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("ECG" OR "EKG") AND "Brugada"

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https://www.readbyqxmd.com/read/30094117/syncopal-episodes-of-arrhythmogenic-right-ventricular-cardiomyopathy-in-a-patient-with-pre-existing-seizure-disorder
#1
James R Kimber, Syed Rafay Ali Sabzwari, Hiwot Ayele
Arrhythmogenic right ventricular cardiomyopathy (ARVC), is a heritable condition that is an important, and under-recognized cause of sudden cardiac death. Microscopically, it is represented by fibrofatty replacement of myocardium involving the right ventricular inflow area, apex, and infundibulum. Common clinical manifestations of ARVC include palpitations, syncope, chest pain, dyspnea, and sudden cardiac death. This is a case of a 25-year-old male with a history of thalassemia, and tonic-clonic seizure status post head trauma with cystic encephalomalacia in left parietal lobe who described recurrent syncope...
June 7, 2018: Curēus
https://www.readbyqxmd.com/read/30094109/a-case-of-brugada-pattern-associated-with-adrenal-insufficiency
#2
Corina Iorgoveanu, Ahmed Zaghloul, Aakash Desai, Kathir Balakumaran, Muhammad Y Adeel
Brugada syndrome (BrS) is an inherited channelopathy disease, caused by genetic changes in transmembrane ion channels. It has an increased risk of sudden cardiac death (SCD) in the absence of a structural heart disease. We report a case in which the presenting electrocardiogram (EKG) exhibited a type 1 Brugada-like pattern during an adrenal crisis with transformation into a type 2 Brugada-like pattern as the crisis improved.
June 6, 2018: Curēus
https://www.readbyqxmd.com/read/30067493/general-anesthesia-attenuates-brugada-syndrome-phenotype-expression-clinical-implications-from-a-prospective-clinical-trial
#3
Giuseppe Ciconte, Vincenzo Santinelli, Josep Brugada, Gabriele Vicedomini, Manuel Conti, Michelle M Monasky, Valeria Borrelli, Walter Castracane, Tommaso Aloisio, Luigi Giannelli, Umberto Di Dedda, Paolo Pozzi, Marco Ranucci, Carlo Pappone
OBJECTIVES: This study investigates the electrocardiographic-electrophysiological effects of administration of anesthetic drugs for general anesthesia (GA) in patients with BrS at high risk of sudden cardiac death (SCD). BACKGROUND: The safety of anesthetic agents in Brugada syndrome (BrS) is under debate. METHODS: All consecutive patients with spontaneous type 1 BrS electrocardiographic (ECG) patterns undergoing epicardial ablation of the arrhythmogenic substrate (AS) under GA were enrolled...
April 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30042696/brugada-syndrome-associated-genetic-loci-are-associated-with-j-point-elevation-and-an-increased-risk-of-cardiac-arrest
#4
Laura Andreasen, Jonas Ghouse, Morten W Skov, Christian T Have, Gustav Ahlberg, Peter V Rasmussen, Allan Linneberg, Oluf Pedersen, Pyotr G Platonov, Stig Haunsø, Jesper H Svendsen, Torben Hansen, Jørgen K Kanters, Morten S Olesen
Introduction: A previous genome-wide association study found three genetic loci, rs9388451, rs10428132, and rs11708996, to increase the risk of Brugada Syndrome (BrS). Since the effect of these loci in the general population is unknown, we aimed to investigate the effect on electrocardiogram (ECG) parameters and outcomes in the general population. Materials and Methods: A cohort of 6,161 individuals (median age 45 [interquartile range (IQR) 40-50] years, 49% males), with available digital ECGs, was genotyped and subsequently followed for a median period of 13 [IQR 12...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30009404/interventricular-differences-in-sodium-current-and-its-potential-role-in-brugada-syndrome
#5
Kirstine Calloe, Gary L Aistrup, José M Di Diego, Robert J Goodrow, Jacqueline A Treat, Jonathan M Cordeiro
Brugada syndrome (BrS) is an inherited disease associated with ST elevation in the right precordial leads, polymorphic ventricular tachycardia (PVT), and sudden cardiac death in adults. Mutations in the cardiac sodium channel account for a large fraction of BrS cases. BrS manifests in the right ventricle (RV), which led us to examine the biophysical and molecular properties of sodium channel in myocytes isolated from the left (LV) and right ventricle. Patch clamp was used to record sodium current (INa ) in single canine RV and LV epicardial (epi) and endocardial (endo) myocytes...
July 2018: Physiological Reports
https://www.readbyqxmd.com/read/29997009/a-novel-three-base-pair-deletion-in-domain-two-of-the-cardiac-sodium-channel-causes-brugada-syndrome
#6
Boon Yew Tan, Luokai Wang, Mahesh Uttamchandani, Hector Barajas-Martinez, Robert Dumaine, Nathalie Morin, Chi Keong Ching, Kah Leng Ho, Daniel Thuan Tee Chong, Weien Chow, Eric Peng Huat Yap, Shabbir Moochhala, Dan Hu, Rita Yu Yin Yong, Wee Siong Teo
INTRODUCTION: Mutations within SCN5A are found in a significant proportion (15-30%) of Brugada syndrome (BrS) cases and impair sodium transport across excitable cardiac cells that mediate ventricular contractions. Genetic testing offers a means to clinically assess and manage affected individuals and their family members. METHODS AND RESULTS: The proband at age 44 years old exhibited a syncopal event during exercise, and presented later with a spontaneous type-I BrS pattern on 12‑lead resting electrocardiogram (ECG)...
July 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29986018/first-degree-atrioventricular-block-on-basal-electrocardiogram-predicts-future-arrhythmic-events-in-patients-with-brugada-syndrome-a-long-term-follow-up-study-from-the-veneto-region-of-northeastern-italy
#7
Federico Migliore, Martina Testolina, Alessandro Zorzi, Emanuele Bertaglia, Maria Silvano, Loira Leoni, Anna Bellin, Cristina Basso, Gaetano Thiene, Giuseppe Allocca, Pietro Delise, Sabino Iliceto, Domenico Corrado
Aims: This study was designed to assess the prognostic value of clinical and electrocardiographic parameters in Brugada syndrome (BrS). Methods and results: The study population included 272 consecutive patients (82% males; mean age 43 ± 12 years), with either a spontaneous (n = 137, 50%) or drug-induced (n = 135, 50%) Type 1 Brugada electrocardiogram (ECG) pattern. The study combined endpoint included sudden cardiac death (SCD), cardiac arrest, and appropriate intervention of implantable cardioverter-defibrillator (ICD)...
July 6, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29967687/pharmacological-therapy-in-brugada-syndrome
#8
REVIEW
Oholi Tovia Brodie, Yoav Michowitz, Bernard Belhassen
Brugada syndrome (BrS) is a cardiac disease caused by an inherited ion channelopathy associated with a propensity to develop ventricular fibrillation. Implantable cardioverter defibrillator implantation is recommended in BrS, based on the clinical presentation in the presence of diagnostic ECG criteria. Implantable cardioverter defibrillator implantation is not always indicated or sufficient in BrS, and is associated with a high device complication rate. Pharmacological therapy aimed at rebalancing the membrane action potential can prevent arrhythmogenesis in BrS...
June 2018: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/29967678/risk-stratification-in-brugada-syndrome-current-status-and-emerging-approaches
#9
REVIEW
Shohreh Honarbakhsh, Rui Providencia, Pier D Lambiase
Brugada syndrome (BrS) is one of the most common inherited channelopathies associated with an increased risk of sudden cardiac death. Appropriate use of an ICD in high-risk patients is life-saving. However, there remains a lack of consensus on risk stratification, and even on the diagnosis of BrS itself. Some argue that people with a type 1 Brugada ECG pattern but no symptoms should not be diagnosed with BrS, and guidelines recommend observation without therapy in these patients. Others argue that the presence of a spontaneous (rather than drug-induced) type 1 ECG pattern alone is enough to label them as high-risk for arrhythmic events, particularly if syncope is also present...
June 2018: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/29961460/brugada-syndrome-in-patients-with-acute-febrile-illness
#10
Stalin Viswanathan, Rajeswari Aghoram
BACKGROUND: Brugada syndrome (BrS) is an inherited electroclinical syndrome and can be occasionally precipitated by fever. The prevalence of Brugada-type electrocardiographic patterns (BTEP) due to febrile illnesses have not been previously studied in India. MATERIALS AND METHODS: Between June 2014 and December 2015, 525 consecutive patients admitted to a government hospital with acute febrile illness were retrospectively enrolled. In addition to their investigations for workup of fever, ECGs were analyzed and BTEP types 1 and 2 were noted...
May 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29953954/progression-of-electrocardiographic-abnormalities-associated-with-initial-ventricular-fibrillation-in-asymptomatic-patients-with-brugada-syndrome
#11
Hiroshi Morita, Masakazu Miyamoto, Atsuyuki Watanabe, Saori Tsukuda, Yoshimasa Morimoto, Satoshi Kawada, Koji Nakagawa, Nobuhiro Nishii, Hiroshi Ito
BACKGROUND: Various risk stratifications in asymptomatic patients with Brugada syndrome (BrS) have been proposed, but the electrophysiological change that promotes ventricular fibrillation (VF) is still unknown. OBJECTIVE: The aim of this study was to clarify the changes in electrocardiographic (ECG) markers at the onset of VF from ECGs recorded when patients were still asymptomatic. METHODS: The subjects of this study included 14 patients with VF and 48 consecutive asymptomatic patients with BrS...
June 25, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29953624/coexistence-of-atrioventricular-accessory-pathways-and-drug-induced-type-1-brugada-pattern
#12
Can Hasdemir, Jimmy Jyh-Ming Juang, Sedat Kose, Umut Kocabas, Mehmet N Orman, Serdar Payzin, Hatice Sahin, Candan Celen, Emin E Ozcan, Ching-Yu Julius Chen, Ramazan Gunduz, Oguzhan E Turan, Oktay Senol, Elena Burashnikov, Charles Antzelevitch
BACKGROUND: Atrial arrhythmias, particularly atrioventricular nodal reentrant tachycardia, can coexist with drug-induced type 1 Brugada electrocardiogram (ECG) pattern (DI-Type1-BrP). The present study was designed to determine the prevalence of DI-Type1-BrP in patients with atrioventricular accessory pathways (AV-APs) and to investigate the clinical, electrocardiographic, electrophysiologic, and genetic characteristics of these patients. METHODS: One-hundred twenty-four consecutive cases of AV-APs and 84 controls underwent an ajmaline challenge test to unmask DI-Type1-BrP...
June 28, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29910587/brugada-syndrome-in-a-4-year-old-child-with-lemierre-syndrome-a-case-report
#13
Sami Alanazi, Hussain Moafa, Faleh Al-Qahtani, Tahir Hameed
Brugada syndrome is a rare arrhythmogenic disease with characteristic electrocardiogram (ECG) findings. Fever represents an important triggering factor. We report the case of a 4-year-old Saudi boy who was diagnosed with Lemierre syndrome and subsequently developed Brugada syndrome.
April 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29908370/gender-differences-in-patients-with-brugada-syndrome-and-arrhythmic-events-data-from-a-survey-on-arrhythmic-events-in-678-patients
#14
Anat Milman, Jean-Baptiste Gourraud, Antoine Andorin, Pieter G Postema, Frederic Sacher, Philippe Mabo, Giulio Conte, Carla Giustetto, Georgia Sarquella-Brugada, Aviram Hochstadt, Sung-Hwan Kim, Jimmy J M Juang, Shingo Maeda, Yoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Eran Leshem, Yoav Michowitz, Michael Rahkovich, Yuka Mizusawa, Elena Arbelo, Zhengrong Huang, Isabelle Denjoy, Yanushi D Wijeyeratne, Carlo Napolitano, Ramon Brugada, Ruben Casado-Arroyo, Jean Champagne, Leonardo Calo, Jacob Tfelt-Hansen, Silvia G Priori, Masahiko Takagi, Christian Veltmann, Pietro Delise, Domenico Corrado, Elijah R Behr, Fiorenzo Gaita, Gan-Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A M Wilde, Pedro Brugada, Kengo F Kusano, Kenzo Hirao, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen
BACKGROUND: There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE: The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in BrS patients with their first AE. METHODS: The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 BrS patients including 619 males (91...
June 13, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29899727/flecainide-induced-brugada-syndrome-in-a-patient-with-skeletal-muscle-sodium-channelopathy-a-case-report-with-critical-therapeutical-implications-and-review-of-the-literature
#15
Michele Cavalli, Barbara Fossati, Raffaele Vitale, Elisa Brigonzi, Vito A G Ricigliano, Lorenzo Saraceno, Rosanna Cardani, Carlo Pappone, Giovanni Meola
Skeletal muscle sodium channelopathies are a group of neuromuscular disorders associated with mutations in the SCN4A gene. Because principal sodium channel isoforms expressed in the skeletal muscles and the heart are distinct one from the other, this condition usually spares cardiac functioning. Nonetheless, evidence on a possible link between skeletal muscle and cardiac sodium channelopathies has emerged in recent years. To date, eight patients bearing pathogenetic mutations in the SCN4A gene and manifesting cardiac electrophysiological alterations have been reported in literature...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29898017/cohort-of-patients-referred-for-brugada-syndrome-investigation-in-an-electrophysiology-service-19-year-registry
#16
Stefan Warpechowski Neto, Tiago Luiz Luz Leiria, Laura Lessa Gaudie Ley, Antonio Lessa Gaudie Ley, Luiza Zwan Dutra, Leonardo Martins Pires, Marcelo Lapa Kruse, Gustavo Glotz de Lima
BACKGROUND: Brugada syndrome (SBr) is an arrhythmic condition characterized by ST-T segment abnormalities in the right precordial leads associated with a high risk of ventricular arrhythmias and sudden death. Local data regarding the clinical characteristics of patients with a typical electrocardiographic (ECG) pattern undergoing electrophysiological study are scarce. OBJECTIVE: To evaluate patients with an ECG pattern suggestive of SBr referred for electrophysiological evaluation in a specialized center...
June 11, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29887371/risk-of-sudden-unexplained-death-after-use-of-dihydroartemisinin-piperaquine-for-malaria-a-systematic-review-and-bayesian-meta-analysis
#17
Xin Hui S Chan, Yan Naung Win, Laura J Mawer, Jireh Y Tan, Josep Brugada, Nicholas J White
BACKGROUND: Dihydroartemisinin-piperaquine is an effective and well tolerated artemisinin-based combination therapy that has been assessed extensively for the prevention and treatment of malaria. Piperaquine, similar to several structurally related antimalarials currently used, can prolong cardiac ventricular repolarisation duration and the electrocardiographic QT interval, leading to concerns about its proarrhythmic potential. We aimed to assess the risk of potentially lethal iatrogenic ventricular arrhythmias in individuals receiving dihydroartemisinin-piperaquine...
August 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29876505/high-risk-electrocardiographic-markers-in-brugada-syndrome
#18
REVIEW
Dimitrios Asvestas, Gary Tse, Adrian Baranchuk, George Bazoukis, Tong Liu, Athanasios Saplaouras, Panagiotis Korantzopoulos, Christina Goga, Michael Efremidis, Antonios Sideris, Konstantinos P Letsas
Several clinical, electrocardiographic (ECG) and electrophysiological markers have been proposed to provide optimal risk stratification in patients with Brugada syndrome (BrS). Of the different markers, only a spontaneous type 1 ECG pattern has clearly shown a sufficiently high predictive value. This review article highlights specific ECG markers based on depolarization and/or repolarization that have been associated with an increased risk of arrhythmic events in patients with BrS.
March 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29868131/dka-induced-brugada-phenocopy-mimicking-stemi
#19
Christian Abrahim, Satish Maharaj
Case presentation: A 47-year-old Caucasian woman with type 1 diabetes presented with epigastric pain and vomiting. She had not been adherent with her diet and insulin therapy for the past 3 weeks. She never had a personal or family history of arrhythmia-related symptoms, ventricular tachycardia or fibrillation (VT/VF) or premature sudden cardiac death (SCD). Examination revealed dry mucosa, tachycardia and epigastric tenderness to palpation. Her ECG showed ST elevations (V1-V3) with associated T wave inversions (figure 1A)...
2018: Heart Asia
https://www.readbyqxmd.com/read/29868128/cardiac-events-occurred-commonly-among-apparently-healthy-filipinos-with-the-brugada-ecg-pattern-in-the-lifecare-cohort
#20
Giselle G Gervacio, Jaime Alfonso Manalo Aherrera, Rody G Sy, Lauro L Abrahan Iv, Michael Joseph Agbayani, Felix Eduardo Punzalan, Elmer Jasper B Llanes, Paul Ferdinand M Reganit, Olivia T Sison, E Shyong Tai, Felicidad V Velandria, Allan Gumatay, Nina T Castillo-Carandang
Background: Brugada syndrome is the mechanism for sudden unexplained death. The Brugada ECG pattern is found in 2% of Filipinos. There is a knowledge gap on the clinical outcome of these individuals. The clinical profile and 5-year cardiac event rate of individuals with the Brugada ECG pattern were determined in this cohort. Methods: This is a sub-study of LIFECARE (Life Course Study in Cardiovascular Disease Epidemiology), a community based cohort enrolling healthy individuals 20 to 50 years old conducted in 2009-2010...
2018: Heart Asia
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