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Procalcitonin and CRP

Ying Wan, Shuang-Shuang Sun, Hai-Yan Fu, Yin-Kun Xu, Qing Liu, Jiang-Tao Yin, Bing Wan
The aim of the present study was to investigate the effects of adjuvant rhubarb on the recovery of patients with heat stroke. A total of 85 patients with heat stroke were randomly assigned to two treatment groups: One group receiving conventional treatment for heat stroke (conventional group) and one group receiving rhubarb supplement in addition to conventional treatment (rhubarb group). Liver and kidney function parameters, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, plasma interleukin-6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP) levels and venous white blood cell count (WBC) were analyzed...
August 2018: Experimental and Therapeutic Medicine
Zhifang Zhao, Xuze Li, Yunxia Zhao, Dongchang Wang, Yahua Li, Le Liu, Tao Sun, Gang Chen
This study assessed whether C-reactive protein (CRP) and procalcitonin (PCT) levels can discriminate between infectious fever and tumor fever (TF) in non-neutropenic patients with nonsmall cell lung cancer (NSCLC).This retrospective clinical study included 96 adults with NSCLC who were admitted to the Third Hospital of Hebei Medical University between July 2015 and July 2017. Febrile, non-neutropenic patients were enrolled. CRP and PCT levels, neutrophil count, and antimicrobial response were evaluated.This study included 26 patients with TF, 49 with localized bacterial infection (LBI), and 21 with bloodstream infection (BSI)...
August 2018: Medicine (Baltimore)
Jing Zhang, Cheng Zhao, Tong Wu, Jiang Su, Xiaodan Wu, Jian Liu, Jing Zhu, Bin Zhou
Objective This study aimed to examine the diagnostic value of serum procalcitonin (PCT) levels for identifying bacterial infection in febrile patients with chronic gouty arthritis. Methods Sixty-six febrile patients with chronic gouty arthritis were divided into non-bacterial infection (n = 45) and bacterial infection groups (n = 21). PCT levels were measured by an immunoassay. Other laboratory parameters, including the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cells (WBCs), and the neutrophil ratio were extracted from medical records...
August 15, 2018: Journal of International Medical Research
Fiona Mendelson, Rulan Griesel, Nicki Tiffin, Molebogeng Rangaka, Andrew Boulle, Marc Mendelson, Gary Maartens
BACKGROUND: Tuberculosis, bacterial community-acquired pneumonia (CAP), and Pneumocystis jirovecii pneumonia (PJP) are the three commonest causes of hospitalisation in HIV-infected adults. Prompt diagnosis and treatment initiation are important to reduce morbidity and mortality, but are hampered by limited diagnostic resources in resource poor settings. C-reactive protein (CRP) and procalcitonin have shown diagnostic utility for respiratory tract infections, however few studies have focussed on their ability to distinguish between tuberculosis, CAP, and PJP in HIV-infected inpatients...
August 14, 2018: BMC Infectious Diseases
Carina Intke, Sini Korpelainen, Sari Hämäläinen, Matti Vänskä, Irma Koivula, Esa Jantunen, Kari Pulkki, Auni Juutilainen
OBJECTIVE: The study aim was to compare the performance of interleukin-1 receptor antagonist (IL-1Ra) to C-reactive protein (CRP) and procalcitonin (PCT) in early prediction of the clinical course of febrile neutropenia. METHODS: The study population consisted of 86 consecutive patients with febrile neutropenia who received intensive chemotherapy for haematological malignancy between November 2009 and November 2012 at the adult haematology ward of Kuopio University Hospital...
August 12, 2018: European Journal of Haematology
Han Wang, Yan Li, Fangfang Zhang, Ning Yang, Na Xie, Yuanli Mao, Boan Li
BACKGROUND: It is difficult to diagnose ascites infection early in cirrhotic patients. The present study was to create and evaluate a new bioscore combined with PCT, sNFI and dCHC in the diagnosis of ascites infection in cirrhotic patients. METHODS: Two hundred and fifty-nine consecutive patients were enrolled; of which 51 patients were culture-positive spontaneous bacterial peritonitis (culture-positive SBP) and 58 patients were culture-negative SBP. The efficacy of procalcitonin(PCT), c-reactive protein (CRP), white blood cell (WBC), mean fluorescence intensity of mature neutrophils(sNFI) and difference in hemoglobin concentration between newly formed and mature red blood cells(dCHC) for diagnosing ascites infection was examined...
August 10, 2018: BMC Infectious Diseases
Hae Jin Shin, Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong, Ju Seok Kim, Jong Seok Joo, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee
In this study, we assess the possibility of using procalcitonin levels to differentiate between inflammatory diarrhea and non-inflammatory diarrhea in acute infectious diarrhea.We reviewed the records of 1176 patients who had symptoms of diarrhea, fever (≥37.8 °C), and abdominal pain between March 2011 and May 2015. After applying exclusion criteria, a sample of 514 patients was considered for study. The patient sample was divided into Group A and Group B for inflammatory diarrhea and non-inflammatory diarrhea, respectively...
August 2018: Medicine (Baltimore)
Hai Peng Yan, Miao Li, Xiu Lan Lu, Yi Min Zhu, Wen-Xian Ou-Yang, Zheng Hui Xiao, Jun Qiu, Shuang Jie Li
BACKGROUND: The mortality rate due to severe sepsis is approximately 30-60%. Sepsis readily progresses to septic shock and multiple organ dysfunction, representing a significant problem in the pediatric intensive care unit (PICU). The aim of this study was to explore the value of plasma mitochondrial DNA (mtDNA) for early diagnosis and prognosis in children with sepsis. METHODS: A total of 123 children with sepsis who were hospitalized in the Hunan Children's Hospital PICU from July 2013 to December 2014 were divided into the general sepsis group (n = 70) and severe sepsis group (n = 53) based on diagnostic standards...
August 9, 2018: BMC Pediatrics
Madalina Macrea, Sabrina Campbell, Thomas Martin, Kris Ann Oursler
BACKGROUND: Overlap syndrome (OS) describes the association of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) in a single individual. Subjects with OS have increased cardiovascular mortality which is presumed to be inflammation-mediated. As a clinical biomarker, an increased neutrophil count correlates with the severity of coronary artery stenosis. OBJECTIVES: As little is known about the role of neutrophils in the underlying inflammatory mechanisms in OS, we aimed to assess the percentage of peripheral neutrophils (PPN) in OS vs in COPD alone...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Yasser Aljabi, Angelo Manca, Jessica Ryan, Amr Elshawarby
AIM: To compare the value of Procalcitonin (PCT) as a marker of surgical site infection to other inflammatory markers, including C-Reactive Protein (CRP), White Cell Count (WCC) and Erythrocyte Sedimentation Rate (ESR) in patients undergoing a number of spinal procedures. This study also aims to describe the biokinetic profile of the above-named markers in patients developing surgical site infection and those remaining infection-free post-operatively. METHODS: 200 patients undergoing four routine elective spinal procedures were included for analysis...
July 25, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Jaana Karhu, Tero Ilmari Ala-Kokko, Tytti Vuorinen, Pasi Ohtonen, Ilkka Julkunen, Hannu Tapani Syrjälä
BACKGROUND: The serum cytokine levels among 45 mechanically ventilated, intensive care unit (ICU)-treated severe community-acquired pneumonia (SCAP) patients with known microbial etiology in three different etiology groups were assessed. METHODS: Blood samples for C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-5, IL-6, IL-10, human interferon gamma induced protein (IP)-10, and TNF-α (tumor necrosis factor alpha) were collected at time points 0, 12, 24, 48, 72 and 96 h after study inclusion...
July 25, 2018: Cytokine
Ya Su, Siqi Feng, Li Luo, Ruixi Liu, Qijian Yi
Kawasaki disease (KD) arises due to the acute inflammation and immune system dysfunction. This study investigated the relationship between the serum level of IL-35 and coronary artery lesions (CALs) in patients with KD. We obtained blood samples from 90 children with KD before intravenous immunoglobulin therapy. Levels of IL-35, IL-6, IL-17A, IL-10, MCP-1 and VEGF were measured in 190 cases, including 4 groups: KD with coronary arterial lesions (n = 46), KD without coronary arteries lesions (n = 44), febrile control group (FC, n = 40) and the normal control group (NC, n = 60)...
July 27, 2018: Clinical and Experimental Medicine
Sehveta Mustafić, Selmira Brkić, Besim Prnjavorac, Albina Sinanović, Humera Porobić Jahić, Sabina Salkić
Aim To investigate predictive value of procalcitonin in diagnosis of sepsis in predicting positive blood culture, and possibility to predict final outcome in septic patients. Method This prospective study involved 106 hospitalized patients who met two or more criteria for systemic inflammatory response syndrome (SIRS). In comparison to Sepsis Related Organ Failure Assessment score (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II score procalcitonin (PCT), C-reactive protein and lactate levels were used to predict final outcome in septic patients (recorded as 28-day survival or non-survival)...
August 1, 2018: Medicinski Glasnik
Jiru Ye, Jing Wang, Feng Zheng, Xiaonan Shao, Suhong Wang, Haoqian Gao
OBJECTIVE: To analyze the risk factors of delirium in intensive care unit (ICU) patients, and to investigate the predictive value of C-reactive protein (CRP), procalcitonin (PCT), lactic acid (Lac) and neuron-specific enolase (NSE) in the diagnosis of ICU delirium. METHODS: The patients admitted to central ICU and respiratory medicine ICU of Changzhou First People's Hospital from August 2016 to November 2017 were enrolled. The patients were divided into two groups according to whether delirium occurred within 7 days or not, which was evaluated by using the confusion assessment method for ICU (CAM-ICU)...
July 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Zeliang Qiu, Kan Shen, Ming Shu, Dongwei Xu, Xingqi Deng, Dechang Chen
OBJECTIVE: To investigate the diagnostic value of Hepcidin as a sepsis biomarker in critically ill adults. METHODS: An observational study was conducted. The patients with suspected or proven infection admitted to intensive care unit (ICU) of Zhoupu Hospital Affiliated to Shanghai University of Medicine and Health Sciences from March 2016 to November 2017 were enrolled. According to the third international consensus definitions for sepsis and septic shock (Sepsis-3), the patients were divided into non-sepsis group and sepsis group, and the septic patients were subdivided into general sepsis subgroup and septic shock subgroup according to the severity of disease...
July 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Itzhak Vitkon-Barkay, Tsilia Lazarovitch, Dror Marchaim, Ronit Zaidenstein, Elizabeth Temkin, Emily T Martin, Hannah E Segaloff, Ilya Litovchik, Victoria Rum, Chana Richter, Oran Tzuman, Zvi Vered, Saar Minha
A significant proportion of patients with acute myocardial infarction (AMI) also present with clinical manifestations of inflammatory response, which may be confused with a concomitant infection. This leads to a dilemma regarding the empiric use of antibiotics. We explored if serum procalcitonin (PCT), which is known to be elevated in bacterial infections, may be utilized to rule-out bacterial infection in AMI patients. In this prospective, single center study, PCT was collected within 48hours from AMI patients...
June 2, 2018: American Journal of Cardiology
Cyril Isenschmid, Jeanice Kalt, Martina Gamp, Theresa Tondorf, Christoph Becker, Kai Tisljar, Stefan Locher, Philipp Schuetz, Stephan Marsch, Sabina Hunziker
INTRODUCTION: Prognostication of cardiac arrest patients admitted to the intensive care unit (ICU) may influence treatment decision, but remains challenging. We evaluated the incremental usefulness of routine blood markers from different biological pathways for predicting fatal outcome and neurological deficits in cardiac arrest patients. METHODS: We prospectively included consecutive, adult cardiac arrest patients upon ICU admission. We recorded initial clinical parameters and measured blood markers of cardiac injury/stress (troponin, BNP, CK), inflammation/infection (WBC, CRP, procalcitonin) and shock (lactate, creatinine, urea)...
July 20, 2018: Resuscitation
B Kanashvili, K Saganelidze, L Ratiani
Recently, the role of biomarkers to assist in the diagnosis and management of infections has been extensively explored. Based on the studies, Procalcitonin and Blood Lactic Acid can provide supportive data to clinical assessment in Polytrauma induced infectious pathology prevention, early evaluation, management of complications and predicting outcomes. We studied the cases of 21 patients who developed Polytrauma induced Sepsis/Septic shock during different stages of hospitalization. We intended to study the dynamic level changes of Procalcitonin and Blood Lactic Acid in terms of Sepsis/Septic shock - induced by different types of trauma, in survived patients...
June 2018: Georgian Medical News
Kristian Berge, Magnus Nakrem Lyngbakken, Gunnar Einvik, Jacob A Winther, Jon Brynildsen, Ragnhild Røysland, Heidi Strand, Geir Christensen, Arne Didrik Høiseth, Torbjørn Omland, Helge Røsjø
BACKGROUND: Procalcitonin (PCT) concentrations increase during bacterial infections and could improve diagnosis of pneumonia and risk stratification in patients with acute dyspnea. METHODS: PCT concentrations were measured <24 h of admission in 310 patients with acute dyspnea and compared to C-reactive protein (CRP) and white blood cells (WBC) in the total cohort and the subset of patients with concomitant acute heart failure (HF). RESULTS: We diagnosed pneumonia in 16 out of 140 patients with acute HF (11%) and in 45 out of 170 patients with non-HF-related dyspnea (27%)...
July 17, 2018: Clinical Biochemistry
L Gai, Y Tong, B-Q Yan
OBJECTIVE: To investigate the diagnostic effect of procalcitonin level in serum for patients with sepsis due to different pathogenic causes. PATIENTS AND METHODS: The clinical data of 132 sepsis patients were analyzed. Those patients were admitted to the Affiliated Hospital of Medical School of Ningbo University from January 2014 to January 2017. According to the blood culture results before antimicrobial therapy, patients were divided into two groups: Gram-negative bacteria group (G- group) and Gram-positive bacteria group (G+ group)...
July 2018: European Review for Medical and Pharmacological Sciences
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