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https://www.readbyqxmd.com/read/29453804/probiotics-affect-one-carbon-metabolites-and-catecholamines-in-a-genetic-rat-model-of-depression
#1
Sandra Tillmann, Hussain M Awwad, Amanda R Eskelund, Giulia Treccani, Juergen Geisel, Gregers Wegener, Rima Obeid
SCOPE: Probiotics may influence one-carbon (C1) metabolism, neurotransmitters, liver function markers, or behavior. METHODS AND RESULTS: Male adult Flinders Sensitive Line rats (model of depression, FSL; n = 22) received Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (10 9 or 10 10 colony-forming units/d) or vehicle for 10 weeks. The controls, Flinders Resistant Line rats (FRL, n = 8), only received vehicle. C1-related metabolites were measured in plasma, urine, and different tissues...
February 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29449933/a-simplified-characterization-of-s-adenosyl-l-methionine-consuming-enzymes-with-1-step-ez-mtase-a-universal-and-straightforward-coupled-assay-for-in-vitro-and-in-vivo-setting
#2
Emmanuel S Burgos, Ryan O Walters, Derek M Huffman, David Shechter
Methyltransferases use S -adenosyl-l-methionine (SAM) to deposit methyl marks. Many of these epigenetic 'writers' are associated with gene regulation. As cancer etiology is highly correlated with misregulated methylation patterns, methyltransferases are emerging therapeutic targets. Successful assignment of methyltransferases' roles within intricate biological networks relies on (1) the access to enzyme mechanistic insights and (2) the efficient screening of chemical probes against these targets. To characterize methyltransferases in vitro and in vivo , we report a highly-sensitive one-step deaminase-linked continuous assay where the S -adenosyl-l-homocysteine (SAH) enzyme-product is rapidly and quantitatively catabolized to S -inosyl-l-homocysteine (SIH)...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29390044/serum-metabolomic-profiling-of-all-cause-mortality-a-prospective-analysis-in-the-alpha-tocopherol-beta-carotene-cancer-prevention-atbc-study-cohort
#3
Jiaqi Huang, Stephanie J Weinstein, Steven C Moore, Andriy Derkach, Xing Hua, Linda M Liao, Fangyi Gu, Alison M Mondul, Joshua N Sampson, Demetrius Albanes
Tobacco use, hypertension, hyperglycemia, overweight, and inactivity are leading causes of overall and cardiovascular disease (CVD) mortality worldwide, yet the relevant metabolic alterations responsible are largely unknown. We conducted a serum metabolomic analysis of 620 men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (1985-2013). During 28 years of follow-up, there were 435 deaths (197 CVD and 107 cancer). The analysis included 406 known metabolites measured with ultra-high performance liquid chromatography/mass spectrometry-gas chromatography/mass spectrometry...
January 30, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29356306/evidence-of-interaction-between-genes-in-the-folate-homocysteine-metabolic-pathway-in-controlling-risk-of-nonsyndromic-oral-cleft
#4
Ping Wang, Tao Wu, Holger Schwender, Hong Wang, Bing Shi, Zhuqing Wang, Yuan Yuan, Dongjing Liu, Mengying Wang, Jing Li, Zhibo Zhou, Hongping Zhu, Terri H Beaty
OBJECTIVE: Little consistent evidence is available for the association between the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and any of the individual genes in the folate/homocysteine metabolic pathway. We investigated the genes in the folate pathway to further clarify its potential influence on the risk of NSCL/P considering gene-gene (G×G) interaction. SUBJECTS AND METHODS: We selected markers in 18 genes from the pathway and applied the Cordell's method to test for G×G interaction using 1,908 NSCL/P case-parent trios ascertained in an international consortium where a genome-wide association study (GWAS) of oral clefts was conducted...
January 22, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29350007/-the-metabolic-profilings-study-of-serum-and-spinal-cord-from-acute-spinal-cord-injury-rats-%C3%A2-h-nmr-spectroscopy
#5
Hua-Hui Hu, Xiao-Long Huang, Ren-Fu Quan, Zong-Bao Yang, Jing-Jing Xu
OBJECTIVE: To establish the rat model of acute spinal cord injury, followed by aprimary study on this model with ¹H NMR based on metabonomics and to explore the metabonomics and biomarkers of spinal cord injury rat. METHODS: Twenty eight-week-old adult male SD rats of clean grade, with body weight of (200±10) g, were divided into sham operation group and model group in accordance with the law of random numbers, and every group had 10 rats. The rats of sham operation group were operated without damaging the spinal cord, and rats of model group were made an animal model of spinal cord incomplete injury according to the modified Allen's method...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29301933/oxidation-of-the-fad-cofactor-to-the-8-formyl-derivative-in-human-electron-transferring-flavoprotein
#6
Peter Augustin, Marina Toplak, Katharina Fuchs, Eva Christine Gerstmann, Ruth Prassl, Andreas Winkler, Peter Macheroux
The heterodimeric human electron transferring flavoprotein (hETF) transfers electrons from at least thirteen different flavin dehydrogenases to the mitochondrial respiratory chain through a non-covalently bound FAD cofactor. Here, we describe the discovery of an irreversible and pH-dependent oxidation of the 8α-methyl group to 8-formyl-FAD (8f-FAD), which represents a unique chemical modification of a flavin cofactor in the human flavoproteome. Furthermore, a set of hETF variants revealed that several conserved amino acid residues in the FAD binding pocket of electron transferring flavoproteins are required for the conversion to the formyl group...
January 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29232572/facile-biological-synthetic-strategy-to-morphologically-aligned-ceo2-zro2-core-nanoparticles-using-justicia-adhatoda-extract-and-ionic-liquid-enhancement-of-its-bio-medical-properties
#7
Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Sundrarajan Mahalingam
In this study, a typical green synthesis route has approached for CeO2/ZrO2 core metal oxide nanoparticles using ionic liquid mediated Justicia adhatoda extract. This synthesis method is carried out at simple room temperature condition to obtain the core metal oxide nanoparticles. XRD, SEM and TEM studies employed to study the crystalline and surface morphological properties under nucleation, growth, and aggregation processes. CeO2/ZrO2 core metal oxides display agglomerated nano stick-like structure with 20-45nm size...
November 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29092879/eggs-early-in-complementary-feeding-increase-choline-pathway-biomarkers-and-dha-a-randomized-controlled-trial-in-ecuador
#8
RANDOMIZED CONTROLLED TRIAL
Lora L Iannotti, Chessa K Lutter, William F Waters, Carlos Andres Gallegos Riofrío, Carla Malo, Gregory Reinhart, Ana Palacios, Celia Karp, Melissa Chapnick, Katherine Cox, Santiago Aguirre, Luis Narvaez, Fernando López, Rohini Sidhu, Pamela Kell, Xuntian Jiang, Hideji Fujiwara, Daniel S Ory, Rebecca Young, Christine P Stewart
Background: Choline status has been associated with stunting among young children. Findings from this study showed that an egg intervention improved linear growth by a length-for-age z score of 0.63. Objective: We aimed to test the efficacy of eggs introduced early in complementary feeding on plasma concentrations of biomarkers in choline pathways, vitamins B-12 and A, and essential fatty acids. Design: A randomized controlled trial, the Lulun ("egg" in Kichwa) Project, was conducted in a rural indigenous population of Ecuador...
December 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29063086/vanadium-v-oxoanions-in-basic-water-solution-a-simple-oxidative-system-for-the-one-pot-selective-conversion-of-l-proline-to-pyrroline-2-carboxylate
#9
Lorenzo Biancalana, Giada Tuci, Fabio Piccinelli, Fabio Marchetti, Marco Bortoluzzi, Guido Pampaloni
The unprecedented, direct chemical oxidation of l-proline to pyrroline-2-carboxylate was achieved in water (pH 9-10) by means of NH4VO3/NH3 or V2O5/MOH (K = Na, K), and the anion was fully characterized as ammonium or alkaline metal salts. Quantitative yield and higher atom economy performance were achieved with the latter system, the alkaline salts being more stable than the ammonium one. Different mixed valence V(iv)/V(v) compounds precipitated from the reaction mixtures depending on the nature of the employed base...
November 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28881522/-dmgdh-gene-related-dimethylglycine-dehydrogenase-deficiency-in-a-case
#10
X L Wang, F Yin, G Y Zhang
No abstract text is available yet for this article.
September 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28867701/a-metabolic-study-on-the-biochemical-effects-of-chiral-illegal-drugs-in-rats-using-1-h-nmr-spectroscopy
#11
Kiyoshi Fukuhara, Akiko Ohno, Ruri Kikura-Hanajiri
Considering the pharmacological effects of chiral drugs, enantiopure drugs may differ from their racemic mixture formulation in efficacy, potency, or adverse effects. Levomethorphan (LVM) and Dextromethorphan (DXM) act on the central nervous system and exhibit different pharmacological features. LVM, the l-stereoisomer of methorphan, shows many similarities to opiates such as heroin, morphine and codeine, including the potential for addiction, while the d-stereoisomer, DXM, does not have the same opioid effect...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28804274/non-invasive-urinary-metabolomic-profiling-discriminates-prostate-cancer-from-benign-prostatic-hyperplasia
#12
Clara Pérez-Rambla, Leonor Puchades-Carrasco, María García-Flores, José Rubio-Briones, José Antonio López-Guerrero, Antonio Pineda-Lucena
INTRODUCTION: Prostate cancer (PCa) is one of the most common malignancies in men worldwide. Serum prostate specific antigen (PSA) level has been extensively used as a biomarker to detect PCa. However, PSA is not cancer-specific and various non-malignant conditions, including benign prostatic hyperplasia (BPH), can cause a rise in PSA blood levels, thus leading to many false positive results. OBJECTIVES: In this study, we evaluated the potential of urinary metabolomic profiling for discriminating PCa from BPH...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28777736/a-pilot-study-of-the-effect-of-human-breast-milk-on-urinary-metabolome-analysis-in-infants
#13
Hiromichi Shoji, Hikari Taka, Naoko Kaga, Naho Ikeda, Tomohiro Kitamura, Yoshiki Miura, Toshiaki Shimizu
BACKGROUND: This study aimed to examine the nutritional effect of breast feeding on healthy term infants by using urinary metabolome analysis. METHODS: Urine samples were collected from 19 and 14 infants at 1 and 6 months, respectively. Infants were separated into two groups: the breast-fed group receiving <540 mL/week of their intake from formula (n=13 at 1 month; n=9 at 6 months); and the formula-fed group receiving no breast milk (BM) (n=6 at 1 month; n=5 at 6 months)...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28697427/nmr-based-metabolomic-study-on-the-toxicological-effects-of-pesticide-diazinon-on-adaptation-to-sea-water-by-endangered-persian-sturgeon-acipenser-persicus-fingerlings
#14
Saeed Hajirezaee, Alireza Mirvaghefi, Hamid Farahmand, Naser Agh
NMR-based metabolomics was applied to explore metabolic impacts of diazinon on sea water adaptation of Persian sturgeon fingerlings, Acipenser persicus. Fingerlings were exposed to sub-lethal concentrations of diazinon in freshwater (FW) for 96 h (short-term trial) and 12 days (long-term trial) and then exposed in brackish water (BW) (12 mg L(-1) salinity) for 24 h. After 96 h and 12 days exposure in FW, identified metabolites (amino acids, osmolytes, energy metabolites) showed different change-patterns compared to control group (P < 0...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28669514/identification-of-urine-metabolites-associated-with-5-year-changes-in-biomarkers-of-glucose-homoeostasis
#15
N Friedrich, T Skaaby, M Pietzner, K Budde, B H Thuesen, M Nauck, A Linneberg
AIM: Metabolomics provides information on pathogenetic mechanisms and targets for interventions, and may improve risk stratification. During the last decade, metabolomics studies were used to gain deeper insight into the pathogenesis of diabetes mellitus. However, longitudinal metabolomics studies of possible subclinical states of disturbed glucose metabolism are limited. Therefore, the aim of this study was to analyze the associations between baseline urinary metabolites and 5-year changes in continuous markers of glucose homoeostasis, including fasting glucose, HbA1c and homoeostasis model assessment of insulin resistance (HOMA-IR) index values...
June 29, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28623324/rapid-discrimination-of-human-oesophageal-squamous-cell-carcinoma-by-mass-spectrometry-based-on-differences-in-amino-acid-metabolism
#16
Zhang Jianyong, Xu Jianjun, Ouyang Yongzhong, Liu Junwen, Lu Haiyan, Yu Dongliang, Peng Jinhua, Xiong Junwen, Chen Huanwen, Wei Yiping
Oesophageal cancer (OC) is associated with high morbidity and mortality, and surgery is the most effective approach to treat it. In order to reduce surgical risks and duration of surgery, we explored a new strategy to determine tumour margins in surgery. In this study, we included 128 cancerous and 128 noncancerous database entries obtained from 32 human patients. Using internal extractive electrospray ionization-MS, in positive ion detection mode, the relative abundances of m/z 104.13, m/z 116.10, m/z 132...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438367/the-effect-of-dietary-supplements-on-clinical-aspects-of-autism-spectrum-disorder-a-systematic-review-of-the-literature
#17
REVIEW
Maria Gogou, George Kolios
BACKGROUND: Autism spectrum disorder is associated with significant social and financial burden and no definite treatment for this entity has been identified, yet. In recent years there has been an increasing interest in the use of dietary interventions as a complementary therapeutic option for these patients. OBJECTIVE: The aim of this systematic review is to provide high evidence level literature data about the effect of dietary supplements on clinical aspects of children with autism...
April 21, 2017: Brain & Development
https://www.readbyqxmd.com/read/28396122/evaluation-of-the-impact-of-gut-microbiota-on-uremic-solute-accumulation-by-a-ce-tofms-based-metabolomics-approach
#18
Eikan Mishima, Shinji Fukuda, Chikahisa Mukawa, Akinori Yuri, Yoshitomi Kanemitsu, Yotaro Matsumoto, Yasutoshi Akiyama, Noriko N Fukuda, Hiroki Tsukamoto, Kei Asaji, Hisato Shima, Koichi Kikuchi, Chitose Suzuki, Takehiro Suzuki, Yoshihisa Tomioka, Tomoyoshi Soga, Sadayoshi Ito, Takaaki Abe
Gut microbiota is involved in the metabolism of uremic solutes. However, the precise influence of microbiota to the retention of uremic solutes in CKD is obscure. To clarify this, we compared adenine-induced renal failure and control mice under germ-free or specific pathogen-free (SPF) conditions, examining the metabolite profiles of plasma, feces, and urine using a capillary electrophoresis time-of-flight mass spectrometry-based approach. Mice with renal failure under germ-free conditions demonstrated significant changes in plasma metabolites...
April 8, 2017: Kidney International
https://www.readbyqxmd.com/read/28341134/metabolic-changes-in-droplet-vitrified-semen-of-wild-endangered-persian-sturgeon-acipenser-persicus-borodin-1997
#19
Amirreza Abed-Elmdoust, Hamid Farahmand, Bagher Mojazi-Amiri, Gholamreza Rafiee, Ruhollah Rahimi
Comparative quantitative metabolite profiling can be used for better understanding of cell functions and dysfunctions in particular circumstances such as sperm banking which is an important approach for cryopreservation of endangered species. Cryopreservation techniques have some deleterious effects on spermatozoa which put the obtained results in controversy. Therefore, in the present study, quantitative (1)H NMR (Nuclear Magnetic Resonance) based metabolite profiling was conducted to evaluate metabolite changes related to energetics and some other detected metabolites in vitrified semen of critically endangered wild Acipenser persicus...
March 21, 2017: Cryobiology
https://www.readbyqxmd.com/read/28262365/-1-h-nmr-based-metabolomics-study-on-repeat-dose-toxicity-of-fine-particulate-matter-in-rats-after-intratracheal-instillation
#20
Yannan Zhang, Hejing Hu, Yanfeng Shi, Xiaozhe Yang, Lige Cao, Jing Wu, Collins Otieno Asweto, Lin Feng, Junchao Duan, Zhiwei Sun
Systemic metabolic effects and toxicity mechanisms of ambient fine particulate matter (PM2.5) remain uncertain. In order to investigate the mechanisms in PM2.5 toxicity, we explored the endogenous metabolic changes and possible influenced metabolic pathways in rats after intratracheal instillation of PM2.5 by using a (1)H nuclear magnetic resonance (NMR)-based metabolomics approach. Liver and kidney histopathology examinations were also performed. Chemical characterization demonstrated that PM2.5 was a complex mixture of elements...
March 2, 2017: Science of the Total Environment
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