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("ECG" OR "EKG") AND "Brugada"

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https://www.readbyqxmd.com/read/30497756/brugada-phenocopy-associated-with-left-ventricular-aneurysm
#1
Enes Elvin Gul, Sohaib Haseeb, Osama Al Amoudi, Adrian Baranchuk
Brugada phenocopies (BrP) are clinical entities that are characterized by ECG patterns identical to those of Brugada syndrome, but are the result of various clinical conditions. We describe the case of a 41-year-old male who exhibited BrP due to a left ventricular aneurysm in the context of chronic coronary artery disease.
November 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30497742/type-1-brugada-phenocopy-in-a-patient-with-acute-pericarditis
#2
Manli Yu, Qin Zhang, Xinmiao Huang, Xianxian Zhao
We herein describe a case of an acute pericarditis, in which type 1 Brugada phenocopy (BrP) was documented. The patient was referred to our hospital due to severe chest pain. The twelve-lead electrocardiogram (ECG) on admission showed type 1 Brugada ECG pattern (coved-type) in the precordial leads. Echocardiography only showed mild pericardial effusion. However, his ST segment elevation returned to normal and chest discomfort disappeared 3 weeks later. Our report addresses the possibility that the coved-type ST-segment elevation cannot be a sensitive finding for Brugada syndrome (BrS)...
November 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30462974/-analysis-of-risk-factors-of-ventricular-arrhythmia-in-patients-with-brugada-syndrome
#3
T T Shen, J Geng, B B Yuan, C Chen, X J Zhou, Q J Shan
Objective: To investigate the risk factors of ventricular arrhythmias in patients with Brugada syndrome. Methods: Clinical data of 60 Brugada syndrome patients admitted in the department of cardiology of the First Affiliated Hospital of Nanjing Medical University from March 2003 to December 2016 were collected and retrospectively analyzed. The age at diagnosis was (43.2±13.1) years (0.6-83.0 years), 98.3% were males ( n= 59), and the patients were followed up to (92±41) months (12-169 months). The 12-lead surface electrocardiogram (ECG) recorded at the time of diagnosis and showing the highest type 1 ST elevation, either spontaneously or after provocative drug test, was used for the analysis...
November 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/30460246/electrophysiological-basis-for-early-repolarization-syndrome
#4
REVIEW
Rubén Casado Arroyo, Juan Sieira, Maciej Kubala, Decebal Gabriel Latcu, Shigo Maeda, Pedro Brugada
During last centuries, Early Repolarization pattern has been interpreted as an ECG manifestation not linked to serious cardiovascular events. This view has been challenged on the basis of sporadic clinical observations that linked the J-wave with ventricular arrhythmias and sudden cardiac death. The particular role of this characteristic pattern in initiating ventricular fibrillation has been sustained by clinical descriptions of a marked and consistent J-wave elevation preceding the onset of the ventricular arrhythmia...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30446243/arrhythmogenic-cardiomyopathy-in-2018-arvc-alvc-or-both
#5
REVIEW
Richard G Bennett, Haris M Haqqani, Antonio Berruezo, Paolo Della Bella, Francis E Marchlinski, Chi-Jen Hsu, Saurabh Kumar
Arrhythmogenic cardiomyopathy (ACM) is now commonly used to describe any form of non-hypertrophic, progressive cardiomyopathy characterised by fibrofatty infiltration of the ventricular myocardium. Right ventricular (RV) involvement refers to the classical arrhythmogenic right ventricular cardiomyopathy, but left ventricular, or bi-ventricular involvement are now recognised. ACM is mostly hereditary and associated with mutations in genes encoding proteins of the intercalated disc. ACM classically manifests as ventricular arrhythmias, and sudden death may be the first presentation of the disease...
October 24, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/30415983/brugada-pattern-exposed-with-administration-of-amiodarone-during-emergent-treatment-of-ventricular-tachycardia
#6
Douglas Robinson, Gregory Hand, Jason Ausman, Anthony Hackett
BACKGROUND: Brugada pattern is a well-known pathological finding on electrocardiogram (ECG) which increases the likelihood of cardiac arrest due to ventricular arrhythmia. These cases generally present in younger patients without evidence of an electrolyte abnormality, structural heart disease, or cardiac ischemia. In many instances, this pattern is either hidden on initial presentation or presents as an incidental finding on an EKG. Often times the Brugada syndrome leads to sudden cardiac death or more rarely can be unmasked with a class 1A or 1C anti-arrhythmic agent...
October 23, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30415571/-ecg-pearl-the-brugada-sign-case-report
#7
János Tomcsányi
An Asian patient was admitted with palpitation. The ECG showed coved-shaped type Brugada pattern with QRS-fragmentations. Early recognition and risk stratification are the most important issues in Brugada syndrome. Orv Hetil. 2018; 159(45): 1848-1850.
November 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/30389905/brugada-syndrome-manifesting-only-during-fever-in-patient-with-septic-shock-secondary-to-post-obstructive-pneumonia
#8
Kristopher S Pfirman, Corey A White, Abiy Kelil, Hemant C Modi
BACKGROUND Brugada syndrome is a cardiac disorder associated with sudden death due to sodium channelopathy, most commonly the SCN5a mutation. There are 3 different patterns of electrocardiogram (ECG) changes characterized as type I, II, and III. ECG patterns consist of variations of incomplete RBBB and ST elevation in anterior precordial leads only. Treatment, if warranted, consists of implantable cardioverter-defibrillator. CASE REPORT A 63-year-old male presented with abdominal pain for 4 days that was persistent, and after further imaging, he was found to have hepatic metastases from a stage IV small cell carcinoma of the lung...
November 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/30389366/channelopathies-that-lead-to-sudden-cardiac-death-clinical-and-genetic-aspects
#9
REVIEW
Jonathan R Skinner, Annika Winbo, Dominic Abrams, Jitendra Vohra, Arthur A Wilde
Forty per cent (40%) of sudden unexpected natural deaths in people under 35 years of age are associated with a negative autopsy, and the cardiac ion channelopathies are the prime suspects in such cases. Long QT syndrome (LQTS), Brugada syndrome (BrS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) are the most commonly identified with genetic testing. The cellular action potential driving the heart cycle is shaped by a specific series of depolarising and repolarising ion currents mediated by ion channels...
October 4, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/30354308/efficacy-of-endocardial-ablation-of-drug-resistant-ventricular-fibrillation-in-brugada-syndrome
#10
Ahmed Karim Talib, Masahiko Takagi, Akira Shimane, Makoto Nakano, Tatsuya Hayashi, Katsunori Okajima, Minami Kentaro, Koji Fukada, Shinya Kowase, Kenji Kurosaki, Junichi Nitta, Mitsushiro Nishizaki, Yoshiaki Yui, Ali Talib, Nobuyuki Sato, Yuichiro Kawamura, Naoyuki Hasebe, Satoshi Aita, Eikou Sai, Yuki Komatsu, Kenji Kuroki, Takashi Kaneshiro, Xu Dongzu, Kazuko Tajiri, Miyako Igarashi, Hiro Yamasaki, Nobuyuki Murakoshi, Koji Kumagai, Yukio Sekiguchi, Akihiko Nogami, Kazutaka Aonuma
Background Both endocardial trigger elimination and epicardial substrate modification are effective in treating ventricular fibrillation (VF) in Brugada syndrome. However, the primary approach and the characteristics of patients who respond to endocardial ablation remain unknown. Methods Among 123 symptomatic Brugada syndrome patients (VF, 63%; syncope, 37%), ablation was performed in 21 VF/electrical storm patients, the majority of whom were resistant to antiarrhythmic drugs. Results Careful endocardial mapping revealed that 81% of the patients had no specific findings, whereas 19% of the patients, who experienced the most frequent VF episodes with notching of the QRS in lead V1 , had delayed low-voltage fractionated endocardial electrograms...
August 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30338262/higher-dispersion-measures-of-conduction-and-repolarization-in-type-1-compared-to-non-type-1-brugada-syndrome-patients-an-electrocardiographic-study-from-a-single-center
#11
Gary Tse, Ka Hou Christien Li, Guangping Li, Tong Liu, George Bazoukis, Wing Tak Wong, Matthew T V Chan, Martin C S Wong, Yunlong Xia, Konstantinos P Letsas, Gary Chin Pang Chan, Yat Sun Chan, William K K Wu
Background: Brugada syndrome (BrS) is a cardiac ion channelopathy that predisposes affected individuals to sudden cardiac death (SCD). Type 1 BrS is thought to take a more malignant clinical course than non-type 1 BrS. We hypothesized that the degrees of abnormal repolarization and conduction are greater in type 1 subjects and these differences can be detected by electrocardiography (ECG). Methods: Electrocardiographic data from spontaneous type 1 and non-type 1 BrS patients were analyzed. ECG parameters were measured from leads V1 to V3...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/30335689/seizures-meds-and-vtach-a-journey-to-a-brugada-diagnosis
#12
David P Fitzgerald, Srikant Das, Matthew P Malone, B Shane Holland, Stephen M Schexnayder
Sudden cardiac arrest of cardiac etiology is rare in children and adolescents and most often occurs with exertion. Conversely, syncope is a common pediatric emergency department complaint but rarely is associated with a serious underlying cardiac disorder. This report describes a case of the channelopathy Brugada syndrome (BrS) as a cause of sudden cardiac arrest in a febrile preadolescent child taking medications known to affect cardiac conduction. The patient received cardiopulmonary resuscitation and was successfully defibrillated...
October 17, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30327734/a-lucky-accident-brugada-syndrome-associated-with-out-of-hospital-cardiac-arrest
#13
Michelle T Lee, Naddi Marah
About 350,000 cases of out-of-hospital cardiac arrest (OHCA) occur yearly in the United States. Unfortunately, even with treatment from emergency medical service (EMS) staff and hospitalization, only 12% survive past discharge for multiple reasons. Classically, Brugada syndrome (BrS) initially presents as a new syncopal episode in young males without obstructive coronary artery disease (CAD). However, in this case report, a patient who emergently presented with a ST-elevation myocardial infarction (STEMI) challenges the stereotypical presentation...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/30299600/rationale-and-design-of-the-eu-cert-icd-prospective-study-comparative-effectiveness-of-prophylactic-icd-implantation
#14
Markus Zabel, Christian Sticherling, Rik Willems, Andrzej Lubinski, Axel Bauer, Leonard Bergau, Frieder Braunschweig, Josep Brugada, Sandro Brusich, David Conen, Iwona Cygankiewicz, Panagiota Flevari, Milos Taborsky, Jim Hansen, Gerd Hasenfuß, Robert Hatala, Heikki V Huikuri, Svetoslav Iovev, Stefan Kääb, Gabriela Kaliska, Jaroslaw D Kasprzak, Lars Lüthje, Marek Malik, Tomas Novotny, Nikola Pavlović, Georg Schmidt, Tchavdar Shalganov, Rajeeva Sritharan, Simon Schlögl, Janko Szavits Nossan, Vassil Traykov, Anton E Tuinenburg, Vasil Velchev, Marc A Vos, Stefan N Willich, Tim Friede, Jesper Hastrup Svendsen, Béla Merkely
AIMS: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) aims to assess its current clinical value. METHODS AND RESULTS: The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries...
October 9, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/30294671/marijuana-induced-type-i-brugada-pattern-a-case-report
#15
Pramod Theetha Kariyanna, Apoorva Jayarangaiah, Sudhanva Hegde, Jonathan D Marmur, Perry Wengrofsky, Mena Yacoub, Michael Post, Samy I McFarlane
Marijuana is the most common drug of abuse in the United States. Marijuana acts on cannabinoid receptors CB1, CB2 and another distinct endothelial receptor. Marijuana is known to cause tachycardia, hypotension and hypertension. Various arrhythmias including atrial fibrillation, atrial flutter, II degree AV block, ventricular fibrillation, ventricular tachycardia, asystole and brugada pattern associated with marijuana use have been reported. We here present an interesting case of Type I Brugada pattern in electrocardiography (ECG) in a 36 year old healthy African American male who presented after smoking four joints...
2018: American journal of medical case reports
https://www.readbyqxmd.com/read/30289750/deletion-in-mice-of-x-linked-brugada-syndrome-and-atrial-fibrillation-associated-kcne5-augments-ventricular-k-v-currents-and-predisposes-to-ventricular-arrhythmia
#16
Jens-Peter David, Ulrike Lisewski, Shawn M Crump, Thomas A Jepps, Elke Bocksteins, Nicola Wilck, Janine Lossie, Torsten K Roepke, Nicole Schmitt, Geoffrey W Abbott
KCNE5 is an X-linked gene encoding KCNE5, an ancillary subunit to voltage-gated potassium (KV ) channels. Human KCNE5 mutations are associated with atrial fibrillation (AF)- and Brugada syndrome (BrS)-induced cardiac arrhythmias that can arise from increased potassium current in cardiomyocytes. Seeking to establish underlying molecular mechanisms, we created and studied Kcne5 knockout ( Kcne5-/0 ) mice. Intracardiac ECG revealed that Kcne5 deletion caused ventricular premature beats, increased susceptibility to induction of polymorphic ventricular tachycardia (60 vs...
October 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30287239/characterization-of-electrocardiographic-findings-in-young-students
#17
Pau Vilardell, Josep Brugada, Jaime Aboal, Pablo Loma-Osorio, Carlos Falces, Rut Andrea, Marc Figueras-Coll, Ramon Brugada
INTRODUCTION AND OBJECTIVES: The resting 12-lead electrocardiogram (ECG) has been used in the evaluation of young asymptomatic individuals to detect pre-existing heart disease, but systematic ECG use is controversial and there are no data on this population in our environment. We aimed to determine the prevalence and spectrum of electrocardiographic findings in a population of secondary school students. METHODS: We conducted an observational, cross-sectional study of resting ECG findings in all 13 to 14-year-old secondary school students in a region of the province of Gerona between 2009 and 2017...
October 1, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/30279931/brugada-syndrome-unmasked-by-malaria-induced-fever
#18
Abdullah Cader, Sheldon M Singh, Mohammad I Zia
Brugada syndrome is typically an autosomal dominant genetic disorder with variable expression, characterized by three specific electrocardiogram (ECG) patterns. While Type I Brugada ECG pattern is used as a classic marker for the disease, it is generally masked from ECG except in special cases such as malaria-induced fever. This vignette highlights a unique clinical scenario that can lead to the unmasking of Brugada type 1 pattern. < Learning objective: Brugada syndrome is associated with ventricular arrhythmias which if left untreated can result in syncope or premature death...
October 2018: Journal of Cardiology Cases
https://www.readbyqxmd.com/read/30195842/multiple-serial-ecgs-aid-with-the-diagnosis-and-prognosis-of-brugada-syndrome
#19
Jesus Castro Hevia, Margarita Dorantes Sanchez, Frank Martinez Lopez, Osmin Castañeda Chirino, Roylan Falcon Rodriguez, Marcelo Puga Bravo, Joanna de Zayas Galguera, Charles Antzelevitch
BACKGROUND: A spontaneous coved-type ST segment elevation in the electrocardiogram (ECG) has long been recognized as a risk stratification tool in patients with Brugada syndrome (BrS). This Type-I ST segment elevation is known to exhibit high dynamicity, fluctuating between coved-type and non-coved ST segment elevation. Our objectives in this study were to: 1) Compare ECG parameters in patients with spontaneous coved-type (Type-I) vs. non-coved-type ST segment ECGs; 2) Determine the variability of these ECG parameters with repeated measurements; and 3) Assess the predictive value of ECG parameters in these two groups during follow-up...
August 30, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30193851/clinical-presentation-and-follow-up-of-women-affected-by-brugada-syndrome
#20
Pauline Berthome, Romain Tixier, Jean Briand, Olivier Geoffroy, Dominique Babuty, Jacques Mansourati, Laurence Jesel, Jean-Marc Dupuis, Paul Bru, Florence Kyndt, Béatrice Guyomarch, Aurélie Thollet, Nathalie Behar, Philippe Mabo, Frédéric Sacher, Vincent Probst, Jean-Baptiste Gourraud
BACKGROUND: Studies in Brugada syndrome (BrS) have mainly consisted of men. OBJECTIVE: The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women. METHODS: Consecutive BrS patients were enrolled from 1993 and followed prospectively. RESULTS: Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = ...
September 5, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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