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Procalcitonin and CRP

Tingting Niu, Yang Liu, Feifei Zhu, Jiayan Ma, Jimin Gao
BACKGROUND: Serological tests are indispensable in the diagnosis of early infection. At present, only procalcitonin (PCT) and C-reactive protein (CRP) are commonly used in clinical practice. Recently, serum amyloid A1 (SAA1) and heparin binding protein (HBP) have been shown to be new biomarkers, because SAA1 is highly sensitive and specific for viral infections, and HBP is predictive for septic shock. In this study, PCT, CRP, HBP, and SAA1 were detected in different combinations to improve the diagnostic accuracy of early infection using the biotin-avidin amplifying system-based time-resolved fluorescent immunoassay (BA-TRFIA)...
October 18, 2018: Journal of Clinical Laboratory Analysis
Eric Gluck, H Bryant Nguyen, Kishore Yalamanchili, Margaret McCusker, Jaya Madala, Frank A Corvino, Xuelian Zhu, Robert Balk
BACKGROUND: Sepsis management guidelines endorse use of biomarkers to support clinical assessment and treatment decisions in septic patients. The impact of biomarkers on improving patient outcomes remains uncertain. METHODS: Retrospective observational study of adult sepsis discharges between January 1, 2012, and December 31, 2015, from Premier Healthcare Database hospitals. Sepsis was defined by an All Patients Refined Diagnosis-Related Group code of 720 (septicemia and disseminated infections)...
2018: PloS One
Sibtain Ahmed, Imran Siddiqui, Lena Jafri, Madiha Hashmi, Aysha Habib Khan, Farooq Ghani
Background: Sepsis is the leading cause of mortality in critically ill patients. Procalcitonin (PCT) is a promising marker for identification of bacterial sepsis. The aim of this study was to determine the diagnostic accuracy of serum PCT concentration in patients with suspected sepsis admitted to mixed medical-surgical Intensive care unit (ICU). Material and methods: A cross-sectional study conducted at section of Chemical Pathology, Department of Pathology and Laboratory Medicine and ICU...
November 2018: Annals of Medicine and Surgery
Tolga Taymaz, Önder Ergönül, Ayda Kebapcı, Rifat Okyay
OBJECTIVE: We aimed to describe the factors associated with antibiotic use in upper respiratory tract infections (URTI) in post-pandemic influenza period. METHODS: We included all the consecutive patients, who applied to emergency and outpatient departments with the symptoms of influenza like illness (ILI) between January and June 2011 in a private 265 bed hospital in Istanbul, Turkey. RESULTS: Out of 1270 patients, 100 were tested for Sreptocococcus A infection and 16 (16%) were found to be positive, 36 were tested for RSV and five patients were found to be positive...
October 10, 2018: International Journal of Infectious Diseases: IJID
Jarosław Pieróg, Michał Bielewicz, Janusz Wójcik, Bartosz Kubisa, Krzysztof Kaseja, Krzysztof Safranow, Barbara Dołęgowska, Piotr Waloszczyk, Tomasz Grodzki
Aim: The aim of this study was to compare the metabolic response in the early postoperative period after radical resection of stage I and II oesophageal cancer applying a minimally invasive procedure and an open procedure involving classical laparotomy and thoracotomy. Material and methods: Serum concentrations of interleukin 6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), and total serum protein (TP) and leukocyte count (WBC) in blood collected on the day of surgery prior to the procedure (day 0) and on days 1, 2 and 7 after the surgery were measured in two groups of patients undergoing oesophageal resection due to cancer: applying a minimally invasive procedure involving laparoscopy and videothoracoscopy (group A) and applying a classical procedure involving full opening of the chest and abdominal cavity (group B)...
September 2018: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
Luis Coelho, Ligia Rabello, Jorge Salluh, Ignacio Martin-Loeches, Alejandro Rodriguez, Saad Nseir, José Andrade Gomes, Pedro Povoa
PURPOSE: Ventilator-associated tracheobronchitis (VAT) has been suggested as an intermediate process between tracheobronchial colonization and ventilator-associated pneumonia (VAP) in patients receiving mechanical ventilation. The aim of this study was to evaluate the ability of C-reactive protein (CRP) and procalcitonin (PCT) to differentiate between VAT and VAP. METHODS: Pre-planned analysis of the prospective multinational TAVeM database, performed on 2960 patients receiving mechanical ventilation for >48 h, including 689 patients with VA-LRTI...
October 2, 2018: Journal of Critical Care
Mateusz Wierdak, Magdalena Pisarska, Beata Kuśnierz-Cabala, Michał Kisielewski, Piotr Major, Jan S Witowski, Piotr Ceranowicz, Marcin Strzałka, Andrzej Budzyński, Michał Pędziwiatr
Introduction: Thanks to laparoscopy and enhanced recovery protocols (ERAS) it is possible to shorten hospitalization. Therefore, it seems reasonable to search for new early markers of infectious complications in order to select patients who are prone to development of complications. Aim: To assess the usefulness of serum levels of C-reactive protein, interleukin-6 and procalcitonin as early indicators of infectious complications in patients after laparoscopic colorectal surgery with ERAS...
September 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Tong-Bo Liu, Mao-Quan Wang, Wei Guan, Yu Jing
OBJECTIVE: To evaluate the diagnostic values of procalcitonin(PCT), C-reactive protein(CRP) and interleukin-6 (IL-6) in patients suffered from hematological diseases with bacterial infection, and to provide further evidence for clinical application. METHODS: A total of 3631 blood cultures, serum levels of PCT and CRP and IL-6 (n=1587) from the inpatients from 2014-01-02 to 2018-01-27 were retrospectively analyzed. The patients were divided into positive (n=208) and negative blood culture (n=3423) groups...
October 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Jian Kang, Ping Gong, Xiao-Dong Zhang, Wen-Juan Wang, Chun-Sheng Li
OBJECTIVE: Early differential diagnosis of an infection in a trauma patient is likely to have a significant influence on the prognosis. In the present study, we evaluated the early differential value of plasma presepsin, procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) on infection in trauma patients. METHODS: Trauma patients were divided into noninfected (n = 89) and infected trauma groups (n = 68); healthy adult volunteers (n = 60) and patients having sterile surgery (n = 60) were enrolled as the controls...
October 4, 2018: Shock
Shuren Guo, Xiaohuan Mao, Ming Liang
BACKGROUND: To predict the prognosis by observing the dynamic change of C-reactive protein (CRP) and procalcitonin (PCT) for hospitalized community-acquired pneumonia (CAP). METHODS: The data were collected from January to December 2017 from the first affiliated Hospital of Zhengzhou University. Demographic and clinical patient information including age, length of hospital stay and Charlson Comorbidity Index (CCI) were recorded. Blood samples were taken for CRP, PCT, and white blood cell count (WBC)...
October 1, 2018: Respiratory Research
In Sul Lee, Young Jin Park, Mi Hyeon Jin, Ji Young Park, Hae Jeong Lee, Sung Hoon Kim, Ju Suk Lee, Cheol Hong Kim, Young Don Kim, Jun Hwa Lee
PURPOSE: To study the usefulness of the procalcitonin (PCT) test in young febrile infants between 1 and 3 months of age. METHODS: We evaluated the medical records of 336 febrile infants between 1 and 3 months of age who visited the Emergency Department or outpatient department of Samsung Changwon Hospital from May 2015 to February 2017, and analyzed the clinical characteristics between infants in the serious bacterial infection (SBI) group and non-SBI group. RESULTS: Among the 336 infants, 38 (11...
September 2018: Korean Journal of Pediatrics
Yuri van der Does, Pleunie P M Rood, Christian Ramakers, Stephanie C E Schuit, Peter Patka, Eric C M van Gorp, Maarten Limper
OBJECTIVES: To effectively reduce the unnecessary use of broad spectrum antibiotics in the emergency department(ED), patients with bacterial infections need to be identified accurately. We investigated the diagnostic value of a combination of biomarkers for bacterial infections CRP and PCT, together with biomarkers for viral infections, TRAIL and IP-10, in identifying suspected and confirmed bacterial infections in a general ED population with fever. METHODS: This is a sub-study in the HiTEMP cohort...
September 27, 2018: Clinical Microbiology and Infection
Mesut Tahta, Mehmet Emin Simsek, Cetin Isik, Mustafa Akkaya, Safa Gursoy, Murat Bozkurt
BACKGROUND: The diagnosis of periprosthetic joint infections (PJI) in patients with inflammatory joint diseases (IJD) could be challenging. Several tests used for diagnosing PJI may be inaccurate due to baseline inflammatory characteristics of such diseases. We aimed to evaluate the accuracy of several infection biomarkers, in a specific subgroup of patients with PJI and IJD. METHODS: From January 2014 to August 2017, patients with resisting pain at the relevant site, following total knee arthroplasty were evaluated prospectively...
September 26, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Stéphane Legriel, Benedicte Grigoresco, Patricia Martel, Matthieu Henry-Lagarrigue, Virginie Lvovschi, Gilles Troché, Marlène Amara, Gwenaelle Jacq, Fabrice Bruneel, Maguy Bernard, Anne Marinier, Jean-Pierre Bedos
BACKGROUND: Early diagnostic orientation for differentiating pneumonia from pneumonitis at the early stage after aspiration would be valuable to avoid unnecessary antibiotic therapy. We assessed the accuracy of procalcitonin (PCT) in diagnosing aspiration pneumonia (AP) in intensive care unit (ICU) patients requiring mechanical ventilation after out-of-hospital coma. METHODS: Prospective observational 2-year cohort study in a medical-surgical ICU. PCT, C-reactive protein (CRP) and white blood cell count (WBC) were measured at admission (H0) and 6 h (H), H12, H24, H48, H96, and H120 after inclusion...
September 28, 2018: Neurocritical Care
Iliana Mani, Alexandra Alexopoulou, Larisa Vasilieva, Emilia Hadziyannis, Danai Agiasotelli, Myrianthi Bei, Theodoros Alexopoulos, Spyros P Dourakis
BACKGROUND/AIM: Human beta-defensin-1 (hBD-1) is a natural antimicrobial peptide expressed in the epithelia of multiple tissues including the digestive tract. In the current study, hBD-1 levels were determined in different subsets of patients with decompensated cirrhosis including acute-on-chronic liver failure (ACLF). In addition, the association with mortality of hBD-1, C-reactive protein (CRP) and procalcitonin (PCT) was assessed. METHODS: 125 patients were divided into 3 groups: 39 with ACLF (derivation cohort), 46 with acute decompensation without ACLF (AD) and 40 with decompensated cirrhosis without an acute event (DC)...
September 27, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Peng Li, Zhenhua Chen, Bing Liu, Kun Li, Hao Wang, Li Lin, Ling He, Jie Wei, Tiancai Liu
Purpose: Sepsis is a potentially fatal systemic body infection with a significant mortality rate worldwide. Although C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin (PCT) might be biomarkers for sepsis diagnosis, PCT is more sensitive and specific than CRP or IL-6. We aimed to establish an efficient immunoassay that precisely detects PCT in human serum for the early diagnosis of sepsis. Materials and methods: We developed a novel amplified luminescent proximity homogeneous assay (AlphaLISA) for the quantitative detection of PCT in serum...
2018: International Journal of Nanomedicine
Birsen Ocakli, Eylem Tuncay, Sinem Gungor, Meltem Sertbas, Nalan Adiguzel, Ilim Irmak, Nezihe Ciftaslan Goksenoglu, Emine Aksoy, Huriye Berk Takir, Ozlem Yazicioglu Mocin, Zuhal Karakurt
Aim: Early identification and treatment of infections in patients using domiciliary non-invasive mechanical ventilation (NIMV) due to chronic respiratory failure (CRF) can reduce hospital admissions. We assessed C-reactive protein (CRP), procalcitonin, and neutrophil lymphocyte ratio (NLR) as indicators of infection/inflammation. Methods: The study was designed as a retrospective, observational, cross-sectional study, and was performed in 2016 in an intensive care unit outpatient clinic in patients using NIMV...
2018: Frontiers in Public Health
Zhonghua Wang, Shouhong Wang, Xiaolong Liao, Weixin Guo, Yan Wu, Shenglong Chen, Jun Liang, Daozheng Huang, Jie Li, Jianyi Wen, Hanbiao Li, Tiehe Qin
OBJECTIVE: To investigate the predictive value of central venous-to-arterial carbon dioxide difference (Pcv-aCO2 ) on the prognosis of elderly patients with sepsis. METHODS: 208 elderly patients who met the diagnostic criteria of the Sepsis-3 and with the age of more than 60 years old, and admitted to intensive care unit (ICU) of Guangdong General Hospital from January to December in 2017 were enrolled. According to the prognosis, the patients were divided into death group (n = 46) and survival group (n = 162)...
August 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Yingmeng Ni, Lin Ding, Youchao Yu, Ranran Dai, Hong Chen, Guochao Shi
Oscillatory positive expiratory pressure (OPEP) devices have been utilized as an adjunct therapy to conventional chest physiotherapy (CPT) to promote the clearance of respiratory secretions in individuals with impaired ability to cough, particularly in chronic diseases. However, few studies have focused on the effectiveness of OPEP in lower respiratory tract infection. In the present study, all patients with lower respiratory tract infections hospitalized in the Department of Pulmonary and Critical Care Medicine, Ruijin Hospital (Shanghai, China) between February 2016 and July 2017 were analyzed...
October 2018: Experimental and Therapeutic Medicine
Rui-Dong Ding, Hong-Jun Zhang
BACKGROUND: The continuous development of drug-resistant tuberculosis in recent years has brought new attention to tuberculosis. linezolid is usually used to treat infection in patients with pulmonary tuberculosis and pneumonia, for it has good effects on Mycobacterium tuberculosis, and has strong antibacterial activity on the drug-resistant strain. This study aims to investigate the effects of linezolid on serum procalcitonin (PCT), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) in patients with pulmonary tuberculosis and pneumonia...
September 2018: Medicine (Baltimore)
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