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"Pacing" AND "Emergency"

Lei Wang, Weining Cheng, Jia Meng, Mickey Speakmon, Jiangping Qiu, Suresh Pillai, Keyan Zhu-Salzman
BACKGROUND: Electron beam (eBeam) irradiation and hermetic storage are safe and effective technologies to protect stored products. Although hypoxic environment improves performance of some irradiated insects, whether hypoxia affects irradiation of storage insects and impacts pest control efficacy remains to be investigated. RESULTS: Using cowpea bruchid (Callosobruchus maculatus) larvae, we showed that, relative to eBeam irradiation under normoxia, the adult emergence rate increased substantially if they were exposed to hypoxia prior to and during eBeam treatment...
August 12, 2018: Pest Management Science
Todd C LaJeunesse, John Everett Parkinson, Paul W Gabrielson, Hae Jin Jeong, James Davis Reimer, Christian R Voolstra, Scott R Santos
The advent of molecular data has transformed the science of organizing and studying life on Earth. Genetics-based evidence provides fundamental insights into the diversity, ecology, and origins of many biological systems, including the mutualisms between metazoan hosts and their micro-algal partners. A well-known example is the dinoflagellate endosymbionts ("zooxanthellae") that power the growth of stony corals and coral reef ecosystems. Once assumed to encompass a single panmictic species, genetic evidence has revealed a divergent and rich diversity within the zooxanthella genus Symbiodinium...
August 2, 2018: Current Biology: CB
Loredana Vesci, Ferdinando Maria Milazzo, Maria Antonietta Stasi, Silvia Pace, Francesco Manera, Carlo Tallarico, Elena Cini, Elena Petricci, Fabrizio Manetti, Rita De Santis, Giuseppe Giannini
Small series of acylguanidine and acylthiourea derivatives were synthesized in gram-scale and assayed for their ability to modulate the Hh signalling pathway. In vitro studies showed a low micromolar inhibitory activity toward tumor cell lines, while the oral administration revealed an excellent ADME profile in vivo. Compound 5 emerged as the most active and safe inhibitor of colon cancer cells both in vitro and in a xenograft mouse model. Based on these data, 5 could be prioritized to further development with the perspective of clinical studies...
July 27, 2018: European Journal of Medicinal Chemistry
Megan M Niedzwiecki, Douglas I Walker, Roel Vermeulen, Marc Chadeau-Hyam, Dean P Jones, Gary W Miller
Derived from the term exposure, the exposome is an omic-scale characterization of the nongenetic drivers of health and disease. With the genome, it defines the phenome of an individual. The measurement of complex environmental factors that exert pressure on our health has not kept pace with genomics and historically has not provided a similar level of resolution. Emerging technologies make it possible to obtain detailed information on drugs, toxicants, pollutants, nutrients, and physical and psychological stressors on an omic scale...
August 10, 2018: Annual Review of Pharmacology and Toxicology
Scarlett O Baird, Christopher Metts, Haley E Conroy, David Rosenfield, Jasper A J Smits
There is a surprising lack of disseminable, community-based interventions for veterans experiencing difficulties during the reintegration process from military to civilian life. Physical Activity and Community Engagement (PACE) is a program which combines routine vigorous-intensity exercise with community engagement. The program builds on emergent evidence supporting the benefits of routine vigorous-intensity exercise among and establishing social connection. Using a randomized controlled trial (N = 60), we will obtain feasibility data and initial effect sizes for the early effects of PACE on reintegration difficulties...
September 2018: Contemporary Clinical Trials Communications
Teresa L Rogstad, Adam C Powell, Yongjia Song, Tristan Cordier, Stephen E Price, James W Long, Uday U Deshmukh, Jeffrey D Simmons
BACKGROUND: Recipients of ICD are likely to have several risk factors that could interfere with successful use of implantable cardioverter defibrillators (ICDs). HYPOTHESIS: Age, sex, and factors indicated in claims are associated with one-year mortality and complications after ICD placement. METHODS: Adult Medicare Advantage patients who underwent outpatient ICD implantation from January 2014 to September 2015 were included. Age, sex, Charlson Comorbidity Index (CCI), prior year hospitalization and emergency department (ED) visit, diabetes, heart failure, ischemic heart disease, and indicators of the need for pacing were evaluated as risk factors...
August 9, 2018: Clinical Cardiology
Ngombo Armando, André Rodrigues, Vasco Pereira, Jorge Sá Silva, Fernando Boavida
The Internet keeps changing at a rapid pace, driven mainly by the emerging concepts and applications that make it aware of the physical world and responsive to user context. The Internet of Things (IoT) concept is quickly giving way to more advanced and highly interactive environments that go well beyond the mere sensing of the physical world. Today, in addition to traditional electronic devices, IoT sensing/actuating includes both software and human-based entities. This paper provides an outlook on the future of sensing/actuating approaches on the Internet at large, which we see increasingly related to all kinds of socially interactive technologies...
August 6, 2018: Sensors
L Hayley Burgess, Karla Miller, Mandelin Cooper, Julia Moody, Jane Englebright, Edward Septimus
BACKGROUND: Antimicrobial stewardship is recommended as a crucial mechanism to reduce the emergence of antimicrobial resistance. The purpose of this article was to describe implementation of antimicrobial management programs (AMPs) across a large health system of community hospitals. METHODS: The initiative was structured in 4 phases. Although each phase was implemented sequentially, facilities could progress at their own pace. Phase goals needed to be met before moving to the next phase...
August 3, 2018: American Journal of Infection Control
Muhammad R Javed, Maria Sadaf, Temoor Ahmed, Amna Jamil, Marium Nawaz, Hira Abbas, Anam Ijaz
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR or more precisely CRISPR-Cas) system has proven to be a highly efficient and simple tool for achieving site-specific genome modifications in comparison to Zinc Finger Nucleases (ZFNs) and Transcription Activator-Like Effector Nucleases (TALENs). The discovery of bacterial defense system that uses RNA-guided DNA cleaving enzymes for producing double-strand breaks along CRISPR has provided an exciting alternative to ZFNs and TALENs for gene editing & regulation, as the CRISPR-associated (Cas) proteins remain the same for different gene targets and only the short sequence of the guide RNA needs to be changed to redirect the site-specific cleavage...
August 4, 2018: Current Microbiology
Siddharth Singh
PURPOSE OF REVIEW: Since the first clinical trial of cortisone in ulcerative colitis in 1955, remarkable progress has been made in the design and conduct of clinical trials in inflammatory bowel diseases (IBD). In this review article, we will discuss evolution of clinical trials in IBD over the last 3-5 years. RECENT FINDINGS: Recognizing limitations intrinsic to clinical disease activity indices in IBD, regulatory authorities have recommended evaluating co-primary endpoints of patient-reported outcomes and endoscopic disease activity in clinical trials...
August 4, 2018: Current Gastroenterology Reports
Jessica Pace, Narcyz Ghinea, Ian Kerridge, Wendy Lipworth
There are increasing demands on regulators and insurers internationally to provide access to medicines more quickly, and often on the basis of less robust evidence of safety, efficacy or cost-effectiveness than have traditionally been required. These demands arise from a number of sources, including those advocating for access to medicines for patients with life-threatening diseases, rare diseases, or subsets of common diseases and where entire populations are threatened in the context of public health emergencies...
July 20, 2018: Health Policy
P-O Cheptou
Background and Aims: As a major evolutionary transition in seed plants, the evolution of plant mating systems has been much debated in evolutionary ecology. Over the last 10 years, well-established patterns of evolution have emerged. On the one hand, experimental studies have shown that self-fertilization is likely to evolve in a few generations (microevolution) as a response to rapid environmental change (e.g. pollinator decline), eventually rescuing a population. On the other, phylogenetic studies have demonstrated that repeated evolution towards self-fertilization (macroevolution) leads to a higher risk of lineage extinction and is thus likely to be disadvantageous in the long term...
July 20, 2018: Annals of Botany
Davide Baratella, Emanuela Bonaiuto, Massimiliano Magro, Jessica de Almeida Roger, Yuta Kanamori, Giuseppina Pace Pereira Lima, Enzo Agostinelli, Fabio Vianello
Polyamines (PAs) are involved in a variety of fundamental physio-pathologic processes. The concentration of these polycations in organs and tissues depends on their endogenous production and oxidation rates, and on their intake from foods. Besides being largely accepted as markers for the progress of several pathologies, PAs may exert themselves different effects on humans, ranging from being positive to be drastically detrimental depending on the organism conditions. Thus, if the determination of polyamines content in tissue samples is of great importance as they could be indicators of several diseases, their quantification in food is fundamental for modulating the diet to respond to a specific human health status...
July 21, 2018: Amino Acids
Esther Cooper, Ann Hutchinson, Zain Sheikh, Paul Taylor, Will Townend, Miriam J Johnson
BACKGROUND: Despite a fast-paced environment, the emergency clinician has a duty to meet the palliative patient's needs. Despite suggested models and interventions, this remains challenging in practice. AIM: To raise awareness of these challenges by exploring the experience of palliative care patients and their families and informal carers attending the emergency department, and of the clinicians caring for them. DESIGN: Qualitative systematic literature review and thematic synthesis...
July 1, 2018: Palliative Medicine
Miya L Barnett, Lauren Brookman-Frazee, Juan Carlos Gonzalez, Chanel Zhan, Adriana Rodriguez, Nicole A Stadnick, Anna S Lau
This study analyzed qualitative therapist reports of adaptations to the delivery of multiple evidence-based practices (EBPs) within the context of a system-driven reform of children's community mental health services to understand how therapists adapt EBPs as well as contexts of these adaptations to identify when these adaptations are made. The study sought to complement and expand upon previous quantitative survey findings of two categories of Augmenting and Reducing/Reordering adaptations to EBPs. Data included interviews from 60 therapists (88...
July 19, 2018: Journal of Clinical Child and Adolescent Psychology
Benjamin J Sieniewicz, Justin Gould, Bradley Porter, Baldeep S Sidhu, Jonathan M Behar, Simon Claridge, Steve Niederer, Christopher A Rinaldi
Cardiac resynchronization therapy (CRT) has emerged as one of the few effective treatments for heart failure. However, up to 50% of patients derive no benefit. Suboptimal left ventricle (LV) lead position is a potential cause of poor outcomes while targeted lead deployment has been associated with enhanced response rates. Image-fusion guidance systems represent a novel approach to CRT delivery, allowing physicians to both accurately track and target a specific location during LV lead deployment. Areas covered: This review will provide a comprehensive evaluation of how to define the optimal pacing site...
July 30, 2018: Expert Review of Medical Devices
Ferdinando Bruno, Suann Errico, Simona Pace, Maxim B Nawrozkij, Arthur S Mkrtchyan, Francesca Guida, Rosa Maisto, Abdurrahman Olgaç, Michele D'Amico, Sabatino Maione, Mario De Rosa, Erden Banoglu, Oliver Werz, Antonio Fiorentino, Rosanna Filosa
The release of pro-inflammatory mediators, such as prostaglandines (PGs) and leukotrienes (LTs), arising from the arachidonic acid (AA) cascade, play a crucial role in initiating, maintaining, and regulating inflammatory processes. New dual inhibitors of 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1), that block, at the same time, the formation of PGE2 and LTs, are currently emerged as a highly interesting drug candidates for better pharmacotherapie of inflammation-related disorders...
July 15, 2018: European Journal of Medicinal Chemistry
Xiukun Wu
Aviation medicine is being recognized as a rising star and an indispensable part of the "trinity" medical emergency network composed of land, water and air. The unparalleled mobility and traffic advantages of aircraft, especially rotorcraft (helicopter), are playing an increasingly important role in rescuing the dying and wounded, especially the critical patients, and thus derive a new medical operation mode. How to adapt to the development of the situation and the progress of the times, give full play to the advantages of aviation medical care? The key factors are improvement of the level of service efficiency, strength of learning, practice courage, innovation, and good at summing up to keep pace with the times...
June 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
George B Stefano, Richard M Kream
Today's medical service delivery platforms provide everything from small urgent care 'offices' to large medical centers. Since 2007, an intermediate entity for care has been established, namely, the micro-hospital. Micro-hospitals are 24-hour, small inpatient facilities with an average of 2 to 10 beds, designed to provide a diversity of healthcare services consistent with community demands. In addition, they seek to combine a cost-effective healthcare vehicle with potential time-dependent triage/transfer capabilities to a nearby large medical center...
July 14, 2018: Medical Science Monitor Basic Research
James Love-Koh, Alison Peel, Juan Carlos Rejon-Parilla, Kate Ennis, Rosemary Lovett, Andrea Manca, Anastasia Chalkidou, Hannah Wood, Matthew Taylor
OBJECTIVE: Precision medicine allows healthcare interventions to be tailored to groups of patients based on their disease susceptibility, diagnostic or prognostic information, or treatment response. We analysed what developments are expected in precision medicine over the next decade and considered the implications for health technology assessment (HTA) agencies. METHODS: We performed a pragmatic literature search to account for the large size and wide scope of the precision medicine literature...
July 13, 2018: PharmacoEconomics
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