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"Midazolam" AND "Emergency"

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https://www.readbyqxmd.com/read/30075875/hospital-emergency-treatment-of-convulsive-status-epilepticus-comparison-of-pathways-from-ten-pediatric-research-centers
#1
Alejandra Vasquez, Marina Gaínza-Lein, Iván Sánchez Fernández, Nicholas S Abend, Anne Anderson, J Nicholas Brenton, Jessica L Carpenter, Kevin Chapman, Justice Clark, William D Gaillard, Tracy Glauser, Joshua Goldstein, Howard P Goodkin, Yi-Chen Lai, Tobias Loddenkemper, Tiffani L McDonough, Mohamad A Mikati, Anuranjita Nayak, Eric Payne, James Riviello, Dmitry Tchapyjnikov, Alexis A Topjian, Mark S Wainwright, Robert C Tasker
OBJECTIVE: We aimed to evaluate and compare the status epilepticus treatment pathways used by pediatric status epilepticus research group (pSERG) hospitals in the United States and the American Epilepsy Society (AES) status epilepticus guideline. METHODS: We undertook a descriptive analysis of recommended timing, dosing, and medication choices in 10 pSERG hospitals' status epilepticus treatment pathways. RESULTS: One pathway matched the timeline in the AES guideline; nine pathways described more rapid timings...
July 11, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/30033870/development-and-evaluation-of-an-anti-epileptic-oral-fast-dissolving-film-with-enhanced-dissolution-and-in-vivo-permeation
#2
Arezou Soroushnai, Fariba Ganji, Ebrahim Vasheghani-Farahani, Hamid Mobedi
The main objective of this novel study was to develop midazolam hydrochloride Fast dissolving oral films (FDFs) using solvent casting method and to evaluate the characteristics of the optimum formulation through in vitro and in vivo analysis. The FDFs are new favorable solid dosage forms that deliver drugs rapidly to the blood circulation system and have great advantages in the emergent control of severe neuropathic attacks in children.Methods and Midazolam nanosuspensions were prepared using the ultrasonic method and then incorporated in the hydroxypropyl methyl cellulose (HPMC)/pullulan polymeric matrix with other excipients like glycerol and cellulose nanofiber as a softener and a compatibilizer, respectively...
July 22, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/30032884/comparison-of-nebulised-dexmedetomidine-ketamine-or-midazolam-for-premedication-in-preschool-children-undergoing-bone-marrow-biopsy
#3
H S Abdel-Ghaffar, S M Kamal, F A El Sherif, S A Mohamed
BACKGROUND: The aim of our study was to compare the efficacy of dexmedetomidine, ketamine, and midazolam for sedative premedication administered by nebuliser 30 min before general anaesthesia in preschool children undergoing bone marrow biopsy and aspiration. METHODS: Ninety children aged 3-7 yr were randomly allocated into three equal groups to be premedicated with either nebulised ketamine 2 mg kg-1 (Group K), dexmedetomidine 2 μg kg-1 (Group D), or midazolam 0...
August 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/30027605/the-pharmacokinetics-of-ketamine-following-intramuscular-injection-to-f344-rats
#4
Benjamin Moeller, Brenna Espelien, Waylon Weber, Philip Kuehl, Melanie Doyle-Eisele, C Edwin Garner, Jacob D McDonald, Efrain Garcia, Robert Raulli, Judith Laney
Ketamine is a glutamate N-methyl-D-aspartate receptor antagonist that is a rapid acting dissociative anesthetic. It has been proposed to be an adjuvant treatment along with other drugs (atropine, midazolam, pralidoxime) used in the current standard of care (SOC) for organophosphate and nerve agent exposures. Ketamine is a pharmaceutical agent that is readily available to most clinicians in emergency departments and possesses a broad therapeutic index with well characterized effects in humans. The objective of this study was to determine the pharmacokinetic profile of ketamine and its active metabolite, norketamine, in F344 rats following single or repeated intramuscular administrations of subanesthetic levels (7...
July 20, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/30019316/use-of-emergency-medication-in-adult-patients-with-epilepsy-a-multicentre-cohort-study-from-germany
#5
Jeannette Kadel, Sebastian Bauer, Anke M Hermsen, Ilka Immisch, Lara Kay, Karl Martin Klein, Susanne Knake, Katja Menzler, Philipp S Reif, Felix Rosenow, Adam Strzelczyk
BACKGROUND: Emergency treatment with benzodiazepines is indicated in prolonged seizures, seizure clusters and status epilepticus. OBJECTIVE: The aim of this study was to evaluate the use of emergency medication in adult patients with epilepsy. PATIENTS AND METHODS: All adult epilepsy patients attending the epilepsy outpatient clinics of the university hospitals in Frankfurt and Marburg in 2015 were asked to participate in this questionnaire-based, retrospective survey...
July 17, 2018: CNS Drugs
https://www.readbyqxmd.com/read/30009226/lidocaine-midazolam-fentanyl-combination-in-controlling-pain-for-reduction-of-anterior-shoulder-dislocation-a-randomized-clinical-trial
#6
Ali Arhami Dolatabadi, Aida Mohammadian, Hamid Kariman
Introduction: Finding a fast-acting compound with minimal side-effects to induce a safe and efficient analgesia with short or medium duration of action is of great interest in the emergency department. The present study has been designed with the aim of comparing the effect of midazolam + fentanyl + lidocaine combination with midazolam + fentanyl + placebo in pain management of anterior shoulder dislocation reduction. Methods: The present two-arm parallel double-blind randomized controlled trial was performed on patients who presented to emergency department with anterior shoulder dislocation...
2018: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/30008467/serotonin-syndrome-in-the-perioperative-setting
#7
Nathan J Smischney, Emily M Pollard, Asha U Nookala, Oludare O Olatoye
BACKGROUND Serotonin syndrome is a life-threatening condition that can lead to neurologic complications and is associated with the use of serotonergic medications. As the use of antidepressant medications has increased, the incidence of perioperative serotonin syndrome has transitioned from a rare diagnosis to one that should be considered as a differential diagnosis for any patient displaying signs of neuroexcitation. CASE REPORT A 70-year-old man (ASA 2) with a history of vestibular migraines (treated with venlafaxine), gastroesophageal reflux disease, and benign prostatic hyperplasia presented to our institution for photoselective vaporization of the prostate...
July 16, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29965991/prehospital-ultrasound-guided-nerve-blocks-improve-reduction-feasibility-of-dislocated-extremity-injuries-compared-to-systemic-analgesia-a-randomized-controlled-trial
#8
Benedikt Büttner, Ashham Mansur, Matthias Kalmbach, José Hinz, Thomas Volk, Karoly Szalai, Markus Roessler, Ingo Bergmann
BACKGROUND: Out-of-hospital analgosedation in trauma patients is challenging for emergency physicians due to associated complications. We compared peripheral nerve block (PNB) with analgosedation (AS) as an analgetic approach for patients with isolated extremity injury, assuming that prehospital required medical interventions (e.g. reduction, splinting of dislocation injury) using PNB are less painful and more feasible compared to AS. METHODS: Thirty patients (aged 18 or older) were randomized to receive either ultrasound-guided PNB (10 mL prilocaine 1%, 10 mL ropivacaine 0...
2018: PloS One
https://www.readbyqxmd.com/read/29962628/prevention-of-emergence-delirium-in-children-a-randomized-study-comparing-two-different-timings-of-administration-of-midazolam
#9
Gerard Gonsalvez, Deepa Baskaran, Vasudeva Upadhyaya
Background: Emergence delirium (ED) is a distressing side effect of sevoflurane anesthesia in children. Midazolam is a widely studied drug for the prevention of ED with conflicting results. Aim Settings and Design: We designed this prospective randomized double-blind study to compare the effect of 0.03 mg/kg midazolam administered at induction and the same dose administered 10 min before the end of surgery in the prevention of ED in children undergoing sevoflurane anesthesia and also the effect on the time to recovery in both groups...
April 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29946649/-effect-of-dexmedetomidine-combined-with-sevoflurane-for-general-anesthesia-during-dental-treatment-in-pediatric-patients
#10
Dong-Dong Chai, Jun Ji
PURPOSE: To evaluate the effect of dexmedetomidine combined with sevoflurane for general anesthesia during dental treatment in pediatric patients. METHODS: One hundred and twenty pediatric patients undergoing dental treatment were randomly divided into sevoflurane combined dexmedetomidine group(D group)and sevoflurane group (S group), 60 children in each group. Children in group D inhaled 4%-6% sevoflurane and intravenously received fentanyl 1 μg/kg, midazolam 0...
February 2018: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29885904/intramuscular-midazolam-olanzapine-ziprasidone-or-haloperidol-for-treating-acute-agitation-in-the-emergency-department
#11
Lauren R Klein, Brian E Driver, James R Miner, Marc L Martel, Michelle Hessel, Jacob D Collins, Gabriella B Horton, Erik Fagerstrom, Rajesh Satpathy, Jon B Cole
STUDY OBJECTIVE: Agitation in the emergency department (ED) can pose a threat to patient and provider safety; therefore, treatment is indicated. The purpose of this study is to compare haloperidol, olanzapine, midazolam, and ziprasidone to treat agitation. METHODS: This was a prospective observational study of consecutive patients receiving intramuscular medication to treat agitation in the ED. Medications were administered according to an a priori protocol in which the initial medication given was predetermined in the following 3-week blocks: haloperidol 5 mg, ziprasidone 20 mg, olanzapine 10 mg, midazolam 5 mg, and haloperidol 10 mg...
June 6, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29882463/joint-bap-napicu-evidence-based-consensus-guidelines-for-the-clinical-management-of-acute-disturbance-de-escalation-and-rapid-tranquillisation
#12
Maxine X Patel, Faisil N Sethi, Thomas Re Barnes, Roland Dix, Luiz Dratcu, Bernard Fox, Marina Garriga, Julie C Haste, Kai G Kahl, Anne Lingford-Hughes, Hamish McAllister-Williams, Aileen O'Brien, Caroline Parker, Brodie Paterson, Carol Paton, Sotiris Posporelis, David M Taylor, Eduard Vieta, Birgit Völlm, Charlotte Wilson-Jones, Laura Woods
The British Association for Psychopharmacology and the National Association of Psychiatric Intensive Care and Low Secure Units developed this joint evidence-based consensus guideline for the clinical management of acute disturbance. It includes recommendations for clinical practice and an algorithm to guide treatment by healthcare professionals with various options outlined according to their route of administration and category of evidence. Fundamental overarching principles are included and highlight the importance of treating the underlying disorder...
June 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29878631/midazolam-as-a-first-line-treatment-for-neonatal-seizures-retrospective-study
#13
Kim Dao, Eric Giannoni, Manuel Diezi, Eliane Roulet-Perez, Sebastien Lebon
Midazolam is commonly used to treat refractory seizures in newborns and as a first-line anti-epileptic drug in children. Its use as first-line treatment of neonatal seizures has not been investigated so far. We retrospectively studied the tolerability of midazolam in 72 newborn infants who received i.v. or i.n. midazolam as first-line treatment for seizures. No major side-effect exclusively due to midazolam was reported. The i.n. route was used for 20 patients (27.8%). Effectiveness could not be formally evaluated due to the absence of systematic electroencephalogram recording while midazolam was administered...
May 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29871784/seizure-cluster-definition-prevalence-consequences-and-management
#14
REVIEW
Saba Jafarpour, Lawrence J Hirsch, Marina Gaínza-Lein, Christoph Kellinghaus, Kamil Detyniecki
PURPOSE: To summarize definitions, prevalence, risk factors, consequences, and acute management of seizure clusters using rescue medications. METHODS: We searched MEDLINE for studies that assessed definitions, clinical characteristics, outcomes, and use of rescue medication for aborting seizure clusters. RESULTS: Different clinical and statistical definitions for seizure clusters have been proposed, including: ≥3 seizures in 24 h, ≥2 seizures in 24 h, and ≥2 seizures in 6 h...
May 21, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29803320/plasma-concentration-based-response-surface-model-predict-better-than-effect-site-concentration-based-model-for-wake-up-time-during-gastrointestinal-endoscopy-sedation
#15
Jing-Yang Liou, Mei-Yung Tsou, Shinju Obara, Lu Yu, Chien-Kun Ting
BACKGROUND: Sedation for esophagogastroduodenoscopy (EGD) and colonoscopy is characterized by rapid patient induction and emergence. The drugs midazolam and alfentanil have long been used for procedural sedation; however, the relationship between plasma or effect-site concentrations (Cp or Ce, respectively) and emergence remains unclear. The aim of this study is to develop patient wake-up prediction models for both Cp and Ce using response surface modeling, a pharmacodynamics tool for assessing patients' responses...
May 23, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29743682/preoperative-screening-for-illicit-drug-use-in-patients-undergoing-emergency-surgery-a-prospective-observational-study
#16
Jingyi Li, He Ma, Ren Liao, Yanjuan Huang, Guiyong Chen
Knowledge of illicit drug users (IDUs) is important because of the comorbidity related to drug use. In this prospective, observational study, we screened 1007 patients undergoing emergency surgery and found that 75 of them (7.5%) were IDUs The results of preoperative screening showed that the rates of HIV and syphilis infection were significantly higher in IDUs (HIV (+) 2.6%, syphilis (+) 10.7%) than in non-IDUs (HIV (+) 0, syphilis (+) 0.5%). Intraoperative consumption of remifentanil (IDUs: 1.85 ± 1...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737196/changing-characteristics-of-a-psychiatric-emergency-care-centre-an-eight-year-follow-up-study
#17
Joanne Seymour, Tristan Chapman, Vladan Starcevic, Kirupamani Viswasam, Vlasios Brakoulias
OBJECTIVE: The objective of this study was to report changes in characteristics of admissions to an established Psychiatric Emergency Care Centre (PECC) eight years after its opening. METHOD: Key clinical characteristics of admissions to the PECC were documented for 327 patients in 2015 and compared with the 477 patients in 2007, which is when the centre first opened. The characteristics of admission were evaluated using an audit of medical records from June to December in both 2007 and 2015...
May 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29730093/adverse-events-and-satisfaction-with-use-of-intranasal-midazolam-for-emergency-department-procedures-in-children
#18
Laurie Malia, V Matt Laurich, Jesse J Sturm
PURPOSE: Procedural sedation is commonly performed in the emergency department (ED). Having safe and fast means of providing sedation and anxiolysis to children is important for the child's tolerance of the procedure, parent satisfaction and efficient patient flow in the ED. OBJECTIVE: To evaluate fasting times associated with the administration of intranasal midazolam (INM) and associated complications. Secondary objectives included assessing provider and caregiver satisfaction scores...
April 30, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29727056/a-comparison-of-ketamine-midazolam-to-propofol-for-procedural-sedation-for-lumbar-puncture-in-pediatric-oncology-by-nonanesthesiologists-a-randomized-comparative-trial
#19
Varsha Chayapathi, Manas Kalra, Anita S Bakshi, Amita Mahajan
BACKGROUND: Both ketamine-midazolam and propofol are frequently used in pediatric oncology units for procedural sedation. However, there are no prospective, randomized comparative trials (RCT) comparing the two groups when the procedure is performed by nonanesthesiologists. OBJECTIVE: To compare ketamine + midazolam (group A) and propofol (group B) as sedative agents for intrathecal chemotherapy with regard to efficacy, side effects, time to induction, time to recovery, and smoothness of recovery...
August 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29723512/a-phase-iii-study-evaluating-the-efficacy-and-safety-of-remimazolam-cns-7056-compared-with-placebo-and-midazolam-in-patients-undergoing-colonoscopy
#20
Douglas K Rex, Raj Bhandari, Taddese Desta, Michael P DeMicco, Cynthia Schaeffer, Kyle Etzkorn, Charles F Barish, Ronald Pruitt, Brooks D Cash, Daniel Quirk, Felix Tiongco, Shelby Sullivan, David Bernstein
BACKGROUND AND AIMS: Remimazolam is an ultrashort-acting benzodiazepine. METHODS: We performed a randomized double-blind comparison of remimazolam to placebo for outpatient colonoscopy. This study design was a requirement of the U.S. Food and Drug Administration. An additional group was randomized to open-label midazolam administered according to its package insert instructions (the randomization ratio for remimazolam:placebo:midazolam was 30:6:10). Study medications were administered under the supervision of the endoscopist, without any involvement of an anesthesia specialist...
April 30, 2018: Gastrointestinal Endoscopy
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