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("ECG" OR "EKG") AND "Brugada"

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https://www.readbyqxmd.com/read/30299600/rationale-and-design-of-the-eu-cert-icd-prospective-study-comparative-effectiveness-of-prophylactic-icd-implantation
#1
Markus Zabel, Christian Sticherling, Rik Willems, Andrzej Lubinski, Axel Bauer, Leonard Bergau, Frieder Braunschweig, Josep Brugada, Sandro Brusich, David Conen, Iwona Cygankiewicz, Panagiota Flevari, Milos Taborsky, Jim Hansen, Gerd Hasenfuß, Robert Hatala, Heikki V Huikuri, Svetoslav Iovev, Stefan Kääb, Gabriela Kaliska, Jaroslaw D Kasprzak, Lars Lüthje, Marek Malik, Tomas Novotny, Nikola Pavlović, Georg Schmidt, Tchavdar Shalganov, Rajeeva Sritharan, Simon Schlögl, Janko Szavits Nossan, Vassil Traykov, Anton E Tuinenburg, Vasil Velchev, Marc A Vos, Stefan N Willich, Tim Friede, Jesper Hastrup Svendsen, Béla Merkely
AIMS: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) aims to assess its current clinical value. METHODS AND RESULTS: The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries...
October 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30294671/marijuana-induced-type-i-brugada-pattern-a-case-report
#2
Pramod Theetha Kariyanna, Apoorva Jayarangaiah, Sudhanva Hegde, Jonathan D Marmur, Perry Wengrofsky, Mena Yacoub, Michael Post, Samy I McFarlane
Marijuana is the most common drug of abuse in the United States. Marijuana acts on cannabinoid receptors CB1, CB2 and another distinct endothelial receptor. Marijuana is known to cause tachycardia, hypotension and hypertension. Various arrhythmias including atrial fibrillation, atrial flutter, II degree AV block, ventricular fibrillation, ventricular tachycardia, asystole and brugada pattern associated with marijuana use have been reported. We here present an interesting case of Type I Brugada pattern in electrocardiography (ECG) in a 36 year old healthy African American male who presented after smoking four joints...
2018: American journal of medical case reports
https://www.readbyqxmd.com/read/30289750/deletion-in-mice-of-x-linked-brugada-syndrome-and-atrial-fibrillation-associated-kcne5-augments-ventricular-k-v-currents-and-predisposes-to-ventricular-arrhythmia
#3
Jens-Peter David, Ulrike Lisewski, Shawn M Crump, Thomas A Jepps, Elke Bocksteins, Nicola Wilck, Janine Lossie, Torsten K Roepke, Nicole Schmitt, Geoffrey W Abbott
KCNE5 is an X-linked gene encoding KCNE5, an ancillary subunit to voltage-gated potassium (KV ) channels. Human KCNE5 mutations are associated with atrial fibrillation (AF)- and Brugada syndrome (BrS)-induced cardiac arrhythmias that can arise from increased potassium current in cardiomyocytes. Seeking to establish underlying molecular mechanisms, we created and studied Kcne5 knockout ( Kcne5-/0 ) mice. Intracardiac ECG revealed that Kcne5 deletion caused ventricular premature beats, increased susceptibility to induction of polymorphic ventricular tachycardia (60 vs...
October 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30287239/characterization-of-electrocardiographic-findings-in-young-students
#4
Pau Vilardell, Josep Brugada, Jaime Aboal, Pablo Loma-Osorio, Carlos Falces, Rut Andrea, Marc Figueras-Coll, Ramon Brugada
INTRODUCTION AND OBJECTIVES: The resting 12-lead electrocardiogram (ECG) has been used in the evaluation of young asymptomatic individuals to detect pre-existing heart disease, but systematic ECG use is controversial and there are no data on this population in our environment. We aimed to determine the prevalence and spectrum of electrocardiographic findings in a population of secondary school students. METHODS: We conducted an observational, cross-sectional study of resting ECG findings in all 13 to 14-year-old secondary school students in a region of the province of Gerona between 2009 and 2017...
October 1, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/30279931/brugada-syndrome-unmasked-by-malaria-induced-fever
#5
Abdullah Cader, Sheldon M Singh, Mohammad I Zia
Brugada syndrome is typically an autosomal dominant genetic disorder with variable expression, characterized by three specific electrocardiogram (ECG) patterns. While Type I Brugada ECG pattern is used as a classic marker for the disease, it is generally masked from ECG except in special cases such as malaria-induced fever. This vignette highlights a unique clinical scenario that can lead to the unmasking of Brugada type 1 pattern. < Learning objective: Brugada syndrome is associated with ventricular arrhythmias which if left untreated can result in syncope or premature death...
October 2018: Journal of Cardiology Cases
https://www.readbyqxmd.com/read/30195842/multiple-serial-ecgs-aid-with-the-diagnosis-and-prognosis-of-brugada-syndrome
#6
Jesus Castro Hevia, Margarita Dorantes Sanchez, Frank Martinez Lopez, Osmin Castañeda Chirino, Roylan Falcon Rodriguez, Marcelo Puga Bravo, Joanna de Zayas Galguera, Charles Antzelevitch
BACKGROUND: A spontaneous coved-type ST segment elevation in the electrocardiogram (ECG) has long been recognized as a risk stratification tool in patients with Brugada syndrome (BrS). This Type-I ST segment elevation is known to exhibit high dynamicity, fluctuating between coved-type and non-coved ST segment elevation. Our objectives in this study were to: 1) Compare ECG parameters in patients with spontaneous coved-type (Type-I) vs. non-coved-type ST segment ECGs; 2) Determine the variability of these ECG parameters with repeated measurements; and 3) Assess the predictive value of ECG parameters in these two groups during follow-up...
August 30, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30193851/clinical-presentation-and-follow-up-of-women-affected-by-brugada-syndrome
#7
Pauline Berthome, Romain Tixier, Jean Briand, Olivier Geoffroy, Dominique Babuty, Jacques Mansourati, Laurence Jesel, Jean-Marc Dupuis, Paul Bru, Florence Kyndt, Béatrice Guyomarch, Aurélie Thollet, Nathalie Behar, Philippe Mabo, Frédéric Sacher, Vincent Probst, Jean-Baptiste Gourraud
BACKGROUND: Studies in Brugada syndrome (BrS) have mainly consisted of men. OBJECTIVE: The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women. METHODS: Consecutive BrS patients were enrolled from 1993 and followed prospectively. RESULTS: Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = ...
September 5, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30177327/inappropriate-icd-shock-due-to-hot-tub-induced-external-electrical-interference
#8
Mohammad Shenasa, Shahriar Heidary, Hossein Shenasa
BACKGROUND: A 72-year-old white male with a history of rapid nonsustained ventricular tachycardia, hypertrophic cardiomyopathy, and intermittent Brugada-type ECG had a single-lead implantable cardioverter-defibrillator (ICD) implantation and received a sudden ICD shock while in the hot tub. To the best of our knowledge this is the first case report of hot tub jet-induced inappropriate ICD shock. METHODS: ICD interrogation and analysis of intracardiac electrograms and event markers...
September 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30167021/development-of-monomorphic-ventricular-tachycardia-in-a-patient-with-fever-induced-brugada-syndrome
#9
Yuriko Sato, Yoshiyasu Aizawa, Taishi Fujisawa, Shogo Ito, Kousuke Katano, Nozomi Fuse, Akira Miyabe, Kimihiro Osada, Ryuuma Ishihara, Atushi Tosaka, Toshitake Tamamura, Taisuke Mizumura, Youichi Sugimura, Kazuaki Nakajima, Yoshinori Katsumata, Takahiko Nishiyama, Takehiro Kimura, Yoshiko Furukawa, Seiji Takatsuki, Kenjiro Kosaki, Keiichi Fukuda
A 50-year-old woman visited the emergency department with a high fever due to pneumonia. Incessant monomorphic ventricular tachycardia occurred and was terminated by intravenous lidocaine. Her ECG during sinus rhythm demonstrated ST segment elevation suggestive of Brugada syndrome (BS). An intensive examination could not detect any structural disease, and typical coved-type ST elevation was unmasked by a pilsicainide injection leading to a diagnosis of BS. An ICD was implanted for secondary prevention of ventricular arrhythmia...
August 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/30147658/calcium-in-brugada-syndrome-questions-for-future-research
#10
REVIEW
Michelle M Monasky, Carlo Pappone, Marco Piccoli, Andrea Ghiroldi, Emanuele Micaglio, Luigi Anastasia
The Brugada syndrome (BrS) is characterized by coved-type ST-segment elevation in the right precordial leads on the electrocardiogram (ECG) and increased risk of sudden cardiac death (SCD). While it is an inheritable disease, determining the true prevalence is a challenge, since patients may report no known family history of the syndrome, present with a normal spontaneous ECG pattern at the time of examination, and test negative for all known BrS-causative genes. In fact, SCD is often the first indication that a person is affected by the syndrome...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30125716/continuous-monitoring-after-second-generation-cryoballoon-ablation-for-paroxysmal-atrial-fibrillation-in-patients-with-cardiac-implantable-electronic-devices
#11
Rajin Choudhury, Hugo-Enrique Coutino, Radu Darciuc, Erwin Ströker, Valentina De Regibus, Giacomo Mugnai, Gaetano Paparella, Muryio Terasawa, Varnavas Varnavas, Francesca Salghetti, Saverio Iacopino, Ken Takarada, Juan-Pablo Abugattas, Juan Sieira, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
BACKGROUND: The second-generation cryoballoon (CB) is effective in achieving pulmonary vein isolation. Continuous monitoring would eliminate any over- or underestimated freedom from atrial fibrillation (AF) postablation. OBJECTIVE: The purpose of this study was to differentiate between arrhythmias occurring after cryoballoon ablation (CBA), detecting true AF in symptomatic patients and detecting silent subclinical AF. METHODS: Between June 2012 and January 2015, 54 patients with a preexisting cardiac implantable electronic device (CIED) who had undergone CBA for paroxysmal atrial fibrillation (PAF) were included in our retrospective study...
August 18, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/30118535/tpte-and-tpte-qt-novel-markers-to-predict-sudden-cardiac-death-in-esrd
#12
Basil M Saour, Jeffrey H Wang, Michael P Lavelle, Roy O Mathew, Mandeep S Sidhu, William E Boden, Joseph D Sacco, Eric J Costanzo, Mohammad A Hossain, Tuhsar Vachharanji, Anas Alrefaee, Arif Asif
INTRODUCTION: Reliable markers to predict sudden cardiac death (SCD) in patients with end stage renal disease (ESRD) remain elusive, but echocardiogram (ECG) parameters may help stratify patients. Given their roles as markers for myocardial dispersion especially in high risk populations such as those with Brugada syndrome, we hypothesized that the Tpeak to Tend (TpTe) interval and TpTe/QT are independent risk factors for SCD in ESRD. METHODS: Retrospective chart review was conducted on a cohort of patients with ESRD starting hemodialysis...
August 16, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/30116678/brugada-syndrome-the-role-of-risk-stratification-in-selecting-patients-for-implantable-cardioverter-defibrillator-placement
#13
REVIEW
Michael Mankbadi, Samira Hassan, Michelle McGee, Bonnie Jan, Sibani Mangal, Jake Altier, Manjunath Harlapur
Brugada syndrome (BS) is an inherited cardiac ion channelopathy that is a rare, but treatable, cause of sudden cardiac death (SCD). There are many studies that explore the management of symptomatic BS, but few trials have been conducted regarding management of asymptomatic Brugada patients. Asymptomatic BS patients are shown to be at increased risk (0.5%-1.5%) for SCD compared to the general population and account for nearly 20% of deaths from SCD in patients with structurally normal hearts. Treatment for asymptomatic BS patients is often debated with the current guidelines allowing for management decisions to be made on a case-by-case basis...
June 13, 2018: Curēus
https://www.readbyqxmd.com/read/30094117/syncopal-episodes-of-arrhythmogenic-right-ventricular-cardiomyopathy-in-a-patient-with-pre-existing-seizure-disorder
#14
James R Kimber, Syed Rafay Ali Sabzwari, Hiwot Ayele
Arrhythmogenic right ventricular cardiomyopathy (ARVC), is a heritable condition that is an important, and under-recognized cause of sudden cardiac death. Microscopically, it is represented by fibrofatty replacement of myocardium involving the right ventricular inflow area, apex, and infundibulum. Common clinical manifestations of ARVC include palpitations, syncope, chest pain, dyspnea, and sudden cardiac death. This is a case of a 25-year-old male with a history of thalassemia, and tonic-clonic seizure status post head trauma with cystic encephalomalacia in left parietal lobe who described recurrent syncope...
June 7, 2018: Curēus
https://www.readbyqxmd.com/read/30094109/a-case-of-brugada-pattern-associated-with-adrenal-insufficiency
#15
Corina Iorgoveanu, Ahmed Zaghloul, Aakash Desai, Kathir Balakumaran, Muhammad Y Adeel
Brugada syndrome (BrS) is an inherited channelopathy disease, caused by genetic changes in transmembrane ion channels. It has an increased risk of sudden cardiac death (SCD) in the absence of a structural heart disease. We report a case in which the presenting electrocardiogram (EKG) exhibited a type 1 Brugada-like pattern during an adrenal crisis with transformation into a type 2 Brugada-like pattern as the crisis improved.
June 6, 2018: Curēus
https://www.readbyqxmd.com/read/30067493/general-anesthesia-attenuates-brugada-syndrome-phenotype-expression-clinical-implications-from-a-prospective-clinical-trial
#16
Giuseppe Ciconte, Vincenzo Santinelli, Josep Brugada, Gabriele Vicedomini, Manuel Conti, Michelle M Monasky, Valeria Borrelli, Walter Castracane, Tommaso Aloisio, Luigi Giannelli, Umberto Di Dedda, Paolo Pozzi, Marco Ranucci, Carlo Pappone
OBJECTIVES: This study investigates the electrocardiographic-electrophysiological effects of administration of anesthetic drugs for general anesthesia (GA) in patients with BrS at high risk of sudden cardiac death (SCD). BACKGROUND: The safety of anesthetic agents in Brugada syndrome (BrS) is under debate. METHODS: All consecutive patients with spontaneous type 1 BrS electrocardiographic (ECG) patterns undergoing epicardial ablation of the arrhythmogenic substrate (AS) under GA were enrolled...
April 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30042696/brugada-syndrome-associated-genetic-loci-are-associated-with-j-point-elevation-and-an-increased-risk-of-cardiac-arrest
#17
Laura Andreasen, Jonas Ghouse, Morten W Skov, Christian T Have, Gustav Ahlberg, Peter V Rasmussen, Allan Linneberg, Oluf Pedersen, Pyotr G Platonov, Stig Haunsø, Jesper H Svendsen, Torben Hansen, Jørgen K Kanters, Morten S Olesen
Introduction: A previous genome-wide association study found three genetic loci, rs9388451, rs10428132, and rs11708996, to increase the risk of Brugada Syndrome (BrS). Since the effect of these loci in the general population is unknown, we aimed to investigate the effect on electrocardiogram (ECG) parameters and outcomes in the general population. Materials and Methods: A cohort of 6,161 individuals (median age 45 [interquartile range (IQR) 40-50] years, 49% males), with available digital ECGs, was genotyped and subsequently followed for a median period of 13 [IQR 12...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30009404/interventricular-differences-in-sodium-current-and-its-potential-role-in-brugada-syndrome
#18
Kirstine Calloe, Gary L Aistrup, José M Di Diego, Robert J Goodrow, Jacqueline A Treat, Jonathan M Cordeiro
Brugada syndrome (BrS) is an inherited disease associated with ST elevation in the right precordial leads, polymorphic ventricular tachycardia (PVT), and sudden cardiac death in adults. Mutations in the cardiac sodium channel account for a large fraction of BrS cases. BrS manifests in the right ventricle (RV), which led us to examine the biophysical and molecular properties of sodium channel in myocytes isolated from the left (LV) and right ventricle. Patch clamp was used to record sodium current (INa ) in single canine RV and LV epicardial (epi) and endocardial (endo) myocytes...
July 2018: Physiological Reports
https://www.readbyqxmd.com/read/29997009/a-novel-three-base-pair-deletion-in-domain-two-of-the-cardiac-sodium-channel-causes-brugada-syndrome
#19
Boon Yew Tan, Luokai Wang, Mahesh Uttamchandani, Hector Barajas-Martinez, Robert Dumaine, Nathalie Morin, Chi Keong Ching, Kah Leng Ho, Daniel Thuan Tee Chong, Weien Chow, Eric Peng Huat Yap, Shabbir Moochhala, Dan Hu, Rita Yu Yin Yong, Wee Siong Teo
INTRODUCTION: Mutations within SCN5A are found in a significant proportion (15-30%) of Brugada syndrome (BrS) cases and impair sodium transport across excitable cardiac cells that mediate ventricular contractions. Genetic testing offers a means to clinically assess and manage affected individuals and their family members. METHODS AND RESULTS: The proband at age 44 years old exhibited a syncopal event during exercise, and presented later with a spontaneous type-I BrS pattern on 12‑lead resting electrocardiogram (ECG)...
July 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29986018/first-degree-atrioventricular-block-on-basal-electrocardiogram-predicts-future-arrhythmic-events-in-patients-with-brugada-syndrome-a-long-term-follow-up-study-from-the-veneto-region-of-northeastern-italy
#20
Federico Migliore, Martina Testolina, Alessandro Zorzi, Emanuele Bertaglia, Maria Silvano, Loira Leoni, Anna Bellin, Cristina Basso, Gaetano Thiene, Giuseppe Allocca, Pietro Delise, Sabino Iliceto, Domenico Corrado
Aims: This study was designed to assess the prognostic value of clinical and electrocardiographic parameters in Brugada syndrome (BrS). Methods and results: The study population included 272 consecutive patients (82% males; mean age 43 ± 12 years), with either a spontaneous (n = 137, 50%) or drug-induced (n = 135, 50%) Type 1 Brugada electrocardiogram (ECG) pattern. The study combined endpoint included sudden cardiac death (SCD), cardiac arrest, and appropriate intervention of implantable cardioverter-defibrillator (ICD)...
July 6, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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