Kashif Rahim, Muhammad Shan, Ihtisham Ul Haq, Muhammad Naveed Nawaz, Sajida Maryam, Mansour S Alturki, Abdulaziz H Al Khzem, Kamel Metwally, Simona Cavalu, Saleh F Alqifari, Galal Yahya
DPP4 (Dipeptidyl-peptidase 4) a versatile protease, emerges as a prominent player in soluble and membrane-bound forms. Its heightened expression has been intimately linked to the initiation and severity of diverse autoimmune diseases, spanning rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (SSc), inflammatory bowel disease, autoimmune diabetes, and even SARS-CoV-2 infection. Operating as a co-stimulator of T cell activity, DPP4 propels T cell proliferation by binding adenosine deaminase (ADA), thereby augmenting the breakdown of adenosine-an influential inhibitor of T cell proliferation...
2024: Journal of Inflammation Research