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"Pacing" AND "Emergency"

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https://www.readbyqxmd.com/read/30552661/moonshot-to-cancer-cure-recruiting-policy-to-break-down-silos
#1
Melissa Simon, Emmanuel Cordova, June M McKoy
Funded by the 21st Century Cures Act, The Beau Biden Cancer Moonshot Initiative is broad, deep, integrative, and intended to expediently address cancer's most vexing problems. Launched in 2015, it is an effort to accelerate the pace of cancer research with a focus on breaking down silos through cross-pollination of research, recruitment of multidisciplinary clinical and basic science research teams, sharing of complex scientific databases, and the creation of public-private research partnerships. This audacious approach to cancer treatment is intended to alleviate the current burden of cancer within countries and across borders...
2019: Cancer Treatment and Research
https://www.readbyqxmd.com/read/30545817/easier-and-faster-is-not-always-better-grounded-theory-of-the-impact-of-large-scale-system-transformation-on-the-clinical-work-of-emergency-medicine-nurses-and-physicians
#2
Elaine Zibrowski, Lisa Shepherd, Kamran Sedig, Richard Booth, Candace Gibson
BACKGROUND: The effectiveness of Lean Thinking as a quality improvement method for health care has been contested due, in part, to our limited contextual understanding of how it affects the working conditions and clinical workflow of nurses and physicians. Although there are some initial indications, arising from prevalence surveys and interviews, that Lean may intensify work performed within medical environments, the evidence base still requires detailed descriptions of the changes that were actually introduced to individuals' clinical workflow and how these changes impacted health care professionals...
December 13, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/30544544/the-power-of-fish-models-to-elucidate-skin-cancer-pathogenesis-and-impact-the-discovery-of-new-therapeutic-opportunities
#3
REVIEW
Sreeja Sarasamma, Yu-Heng Lai, Sung-Tzu Liang, Kechun Liu, Chung-Der Hsiao
Animal models play important roles in investigating the pathobiology of cancer, identifying relevant pathways, and developing novel therapeutic tools. Despite rapid progress in the understanding of disease mechanisms and technological advancement in drug discovery, negative trial outcomes are the most frequent incidences during a Phase III trial. Skin cancer is a potential life-threatening disease in humans and might be medically futile when tumors metastasize. This explains the low success rate of melanoma therapy amongst other malignancies...
December 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30540613/development-and-usability-testing-of-the-society-for-pediatric-anesthesia-pedi-crisis-mobile-application
#4
Anna Clebone, Kim M Strupp, Gina Whitney, Michael R Anderson, Jeffrey Hottle, James Fehr, Myron Yaster, Laura E Schleelein, Barbara K Burian, Jorge A Galvez, Justin L Lockman, David Polaner, Natalie R Barnett, Michael J Keane, Shashikanth Manikappa, Stephen Gleich, Robert S Greenberg, Ariel Vincent, Sarah L Oswald, Red Starks, Scott Licata
When life-threatening, critical events occur in the operating room, the fast-paced, high-distraction atmosphere often leaves little time to think or deliberate about management options. Success depends on applying a team approach to quickly implement well-rehearsed, systematic, evidence-based assessment and treatment protocols. Mobile devices offer resources for readily accessible, easily updatable information that can be invaluable during perioperative critical events. We developed a mobile device version of the Society for Pediatric Anesthesia 26 Pediatric Crisis paper checklists-the Pedi Crisis 2...
December 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30528686/health-care-cost-analysis-of-enhanced-pacing-modalities-in-bradycardia-patients-portuguese-case-study-on-the-results-of-the-minerva-trial
#5
João de Sousa, Pedro Marques, Vítor Martins, António Hipólito-Reis, Luís Duarte, Inês Joaquim, Diogo Monteiro, Giuseppe Boriani, Claudia Wolff, Andrea Grammatico, Luigi Padeletti
INTRODUCTION: The MINERVA trial established that atrial preventive pacing and atrial antitachycardia pacing (DDDRP) in combination with managed ventricular pacing (MVP) reduces progression to permanent atrial fibrillation (AF) in patients with paroxysmal or persistent AF and bradycardia who need cardiac pacing, compared to standard dual-chamber pacing (DDDR). It was shown that AF-related health care utilization was significantly lower in the DDDRP + MVP group than in the control group...
December 6, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/30525959/early-emergence-of-discrepancy-in-adaptive-behavior-and-cognitive-skills-in-toddlers-with-autism-spectrum-disorder
#6
Jessica Bradshaw, Scott Gillespie, Cheryl Klaiman, Ami Klin, Celine Saulnier
Individuals with autism spectrum disorder and average IQ exhibit a widening discrepancy between lagging adaptive skills relative to their cognitive potential, but it is unknown when this discrepancy emerges in development. To address this important question, we measured adaptive and cognitive skills longitudinally, from 12-36 months, in 96 low-risk typically developing infants and 69 high-risk siblings of children with autism spectrum disorder who at 36 months were diagnosed with autism spectrum disorder ( N = 21), the broader autism phenotype ( N = 19), or showed no concerns (unaffected; N = 29)...
December 7, 2018: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/30523511/single-brand-dual-chamber-discriminators-to-prevent-inappropriate-shocks-in-patients-implanted-with-prophylactic-implantable-cardioverter-defibrillators-a-propensity-weighted-comparison-of-single-and-dual-chamber-devices
#7
Sem Briongos-Figuero, Ana Sánchez, M Luisa Pérez, José B Martínez-Ferrer, Enrique García, Xavier Viñolas, Ángel Arenal, Javier Alzueta, Nuria Basterra, Aníbal Rodríguez, Ignacio Lozano, Roberto Muñoz-Aguilera
PURPOSE: Comparisons of the efficacy of dual- vs. single-chamber implantable cardioverter defibrillators (ICDs) in preventing inappropriate shocks have had contradictory results. We investigated whether dual-chamber devices have a lower risk of inappropriate shocks and the specific role of supraventricular tachycardia (SVT) discriminators. METHODS: All heart failure (HF) patients without an indication for pacing and implanted with a prophylactic ICD were recruited from the nationwide multicenter UMBRELLA registry...
December 6, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/30514728/sudden-onset-severe-presyncope-in-a-67-year-old-man
#8
Katie Hannah Sanders, Claire A Martin, Munmohan Virdee
A 67-year-old man presented to the emergency department with sudden onset of severe presyncope. He reported that he had a permanent pacemaker implanted in 2006 following atrioventricular node ablation for persistent atrial fibrillation (AF). After suffering increasing shortness of breath, he underwent upgrade to cardiac resynchronisation therapy (CRT) in 2016. He denied any recent falls, interventions or changes in medication. ECG monitoring showed AF with a broad ventricular escape rhythm at around 25 bpm with pauses of up to 3 s...
December 4, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30508679/robust-neurocognitive-individual-differences-in-grammatical-agreement-processing-a-latent-variable-approach
#9
Darren Tanner
Many neurocognitive accounts of language processing presume that neural responses detected in grand mean analyses of cortical electrophysiological activity reflect the normative brain response in the population under investigation. However, emerging work now shows that individuals' brain responses can vary systematically in both the size and type of effect elicited. The present research therefore examined individual differences in neural activity elicited by grammatical agreement anomalies during language comprehension in a large cohort of highly literate, monolingual English speakers (N = 114), a population generally assumed to be relatively homogenous in terms of linguistic knowledge and processing...
November 1, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/30485624/direct-evidence-for-the-polymeric-nature-of-polydopamine
#10
Peyman Delparastan, Katerina Malollari, Haeshin Lee, Phillip Messersmith
Inspired by the adhesive proteins of mussels, polydopamine (pDA) has emerged as one of the most widely employed methods for functionalizing material surfaces, fueled in part by the versatility, simplicity, and spontaneity of pDA film deposition on most materials upon immersion in an alkaline aqueous solution of dopamine. However, the rapid adoption of pDA for surface modification over the last decade stands in stark contrast to the slow pace in understanding the composition of pDA. Numerous attempts to elucidate the formation mechanism and structure of this fascinating material have resulted in little consensus mainly due to the insoluble nature of pDA; which renders most conventional methods of polymer molecular weight characterization ineffective...
November 28, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30482688/dissecting-the-synapse-and-frequency-dependent-network-mechanisms-of-in-vivo-hippocampal-sharp-wave-ripples
#11
Juan F Ramirez-Villegas, Konstantin F Willeke, Nikos K Logothetis, Michel Besserve
Hippocampal ripple oscillations likely support reactivation of memory traces that manifest themselves as temporally organized spiking of sparse neuronal ensembles. However, the network mechanisms concurring to achieve this function are largely unknown. We designed a multi-compartmental model of the CA3-CA1 subfields to generate biophysically realistic ripple dynamics from the cellular level to local field potentials. Simulations broadly parallel in vivo observations and support that ripples emerge from CA1 pyramidal spiking paced by recurrent inhibition...
October 23, 2018: Neuron
https://www.readbyqxmd.com/read/30470548/zinc-based-biomaterials-for-regeneration-and-therapy
#12
REVIEW
Yingchao Su, Irsalan Cockerill, Yadong Wang, Yi-Xian Qin, Lingqian Chang, Yufeng Zheng, Donghui Zhu
Zinc has been described as the 'calcium of the twenty-first century'. Zinc-based degradable biomaterials have recently emerged thanks to their intrinsic physiological relevance, biocompatibility, biodegradability, and pro-regeneration properties. Zinc-based biomaterials mainly include: metallic zinc alloys, zinc ceramic nanomaterials, and zinc metal-organic frameworks (MOFs). Metallic zinc implants degrade at a desirable rate, matching the healing pace of local tissues, and stimulating remodeling and formation of new tissues...
November 20, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/30468889/leukotriene-mediated-sex-dimorphism-in-murine-asthma-like-features-during-allergen-sensitization
#13
Antonietta Rossi, Fiorentina Roviezzo, Rosalinda Sorrentino, Maria A Riemma, Ida Cerqua, Rossella Bilancia, Giuseppe Spaziano, Fabiana Troisi, Simona Pace, Aldo Pinto, Bruno D'Agostino, Oliver Werz, Giuseppe Cirino
The incidence and severity of asthma preponderate in women versus men. Leukotrienes (LTs) are lipid mediators involved in asthma pathogenesis, and sex disparities in LT biosynthesis and anti-LT pharmacology in inflammation have recently emerged. Here, we report on sex dimorphism in LT production during allergen sensitization and its correlation to lung function. While high plasma levels of IgE, as sensitization index, were elevated in both sexes, LT levels increased only in lungs of female ovalbumin-sensitized BALB/c mice...
November 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30466843/the-efficacy-of-his-bundle-pacing-lessons-learned-from-implementation-for-the-first-time-at-an-experienced-electrophysiology-center
#14
Advay G Bhatt, Dan L Musat, Nicolle Milstein, Jacqueline Pimienta, Laura Flynn, Tina Sichrovsky, Mark W Preminger, Suneet Mittal
OBJECTIVES: This study sought to evaluate the clinical and procedural characteristics impacting outcomes during implementation of a His bundle pacing (HBP) program in a real-world setting. BACKGROUND: Right ventricular pacing is associated with an elevated risk of heart failure, but device reprogramming and upgrades have significant challenges. HBP has emerged as an alternative and is reported to be highly successful in the hands of highly experienced centers. METHODS: All patients referred for permanent pacemaker implantation at the Valley Hospital (Ridgewood, New Jersey) between October 2015 and October 2017 were evaluated; a subset of 24% was selected for HBP...
November 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/30466328/patients-experiences-of-unilateral-spatial-neglect-between-stroke-onset-and-discharge-from-inpatient-rehabilitation-a-thematic-analysis-of-qualitative-interviews
#15
Bernadette C Tobler-Ammann, Andrea Weise, Ruud H Knols, Martin J Watson, Judith M Sieben, Rob A de Bie, Eling D de Bruin
PURPOSE: The purpose of this qualitative study was to explore how stroke patients with unilateral spatial neglect experience; (a) performance in activities of daily living; (b) alterations in bodily perceptions; and (c) personal hopes and expectations, looking at the period between stroke onset and discharge from inpatient rehabilitation. MATERIALS AND METHODS: We conducted individual semi-structured interviews with 7 (5 men, 2 women, mean age 69 years) consecutively sampled participants...
November 22, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/30464132/recruitment-of-complete-right-bundle-branch-block-by-permanent-para-hisian-pacing
#16
Tatsuhiko Kataoka, Shinsuke Miyazaki, Kenichi Kaseno, Kanae Hasegawa, Naoki Amaya, Hiroshi Tada
His-bundle pacing has recently emerged as a means to maintain a physiological ventricular activation and eliminate the risk of pacing-induced myopathy associated with traditional right ventricular pacing. With His-bundle pacing, the exact stimulated structure and resulting excitation wavefront may be highly dependent on the pacing output, dimensions of the stimulatory electrodes, and orientation of the cathode and anode relative to the approximated conduction tissue and surrounding myocardium, owing to the juxtaposition of tissues with very different conduction properties...
November 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30426465/feasibility-and-safety-of-exclusive-echocardiography-guided-intravenous-temporary-pacemaker-implantation
#17
Aref El Nasasra, Hilmi Alnsasra, Doron Zahger, Tsahi T Lerman, Sergio Kobal, Carlos Cafri, Moti Haim, Lior Fuchs, Avi Shimony
BACKGROUND: The standard approach for urgent trans-venous temporary cardiac pacemaker (TVTP) implantation is fluoroscopy guidance. The delay in activation of the fluoroscopy-room and the transfer of unstable patients may be life-threatening. Echocardiography-guided TP implantation may increase the safety of the patients by obviating the need for in-hospital transfer. We examined the feasibility and safety of echocardiography-guided vs. fluoroscopy-guided TVTP implantation. METHODS: From January 2015 to September 2017 data for consecutive patients who needed emergent TVTP implantation were retrospectively reviewed...
November 13, 2018: Journal of Echocardiography
https://www.readbyqxmd.com/read/30425668/emergence-of-skilled-behaviors-in-professional-amateur-and-junior-cricket-batsmen-during-a-representative-training-scenario
#18
Jonathan D Connor, Damian Farrow, Ian Renshaw
The aim of this study was to explore the emergence of skilled behaviors, in the form of actions, cognitions and emotions, between professional state level cricket batters and their lesser skilled counterparts. Twenty-two male cricket batsmen ( n = 6 state level; n = 8 amateur grade club level, n = 8 junior state representative level) participated in a game scenario training session against right arm pace bowlers ( n = 6 amateur senior club). The batsmen were tasked with scoring as many runs as possible during a simulated limited-overs game...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30417960/massive-his-bundle-injury-current-corresponds-with-acute-trauma-and-slowing-of-conduction-that-has-to-subside-before-pacing-threshold-assessment
#19
Marek Jastrzębski, Paweł Moskal, Danuta Czarnecka
His bundle (HB) pacing emerges as a potential new standard ventricular pacing option. The presented tracings were recorded on an electrophysiology system during HB pacemaker implantation in a 72-year-old patient with heart failure and chronic atrial fibrillation This article is protected by copyright. All rights reserved.
November 12, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/30416469/enacting-phenomenological-gestalts-in-ultra-trail-running-an-inductive-analysis-of-trail-runners-courses-of-experience
#20
Nadège Rochat, Vincent Gesbert, Ludovic Seifert, Denis Hauw
Using an enactive approach to trail runners' activity, this study sought to identify and characterize runners' phenomenological gestalts, which are forms of experience that synthesize the heterogeneous sensorimotor, cognitive and emotional information that emerges in race situations. By an in-depth examination of their meaningful experiences, we were able to highlight the different typologies of interactions between bodily processes (e.g., sensations and pains), behaviors (e.g., actions and strategies), and environment (e...
2018: Frontiers in Psychology
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