Groves, Jacqueline P Williams, Eric Hernady, Christina Reed, Bruce Fenton, Tanzy Love, Jacob N Finkelstein, Carl J Johnston
Biomarkers could play an essential role during triage in the aftermath of a radiological event, where exposure to radiation will be heterogeneous and complicated by concurrent trauma. Used alongside biodosimetry, biomarkers can identify victims in need of treatment for acute radiation effects, and might also provide valuable information on later developing consequences that need to be addressed as part of a treatment strategy. Indeed, because the lung is particularly sensitive to radiation and resultant late effects not only affect quality of life, but can also lead to morbidity, the risk of developing downstream pulmonary complications in exposed individuals requires assessment...
August 17, 2018: Radiation Research
https://www.readbyqxmd.com/read/30116539/dose-modification-and-dose-intensity-during-treatment-with-pirfenidone-analysis-of-pooled-data-from-three-multinational-phase-iii-trials
#9
Steven D Nathan, Lisa H Lancaster, Carlo Albera, Marilyn K Glassberg, Jeffrey J Swigris, Frank Gilberg, Klaus-Uwe Kirchgaessler, Susan L Limb, Ute Petzinger, Paul W Noble
Introduction: Temporary dose modifications, such as reductions or interruptions, may allow patients to better manage adverse events (AEs) associated with pirfenidone use and continue treatment for idiopathic pulmonary fibrosis (IPF). However, the impact of such dosing adjustments on efficacy and safety is uncertain. Methods: Patients randomised to receive treatment with pirfenidone 2403 mg/day or placebo in the Clinical Studies Assessing Pirfenidone in Idiopathic Pulmonary Fibrosis: Research of Efficacy and Safety Outcomes (CAPACITY (Study 004 (NCT00287716)) and Study 006 (NCT00287729))) and Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis (ASCEND (Study 016 (NCT01366209)) trials were included in the analysis (n=1247)...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/30116400/paeoniflorin-inhibits-il-1%C3%AE-induced-mmp-secretion-via-the-nf-%C3%AE%C2%BAb-pathway-in-chondrocytes
#10
Peng-Fei Hu, Fang-Fang Sun, Li-Feng Jiang, Jia-Peng Bao, Li-Dong Wu
Paeoniflorin serves important cellular roles, exerting anti-cancer, anti-inflammatory and anti-pulmonary fibrosis effects and possesses immune-modulatory properties. However, the exact role of paeoniflorin in the pathogenesis of osteoarthritis (OA) remains unclear. The aim of the present study was to investigate the effects of paeoniflorin on articular surfaces in vitro . Rat chondrocytes were cultured in vitro and an MTT assay was performed to assess chondrocyte survival. Following treatment with interleukin (IL)-1β and paeoniflorin, the production of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) was examined using reverse transcription-quantitative polymerase chain reaction and western blotting...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30116277/pulmonary-function-and-hospital-admission-in-patients-with-cystic-fibrosis-based-on-household-second-hand-smoking
#11
Maryam Hassanzad, Shabnam Eslampanah, Mohammadreza Modaresi, Sabereh Tashayoie-Nejad, Ali Akbar Velayati
Background: Smoking is a known predisposing factor to exacerbations in CF patients. But the effects of second-hand tobacco smoking are not yet clear. Hence, this study determined the clinical and spirometric presentations and urinary cotinine levels among cystic fibrosis patients over seven years of age in relation to their parent's smoking history. Materials and Methods: In this cross-sectional comparative study, 58 consecutive cystic fibrosis patients older than seven years of age were enrolled...
January 2018: Tanaffos
https://www.readbyqxmd.com/read/30115119/evaluation-of-99m-tc-rhannexin-v-128-spect-ct-as-a-diagnostic-tool-for-early-stages-of-interstitial-lung-disease-associated-with-systemic-sclerosis
#12
Janine Schniering, Li Guo, Matthias Brunner, Roger Schibli, Shuang Ye, Oliver Distler, Martin Béhé, Britta Maurer
BACKGROUND: Given the need for early detection of organ involvement in systemic sclerosis, we evaluated 99m Tc-rhAnnexin V-128 for the detection of early stages of interstitial lung disease (ILD) in respective animal models using single photon emission computed tomography (SPECT/CT). METHODS: In bleomycin (BLM)-challenged mice, fos-related antigen 2 (Fra-2) transgenic (tg) mice and respective controls, lung injury was evaluated by analysis of hematoxylin and eosin (HE) and Sirius red staining, with semi-quantification of fibrosis by the Ashcroft score...
August 16, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/30114692/identifying-barriers-to-idiopathic-pulmonary-fibrosis-treatment-a-survey-of-patient-and-physician-views
#13
Toby M Maher, Jeffrey J Swigris, Michael Kreuter, Marlies Wijsenbeek, Nicola Cassidy, Lucy Ireland, Judit Axmann, Steven D Nathan
BACKGROUND: Antifibrotics are recommended for the treatment of individuals with idiopathic pulmonary fibrosis (IPF), but treatment use remains at ∼60%. OBJECTIVE: To investigate the views of individuals with IPF and pulmonologists on the diagnosis and management of IPF to understand treatment patterns. METHODS: Interviews and/or online surveys were completed by patients and pulmonologists from Canada, France, Germany, Italy, Spain, and the UK...
August 16, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/30114688/associated-pulmonary-hypertension-is-an-independent-contributor-to-exercise-intolerance-in-chronic-fibrosing-interstitial-pneumonias
#14
David K Yoo, Maurizio Zompatori, Annapina Barrile, Giorgia Rossi, Dejanira D'Amato, Gianluigi Sergiacomi, Paola Rogliani, Marco Mura
BACKGROUND: Associated pulmonary hypertension (APH) is frequently observed in fibrosing interstitial pneumonias (FIP), such as idiopathic pulmonary fibrosis (IPF). APH is associated with worse prognosis, but it remains unclear whether it is associated with greater functional impairment. Six-minute walk distance (6MWD) is widely used to assess functional capacity in pulmonary hypertension and FIP. OBJECTIVES: To investigate if APH independently contributes to exercise intolerance in FIP, irrespective of the extent of underlying fibrosis...
August 16, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/30114262/high-sensitivity-c-reactive-protein-in-heart-failure-with-preserved-ejection-fraction
#15
Hilary M DuBrock, Omar F AbouEzzeddine, Margaret M Redfield
BACKGROUND: Microvascular inflammation may contribute to the pathogenesis of both heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension (PH). We investigated whether the inflammation biomarker C-reactive protein (CRP) was associated with clinical characteristics, disease severity or PH in HFpEF. METHODS: Patients in the Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart failure (RELAX) trial had baseline high-sensitivity CRP levels measured (n = 214)...
2018: PloS One
https://www.readbyqxmd.com/read/30114238/lung-cancer-in-idiopathic-pulmonary-fibrosis-a-systematic-review-and-meta-analysis
#16
AliReza JafariNezhad, Mohammad Hossein YektaKooshali
BACKGROUND: There are many epidemiological pieces of evidence that show IPF patients have the highest risk of lung cancer. We conducted a systematic review of all published data to define the characteristics of lung cancer that develops in IPF by performing a meta-analysis. METHOD: This study was performed based on the PRISMA guideline. Documents gathered by searching through the Web of Sciences, Scopus, PubMed/Medline, OVID, and COCHRANE databases which published before 03/25/2018 that related to lung cancer in IPFs' patients...
2018: PloS One
https://www.readbyqxmd.com/read/30114189/aav9-mediated-telomerase-activation-does-not-accelerate-tumorigenesis-in-the-context-of-oncogenic-k-ras-induced-lung-cancer
#17
Miguel A Muñoz-Lorente, Paula Martínez, Águeda Tejera, Kurt Whittemore, Ana Carolina Moisés-Silva, Fàtima Bosch, Maria A Blasco
Short and dysfunctional telomeres are sufficient to induce a persistent DNA damage response at chromosome ends, which leads to the induction of senescence and/or apoptosis and to various age-related conditions, including a group of diseases known as "telomere syndromes", which are provoked by extremely short telomeres owing to germline mutations in telomere genes. This opens the possibility of using telomerase activation as a potential therapeutic strategy to rescue short telomeres both in telomere syndromes and in age-related diseases, in this manner maintaining tissue homeostasis and ameliorating these diseases...
August 2018: PLoS Genetics
https://www.readbyqxmd.com/read/30112991/novel-therapeutic-potential-of-mitogen-activated-protein-kinase-activated-protein-kinase-2-mk2-in-chronic-airway-inflammatory-disorders
#18
Rakesh Kumar Singh, Abul Kalam Najmi
OBJECTIVE: The primary focus of this review is to highlight the current and emerging pro-inflammatory role of MK2 kinase signaling in p38MAPK pathway and to provide a detailed evaluation on the prospects of MK2 inhibition with special emphasis on the etiology of chronic inflammatory airway diseases, such as asthma, idiopathic pulmonary fibrosis, lung cancer, acute lung injury and acute respiratory distress syndrome. BACKGROUND: Mitogen-activated protein kinase-activated protein kinase 2 (MK2) is a serine-threonine kinase downstream to p38MAPK and is activated directly by stress and inflammatory signal through p38 phosphorylation...
August 16, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/30112923/effect-of-endoscopic-sinus-surgery-on-bronchiectasis-patients-with-chronic-rhinosinusitis
#19
Jesada Kanjanaumporn, Peter H Hwang
Background The concept of unified airway disease has linked bronchiectasis with chronic rhinosinusitis (CRS), much in the same way as in asthma and CRS. Although the outcomes of endoscopic sinus surgery (ESS) on comorbid asthma have been relatively well studied, the outcomes of ESS on comorbid bronchiectasis have rarely been examined. Objective We sought to determine sinonasal and pulmonary clinical outcomes of ESS in bronchiectasis patients with CRS. Method We reviewed all bronchiectasis patients who had ESS for CRS at our institution from 2006 to present...
August 16, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/30112104/pm2-5-induced-cardiac-hypertrophy-via-creb-gsk3b-sos1-pathway-and-metabolomics-alterations
#20
Kuan-Lun Li, Yen-Chang Lin
The particle matter with diameter less 2.5μm (PM2.5) easier to adsorb toxic substance, and interfere with pulmonary gas exchange. In this study, cardioprotective effects of low molecular weight (LMW) fucoidan in cardiac hypertrophy subjects induced by PM2.5 exposure was conducted by measuring QT interval, Blood pressure, cardiac structure, metabolites and proteins expression in different organs. After PM2.5 exposure, increase in blood pressure, abnormal cardiac function (Prolongation of Action Potential Duration and QT Interval), and structral remodeling (cardiac hypertrophy and fibrosis) were recorded...
July 20, 2018: Oncotarget
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