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https://www.readbyqxmd.com/read/30544473/lambda-like-st-segment-elevation-in-acute-myocardial-infarction-triggered-by-coronary-spasm-may-be-a-new-risk-predictor-for-lethal-ventricular-arrhythmia-a-case-report
#1
Guangqiang Wang, Na Zhao, Chuanhuan Zhang, Shu Zhong, Xuexun Li
RATIONALE: The lambda-like ST-elevation electrocardiography (ECG) pattern is extremely rare in patients with type 2 myocardial infarction (T2MI) triggered by coronary spasm. When this ECG pattern appears, sudden cardiac death (SCD) caused by lethal ventricular arrhythmia may occur because clinicians do not pay sufficient attention to this phenomenon. PATIENT CONCERNS: We describe a 41-year-old man who presented with steep down-sloping ST-segment elevation, paroxysmal ventricular tachycardia, severe sinus bradycardia, and intermittent complete atrioventricular block on ECG during the sudden recurrence of clinical symptoms...
December 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30541356/qrs-area-is-a-strong-determinant-of-outcome-in-cardiac-resynchronization-therapy
#2
Antonius M W van Stipdonk, Iris Ter Horst, Marielle Kloosterman, Elien B Engels, Michiel Rienstra, Harry J G M Crijns, Marc A Vos, Isabelle C van Gelder, Frits W Prinzen, Mathias Meine, Alexander H Maass, Kevin Vernooy
BACKGROUND: The combination of left bundle branch block (LBBB) morphology and QRS duration is currently used to select patients for cardiac resynchronization therapy (CRT). These parameters, however, have limitations. This study evaluates the value of QRS area compared with that of QRS duration and morphology in the association with clinical and echocardiographic outcomes in a large cohort of CRT patients. METHODS: A retrospective multicentre study was conducted in 1492 CRT patients...
December 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30536153/heart-involvement-in-patients-with-myotonic-dystrophy-type-2
#3
Stojan Peric, Bogdan Bjelica, Ksenija Aleksic, Masa Kovacevic, Edita Cvitan, Gorana Mandic Stojmenovic, Vidosava Rakocevic Stojanovic
Myotonic dystrophy type 2 (DM2) is a slowly progressive, autosomal-dominant disease. This is a multisystemic disorder that affects the heart, which is one of the main causes of morbidity and mortality in DM2. The aim of the study was to define cardiac impairments in patients with DM2 and its association with sociodemographic and clinical features of patients. This retrospective study comprised 62 adult patients with DM2 hospitalized at the Neurology Clinic, Clinical Center of Serbia from 2013 until 2018, who underwent electrocardiography (ECG) and echocardiography examinations...
December 7, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/30522711/-pulmonary-embolism-and-complete-atrioventricular-block
#4
J J N'Djessan, H Yao, A Ekou, E Ehouman, A Adoubi, I Kouamé, C Konin
Complete atrioventricular block is a rare complication of pulmonary embolism. We describe the case of a black African patient, aged 42 years, who presented to the emergency department of Abidjan Heart Institute for sudden onset dyspnea and hemoptysis. ECG revealed a third degree atrioventricular block. Computed tomographic angiography showed proximal pulmonary embolism of the right main pulmonary artery. To our knowledge, this is the first case of complete atrioventricular block in pulmonary embolism in Sub-Saharan Africa...
December 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/30497763/yield-and-consistency-of-arrhythmia-detection-with-patch-electrocardiographic-monitoring-the-multi-ethnic-study-of-atherosclerosis
#5
Susan R Heckbert, Thomas R Austin, Paul N Jensen, James S Floyd, Bruce M Psaty, Elsayed Z Soliman, Richard A Kronmal
BACKGROUND: Patch electrocardiographic (ECG) monitors permit extended noninvasive ambulatory monitoring. To guide use of these devices, information is needed about their performance. We sought to determine in a large general population sample the acceptability of patch ECG monitors, the yield of arrhythmia detection, and the consistency of findings in participants monitored twice. METHODS: In the Multi-Ethnic Study of Atherosclerosis, 1122 participants completed one or two monitoring episodes using the Zio Patch XT, a single-channel ECG patch monitor capable of recording for 14 days...
November 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30497757/prognostic-value-of-frontal-qrs-t-angle-in-patients-undergoing-myocardial-revascularization-or-cardiac-valve-surgery
#6
Davide Lazzeroni, Matteo Bini, Umberto Camaiora, Paolo Castiglioni, Luca Moderato, Pietro Tito Ugolotti, Lorenzo Brambilla, Valerio Brambilla, Paolo Coruzzi
BACKGROUND: An abnormal frontal QRS-T angle (fQRSTa) is associated with increased risk of death in primary and secondary cardiovascular prevention. The aim of this study was to evaluate the fQRSTa prognostic role in patients undergoing myocardial revascularization and/or cardiac valve surgery. METHODS: We enrolled and prospectively followed for 48 ± 26 months 939 subjects with available QRS and T axis data; mean age was 68 ± 12 years, 449 patients (48%) underwent myocardial revascularization, 333 (35%) cardiac valve surgery, 94 (10%) valve plus bypass graft surgery and 63 (7%) cardiac surgery for other cardiovascular (CV) diseases...
November 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30497736/atypical-advanced-interatrial-blocks-definition-and-electrocardiographic-recognition
#7
Antoni Bayés de Luna, Luis Alberto Escobar-Robledo, David Aristizabal, Danilo Weir Restrepo, Guiomar Mendieta, Albert Massó van Roessel, Roberto Elosua, Antoni Bayés-Genís, Manuel Martínez-Sellés, Adrian Baranchuk
The diagnosis of advanced interatrial block (A-IAB) is done by surface ECG analysis when the P-wave ≥120 ms with biphasic (±) morphology in leads II, III and aVF. In this brief communication, we advance a new concept involving atypical patterns of A-IAB due to changes about the morphology or duration of the P-wave. It remains to be determined its real prevalence in different clinical scenarios, and whether these atypical ECG patterns should be considered as predictors of atrial fibrillation/stroke.
November 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30483958/safety-of-regadenoson-positon-emission-tomography-stress-testing-in-orthotopic-heart-transplant-patients
#8
John J Lazarus, Ashraf Saleh, Michael Ghannam, Keith Aaronson, Monica Colvin, Frank Pagani, Todd Koelling, James R Corbett, Richard L Weinberg, Venkatesh L Murthy, Matthew C Konerman
OBJECTIVES: We sought to determine the safety of regadenoson (REG) stress testing in patients who have undergone orthotopic heart transplantation (OHT). BACKGROUND: Routine screening for cardiac allograft vasculopathy (CAV) is necessary after OHT. Adenosine stress is contraindicated after heart transplantation due to supersensitivity in denervated hearts. Safety of regadenoson stress following OHT has not been well studied. METHODS: We retrospectively reviewed data from OHT patients (N = 123) who were referred to REG stress testing...
November 27, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/30483130/screening-and-identification-of-cardioprotective-compounds-from-wenxin-keli-by-activity-index-approach-and-in-vivo-zebrafish-model
#9
Hao Liu, Xuechun Chen, Xiaoping Zhao, Buchang Zhao, Ke Qian, Yang Shi, Mirko Baruscotti, Yi Wang
Wenxin Keli (WXKL) is a widely used Chinese botanical drug for the treatment of arrhythmia, which is consisted of four herbs and amber. In the present study, we analyzed the chemical composition of WXKL using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) to tentatively identify 71 compounds. Through typical separate procession, the total extract of WXKL was divided into fractions for further bioassays. Cardiomyocytes and zebrafish larvae were applied for assessment. In vivo arrhythmia model in Cmlc2-GFP transgenic zebrafish was induced by terfenadine, which exhibited obvious reduction of heart rate and occurrence of atrioventricular block...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30476637/association-between-t-wave-discordance-and-the-development-of-heart-failure-in-left-bundle-branch-block-patients-results-from-the-copenhagen-ecg-study
#10
Johannes Riis Jensen, Kristian Kragholm, Karoline Willum Bødker, Rikke Mortensen, Claus Graff, Adrian Pietersen, Jonas Bille Nielsen, Christoffer Polcwiartek, Bhupendar Tayal, Christian Torp-Pedersen, Peter Søgaard, Steen Møller Hansen
BACKGROUND: In left bundle branch block (LBBB), discrepancies between depolarization and repolarization of the heart can be assessed by similar direction (concordant) or opposite direction (discordant) of the lateral T-waves compared to the direction of the QRS complex and by the QRS-T angle. We examined the association between discordant T-waves and high QRS-T angles for heart failure development in primary care LBBB patients. METHODS: Between 2001 and 2011, we identified 2540 patients from primary care with LBBB without overt heart failure...
November 5, 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/30462207/comparison-of-electrocardiogram-characteristics-and-pacing-parameters-between-left-bundle-branch-pacing-and-right-ventricular-pacing-in-patients-receiving-pacemaker-therapy
#11
Keping Chen, Yuqiu Li, Yan Dai, Qi Sun, Bin Luo, Chao Li, Shu Zhang
Aims: This study explores the feasibility of left bundle branch pacing (LBBP) and characterizes electrocardiogram (ECG) patterns during the pacing in comparison with conventional right ventricular pacing (RVP). Methods and results: Forty pacing-indicated patients were prospectively enrolled. Twenty patients underwent LBBP (the LBBP group), and 20 patients underwent RVP (the RVP group). Left bundle branch pacing was achieved by transseptal method in the basal ventricular septum...
November 20, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/30453697/an-eigenecg-network-approach-based-on-pcanet-for-personal-identification-from-ecg-signal
#12
Jae-Neung Lee, Yeong-Hyeon Byeon, Sung-Bum Pan, Keun-Chang Kwak
We herein propose an EigenECG Network (EECGNet) based on the principal component analysis network (PCANet) for the personal identification of electrocardiogram (ECG) from human biosignal data. The EECGNet consists of three stages. In the first stage, ECG signals are preprocessed by normalization and spike removal. The R peak points in the preprocessed ECG signals are detected. Subsequently, ECG signals are transformed into two-dimensional images to use as the input to the EECGNet. Further, we perform patch-mean removal and PCA algorithm similar to the PCANet from the transformed two-dimensional images...
November 18, 2018: Sensors
https://www.readbyqxmd.com/read/30447156/assessment-of-multi-ion-channel-block-in-a-phase-1-randomized-study-design-results-of-the-cipa-phase-1-ecg-biomarker-validation-study
#13
Jose Vicente, Robbert Zusterzeel, Lars Johannesen, Roberto Ochoa-Jimenez, Jay W Mason, Carlos Sanabria, Sarah Kemp, Philip T Sager, Vikram Patel, Murali K Matta, Jiang Liu, Jeffry Florian, Christine Garnett, Norman Stockbridge, David G Strauss
Balanced multi-ion channel-blocking drugs have low torsade risk because they block inward currents. The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative proposes to use an in-silico cardiomyocyte model to determine the presence of balanced block, and absence of J-Tpeakc prolongation would be expected for balanced blockers. This study included 3 balanced blockers in a 10-subject per drug parallel-design; lopinavir/ritonavir and verapamil met the primary endpoint of ΔΔJ-Tpeakc upper bound <10 ms, while ranolazine did not (upper bounds of 8...
November 17, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/30440614/removal-of-electrocardiogram-interference-from-diaphragmatic-electromyogram-signals-using-sliding-singular-spectrum-analysis
#14
Muzammil Saeed, Stephen R Alty
Over recent years, Singular Spectrum Analysis (SSA) has gained popularity as an effective means to denoise biologically sourced single channel signals, especially Electromyogram (EMG) and Electrocardiogram (ECG) signals amongst others. There are numerous applications whereby the signal acquisition process results in the mixing of both types of signals along with body motion artifacts and the inevitable electromagnetic interference. Both ECG and EMG signals are very useful to physicians, though preferably in isolation, though they rarely present themselves in this manner...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/30431601/complete-heart-block-in-systemic-sclerosis-a-case-report-and-literature-review
#15
REVIEW
Qinghai Wang, Yinghui Shang, Shicheng Li, Yanxiang Wu, Chenyu Wang, Xiaowei Yan
RATIONALE: Complete heart block (CHB) is a common clinical manifestation. Systemic sclerosis (SSc) is a rare etiology of CHB that has not received enough attention. Whether pacemaker implantation is required remains inconclusive, especially when patients have no symptoms or mild symptoms of CHB. PATIENT CONCERNS: In this study, we report the case of a 48-year-old Chinese male who suffers from SSc and CHB. DIAGNOSE: The patient was previously diagnosed with left anterior hemiblock (LAHB) and right bundle block with normal heart function...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30396342/retrieving-hidden-atrial-repolarization-waves-from-standard-surface-ecgs
#16
Wei-Hua Tang, Wen-Hsien Ho, Yenming J Chen
BACKGROUND: This study estimates atrial repolarization activities (Ta waves), which are typically hidden most of the time from body surface electrocardiography when diagnosing cardiovascular diseases. The morphology of Ta waves has been proven to be an important marker for the early sign of inferior injury, such as acute atrial infarction, or arrhythmia, such as atrial fibrillation. However, Ta waves are usually unseen except during conduction system malfunction, such as long QT interval or atrioventricular block...
November 6, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/30391075/p-wave-terminal-force-in-lead-v1-is-a-predictive-indicator-for-the-diagnosis-of-tuberculous-constrictive-pericarditis
#17
Yanhong Ren, Junke Qiu, Zelin Li, Cheng Li
OBJECTIVES: The purpose of this study is to explore the value of P-wave terminal force in lead V1 (PTFV1) in the clinical diagnosis of tuberculous constrictive pericarditis (TCP). METHODS: A total of 53 patients with TCP and 64 patients with tuberculous exudative pericarditis were enrolled in this retrospective study. The demographic and clinical characteristics were collected, including gender, age, the course of disease and New York Heart Association (NYHA) classification...
October 31, 2018: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/30390680/galectin-3-predicts-response-and-outcomes-after-cardiac-resynchronization-therapy
#18
Clémentine Andre, Eric Piver, Romain Perault, Arnaud Bisson, Julien Pucheux, Emmanuelle Vermes, Bertrand Pierre, Laurent Fauchier, Dominique Babuty, Nicolas Clementy
BACKGROUND: Cardiac resynchronization therapy (CRT) reduces symptoms, morbidity and mortality in chronic heart failure patients with wide QRS complexes. However, approximately one third of CRT patients are non-responders. Myocardial fibrosis is known to be associated with absence of response. We sought to see whether galectin-3, a promising biomarker involved in fibrosis processes, could predict response and outcomes after CRT. METHODS: Consecutive patients eligible for implantation of a CRT device with a typical left bundle branch block ≥ 120 ms were prospectively included...
November 3, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/30373444/localization-of-left-ventricular-lead-electrodes-in-relation-to-myocardial-scar-in-patients-undergoing-cardiac-resynchronization-therapy
#19
Arnaud Bisson, Julien Pucheux, Clémentine Andre, Anne Bernard, Bertrand Pierre, Dominique Babuty, Laurent Fauchier, Nicolas Clementy
Background The efficacy of cardiac resynchronization therapy may be reduced in the event of pacing within myocardial fibrosis. We aimed to develop a method to determine the anatomical relationships between the left ventricular ( LV ) lead and myocardial fibrosis. Methods and Results In consecutive patients indicated for cardiac resynchronization therapy, cardiovascular magnetic resonance imaging with late gadolinium enhancement assessment was performed before implantation. After implantation, an injected computed tomography scanner ( CT scan) was performed...
November 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30366889/histologically-confirmed-case-of-complete-atrioventricular-block-due-to-hepatocellular-carcinoma
#20
Takuro Nishiwaki, Norihiko Yamamoto, Yoshihumi Hirokawa, Yoshiyuki Takei
A 72-year-old man, who had been diagnosed as having hepatocellular carcinoma (HCC) with multiple extrahepatic metastasis, complained a general fatigue which appeared 2 weeks before admission. Because bradycardia was detected on physical examination, ECG was performed which revealed the complete atrioventricular (AV) block. We stopped Ca-blocker and β-blocker, but the bradycardia persisted. He was admitted to our hospital for an emergent pacemaker implantation. On admission, he complained dyspnoea. After the surgery, he died due to deterioration of heart failure...
October 25, 2018: BMJ Case Reports
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