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"Pacing" AND "Emergency"

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https://www.readbyqxmd.com/read/30337038/gastrointestinal-neuropathies-new-insights-and-emerging-therapies
#1
REVIEW
Marcella Pesce, Osvaldo Borrelli, Efstratios Saliakellis, Nikhil Thapar
The bewildering complexity of the enteric nervous system makes it susceptible to develop a wide array of motility disorders, collectively called enteric neuropathies. These gastrointestinal conditions are among the most challenging to manage, mainly given poor characterization of their etiopathophysiology and outcomes. Not surprisingly, therefore, targeted or curative therapies for enteric neuropathies are lacking and management is largely symptomatic. Nonetheless, recent advances in neurogastroenterology have witnessed improvements in established strategies, such as intestinal transplantation and the emergence of new treatments including novel drugs, electrical pacing, and manipulation of fecal microbiota, as well as stem cell and gene therapy...
December 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/30327413/preferred-learning-modalities-and-practice-for-critical-skills-a-global-survey-of-paediatric-emergency-medicine-clinicians
#2
Simon S Craig, Marc Auerbach, John Alexander Cheek, Franz E Babl, Ed Oakley, Lucia Nguyen, Arjun Rao, Sarah Dalton, Mark D Lyttle, Santiago Mintegi, Joshua Nagler, Rakesh D Mistry, Andrew Dixon, Pedro Rino, Guillermo Kohn-Loncarica, Stuart R Dalziel
OBJECTIVE: To describe senior paediatric emergency clinician perspectives on the optimal frequency of and preferred modalities for practising critical paediatric procedures. METHODS: Multicentre multicountry cross-sectional survey of senior paediatric emergency clinicians working in 96 EDs affiliated with the Pediatric Emergency Research Network. RESULTS: 1332/2446 (54%) clinicians provided information on suggested frequency of practice and preferred learning modalities for 18 critical procedures...
October 16, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/30316733/assessing-the-discharge-instructing-in-the-emergency-department-patient-perspective
#3
M Mäkinen, M Castrén, K Huttunen, S Sundell, J Kaartinen, M Ben-Meir, M Renholm
OBJECTIVE: The objective of the study is to assess how well the emergency department (ED) personnel succeed in instructing the patient at discharge. METHODS: In November and December 2016 at Peijas Hospital ED, Finland, a structured questionnaire was conducted during a phone interview on patients the day after discharge. RESULTS: A total of 132 patients interviewed. Ninety percent had received discharge instructions from the ED staff, most of them (75%) about medication...
October 10, 2018: International Emergency Nursing
https://www.readbyqxmd.com/read/30312376/access-to-specialists-and-emergency-department-visits-in-inflammatory-bowel-disease-a-population-based-study
#4
Geoffrey C Nguyen, Shelley Bouchard, Christina Diong
Background and Aims: The number of inflammatory bowel disease (IBD) related visits to the emergency department (ED) is increasing in North America. Our study evaluates the relationship between access to specialists and utilization of ED services. Methods: We conducted a population-based study of all IBD patients in the Ontario in 2014-2015 to measure utilization of non-emergent IBD care by specialists (NICS) and ED visits. After characterizing regional variation in access to gastroenterologists and region-wide implementation of NICS, we constructed regression models to determine whether they were predictors of individual utilization of NICS and ED services...
October 12, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/30283477/genome-editing-in-rice-recent-advances-challenges-and-future-implications
#5
REVIEW
Rukmini Mishra, Raj Kumar Joshi, Kaijun Zhao
Rice ( Oryza sativa L.) is the major food source for more than three billion people of the world. In the last few decades, the classical, mutational, and molecular breeding approaches have brought about tremendous increase in rice productivity with the development of novel rice varieties. However, stagnation in rice yield has been reported in recent decade owing to several factors including the emergence of pests and phyto pathogens, climate change, and other environmental issues posing great threat to global food security...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30279900/pacemaker-malfunction-after-acute-myocardial-infarction-in-a-patient-with-wrap-around-left-anterior-descending-artery-supplying-the-right-ventricular-apex
#6
Tomohiko C Umei, Toru Awaya, Osamu Okazaki, Hisao Hara, Yukio Hiroi
A 50-year-old man with a dual-chamber pacemaker was admitted to our hospital complaining of chest pain. Anterior ST segment elevation myocardial infarction (STEMI) was diagnosed. Emergency coronary angiography revealed total occlusion of the proximal left anterior descending artery (LAD), and primary percutaneous coronary intervention was performed. Angiograms showed that the LAD was wrapped around the apex of both ventricles. On day 8, ventricular fibrillation and cardiopulmonary arrest occurred due to elevation of the pacing threshold because of pacemaker malfunction...
July 2018: Journal of Cardiology Cases
https://www.readbyqxmd.com/read/30279465/ecological-conditions-drive-pace-of-life-syndromes-by-shaping-relationships-between-life-history-physiology-and-behaviour-in-two-populations-of-eastern-mosquitofish
#7
Giovanni Polverino, Francesca Santostefano, Carlos Díaz-Gil, Thomas Mehner
The pace-of-life syndrome (POLS) hypothesis predicts variation in behaviour and physiology among individuals to be associated with variation in life history. Thus, individuals on the "fast" end of POLS continuum grow faster, exhibit higher metabolism, are more risk prone, but die earlier than ones on the "slow" end. Empirical support is nevertheless mixed and modelling studies suggested POLS to vary along selection gradients. Therefore, including ecological variation when testing POLS is vastly needed to determine whether POLS is a fixed construct or the result of specific selection processes...
October 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30279372/assay-challenges-for-emerging-infectious-diseases-the-zika-experience
#8
REVIEW
Christine C Roberts, Joel N Maslow
From the perspective of vaccine development, it is imperative to accurately diagnose target infections in order to exclude subjects with prior exposure from evaluations of vaccine effectiveness, to track incident infection during the course of a clinical trial and to differentiate immune reactions due to natural infections from responses that are vaccine related. When vaccine development is accelerated to a rapid pace in response to emerging infectious disease threats, the challenges to develop such diagnostic tools is even greater...
October 2, 2018: Vaccines
https://www.readbyqxmd.com/read/30269615/drug-pharmacomicrobiomics-and-toxicomicrobiomics-from-scattered-reports-to-systematic-studies-of-drug-microbiome-interactions
#9
Ramy K Aziz, Shaimaa M Hegazy, Reem Yasser, Mariam R Rizkallah, Marwa T ElRakaiby
Pharmacomicrobiomics and toxicomicrobiomics study how variations within the human microbiome (the combination of human-associated microbial communities and their genomes) affect drug disposition, action, and toxicity. These emerging fields, interconnecting microbiology, bioinformatics, systems pharmacology, and toxicology, complement pharmacogenomics and toxicogenomics, expanding the scope of precision medicine. Areas covered: This article reviews some of the most recently reported pharmacomicrobiomic and toxicomicrobiomic interactions...
October 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/30269612/unprecedented-pace-and-partnerships-the-story-of-and-lessons-learned-from-one-ebola-vaccine-program
#10
Swati B Gupta, Beth-Ann Coller, Mark Feinberg
The Ebola epidemic in West Africa from 2014 to 2016 was unique in its size, location, and duration; this article reviews the experiences and lessons learned for one vaccine candidate developed during the outbreak and discusses critical gaps that still exist today which will need to be addressed for successful end to end emerging infectious disease vaccine product development in the future. Areas Covered: Through the formation of numerous international partnerships, the rVSVΔG-ZEBOV-GP vaccine advanced through Phase I/II/III clinical trials which resulted in favorable Phase III efficacy results...
October 1, 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/30255304/leadless-pacing
#11
J Sperzel, C Hamm, A Hain
Leadless self-contained intracardiac pacemakers were developed with the aim of abolishing the short- and long-term risk of lead- and pocket-related complications associated with transvenous devices. Leadless pacemakers promise minimally invasive procedures, long battery lives, and small amounts of foreign materials in the body. Experiences with the pioneering single-chamber devices have provided reasons for optimism about the future of the leadless concept. In the future, as more patients receive and live longer with implantable devices, the total risk of procedure- and lead-related complications is expected to increase, adding a sense of urgency to the need for leadless alternatives to transvenous pacemakers...
September 25, 2018: Herz
https://www.readbyqxmd.com/read/30248966/sensoring-a-generative-system-to-create-user-controlled-melodies
#12
María Navarro-Cáceres, Wataru Hashimoto, Sara Rodríguez-González, Belén Pérez-Lancho, Juan Manuel Corchado
The automatic generation of music is an emergent field of research that has attracted the attention of countless researchers. As a result, there is a broad spectrum of state of the art research in this field. Many systems have been designed to facilitate collaboration between humans and machines in the generation of valuable music. This research proposes an intelligent system that generates melodies under the supervision of a user, who guides the process through a mechanical device. The mechanical device is able to capture the movements of the user and translate them into a melody...
September 21, 2018: Sensors
https://www.readbyqxmd.com/read/30239069/the-emergency-medicine-specimen-bank-an-innovative-approach-to-biobanking-in-acute-care
#13
Jessica L Saben, Shelby K Shelton, Andrew J Hopkinson, Brandon J Sonn, Eleanor B Mills, Makayla Welham, Megan Westmoreland, Richard Zane, Adit A Ginde, Kelly Bookman, Justin Oeth, Mark Chavez, Michael DeVivo, Alison Lakin, John Heldens, Laurie Blumberg Romero, Michael J Ames, Emily R Roberts, Matthew Taylor, Kristy Crooks, Stephen J Wicks, Kathleen C Barnes, Andrew A Monte
The Emergency Medicine Specimen Bank (EMSB) was developed to facilitate precision medicine in acute care. The EMSB is a biorepository of clinical health data and biospecimens collected from all adult, English- or Spanish-speaking individuals who are able and willing to provide consent and are treated at the UCHealth - University of Colorado Hospital Emergency Department (UCH-ED). The EMSB is the first acute care biobank that seeks to enroll all patients, with all conditions who present to the ED. Acute care biobanking presents many challenges that are unique to acute care settings such as providing informed consent in a uniquely stressful and fast-paced environment and collecting, processing, and storing samples for tens of thousands of patients per year...
September 21, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/30236154/gender-differences-in-the-comprehension-of-care-plans-in-an-emergency-department-setting
#14
Shachaf Shiber, Rona Zuker-Herman, Michael J Drescher, Marek Glezerman
BACKGROUND: Previous studies have shown that, in a variety of health care settings, patients often do not understand what health care professionals tell them about their diagnoses and care plans; this is particularly true among male patients. Emergency department (ED) settings present unique challenges to communication with patients due to the rapid pace of activity, substantial changes in personnel over the course of the day and the week, and the need for fast decision-making processes...
September 18, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/30230930/the-emergence-of-multiword-utterances-in-children-with-down-syndrome
#15
Lara Draghi, Laura Zampini
Morphosyntax is one of the most impaired aspects of language development in children with Down syndrome. The present study aimed to assess the emergence of multiword utterances in this population. Sixteen Italian-speaking children with Down syndrome were followed from 36 to 48 months of age. Data derived from an analysis of their spontaneous productions showed that although the mean productivity of multiword utterances increased over the three time points (36, 42 and 48 months), different growth patterns of early syntactic development could be identified: (1) null or marginal development; (2) a gradual increase in multiword production over time; (3) an increase in the production of more complex multiword utterances and a decrease or inverted U-shaped profile in the production of simpler multiword productions; (4) an inverted U-shaped profile in multiword productions...
September 19, 2018: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/30228692/the-goldilocks-zone-for-exercise-not-too-little-not-too-much
#16
James H O'Keefe, Evan L O'Keefe, Carl J Lavie
Homo sapiens are evolutionarily adapted to be very physically active throughout life, and thus habitual physical activity (PA) is essential for well-being and longevity. Never the less, middle-aged and older individuals engaging in excessive strenuous endurance exercise appear to be at increased risk for a variety of adverse cardiovascular (CV) effects including atrial fibrillation, myocardial fibrosis, and coronary atherosclerosis. An emerging body of evidence indicates U-shaped or reverse J-shaped curves whereby low doses and moderate doses of PA significantly reduce long-term risks for both total mortality and CV mortality, however, at very high doses of chronic strenuous exercise much of the protection against early mortality and CV disease is lost...
March 2018: Missouri Medicine
https://www.readbyqxmd.com/read/30222772/lower-limb-sagittal-kinematic-and-kinetic-modeling-of-very-slow-walking-for-gait-trajectory-scaling
#17
Andrew J J Smith, Edward D Lemaire, Julie Nantel
Lower extremity powered exoskeletons (LEPE) are an emerging technology that assists people with lower-limb paralysis. LEPE for people with complete spinal cord injury walk at very slow speeds, below 0.5m/s. For the able-bodied population, very slow walking uses different neuromuscular, locomotor, postural, and dynamic balance control. Speed dependent kinetic and kinematic regression equations in the literature could be used for very slow walking LEPE trajectory scaling; however, kinematic and kinetic information at walking speeds below 0...
2018: PloS One
https://www.readbyqxmd.com/read/30192688/legal-and-ethical-issues-surrounding-the-use-of-crowdsourcing-among-healthcare-providers
#18
Max H Sims, Margie Hodges Shaw, Seth Gilbertson, Joseph Storch, Marc W Halterman
As the pace of medical discovery widens the knowledge-to-practice gap, technologies that enable peer-to-peer crowdsourcing have become increasingly common. Crowdsourcing has the potential to help medical providers collaborate to solve patient-specific problems in real time. We recently conducted the first trial of a mobile, medical crowdsourcing application among healthcare providers in a university hospital setting. In addition to acknowledging the benefits, our participants also raised concerns regarding the potential negative consequences of this emerging technology...
September 7, 2018: Health Informatics Journal
https://www.readbyqxmd.com/read/30188824/patterns-and-pace-quantifying-diverse-exploration-behavior-with-visualizations-on-the-web
#19
Mi Feng, Evan Peck, Lane Harrison
The diverse and vibrant ecosystem of interactive visualizations on the web presents an opportunity for researchers and practitioners to observe and analyze how everyday people interact with data visualizations. However, existing metrics of visualization interaction behavior used in research do not fully reveal the breadth of peoples' open-ended explorations with visualizations. One possible way to address this challenge is to determine high-level goals for visualization interaction metrics, and infer corresponding features from user interaction data that characterize different aspects of peoples' explorations of visualizations...
September 4, 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/30187536/developing-a-conceptual-framework-for-patient-safety-culture-in-emergency-department-a-review-of-the-literature
#20
REVIEW
Muhammad Ahmed Alshyyab, Gerard FitzGerald, Kaeleen Dingle, Joseph Ting, Paula Bowman, Frances B Kinnear, Erika Borkoles
Patient safety culture is a critical component of modern health care. However, the high-paced, unpredictable nature of the emergency department (ED) environment may impact adversely on it. The aim of this paper is to explore the concept of patient safety culture as it may apply to emergency health care, and to propose a conceptual framework that could form the basis for interventions designed to improve it. This is a systematic review of the literature. A search was undertaken of common electronic bibliographic databases using key words such as safety culture, safety climate, and Emergency Department...
September 5, 2018: International Journal of Health Planning and Management
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