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https://www.readbyqxmd.com/read/28894240/understanding-of-multi-level-resistive-switching-mechanism-in-geox-through-redox-reaction-in-h2o2-sarcosine-prostate-cancer-biomarker-detection
#1
Subhranu Samanta, Sheikh Ziaur Rahaman, Anisha Roy, Surajit Jana, Somsubhra Chakrabarti, Rajeswar Panja, Sourav Roy, Mrinmoy Dutta, Sreekanth Ginnaram, Amit Prakash, Siddheswar Maikap, Hsin-Ming Cheng, Ling-Na Tsai, Jian-Tai Qiu, Samit K Ray
Formation-free multi-level resistive switching characteristics by using 10 nm-thick polycrystalline GeOx film in a simple W/GeOx/W structure and understanding of switching mechanism through redox reaction in H2O2/sarcosine sensing (or changing Ge°/Ge(4+) oxidation states under external bias) have been reported for the first time. Oxidation states of Ge(0)/Ge(4+) are confirmed by both XPS and H2O2 sensing of GeOx membrane in electrolyte-insulator-semiconductor structure. Highly repeatable 1000 dc cycles and stable program/erase (P/E) endurance of >10(6) cycles at a small pulse width of 100 ns are achieved at a low operation current of 0...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871787/nmr-spectroscopy-based-metabolomics-of-drosophila-model-of-huntington-s-disease-suggests-altered-cell-energetics
#2
Virender Singh, Raj Kumar Sharma, Thamarailingam Athilingam, Pradip Sinha, Neeraj Sinha, Ashwani Kumar Thakur
Huntington's disease (HD) is a neurodegenerative disorder induced by aggregation of the pathological form of Huntingtin protein that has expanded polyglutamine (polyQ) repeats. In the Drosophila model, for instance, expression of transgenes with polyQ repeats induce HD-like pathologies progressively correlating with the increasing lengths of these repeats. Previous studies on both animal models and clinical samples have revealed metabolite imbalances during HD progression. To further explore the physiological processes linked to metabolite imbalances during HD, we have investigated 1D (1)H NMR spectroscopy-based metabolomics profile of Drosophila HD model...
September 5, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28870830/an-improved-amperometric-creatinine-biosensor-based-on-nanoparticles-of-creatininase-creatinase-and-sarcosine-oxidase
#3
Parveen Kumar, Ranjana Jaiwal, C S Pundir
An improved amperometric biosensor for detection of creatinine was developed based on immobilization of nanoparticles (NPs) of creatininase (CA), creatinase (CI), and sarcosine oxidase (SOx) onto glassy carbon (GC) electrode. Transmission electron microscopy (TEM) and fourier transform infrared spectroscopy (FTIR) were employed for characterization of enzyme nanoparticles (ENPs). The GC electrode was characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectra (EIS) at different stages of its amendment...
September 1, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28868667/preparation-of-novel-deuterated-cyclosporin-a-standards-for-quantitative-lc-ms-analysis
#4
Remigiusz Bąchor, Alicja Kluczyk, Piotr Stefanowicz, Zbigniew Szewczuk
The investigation on the synthesis of α-C deuterated analogues of cyclosporine A (CsA) in N-methylated amino acid residues was performed. The reaction based on our previous report (Bachor et al. 2014 J Mass Spectrom 49, 43-49), proceeds in the presence of bases like TBD or MTBD at pH 13.4. The obtained results suggest the possibility of introduction of three deuterons, two at the α-C of sarcosine and one at the chiral α-C atom of 2-N-methyl-(R)-((E)-2-butenyl)-4-methyl-L-threonine residue. The stability of the obtained isotopologues was analyzed both under neutral or acidic conditions and the obtained results revealed that the introduced deuterons do not undergo back-exchange...
September 4, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28846033/metabolic-alterations-of-qinghai-tibet-plateau-pikas-in-adaptation-to-high-altitude
#5
Xue-Feng Cao, Zhen-Zhong Bai, Lan Ma, Shuang Ma, Ri-Li Ge
Cao, Xue-Feng, Zhen-Zhong Bai, Lan Ma, Shuang Ma, and Ri-Li Ge. Metabolic alterations of Qinghai-Tibet plateau pikas in adaptation to high altitude. High Alt Med Biol. 18:219-225, 2017.-To determine specific metabolic alterations in the myocardium of plateau pikas (Ochotona curzoniae) and potential metabolic biomarkers involved in their adaptation to the high-altitude environment of the Qinghai-Tibet Plateau. Ten pikas were captured by traps in the Kekexili Reserve (4630 m a.s.l; n = 5) and at the foot of the Laji Mountain (2600 m a...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28841024/pharmacometabolomics-in-endogenous-drugs-a-new-approach-for-predicting-the-individualized-pharmacokinetics-of-cholic-acid
#6
Zhixin Zhang, Hao Gu, Huizhen Zhao, Yuehong Liu, Shuang Fu, Meiling Wang, Wenjuan Zhou, Ziye Xie, Honghong Yu, Zhenghai Huang, Xiaoyan Gao
The evaluation of individual variability in endogenous drugs' metabolism and disposition is a very challenging task. Here, we developed and validated a metabotype to pharmacokinetics (PK) matching approach by taking cholic acid as an example to predict the individualized PK of endogenous drugs. The stable isotope-labeled cholic acid was selected as the substitute analyte of cholic acid to ensure the accurate measurement of blood concentration. First, large-scale metabolite profiling studies were performed on the predose urine samples of 28 rats...
August 25, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28832933/synthesis-and-gelation-of-copolypept-o-ides-with-random-and-block-structure
#7
Yan Xiao, Jianqiang Wang, Jun Zhang, Andreas Heise, Meidong Lang
Copolypept(o)ides of polysarcosine (PSar) and poly(N-isopropyl-L-glutamine) (PIGA) with random and block sequence structures were synthesized by ring-opening polymerization (ROP) of sarcosine N-carboxyanhydrides (Sar-NCA) and γ-benzyl-l-glutamate N-carboxyanhydrides (BLG-NCA) and post modification. With different distribution of Sar along the main chain, H-bonding pattern and secondary structure of polypeptides were turned, as well as aggregation and gelation behavior. Both copolypept(o)ides formed hydrogels above their critical gelation concentrations (CGCs) without thermo-sensitivity, which was normally reserved for PEG copolypeptides (eg, PEG-b-PIGA)...
August 18, 2017: Biopolymers
https://www.readbyqxmd.com/read/28831683/oligopeptide-transport-in-rat-lung-alveolar-epithelial-cells-is-mediated-by-pept2
#8
Hovhannes J Gukasyan, Tomomi Uchiyama, Kwang-Jin Kim, Carsten Ehrhardt, Sharon K Wu, Zea Borok, Edward D Crandall, Vincent H L Lee
PURPOSE: Studies were conducted in primary cultured rat alveolar epithelial cell monolayers to characterize peptide transporter expression and function. METHODS: Freshly isolated rat lung alveolar epithelial cells were purified and cultured on permeable support with and without keratinocyte growth factor (KGF). Messenger RNA and protein expression of Pept1 and Pept2 in alveolar epithelial type I- and type II-like cell monolayers (±KGF, resp.) were examined by RT-PCR and Western blotting...
August 22, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28817702/global-gene-expression-analysis-of-the-response-of-physic-nut-jatropha-curcas-l-to-medium-and-long-term-nitrogen-deficiency
#9
Qi Kuang, Sheng Zhang, Pingzhi Wu, Yaping Chen, Meiru Li, Huawu Jiang, Guojiang Wu
Jatropha curcas L. is an important biofuel plant with excellent tolerance of barren environments. However, studies on the regulatory mechanisms that operate in this plant in response to nitrogen (N) shortage are scarce. In this study, genome-wide transcriptional profiles of the roots and leaves of 8-week old physic nut seedlings were analyzed after 2 and 16 days of N starvation. Enrichment results showed that genes associated with N metabolism, processing and regulation of RNA, and transport predominated among those showing alterations in expression...
2017: PloS One
https://www.readbyqxmd.com/read/28813537/metabolite-patterns-predicting-sex-and-age-in-participants-of-the-karlsruhe-metabolomics-and-nutrition-karmen-study
#10
Manuela J Rist, Alexander Roth, Lara Frommherz, Christoph H Weinert, Ralf Krüger, Benedikt Merz, Diana Bunzel, Carina Mack, Björn Egert, Achim Bub, Benjamin Görling, Pavleta Tzvetkova, Burkhard Luy, Ingrid Hoffmann, Sabine E Kulling, Bernhard Watzl
Physiological and functional parameters, such as body composition, or physical fitness are known to differ between men and women and to change with age. The goal of this study was to investigate how sex and age-related physiological conditions are reflected in the metabolome of healthy humans and whether sex and age can be predicted based on the plasma and urine metabolite profiles. In the cross-sectional KarMeN (Karlsruhe Metabolomics and Nutrition) study 301 healthy men and women aged 18-80 years were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28803626/putting-the-piezolyte-hypothesis-under-pressure
#11
Christina M Papini, Pranav P Pandharipande, Catherine A Royer, George I Makhatadze
A group of small molecules that stabilize proteins against high hydrostatic pressure has been classified as piezolytes, a subset of stabilizing cosolutes. This distinction would imply that piezolytes counteract the effects of high hydrostatic pressure through effects on the volumetric properties of the protein. The purpose of this study was to determine if cosolutes proposed to be piezolytes have an effect on the volumetric properties of proteins through direct experimental measurements of volume changes upon unfolding of model proteins lysozyme and ribonuclease A, in solutions containing varying cosolute concentrations...
September 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28782586/breaking-the-mirror-l-amino-acid-deaminase-a-novel-stereoselective-biocatalyst
#12
REVIEW
Gianluca Molla, Roberta Melis, Loredano Pollegioni
Enantiomerically pure amino acids are of increasing interest for the fine chemical, agrochemicals and pharmaceutical industries. During past years l-amino acids have been produced from deracemization of dl-solution employing the stereoselective flavoenzyme d-amino acid oxidase. On the other hand, the isolation of corresponding d-isomer was hampered by the scarce availability of a suitable l-amino acid oxidase activity. On this side, l-amino acid deaminase (LAAD), only present in the Proteus bacteria, represents a suitable alternative...
November 1, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28777736/a-pilot-study-of-the-effect-of-human-breast-milk-on-urinary-metabolome-analysis-in-infants
#13
Hiromichi Shoji, Hikari Taka, Naoko Kaga, Naho Ikeda, Tomohiro Kitamura, Yoshiki Miura, Toshiaki Shimizu
BACKGROUND: This study aimed to examine the nutritional effect of breast feeding on healthy term infants by using urinary metabolome analysis. METHODS: Urine samples were collected from 19 and 14 infants at 1 and 6 months, respectively. Infants were separated into two groups: the breast-fed group receiving <540 mL/week of their intake from formula (n=13 at 1 month; n=9 at 6 months); and the formula-fed group receiving no breast milk (BM) (n=6 at 1 month; n=5 at 6 months)...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28740550/boosting-the-peroxidase-like-activity-of-nanostructured-nickel-by-inducing-its-3-oxidation-state-in-lanio3-perovskite-and-its-application-for-biomedical-assays
#14
Xiaoyu Wang, Wen Cao, Li Qin, Tingsheng Lin, Wei Chen, Shichao Lin, Jia Yao, Xiaozhi Zhao, Min Zhou, Cheng Hang, Hui Wei
Catalytic nanomaterials with intrinsic enzyme-like activities, called nanozymes, have recently attracted significant research interest due to their unique advantages relative to natural enzymes and conventional artificial enzymes. Among the nanozymes developed, particular interests have been devoted to nanozymes with peroxidase mimicking activities because of their promising applications in biosensing, bioimaging, biomedicine, etc. Till now, lots of functional nanomaterials have been used to mimic peroxidase...
2017: Theranostics
https://www.readbyqxmd.com/read/28702505/human-snorna-93-is-processed-into-a-microrna-like-rna-that-promotes-breast-cancer-cell-invasion
#15
Dillon G Patterson, Justin T Roberts, Valeria M King, Dominika Houserova, Emmaline C Barnhill, Aline Crucello, Caroline J Polska, Lucas W Brantley, Garrett C Kaufman, Michael Nguyen, Megann W Santana, Ian A Schiller, Julius S Spicciani, Anastasia K Zapata, Molly M Miller, Timothy D Sherman, Ruixia Ma, Hongyou Zhao, Ritu Arora, Alexander B Coley, Melody M Zeidan, Ming Tan, Yaguang Xi, Glen M Borchert
Genetic searches for tumor suppressors have recently linked small nucleolar RNA misregulations with tumorigenesis. In addition to their classically defined functions, several small nucleolar RNAs are now known to be processed into short microRNA-like fragments called small nucleolar RNA-derived RNAs. To determine if any small nucleolar RNA-derived RNAs contribute to breast malignancy, we recently performed a RNA-seq-based comparison of the small nucleolar RNA-derived RNAs of two breast cancer cell lines (MCF-7 and MDA-MB-231) and identified small nucleolar RNA-derived RNAs derived from 13 small nucleolar RNAs overexpressed in MDA-MB-231s...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28676336/quantitative-proteomic-analysis-of-iron-regulated-outer-membrane-proteins-in-aeromonas-hydrophila-as-potential-vaccine-candidates
#16
Yuqian Wang, Huarong Chen, Zhuang Guo, Lina Sun, Yuying Fu, Tao Li, Wenxiong Lin, Xiangmin Lin
The iron-regulated outer membrane protein (OMP) of Aeromonas hydrophila is an effective vaccine candidate, but its intrinsic functional components are largely unknown. In this study, we compared the differentially expressed sarcosine-insoluble fractions of A. hydrophila in iron-limited and normal medium using tandem mass tag labeling-based quantitative proteomics, and identified 91 upregulated proteins including 21 OMPs and 83 downregulated proteins including 10 OMPs. Subsequent bioinformatics analysis showed that iron chelate transport-related proteins were enriched in increasing abundance, whereas oxidoreductase activity and translation-related proteins were significantly enriched in decreasing abundance...
July 1, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28636478/pathway-and-rate-limiting-step-of-glyphosate-degradation-by-aspergillus-oryzae-a-f02
#17
Gui-Ming Fu, Yan Chen, Ru-Yi Li, Xiao-Qiang Yuan, Cheng-Mei Liu, Bin Li, Yin Wan
Aspergillus oryzae A-F02, a glyphosate-degrading fungus, was isolated from an aeration tank in a pesticide factory. The pathway and rate-limiting step of glyphosate (GP) degradation were investigated through metabolite analysis. GP, aminomethylphosphonic acid (AMPA), and methylamine were detected in the fermentation liquid of A. oryzae A-F02, whereas sarcosine and glycine were not. The pathway of GP degradation in A. oryzae A-F02 was revealed: GP was first degraded into AMPA, which was then degraded into methylamine...
June 21, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28616992/coherent-experimental-and-simulation-approach-to-explore-the-underlying-mechanism-of-denaturation-of-stem-bromelain-in-osmolytes
#18
Anjeeta Rani, Mohamed Taha, Pannuru Venkatesu, Ming-Jer Lee
Characterization of a protein in the context of its environment is of crucial importance for a complete understanding of its function. Although biophysical techniques provide powerful tools for studying the stability and activity of the enzyme in the presence of various cosolvents, an approach of combining both experimental techniques and molecular dynamic (MD) simulations may lead to the mechanistic insight into the interactions governing the stability of an enzyme. The knowledge of these interactions can be further utilized for range of modifications in the wild form of an enzyme for various pharmaceutical applications...
June 30, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28594555/effect-of-aging-on-the-absorption-of-small-peptides-in-spontaneously-hypertensive-rats
#19
Vu Thi Hanh, Weilin Shen, Mitsuru Tanaka, Aino Siltari, Riita Korpela, Toshiro Matsui
In the present study, we aimed to evaluate the effect of aging on the absorption of small peptides in spontaneously hypertensive rats (SHRs). Three kinds of dipeptides, glycyl-sarcosine (Gly-Sar), Trp-His, and captopril (a dipeptidomimetic drug), a Gly-Sar-Sar tripeptide, a Gly-Sar-Sar-Sar tetrapeptide, and a Gly-Sar-Sar-Sar-Sar pentapeptide were administered at doses of 10 mg/kg each to 8- and 40-week-old SHRs. The peptides were all detected in their intact forms in the blood. There was a significantly promoted absorption of di/tripeptides in aged SHRs compared with young SHRs...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28552337/one-pot-microwave-assisted-stereoselective-synthesis-of-novel-dihydro-2-h-spiro-indene-2-1-pyrrolo-3-4-c-pyrrole-tetraones-and-evaluation-of-their-antimycobacterial-activity-and-inhibition-of-ache
#20
Chelliah Bharkavi, Sundaravel Vivek Kumar, Mohamed Ashraf Ali, Hasnah Osman, Shanmugam Muthusubramanian, Subbu Perumal
An efficient one-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-tetraone derivatives through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ from ninhydrin and sarcosine with a series of 1-aryl-1H-pyrrole-2,5-diones is described. The synthesised compounds were screened for their antimycobacterial and AChE inhibition activities. Compound 4b (IC50 1.30µM) has been found to display twelve fold antimycobacterial activity compared to cycloserine and it is thirty seven times more active than pyrimethamine...
July 15, 2017: Bioorganic & Medicinal Chemistry Letters
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