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"Droperidol" AND "Emergency"

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https://www.readbyqxmd.com/read/30031556/the-characteristics-and-prevalence-of-agitation-in-an-urban-county-emergency-department
#1
James R Miner, Lauren R Klein, Jon B Cole, Brian E Driver, Johanna C Moore, Jeffrey D Ho
STUDY OBJECTIVE: We seek to determine the characteristics and prevalence of agitation among patients in an urban county emergency department (ED). METHODS: This was a prospective observational study of ED patients at an urban Level I trauma center. All ED patients were screened during daily randomized 8-hour enrollment periods. Adult agitated patients, defined as having an altered mental status score greater than 1, were included. Trained research volunteers collected demographics and baseline data, including the presenting altered mental status score, use and type of restraints, and whether any initial sedative was given...
July 18, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29882463/joint-bap-napicu-evidence-based-consensus-guidelines-for-the-clinical-management-of-acute-disturbance-de-escalation-and-rapid-tranquillisation
#2
Maxine X Patel, Faisil N Sethi, Thomas Re Barnes, Roland Dix, Luiz Dratcu, Bernard Fox, Marina Garriga, Julie C Haste, Kai G Kahl, Anne Lingford-Hughes, Hamish McAllister-Williams, Aileen O'Brien, Caroline Parker, Brodie Paterson, Carol Paton, Sotiris Posporelis, David M Taylor, Eduard Vieta, Birgit Völlm, Charlotte Wilson-Jones, Laura Woods
The British Association for Psychopharmacology and the National Association of Psychiatric Intensive Care and Low Secure Units developed this joint evidence-based consensus guideline for the clinical management of acute disturbance. It includes recommendations for clinical practice and an algorithm to guide treatment by healthcare professionals with various options outlined according to their route of administration and category of evidence. Fundamental overarching principles are included and highlight the importance of treating the underlying disorder...
June 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29643708/evidence-based-review-and-appraisal-of-the-use-of-droperidol-in-the-emergency-department
#3
REVIEW
Pei-Chun Lai, Yen-Ta Huang
Droperidol is a short-acting, potent dopamine D2 antagonist that can pass through the blood-brain barrier. A black box warning was issued for droperidol by the United States Food and Drug Administration in 2001 because of a risk of development of torsades de pointes induced by QT prolongation. Many experts feel that the incidence of arrhythmia is overestimated, and low-dose droperidol is almost always used by anesthesiologists for postoperative nausea and vomiting. In this review, we used evidence-based analysis to appraise high-quality studies with a low risk of bias published after 2001 on the use of droperidol in the emergency department (ED)...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29623620/economic-evaluation-of-midazolam-droperidol-combination-versus-droperidol-or-olanzapine-for-the-management-of-acute-agitation-in-the-emergency-department-a-within-trial-analysis
#4
Celene Y L Yap, Ya-Seng Arthur Hsueh, Jonathan C Knott, David McD Taylor, Esther W Chan, David C M Kong
BACKGROUND: The combination of midazolam and droperidol has proven superior to droperidol or olanzapine monotherapy in the management of acute agitation in emergency departments (EDs). OBJECTIVE: This is the first economic analysis to evaluate the cost-benefit and cost effectiveness of the midazolam-droperidol combination compared with droperidol or olanzapine for the management of acute agitation in EDs. METHODS: This analysis used data derived from a randomised, controlled, double-blind clinical trial conducted in two metropolitan Australian EDs between October 2014 and August 2015...
June 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29558224/a-prospective-before-and-after-study-of-droperidol-for-prehospital-acute-behavioral-disturbance
#5
Colin B Page, Lachlan E Parker, Stephen J Rashford, Emma Bosley, Katherine Z Isoardi, Frances E Williamson, Geoffrey K Isbister
STUDY OBJECTIVE: Acute behavioral disturbance is a common problem for emergency medical services. We aimed to investigate the safety and effectiveness of droperidol compared to midazolam in the prehospital setting. METHODS: This was a prospective before and after study comparing droperidol to midazolam for prehospital acute behavioral disturbance, when the state ambulance service changed medications. The primary outcome was the proportion of adverse effects (airway intervention, oxygen saturation < 90%, respiratory rate < 12, systolic blood pressure < 90 mmHg, sedation assessment tool score -3 and dystonic reactions) in patients receiving sedation...
March 20, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29361326/evidence-based-review-of-pharmacotherapy-for-acute-agitation-part-1-onset-of-efficacy
#6
Leslie S Zun
BACKGROUND: The main goal of antipsychotic medication in the management of acute agitation in the emergency department is to rapidly induce calm without oversedation, enabling patients to participate in their own care. However, there is a paucity of comparative studies, particularly with newer fast-acting second-generation antipsychotic agents. OBJECTIVE OF THE REVIEW: This structured evidence-based review compared the onset of efficacy of antipsychotic treatments for acute agitation using data from randomized controlled trials identified by a literature search of the PubMed database...
March 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29251645/dopamine-d2-receptor-antagonist-droperidol-deepens-sevoflurane-anesthesia
#7
Ryuhei Araki, Kazuko Hayashi, Teiji Sawa
BACKGROUND: Although midbrain dopaminergic pathways are known to contribute to arousal and emergence from anesthesia, few reports exist regarding the anesthetic effects of dopamine D2 receptor antagonism in humans. This study examined the effect of the D2 receptor antagonist droperidol on sevoflurane anesthesia by examining α and slow wave electroencephalogram oscillations. METHODS: Forty-five patients, age 20 to 60 yr, were enrolled. Frontal electroencephalograms were continuously collected for offline analysis via Bispectral Index monitoring...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/28160494/intravenous-midazolam-droperidol-combination-droperidol-or-olanzapine-monotherapy-for-methamphetamine-related-acute-agitation-subgroup-analysis-of-a-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Celene Y L Yap, David McD Taylor, Jonathan C Knott, Simone E Taylor, Georgina A Phillips, Jonathan Karro, Esther W Chan, David C M Kong, David J Castle
AIM: To examine the efficacy and safety of (1) midazolam-droperidol versus droperidol and (2) midazolam-droperidol versus olanzapine for methamphetamine-related acute agitation. DESIGN AND SETTING: A multi-centre, randomized, double-blind, controlled, clinical trial was conducted in two Australian emergency departments, between October 2014 and September 2015. PARTICIPANTS: Three hundred and sixty-one patients, aged 18-65 years, requiring intravenous medication sedation for acute agitation, were enrolled into this study...
July 2017: Addiction
https://www.readbyqxmd.com/read/27745766/midazolam-droperidol-droperidol-or-olanzapine-for-acute-agitation-a-randomized-clinical-trial
#9
RANDOMIZED CONTROLLED TRIAL
David McD Taylor, Celene Y L Yap, Jonathan C Knott, Simone E Taylor, Georgina A Phillips, Jonathan Karro, Esther W Chan, David C M Kong, David J Castle
STUDY OBJECTIVE: We aim to determine the most efficacious of 3 common medication regimens for the sedation of acutely agitated emergency department (ED) patients. METHODS: We undertook a randomized, controlled, double-blind, triple-dummy, clinical trial in 2 metropolitan EDs between October 2014 and August 2015. Patients aged 18 to 65 years and requiring intravenous medication sedation for acute agitation were enrolled and randomized to an intravenous bolus of midazolam 5 mg-droperidol 5 mg, droperidol 10 mg, or olanzapine 10 mg...
March 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27599617/polysubstance-induced-relapse-of-schizoaffective-disorder-refractory-to-high-dose-antipsychotic-medications-a-case-report
#10
Murray G Tucker, Sebastian Kekulawala, Michelle Kent, Sam Mostafa, Richard Harvey
BACKGROUND: The high prevalence of comorbid illicit drug use in persons with chronic psychotic illness represents a strong determinant of psychotic relapse and rehospitalization. Epidemiological studies indicate changing patterns of illicit drug use in Australia, which are concerning because of increased use of crystal methamphetamine, also known as "ice." An important complication of habitual use of crystal methamphetamine is the development of a dose-dependent acute psychotic reaction...
September 6, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27422566/good-clinical-guidelines-must-define-the-setting-patients-and-evidence-benzodiazepines-versus-droperidol-for-acute-behavioural-disturbance-in-the-emergency-department
#11
Geoffrey K Isbister, Nicholas A Buckley
No abstract text is available yet for this article.
December 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/26899459/ketamine-as-rescue-treatment-for-difficult-to-sedate-severe-acute-behavioral-disturbance-in-the-emergency-department
#12
Geoffrey Kennedy Isbister, Leonie A Calver, Michael A Downes, Colin B Page
STUDY OBJECTIVE: We investigate the effectiveness and safety of ketamine to sedate patients with severe acute behavioral disturbance who have failed previous attempts at sedation. METHODS: This was a prospective study of patients given ketamine for sedation who had failed previous sedation attempts. Patients with severe acute behavioral disturbance requiring parenteral sedation were treated with a standardized sedation protocol including droperidol. Demographics, drug dose, observations, and adverse effects were recorded...
May 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/26720055/a-large-retrospective-cohort-of-patients-receiving-intravenous-olanzapine-in-the-emergency-department
#13
Marc L Martel, Lauren R Klein, Robert L Rivard, Jon B Cole
BACKGROUND: Olanzapine is an atypical antipsychotic with similar pharmacologic properties to droperidol. Due to the current droperidol shortage, the authors' clinical practice has been to substitute olanzapine for droperidol in many situations. At this time, olanzapine is U.S. Food and Drug Administration approved for oral and intramuscular (IM) use only, but due to its increased utility, intravenous (IV) olanzapine was recently approved for use in the study emergency department (ED)...
January 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/26433424/first-generation-antipsychotics-are-often-prescribed-in-the-emergency-department-but-are-often-not-administered-with-adjunctive-medications
#14
MULTICENTER STUDY
Ashleigh Campillo, Edward Castillo, Gary M Vilke, Austin Hopper, Victoria Ryan, Michael P Wilson
BACKGROUND: Although first-generation antipsychotics (FGAs) have long been used in the emergency department (ED) to treat acute agitation, little is known about how these medications are used in modern clinical practice. In particular, little work has been published about whether ED clinicians administer FGAs with adjunctive medications in accordance with expert guidelines or the prescribing practices of FGAs over time. OBJECTIVES: 1) To provide a comparison of the frequency with which FGAs are administered with adjunctive benzodiazepines or anticholinergic medications...
December 2015: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26411330/drugs-for-the-treatment-of-nausea-and-vomiting-in-adults-in-the-emergency-department-setting
#15
REVIEW
Jeremy S Furyk, Robert A Meek, Diana Egerton-Warburton
BACKGROUND: Nausea and vomiting is a common and distressing presenting complaint in emergency departments (ED). The aetiology of nausea and vomiting in EDs is diverse and drugs are commonly prescribed. There is currently no consensus as to the optimum drug treatment of nausea and vomiting in the adult ED setting. OBJECTIVES: To provide evidence of the efficacy and safety of antiemetic medications in the management of nausea and vomiting in the adult ED setting. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2014, Issue 8), MEDLINE (OvidSP) (January 1966 to August 2014), EMBASE (OvidSP) (January 1980 to August 2014) and ISI Web of Science (January 1955 to August 2014)...
September 28, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26116221/training-the-mind-and-the-food-and-drug-administration-on-droperidol
#16
EDITORIAL
David H Newman
No abstract text is available yet for this article.
September 2015: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/26043843/prescribing-preferences-in-rapid-tranquillisation-a-survey-in-belgian-psychiatrists-and-emergency-physicians
#17
COMPARATIVE STUDY
Chris Bervoets, Ella Roelant, Jürgen De Fruyt, Hella Demunter, Barry Dekeyser, Leen Vandenbussche, Koen Titeca, Guido Pieters, Bernard Sabbe, Manuel Morrens
BACKGROUND: The pharmacotherapeutic management of agitation is a common clinical challenge. Pharmacotherapy is frequently used, the use of published guidelines is not known. The purpose of this study was twofold; to describe the prescribing patterns of psychiatrists and emergency physicians and to evaluate to which extent guidelines are used. METHODS: A cross-sectional survey in the Dutch-speaking part of Belgium is carried out in 39 psychiatric hospitals, 11 psychiatric wards of a general hospital and 61 emergency departments...
2015: BMC Research Notes
https://www.readbyqxmd.com/read/25890395/the-safety-and-effectiveness-of-droperidol-for-sedation-of-acute-behavioral-disturbance-in-the-emergency-department
#18
Leonie Calver, Colin B Page, Michael A Downes, Betty Chan, Frances Kinnear, Luke Wheatley, David Spain, Geoffrey Kennedy Isbister
STUDY OBJECTIVE: We investigate the safety and effectiveness of droperidol for sedation of acute behavioral disturbance in the emergency department (ED). METHODS: This was a prospective observational study in 6 EDs (August 2009 to April 2013). Adult patients requiring parenteral sedation for acute behavioral disturbance received droperidol 10 mg. If this did not sedate the patient within 15 minutes, further sedation was allowed but droperidol 10 mg was recommended as part of a sedation protocol...
September 2015: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/25837231/american-academy-of-emergency-medicine-position-statement-safety-of-droperidol-use-in-the-emergency-department
#19
REVIEW
Jack Perkins, Jeffrey D Ho, Gary M Vilke, Gerard DeMers
BACKGROUND: Droperidol (Inapsine®, Glaxosmithkline, Brent, UK) is a butyrophenone used in emergency medicine practice for a variety of uses. QT prolongation is a well-known adverse effect of this class of medications. Of importance to note, QT prolongation is noted with multiple medication classes, and droperidol increases QT interval in a dose-dependent fashion among susceptible individuals. The primary goal of this literature search was to determine the reported safety issues of droperidol in emergency department management of patients...
July 2015: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25416184/droperidol-for-the-treatment-of-acute-migraine-headaches
#20
REVIEW
Michael C Thomas, Megan E Musselman, Justin Shewmaker
OBJECTIVE: To evaluate the safety and efficacy of droperidol for the relief of acute migraine headaches. DATA SOURCES: A MEDLINE search (1946 to August 2014) was performed using the following keywords and associated medical subject headings: droperidol, inapsine, headache, migraine, and migraine disorder. STUDY SELECTION AND DATA EXTRACTION: The search was conducted to identify randomized controlled trials comparing droperidol with placebo or an active control in adult patients with acute migraine headaches that were published in English...
February 2015: Annals of Pharmacotherapy
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