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"Ondansetron" AND "Metoclopramide"

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https://www.readbyqxmd.com/read/30239072/assessment-of-discharge-treatment-prescribed-to-women-admitted-to-hospital-for-hyperemesis-gravidarum
#1
Linda Fiaschi, Gemma Housley, Catherine Nelson-Piercy, Jack Gibson, Ayokunnu Raji, Shilpa Deb, Laila J Tata
AIMS: Prescribing drug treatment for the management of hyperemesis gravidarum (HG), the most severe form of nausea and vomiting in pregnancy, remains controversial. Since most manufacturers do not recommend prescribing antiemetics during pregnancy, little is known regarding which treatments are most prevalent among pregnant patients. Here, we report for the first time, evidence of actual treatments prescribed in English hospitals. METHODS: A retrospective pregnancy cohort was constructed using anonymised electronic records in the Nottingham University Hospitals Trust system for all women who delivered between January 2010 and February 2015...
September 21, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/30184034/incidence-of-nausea-and-vomiting-after-fast-track-anaesthesia-for-heart-surgery
#2
Emad Mohamed Hijazi, Hayel Edwan, Nabil Al-Zoubi, Hadi Radaideh
OBJECTIVE: The aim of this study was to evaluate the incidence of postoperative nausea and vomiting (PONV) after fast-track cardiac anesthesia (FTCA) in the first 24-48 hours in the cardiac intensive care unit (CICU) after open-heart surgery, risk factors for PONV and its influence on CICU length of stay. METHODS: A prospective observational study from January 1, 2013 to the end of December 2015 was performed in the CICU of a university hospital in the north of Jordan and Queen Alia Heart Institute, Amman, Jordan...
July 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/30111294/minimal-effective-weight-based-dosing-of-ondansetron-to-reduce-hypotension-in-cesarean-section-under-spinal-anesthesia-a-randomized-controlled-superiority-trial
#3
Maliwan Oofuvong, Thitikan Kunapaisal, Orarat Karnjanawanichkul, Nussara Dilokrattanaphijit, Jaranya Leeratiwong
BACKGROUND: The weight-based dosing of ondansetron to reduce hypotension has never been investigated. The aim of this study is to determine the optimal dose of ondansetron required based on the patient's weight to reduce hypotension following spinal anesthesia for cesarean section. METHODS: In this prospective, triple-blinded, parallel group, randomized controlled trial, a total of 228 pregnant women were randomized to receive either normal saline (group NS) or ondansetron 0...
August 15, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29561296/potential-clinical-and-immunotherapeutic-utility-of-talimogene-laherparepvec-for-patients-with-melanoma-after-disease-progression-on-immune-checkpoint-inhibitors-and-braf-inhibitors
#4
Jason Chesney, Yoannis Imbert-Fernandez, Sucheta Telang, Mary Baum, Smita Ranjan, Mostafa Fraig, Nicolas Batty
Talimogene laherparepvec is a genetically modified herpes simplex virus type 1-based oncolytic immunotherapy for the local treatment of unresectable subcutaneous and nodal tumors in patients with melanoma recurrent after initial surgery. We report on two patients with melanoma who, after progression on numerous systemic therapies, derived clinical benefit from talimogene laherparepvec in an expanded-access protocol (ClinicalTrials.gov, NCT02147951). Intralesional talimogene laherparepvec (day 1, ≤4 ml 10 PFU/ml; after 3 weeks, ≤4 ml 10 PFU/ml every 2 weeks) was administered until complete response, no injectable tumors, progressive disease, or intolerance occurred...
June 2018: Melanoma Research
https://www.readbyqxmd.com/read/28814338/anti-nausea-effects-and-pharmacokinetics-of-ondansetron-maropitant-and-metoclopramide-in-a-low-dose-cisplatin-model-of-nausea-and-vomiting-in-the-dog-a-blinded-crossover-study
#5
COMPARATIVE STUDY
Hannah Kenward, Jonathan Elliott, Terry Lee, Ludovic Pelligand
BACKGROUND: Nausea is a subjective sensation which is difficult to measure in non-verbal species. The aims of this study were to determine the efficacy of three classes of antiemetic drugs in a novel low dose cisplatin model of nausea and vomiting and measure change in potential nausea biomarkers arginine vasopressin (AVP) and cortisol. A four period cross-over blinded study was conducted in eight healthy beagle dogs of both genders. Dogs were administered 18 mg/m2 cisplatin intravenously, followed 45 min later by a 15 min infusion of either placebo (saline) or antiemetic treatment with ondansetron (0...
August 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28778685/bromopride-metoclopramide-or-ondansetron-for-the-treatment-of-vomiting-in-the-pediatric-emergency-department-a-randomized-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Matias Epifanio, Janete de L Portela, Jefferson P Piva, Cristina H Targa Ferreira, Edgar E Sarria, Rita Mattiello
OBJECTIVE: To compare the effectiveness of a single intramuscular dose of bromopride, metoclopramide, or ondansetron for treating vomiting. METHODS: Randomized controlled trial including children 1-12 years of age presenting with acute vomiting at the pediatric emergency department. OUTCOMES: Number of children that stopped vomiting at one, six, and 24h following treatment; episodes of diarrhea; acceptance of oral liquids; intravenous rehydration; return to hospital and side effects...
January 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/28749713/safety-considerations-surrounding-use-of-treatment-options-for-nausea-and-vomiting-in-pregnancy
#7
REVIEW
Gideon Koren
Nausea and vomiting of pregnancy (NVP) is the most prevalent medical condition during gestation, affecting up to 85% of pregnant women. Many of them hesitate to use medications due to perceived fetal risks. Areas covered: There are two main aspects to medication safety in NVP: The fetal safety of drugs used to treat NVP symptoms, and the risks of untreated NVP. While mild and moderate NVP are not associated with major increase in fetal or maternal risks, and may render protective fetal effects, they have major impact on the quality of life of the mother...
November 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28713660/a-cross-sectional-pharmacoepidemiological-study-of-the-utilization-pattern-of-pre-anesthetic-medications-in-major-surgical-procedures-in-a-tertiary-care-hospital
#8
Madhuri Kulkarni, Anant Patil
OBJECTIVE : A study of the utilization pattern of pre-anesthetic medications in major surgical procedures. MATERIAL AND METHODS : A cross-sectional, pharmacoepidemiological study was conducted among patients undergoing surgical procedures in routine or emergency conditions under general anesthesia. The utilization of pre-anesthetic medicines in all patients was reported. RESULTS: A total of 110 patients (mean age - 42.36 years; 57.27% males) were enrolled...
June 13, 2017: Curēus
https://www.readbyqxmd.com/read/28532137/the-comparative-study-of-ondansetron-and-metoclopramide-effects-in-reducing-nausea-and-vomiting-after-laparoscopic-cholecystectomy
#9
RANDOMIZED CONTROLLED TRIAL
Khatereh Isazadehfar, Masoud Entezariasl, Bita Shahbazzadegan, Zahra Nourani, Yousef Shafaee
Postoperative nausea and vomiting (PONV) are one of the most common complications of anesthesia and without prophylactic intervention occurs by about one-third of patients under general anesthesia. The aim of this study was to compare the efficacy of ondansetron and metoclopramide in reducing PONV after laparoscopic cholecystectomy. In this study, 60 patients undergoing laparoscopic cholecystectomy were randomly allocated into two equal groups (n=30), and in the first group 10 mg metoclopramide and in the second group 4 mg ondansetron preoperatively were injected...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28349496/a-phase-ii-randomized-double-blind-placebo-controlled-study-of-6-gingerol-as-an-anti-emetic-in-solid-tumor-patients-receiving-moderately-to-highly-emetogenic-chemotherapy
#10
RANDOMIZED CONTROLLED TRIAL
J Konmun, K Danwilai, N Ngamphaiboon, B Sripanidkulchai, A Sookprasert, S Subongkot
6-Gingerol is a natural compound extracted from ginger. Preclinical studies demonstrated that 6-gingerol has an anti-emetic activity by inhibiting neurokinin-1, serotonin, and dopamine receptors. Several clinical trials examined crude ginger powder for preventing chemotherapy-induced nausea and vomiting (CINV), but none of them was conducted with a standardized bioactive compound. Patients who received moderately to highly emetogenic adjuvant chemotherapy were randomized to receive 6-gingerol 10 mg or placebo orally twice daily for 12 weeks...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28322837/role-of-prostanoid-ep-3-1-receptors-in-mechanisms-of-emesis-and-defaecation-in-ferrets
#11
Kelvin K W Kan, Man K Wai, Robert L Jones, John A Rudd
Prostanoid EP receptor agonists are used for a number of clinical indications but may be associated with gastric disturbance. In the present studies we used the ferret and sulprostone (30µg/kg, i.p.) to investigate the role of EP3/1 receptors in mechanisms of emesis and defaecation. The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0...
May 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28220993/antiemetic-use-among-pregnant-women-in-the-united-states-the-escalating-use-of-ondansetron
#12
Lockwood G Taylor, Steven T Bird, Leyla Sahin, Melissa S Tassinari, Patty Greene, Marsha E Reichman, Susan E Andrade, Katherine Haffenreffer, Sengwee Toh
PURPOSE: To examine ondansetron use in pregnancy in the context of other antiemetic use among a large insured United States population of women delivering live births. METHODS: We assessed ondansetron and other antiemetic use among pregnant women delivering live births between 2001 and 2015 in 15 data partners contributing data to the Mini-Sentinel Distributed Database. We identified live birth pregnancies using a validated algorithm, and all forms of ondansetron and other available antiemetics were identified using National Drug Codes or procedure codes...
May 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28198032/comparative-efficacy-of-metoclopramide-ondansetron-and-maropitant-in-preventing-parvoviral-enteritis-induced-emesis-in-dogs
#13
RANDOMIZED CONTROLLED TRIAL
E Yalcin, G O Keser
The aim of the study was to evaluate the efficiencies of selected anti-emetic drugs (metoclopramide, ondansetron and maropitant) in preventing vomiting in the treatment of canine parvoviral enteritis. We designed a randomized, prospective clinical study. PVE quick ELISA test-positive dogs between 4 and 12 months of age were included in the study. Each of metoclopramide, ondansetron, maropitant and control group had 8 dogs. Metoclopramide and ondansetron were administered as 0.5 mg/kg doses three times a day via intravenous route, and maropitant was administered as 1 mg/kg doses once a day subcutaneously...
December 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28108820/prevention-of-chemotherapy-induced-nausea-the-role-of-neurokinin-1-nk-1-receptor-antagonists
#14
REVIEW
Snežana M Bošnjak, Richard J Gralla, Lee Schwartzberg
Chemotherapy-induced nausea (CIN) has a significant negative impact on the quality of life of cancer patients. The use of 5-hydroxytryptamine-3 (5-HT3 ) receptor antagonists (RAs) has reduced the risk of vomiting, but (except for palonosetron) their effect on nausea, especially delayed nausea, is limited. This article reviews the role of NK1 RAs when combined with 5-HT3 RA-dexamethasone in CIN prophylaxis. Aprepitant has not shown consistent superiority over a two-drug (ondansetron-dexamethasone) combination in nausea control after cisplatin- or anthracycline-cyclophosphamide (AC)-based highly emetogenic chemotherapy (HEC)...
May 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28070660/treatment-options-for-hyperemesis-gravidarum
#15
REVIEW
Amy Abramowitz, Emily S Miller, Katherine L Wisner
Hyperemesis gravidarum (HG) is a severe and prolonged form of nausea and/or vomiting during pregnancy. HG affects 0.3-2% of pregnancies and is defined by dehydration, ketonuria, and more than 5% body weight loss. Initial pharmacologic treatment for HG includes a combination of doxylamine and pyridoxine. Additional interventions include ondansetron or dopamine antagonists such as metoclopramide or promethazine. The options are limited for women who are not adequately treated with these medications. We suggest that mirtazapine is a useful drug in this context and its efficacy has been described in case studies...
June 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27816366/comparison-of-ramosetron-with-ondansetron-for-prevention-of-intrathecal-morphine-induced-nausea-and-vomiting-after-primary-total-knee-arthroplasty-a-randomized-control-trial
#16
RANDOMIZED CONTROLLED TRIAL
Piya Pinsornsak, Mungkorn Teeyaphudit, Chaivet Ruetiwarangkoon, Adisai Chaiwuttisak
BACKGROUND: Spinal anesthesia with intrathecal morphine is a reliable, easy to apply, and cost effective method for controlling pain after total knee arthroplasty (TKA). However, postoperative nausea and vomiting (PONV) is a major concern. 5-Hydroxytryptamine receptor 3 (5-HT3 ) antagonists like ondansetron and ramosetron are commonly used for preventing PONV, but the optimal choice remains unclear. We conducted a study to assess the effectiveness of ramosetron and ondansetron, hypothesizing that the longer acting ramosetron may be better than ondansetron in the first 48 hours after TKA, performed with spinal anesthesia and intrathecal morphine...
March 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27731292/treatments-for-hyperemesis-gravidarum-and-nausea-and-vomiting-in-pregnancy-a-systematic-review-and-economic-assessment
#17
REVIEW
Amy O'Donnell, Catherine McParlin, Stephen C Robson, Fiona Beyer, Eoin Moloney, Andrew Bryant, Jennifer Bradley, Colin Muirhead, Catherine Nelson-Piercy, Dorothy Newbury-Birch, Justine Norman, Emma Simpson, Brian Swallow, Laura Yates, Luke Vale
BACKGROUND: Nausea and vomiting in pregnancy (NVP) affects up to 85% of all women during pregnancy, but for the majority self-management suffices. For the remainder, symptoms are more severe and the most severe form of NVP - hyperemesis gravidarum (HG) - affects 0.3-1.0% of pregnant women. There is no widely accepted point at which NVP becomes HG. OBJECTIVES: This study aimed to determine the relative clinical effectiveness and cost-effectiveness of treatments for NVP and HG...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27701665/treatments-for-hyperemesis-gravidarum-and-nausea-and-vomiting-in-pregnancy-a-systematic-review
#18
REVIEW
Catherine McParlin, Amy O'Donnell, Stephen C Robson, Fiona Beyer, Eoin Moloney, Andrew Bryant, Jennifer Bradley, Colin R Muirhead, Catherine Nelson-Piercy, Dorothy Newbury-Birch, Justine Norman, Caroline Shaw, Emma Simpson, Brian Swallow, Laura Yates, Luke Vale
Importance: Nausea and vomiting affects approximately 85% of pregnant women. The most severe form, hyperemesis gravidarum, affects up to 3% of women and can have significant adverse physical and psychological sequelae. Objective: To summarize current evidence on effective treatments for nausea and vomiting in pregnancy and hyperemesis gravidarum. Evidence Review: Databases were searched to June 8, 2016. Relevant websites and bibliographies were also searched...
October 4, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27677233/-5-ht3-antagonists-as-a-substitute-for-metoclopramide-and-domperidone-a-literature-review
#19
I Mouch, J R B J Brouwers, E van 't Riet, P Nieboer, M H Otten, F G A Jansman
OBJECTIVE: To investigate whether the anti-emetics metoclopramide and domperidone can be replaced by 5-HT3-antagonists, as side effects restrict use of these dopamine antagonists. DESIGN: Systematic review. METHOD: We searched the Embase and PubMed databases for articles published in the period 1995-October 2015, in which the efficacy or side effects of metoclopramide or domperidone were compared with at least one of the 5-HT3-antagonists ondansetron, granisetron, tropisetron or palonosetron...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27168518/interventions-for-treating-hyperemesis-gravidarum
#20
REVIEW
Rupsa C Boelig, Samantha J Barton, Gabriele Saccone, Anthony J Kelly, Steve J Edwards, Vincenzo Berghella
BACKGROUND: Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy affecting 0.3% to 1.0% of pregnancies, and is one of the most common indications for hospitalization during pregnancy. While a previous Cochrane review examined interventions for nausea and vomiting in pregnancy, there has not yet been a review examining the interventions for the more severe condition of hyperemesis gravidarum. OBJECTIVES: To assess the effectiveness and safety, of all interventions for hyperemesis gravidarum in pregnancy up to 20 weeks' gestation...
May 11, 2016: Cochrane Database of Systematic Reviews
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