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("ECG" OR " EKG") AND ("Ventricular Tachycardia" OR "VT")

Elisabeth Kaiser, Qinghai Tian, Michael Wagner, Monika Barth, Wenying Xian, Laura Schroeder, Sandra Ruppenthal, Lars Kaestner, Ulrich Boehm, Philipp Wartenberg, Huiyan Lu, Sara M McMillin, Derek B Bone, Jürgen Wess, Peter Lipp
Aims: Signaling via Gq-coupled receptors is of profound importance in many cardiac diseases such as hypertrophy and arrhythmia. Nevertheless, owing to their widespread expression and the inability to selectively stimulate such receptors in vivo, their relevance for cardiac function is not well understood. We here use DREADD technology to understand the role of Gq-coupled signaling in vivo in cardiac function. Methods and Results: We generated a novel transgenic mouse line that expresses a Gq-coupled DREADD (Dq) in striated muscle under the control of the MCK promotor...
October 13, 2018: Cardiovascular Research
Leanne Jane Eveson, A Williams
We present the case of a 50-year-old, fit, asymptomatic gurkha officer. At a routine medical, an ECG showed T-wave inversion in the chest leads V3-6. Transthoracic echo showed left ventricular apical hypertrophy and cavity obliteration consistent with apical hypertrophic cardiomyopathy (ApHCM). Cardiac magnetic resonance imaging showed apical and inferior wall hypertrophy in the left ventricle with no aneurysm or scarring. A 24-hour monitor showed normal sinus rhythm with no evidence of non-sustained ventricular tachycardia...
October 12, 2018: Journal of the Royal Army Medical Corps
Pramod Theetha Kariyanna, Apoorva Jayarangaiah, Sudhanva Hegde, Jonathan D Marmur, Perry Wengrofsky, Mena Yacoub, Michael Post, Samy I McFarlane
Marijuana is the most common drug of abuse in the United States. Marijuana acts on cannabinoid receptors CB1, CB2 and another distinct endothelial receptor. Marijuana is known to cause tachycardia, hypotension and hypertension. Various arrhythmias including atrial fibrillation, atrial flutter, II degree AV block, ventricular fibrillation, ventricular tachycardia, asystole and brugada pattern associated with marijuana use have been reported. We here present an interesting case of Type I Brugada pattern in electrocardiography (ECG) in a 36 year old healthy African American male who presented after smoking four joints...
2018: American journal of medical case reports
Jens-Peter David, Ulrike Lisewski, Shawn M Crump, Thomas A Jepps, Elke Bocksteins, Nicola Wilck, Janine Lossie, Torsten K Roepke, Nicole Schmitt, Geoffrey W Abbott
KCNE5 is an X-linked gene encoding KCNE5, an ancillary subunit to voltage-gated potassium (KV ) channels. Human KCNE5 mutations are associated with atrial fibrillation (AF)- and Brugada syndrome (BrS)-induced cardiac arrhythmias that can arise from increased potassium current in cardiomyocytes. Seeking to establish underlying molecular mechanisms, we created and studied Kcne5 knockout ( Kcne5-/0 ) mice. Intracardiac ECG revealed that Kcne5 deletion caused ventricular premature beats, increased susceptibility to induction of polymorphic ventricular tachycardia (60 vs...
October 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Aamir H Khan, Maryam H Khan, Hunaina Shahab, Qamaruddin Roziman
Antidromic atrioventricular reentrant tachycardia (aAVRT) is rare compared to orthodromic atrioventricular reentrant tachycardia (oAVRT). An aAVRT that is dependent on a unidirectional, decremental accessory pathway (AP) is even rarer. Idiopathic ventricular tachycardias (iVT) that have benign prognoses and respond well to medical therapy can be confused with aAVRTs dependent on APs having ventricular insertion sites close to the iVT focus and have a real risk of sudden death. The preferred approach of ablation for such tachycardias with anterograde conduction only is a retrograde aortic approach, which facilitates the mapping of the earliest ventricular activation during atrial pacing or tachycardia from the ventricular side...
July 27, 2018: Curēus
Daniele Muser, Pasquale Santangeli, Joseph B Selvanayagam, Gaetano Nucifora
Ventricular Arrhythmias (VAs) may present with a wide spectrum of clinical manifestations ranging from mildly symptomatic frequent premature ventricular contractions to life-threatening events such as sustained ventricular tachycardia, ventricular fibrillation and sudden cardiac death. Myocardial scar plays a central role in the genesis and maintenance of re-entrant arrhythmias which are commonly associated with SHD such as ischemic heart disease, healed myocarditis and non-ischemic cardiomyopathies. However, the arrhythmogenic substrate may remain unclear in up to 50% of the cases after a routine diagnostic workup comprehensive of 12-lead surface ECG, transthoracic echocardiography and coronary angiography/computed tomography...
September 24, 2018: Current Cardiology Reviews
S Schumann, L Vimlati, R Kawati, J Guttmann, M Lichtwarck-Aschoff
BACKGROUND: Low positive end-expiratory pressure (PEEP) can result in alveolar derecruitment, and high PEEP or high tidal volume (VT ) in lung overdistension. We investigated cardiogenic oscillations (COS) in the airway pressure signal to investigate whether these oscillations can assess unfavourable intratidal events. COS induce short instantaneous compliance increases within the pressure-volume curve, and consequently in the compliance-volume curve. We hypothesised that increases in COS-induced compliance reflect non-linear intratidal respiratory system mechanics...
October 2018: British Journal of Anaesthesia
M B Plotnikov, G A Chernysheva, V I Smol'yakova, T M Plotnikova, S V Sysolyatin, Y A Kryukov
We studied anti-ischemic activity of n-tyrozol under conditions of repeated transient myocardial ischemia in rats caused by repeated (5×3 min) occlusion of the left coronary artery. n-Tyrozol administered intraperitoneally in a dose of 20 mg/kg daily over 4 days before the ischemia modeling (the last injection 15 min prior to the start of the experiment) produced a clear-cut anti-ischemic effect: it reduced ST elevation and promoted more complete recovery of ECG during reperfusion. During reperfusion periods, n-tyrozol significantly decreased the risk of ventricular fibrillation and shortened the duration of tachyarrhythmia episodes (ventricular tachycardia and fibrillation)...
September 2018: Bulletin of Experimental Biology and Medicine
Jesus Castro Hevia, Margarita Dorantes Sanchez, Frank Martinez Lopez, Osmin Castañeda Chirino, Roylan Falcon Rodriguez, Marcelo Puga Bravo, Joanna de Zayas Galguera, Charles Antzelevitch
BACKGROUND: A spontaneous coved-type ST segment elevation in the electrocardiogram (ECG) has long been recognized as a risk stratification tool in patients with Brugada syndrome (BrS). This Type-I ST segment elevation is known to exhibit high dynamicity, fluctuating between coved-type and non-coved ST segment elevation. Our objectives in this study were to: 1) Compare ECG parameters in patients with spontaneous coved-type (Type-I) vs. non-coved-type ST segment ECGs; 2) Determine the variability of these ECG parameters with repeated measurements; and 3) Assess the predictive value of ECG parameters in these two groups during follow-up...
August 30, 2018: International Journal of Cardiology
Ana Fidalgo, Leticia Fernandez-Friera, Jorge Solis
CLINICAL INTRODUCTION: A 52-year-old woman with shortness of breath and palpitations was referred to a cardiologist. A 24-hour Holter demonstrated high density (37%) of ventricular premature beats (VPBs) and long runs of non-sustained (eventually sustained) monomorphic ventricular tachycardia (VT) with the same morphology as several VPBs detected in a 12-lead ECG (figure 1A). A transthoracic echocardiogram was performed, and the patient's evaluation was completed with a functional and gadolinium-enhanced cardiovascular MR (CMR) study (figure 1B,C) to assess structural heart disease...
September 4, 2018: Heart: Official Journal of the British Cardiac Society
Shijie Zhou, B Milan Horáček, James W Warren, Amir AbdelWahab, John L Sapp
BACKGROUND: Rapid accurate localization of the site of ventricular activation origin during catheter ablation for ventricular arrhythmias could facilitate the procedure. Electrocardiographic imaging (ECGI) using large lead sets can localize the origin of ventricular activation. We have developed an automated method to identify sites of early ventricular activation in real time using the 12-lead ECG. We aim to compare the localization accuracy of ECGI and the automated method, identifying pacing sites/VT exit based on a patient-specific model...
July 29, 2018: Journal of Electrocardiology
Yoav Michowitz, Bernard Belhassen
Verapamil-sensitive left fascicular monomorphic ventricular tachycardia (LF-VT) was first described ~4 decades ago. Our knowledge regarding this arrhythmia is evolving continuously. The current review aims to highlight up to date aspects of this arrhythmia focusing on its ECG recognition, new considerations of the reentrant circuit, ablation targets in inducible and non-inducible patients and the approach to LF-VT with multiform morphology.
September 2018: Journal of Electrocardiology
Mohammad Shenasa, Shahriar Heidary, Hossein Shenasa
BACKGROUND: A 72-year-old white male with a history of rapid nonsustained ventricular tachycardia, hypertrophic cardiomyopathy, and intermittent Brugada-type ECG had a single-lead implantable cardioverter-defibrillator (ICD) implantation and received a sudden ICD shock while in the hot tub. To the best of our knowledge this is the first case report of hot tub jet-induced inappropriate ICD shock. METHODS: ICD interrogation and analysis of intracardiac electrograms and event markers...
September 2018: Journal of Electrocardiology
Satish Misra, Peter van Dam, Jonathan Chrispin, Fabrizio Assis, Ali Keramati, Aravindan Kolandaivelu, Ronald Berger, Harikrishna Tandri
BACKGROUND: View into Ventricular Onset (VIVO) is a novel ECGI system that uses 3D body surface imaging, myocardial CT/MRI, and 12‑lead ECG to localize earliest ventricular activation through analysis of simulated and clinical vector cardiograms. OBJECTIVE: To evaluate the accuracy of VIVO for the localization of ventricular arrhythmias (VA). METHODS: In twenty patients presenting for catheter ablation of VT [8] or PVC [12], VIVO was used to predict the site earliest activation using 12‑lead ECG of the VA...
September 2018: Journal of Electrocardiology
Yuriko Sato, Yoshiyasu Aizawa, Taishi Fujisawa, Shogo Ito, Kousuke Katano, Nozomi Fuse, Akira Miyabe, Kimihiro Osada, Ryuuma Ishihara, Atushi Tosaka, Toshitake Tamamura, Taisuke Mizumura, Youichi Sugimura, Kazuaki Nakajima, Yoshinori Katsumata, Takahiko Nishiyama, Takehiro Kimura, Yoshiko Furukawa, Seiji Takatsuki, Kenjiro Kosaki, Keiichi Fukuda
A 50-year-old woman visited the emergency department with a high fever due to pneumonia. Incessant monomorphic ventricular tachycardia occurred and was terminated by intravenous lidocaine. Her ECG during sinus rhythm demonstrated ST segment elevation suggestive of Brugada syndrome (BS). An intensive examination could not detect any structural disease, and typical coved-type ST elevation was unmasked by a pilsicainide injection leading to a diagnosis of BS. An ICD was implanted for secondary prevention of ventricular arrhythmia...
August 2018: Journal of Arrhythmia
Alessandro Zorzi, Giulio Mastella, Alberto Cipriani, Giampaolo Berton, Alvise Del Monte, Beatrice Gusella, Alberto Nese, Leonardo Portolan, Federico Sciacca, Suada Tikvina, Saverio Tollot, Domenico Trovato, Sabino Iliceto, Maurizio Schiavon, Domenico Corrado
Background Whether prolonged and intense exercise increases the incidence of ventricular arrhythmias in middle-aged athletes remains to be established. Design Prospective, case-control. Methods We studied 134 healthy competitive athletes >30 years old (median age 45 (39-51) years, 83% males) who had been engaged in 9 ± 2 h per week of endurance sports activity (running, cycling, triathlon) for 13 ± 4 consecutive years. One hundred and thirty-four age- and gender-matched individuals served as controls...
August 30, 2018: European Journal of Preventive Cardiology
Daniel Cortez, Nandita Sharma, Jason R Imundo
INTRODUCTION: Noncompaction cardiomyopathy (NCCM) patients may develop sustained ventricular arrhythmias (VA). Currently no known electrocardiogram (ECG) parameter has demonstrated predictive value for VA development. The spatial QRS-T angle has demonstrated ability to identify VA in other cardiomyopathy populations. METHODS: A total of 39 patients with NCCM, defined by compact to non-compact ratio of >2.3 by magnetic resonance imaging, were assessed. The first ECG taken at time of MRI was assessed utilizing the heart rate, the QRS duration (QRSd), the corrected QT interval (QTc), and the spatial QRS-T angle (SPQRS-T angle, three-dimensional angle between the QRS and T-wave vectors) were assessed...
August 27, 2018: Annals of Noninvasive Electrocardiology
Michelle M Monasky, Carlo Pappone, Marco Piccoli, Andrea Ghiroldi, Emanuele Micaglio, Luigi Anastasia
The Brugada syndrome (BrS) is characterized by coved-type ST-segment elevation in the right precordial leads on the electrocardiogram (ECG) and increased risk of sudden cardiac death (SCD). While it is an inheritable disease, determining the true prevalence is a challenge, since patients may report no known family history of the syndrome, present with a normal spontaneous ECG pattern at the time of examination, and test negative for all known BrS-causative genes. In fact, SCD is often the first indication that a person is affected by the syndrome...
2018: Frontiers in Physiology
Roy M John, Eric T Shinohara, Michael Price, William G Stevenson
Ablation of cardiac tissue using focused radiotherapy to control ventricular tachycardia (VT) is a novel therapeutic consideration in the management of ventricular arrhythmias associated with structural heart disease. Segments of ventricular myocardium that act as substrates for ventricular tachycardia can be identified by the use of invasive mapping techniques or non-invasive ECG incorporating multi-electrode body surface recordings and cardiac imaging. Early case series have demonstrated a consistent decrease in VT burden and sufficient acute safety to expand to more detailed multicenter studies...
August 11, 2018: Computers in Biology and Medicine
Tanawat Attachaipanich, Rungroj Krittayaphong
BACKGROUND: Fragmented QRS (fQRS) complex is an electrocardiographic pattern that reflects the inhomogeneity of ventricular depolarization. The aims of this study were to determine the prognostic significance of fQRS for predicting in-hospital life-threatening arrhythmic complications in ST-elevation myocardial infarction (STEMI) patients, and to identify the most appropriate duration of cardiac rhythm monitoring in STEMI patients with fQRS. METHODS: Patients diagnosed with and treated for STEMI at Siriraj Hospital (Bangkok, Thailand) during 2009-2012 were enrolled...
August 17, 2018: Annals of Noninvasive Electrocardiology
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