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Ramosetron

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https://www.readbyqxmd.com/read/30480776/adverse-side-effects-of-dexamethasone-in-surgical-patients
#1
REVIEW
Jorinde Aw Polderman, Violet Farhang-Razi, Susan Van Dieren, Peter Kranke, J Hans DeVries, Markus W Hollmann, Benedikt Preckel, Jeroen Hermanides
BACKGROUND: In the perioperative period, dexamethasone is widely and effectively used for prophylaxis of postoperative nausea and vomiting (PONV), for pain management, and to facilitate early discharge after ambulatory surgery.Long-term treatment with steroids has many side effects, such as adrenal insufficiency, increased infection risk, hyperglycaemia, high blood pressure, osteoporosis, and development of diabetes mellitus. However, whether a single steroid load during surgery has negative effects during the postoperative period has not yet been studied...
November 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30152137/adverse-side-effects-of-dexamethasone-in-surgical-patients
#2
REVIEW
Jorinde Aw Polderman, Violet Farhang-Razi, Susan Van Dieren, Peter Kranke, J Hans DeVries, Markus W Hollmann, Benedikt Preckel, Jeroen Hermanides
BACKGROUND: In the perioperative period, dexamethasone is widely and effectively used for prophylaxis of postoperative nausea and vomiting (PONV), for pain management, and to facilitate early discharge after ambulatory surgery.Long-term treatment with steroids has many side effects, such as adrenal insufficiency, increased infection risk, hyperglycaemia, high blood pressure, osteoporosis, and development of diabetes mellitus. However, whether a single steroid load during surgery has negative effects during the postoperative period has not yet been studied...
August 28, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30132170/recent-advances-in-pharmacological-research-on-the-management-of-irritable-bowel-syndrome
#3
REVIEW
Yoonjin Nam, Young Sil Min, Uy Dong Sohn
Irritable bowel syndrome (IBS), a common gastrointestinal (GI) disorder, is associated with various factors, including lifestyle, infection, stress, intestinal flora, and related diseases. The pharmacotherapeutic stimulation of receptors and downstream signaling pathways is effective in reducing IBS symptoms; however, it is still associated with adverse effects. Various receptors related to GI motility and visceral hypersensitivity should be considered to enhance the benefit/risk ratio of IBS treatments. This review discusses recent pharmacological advances in IBS management...
October 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30075513/continuous-administration-of-ramosetron-with-patient-controlled-analgesia-after-laparoscopic-distal-gastrectomy-does-not-delay-postoperative-bowel-function-recovery-a-prospective-randomized-double-blinded-study
#4
RANDOMIZED CONTROLLED TRIAL
Hong Soo Jung, Jaewon Huh, Youngchan Kim, Sang Hyun Hong, Jaemin Lee
BACKGROUND: Currently, 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are indicated to slow gastrointestinal motility in the diarrhea-predominant subtype of irritable bowel syndrome. They are commonly used to prevent or treat postoperative nausea and vomiting (PONV) and opioid-induced nausea and vomiting (OINV). We conducted a prospective, randomized, double-blinded study to investigate whether the continuous administration of ramosetron, a selective 5-HT3 receptor antagonist, for preventing PONV and/or OINV after laparoscopic distal gastrectomy (LDG) might influence bowel function recovery...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30016361/correction-association-of-nefopam-use-with-postoperative-nausea-and-vomiting-in-gynecological-patients-receiving-prophylactic-ramosetron-a-retrospective-study
#5
Sun-Kyung Park, Seokha Yoo, Won Ho Kim, Young-Jin Lim, Jae-Hyon Bahk, Jin-Tae Kim
[This corrects the article DOI: 10.1371/journal.pone.0199930.].
2018: PloS One
https://www.readbyqxmd.com/read/29977907/nephrotoxicity-evaluation-on-cisplatin-combined-with-5-ht-3-receptor-antagonists-a-retrospective-study
#6
Wen Kou, Hongyan Qin, Shahbaz Hanif, Xinan Wu
Objective: 5-HT3 receptor antagonist (ondansetron) has been reported to have nephrotoxic effect when combined with cisplatin in mice; however, little evidence exists in explaining its nephrotoxic effects on patients. The aim of this present study was to investigate whether 5-HT3 receptor antagonist could enhance or aggravate the incidence of cisplatin-induced nephrotoxicity in patients. Methods: We retrospectively reviewed 600 tumor patients which were treated with cisplatin ( ⩾ 60 mg/m2 ) as a first-time chemotherapy and combined with 5-HT3 receptor antagonist (i...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29977312/acupuncture-for-diarrhoea-predominant-irritable-bowel-syndrome-a-network-meta-analysis
#7
REVIEW
Lingping Zhu, Yunhui Ma, Shasha Ye, Zhiqun Shu
Background: The objective of this study was to compare the efficacy and side effects of acupuncture, sham acupuncture, and drugs in the treatment of diarrhoea-predominant irritable bowel syndrome. Methods: Randomized controlled trials (RCTs) assessing the effects of acupuncture and drugs were comprehensively retrieved from electronic databases (such as PubMed, Cochrane Library, Embase, CNKI, Wanfang Database, VIP Database, and CBM) up to December 2017. Additional references were obtained from review articles...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29953514/association-of-nefopam-use-with-postoperative-nausea-and-vomiting-in-gynecological-patients-receiving-prophylactic-ramosetron-a-retrospective-study
#8
Sun-Kyung Park, Seokha Yoo, Won Ho Kim, Young-Jin Lim, Jae-Hyon Bahk, Jin-Tae Kim
BACKGROUND: Postoperative nausea and vomiting (PONV) is a common adverse effect of opioid-based intravenous patient-controlled analgesia (IV PCA). Nefopam has been considered as a good candidate for inclusion in multimodal analgesia because of its opioid sparing effect, but it can be emetic. This study aims to examine whether the use of nefopam combined with fentanyl in IV PCA was associated with the higher incidence of PONV in patients receiving prophylactic ramosetron after gynecological surgery...
2018: PloS One
https://www.readbyqxmd.com/read/29618928/comparison-of-ramosetron-and-ondansetron-for-the-treatment-of-established-postoperative-nausea-and-vomiting-after-laparoscopic-surgery-a-prospective-randomized-double-blinded-multicenter-trial
#9
Yong Seon Choi, Hye-Min Sohn, Sang-Hwan Do, Kyeong Tae Min, Jae Hee Woo, Hee Jung Baik
Background: Postoperative nausea and vomiting (PONV) is a common complication after surgery, which increases physical and psychological discomfort and delays recovery. The aim of this study was to test the hypothesis that ramosetron is comparable to ondansetron for the treatment of established PONV after laparoscopic surgery using a prospective, randomized, double-blinded, noninferiority study. Methods: Patients who had at least two risk factors of PONV and underwent laparoscopic surgery under general anesthesia were assessed for eligibility...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29535986/efficacy-and-safety-of-ramosetron-injection-for-nausea-and-vomiting-in-colorectal-cancer-patients-undergoing-a-laparoscopic-colectomy-a-randomized-double-blind-comparative-study
#10
Han Eol Park, Min Ki Kim, Won-Kyung Kang
Purpose: A laparoscopic colectomy in colorectal-cancer patients is usually associated with a high risk of postoperative nausea and vomiting (PONV). The purpose of this study is to evaluate the efficacy of injection of long-acting 5-hydroxytryptamine type 3 (5-HT3 ) receptor antagonist for the reduction of PONV in patients with colorectal cancer. Methods: A total of 48 patients scheduled to undergo a laparoscopic colectomy for colorectal cancer were randomized in a double-blinded fashion...
February 2018: Annals of Coloproctology
https://www.readbyqxmd.com/read/29451407/advancements-in-drug-development-for-diarrhea-predominant-irritable-bowel-syndrome
#11
REVIEW
Giovanni Dothel, Maria Raffaella Barbaro, Emanuel Raschi, Giovanni Barbara, Fabrizio De Ponti
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common disorder characterized by a complex pathophysiology hampering optimal targeted drug development. Recent advances in our understanding of key underlying mechanisms prompted novel therapeutics including novel pharmacological approaches. Areas covered: This review summarizes the latest advancements in the pipeline of IBS-D drugs focusing on new pharmacological targets, efficacy and safety of medicinal products considering the recent harmonization of regulatory requirements by the FDA and the EMA...
March 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29310568/ramosetron-for-the-treatment-of-irritable-bowel-syndrome-with-diarrhea-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Qingqing Qi, Yan Zhang, Feixue Chen, Xiuli Zuo, Yanqing Li
BACKGROUND: Ramosetron is a potent and selective serotonin type 3 receptor antagonist. This meta-analysis aimed to analyze the efficacy and safety of ramosetron for irritable bowel syndrome with diarrhea (IBS-D). METHODS: Pubmed, MEDLINE, EMBASE and the Cochrane Library were searched for randomized controlled trials investigating the efficacy and safety of ramosetron for IBS-D. Risk of bias was assessed as described in the Cochrane handbook. A random effects model was used to calculate the effects of ramosetron vs placebo on symptomatic improvements, including relief of overall IBS symptoms, relief of abdominal discomfort/pain, improvement in abnormal bowel habits, and improvement in stool consistency, expressed as pooled relative risks (RRs) with 95% confidence interval (CI)...
January 8, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29284389/efficacy-and-safety-of-serotonin-receptor-ligands-in-the-treatment-of-irritable-bowel-syndrome-a-review
#13
Agata Binienda, Martin Storr, Jakub Fichna, Maciej Salaga
BACKGROUND: Irritable bowel syndrome (IBS) is a chronic, recurrent bowel disorder with an unknown etiology, which is most likely multifactorial. Increased mucosal permeability, visceral hypersensitivity and activation status of intestinal mucosal immune cells cause changes in gastrointestinal (GI) motility, secretion and sensation observed in the course of IBS. Permanent, cumbersome symptoms, such as diarrhea, constipation and abdominal pain greatly lower the quality of life of IBS patients...
2018: Current Drug Targets
https://www.readbyqxmd.com/read/29180891/effect-of-oxycodone-patient-controlled-intravenous-analgesia-after-cesarean-section-a-randomized-controlled-study
#14
Jing-Jing Nie, Shen Sun, Shao-Qiang Huang
Background: Oxycodone is a semisynthetic μ-opioid receptor agonist with a potentially good analgesic efficacy in visceral pain. This study aims to compare the efficacy of oxycodone with sufentanil patient-controlled intravenous analgesia (PCIA). Methods: One hundred and twenty primiparas undergoing elective cesarean section were randomized into four groups by different drugs of PCIA: group S (sufentanil 100 μg), group OS1 (sufentanil 70 μg, oxycodone 30 mg), group OS2 (sufentanil 50 μg, oxycodone 50 mg), and group O (oxycodone 100 mg)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28977021/comparative-efficacy-of-ramosetron-and-ondansetron-in-preventing-postoperative-nausea-and-vomiting-an-updated-systematic-review-and-meta-analysis-with-trial-sequential-analysis
#15
REVIEW
Ayako Yokoi, Takahiro Mihara, Koui Ka, Takahisa Goto
BACKGROUND: Postoperative nausea and vomiting is a distressing complication of surgery, and 5-HT3 receptor antagonists are often prescribed to prevent it. Ondansetron is the agent typically administered to prevent postoperative nausea and vomiting. Although ramosetron has a longer duration of action than ondansetron, it remains unclear whether ramosetron is the more effective medication. We performed an updated meta-analysis on the comparative efficacy of ramosetron and ondansetron in preventing postoperative nausea and vomiting...
2017: PloS One
https://www.readbyqxmd.com/read/28833224/retraction-prevention-of-vomiting-after-tonsillectomy-in-children-granisetron-versus-ramosetron-by-dr-yoshitaka-fujii
#16
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Laryngoscope
https://www.readbyqxmd.com/read/28833222/retraction-prevention-of-nausea-and-vomiting-after-middle-ear-surgery-granisetron-versus-ramosetron-by-dr-yoshitaka-fujii
#17
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Laryngoscope
https://www.readbyqxmd.com/read/28541001/efficacy-of-palonosetron-vs-ramosetron-for-the-prevention-of-postoperative-nausea-and-vomiting-a-meta-analysis-of-randomized-controlled-trials
#18
COMPARATIVE STUDY
Min Soo Kim, Jin Ha Park, Yong Seon Choi, Sang Hun Park, Seokyung Shin
PURPOSE: This study was designed as a meta-analysis of randomized controlled trials (RCTs) that included the comparison of palonosetron and ramosetron for postoperative nausea and vomiting (PONV) prophylaxis. MATERIALS AND METHODS: A systematic search was conducted for the PubMed, EMBASE, Web of Science, CENTRAL, KoreaMed, and Google Scholar databases (PROSPERO protocol number CRD42015026009). Primary outcomes were the incidences of postoperative nausea (PON) and postoperative vomiting (POV) during the first 48 hrs after surgery...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28525981/combination-of-gabapentin-and-ramosetron-for-the-prevention-of-postoperative-nausea-and-vomiting-after-gynecologic-laparoscopic-surgery-a-prospective-randomized-comparative-study
#19
RANDOMIZED CONTROLLED TRIAL
Kyung Mi Kim, Jin Huh, Soo Kyung Lee, Eun Young Park, Jung Min Lee, Hyo Ju Kim
BACKGROUND: As a drug originally introduced for its anticonvulsant effects, gabapentin has been recently shown to be effective in the treatment of nausea and vomiting in various clinical settings. This study compared the antiemetic efficacy of oral gabapentin, intravenous ramosetron and gabapentin plus ramosetron in patients receiving fentanyl-based patient-controlled analgesia after laparoscopic gynecologic surgery. METHODS: One hundred and thirty two patients undergoing laparoscopic gynecologic surgery under general anesthesia were allocated randomly into three groups: group G received 300 mg oral gabapentin 1 h before anesthesia, group R received 0...
May 19, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28414700/efficacy-of-single-dose-and-2-dose-intravenous-administration-of-ramosetron-in-preventing-postoperative-nausea-and-vomiting-after-laparoscopic-gynecologic-operation-a-randomized-double-blind-placebo-controlled-phase-2-trial
#20
RANDOMIZED CONTROLLED TRIAL
Banghyun Lee, Kidong Kim, Dong Hoon Suh, Hyun-Jung Shin, Jae Hong No, Jung Ryeol Lee, Byung Chul Jee, Jung Won Hwang, Sang Hwan Do, Yong Beom Kim
This randomized trial investigated whether a 2-dose administration of intravenous ramosetron (5-hydroxytryptamine type 3 receptor antagonist) is more effective than a single-dose administration in preventing postoperative nausea and vomiting (PONV) in 89 patients who were scheduled to undergo laparoscopic operation for benign gynecologic diseases and to receive intravenous patient-controlled analgesia for relief of postoperative pain. After assignment at a ratio of 1:1, intravenous ramosetron (0.3 mg) was initially administered at the end of skin closure in all patients...
June 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
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