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Cerebral vein thrombosis

Mohammad Selim, Amandeep Rakhra, Thamer Kassim, Rouhin Sen, Javaneh Jabbari, Carrie Valenta
A case of 43-year-old female presented to the emergency department (ED) with a new onset grand mal tonic-clonic seizure lasting at least two minutes with post-ictal confusion. Imaging was consistent with cerebral sinus venous thrombosis (CSVT) associated with intracranial hemorrhage. After ruling out most common causes of thrombosis, the etiology was attributed to estrogen vaginal ring. The patient was treated with anticoagulation therapy and had increasing hemorrhagic changes in the first few days, which eventually improved...
August 5, 2018: Curēus
Y Liu, D C Han, Y L Hu, L M Chen, J C Li, Y W Su, C X Hu
Objective: To summarize the clinical presentations and imaging features of cerebral venous sinus thrombosis (CVST) in 5 newborns. Methods: The clinical data of 5 newborns with CVST admitted to Department of Neonatology of Maternal and Children Hospital of Hubei Province from February 2017 to April 2018 were analyzed retrospectively. The risk factors, clinical presentations, imaging manifestations and treatment of CVST were investigated. Results: Of the 5 full term neonates, 4 were males and 1 female, with 4 aged less than 7 days and 1 more than 7 days; one with the history of maternal gestational diabetes mellitus, one with maternal gestational hypertension...
October 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Sara Degl'Innocenti, Nicola Della Camera, Cristian Falzone, Carlo Cantile
Intravascular lymphoma (IVL) is a rare angiotropic large-cell lymphoma in which neoplastic lymphocytes proliferate within the lumina of small blood vessels in the absence of a primary extravascular mass or leukemia. This study included 10 cases of canine IVL restricted to the CNS. Dogs had an average age of 8 years and neurological signs mainly referred to brain involvement such as depression, seizures, and ambulatory deficits. Gross examination at necropsy showed focal extensive or multiple hemorrhagic areas mainly distributed in the telencephalon and diencephalon...
October 5, 2018: Veterinary Pathology
Kyle H Cichos, Eva J Lehtonen, Gerald McGwin, Brent A Ponce, Elie S Ghanem
INTRODUCTION: Orthopaedic surgeons are wary of patients with neuromuscular (NM) diseases as a result of perceived poor outcomes and lack of data regarding complication risks. We determined the prevalence of patients with NM disease undergoing total joint arthroplasty (TJA) and characterized its relationship with in-hospital complications, prolonged length of stay, and total charges. METHODS: Data from the Nationwide Inpatient Sample from 2005 to 2014 was used for this retrospective cohort study to identify 8,028,435 discharges with total joint arthroplasty...
October 2, 2018: Journal of the American Academy of Orthopaedic Surgeons
Anne Kuitunen, Marjatta Sinisalo, Annukka Vahtera, Leena Hiltunen, Kaija Javela, Outi Laine
BACKGROUND: Heparin-induced thrombocytopenia (HIT) usually appears at 5 to 10 days after initiation of heparin. Autoimmune HIT can arise after discontinuation of heparin treatment (delayed-onset HIT) or without any preceding heparin exposure (spontaneous HIT syndrome). CASE REPORT: This case presents a course of autoimmune HIT with delayed onset. The patient was hospitalized due to influenza pneumonia and received low-molecular-weight heparin thromboprophylaxis for 9 days...
October 4, 2018: Transfusion
Ylenia Ingrasciotta, Salvatore Crisafulli, Valeria Pizzimenti, Ilaria Marcianò, Anna Mancuso, Giuseppe Andò, Salvatore Corrao, Piera Capranzano, Gianluca Trifirò
Since 2008, new oral anticoagulants (NOACs) have been approved for the prevention of venous thromboembolism (VTE) in patients receiving hip or knee replacement surgery, prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF), treatment of deep vein thrombosis (DVT), and pulmonary embolism (PE). Premarketing randomized clinical trials (RCTs) of NOACs demonstrated their non-inferiority in terms of efficacy vs. warfarin (traditional oral anticoagulant - TOA), with lower risk of serious adverse drug reactions, especially cerebral hemorrhages...
October 2018: Expert Opinion on Drug Metabolism & Toxicology
Joseph J Shatzel, Matthew O'Donnell, Sven R Olson, Matthew R Kearney, Molly M Daughety, Justine Hum, Khanh P Nguyen, Thomas G DeLoughery
Thrombosis of unusual venous sites encompasses a large part of consultative hematology, and is encountered routinely by practicing hematologists. Contrary to the more commonly encountered lower extremity venous thrombosis and common cardiovascular disorders, the various thromboses outlined in this review have unique presentations, pathophysiology, workup and treatments that all hematologists should be aware of. This review attempts to outline the most up to date literature on cerebral, retinal, upper extremity, hepatic, portal, splenic, mesenteric and renal vein thrombosis, focusing on the incidence, pathophysiology, provoking factors and current recommended treatments for each type of unusual thrombosis to provide a useful and practical review for the hematologist...
September 28, 2018: European Journal of Haematology
Gourav Goyal, Abhishek Charan, Rambir Singh
Introduction: Cerebral venous sinus thrombosis (CVST) is an unusual cause of stroke with potentially serious consequences. This study was designed to investigate the clinical and neuroimaging features in patients with CVST and to analyze the predictors of brain parenchymal lesions. Materials and Methods: A retrospective study of 181 patients with CVST was conducted in a tertiary care hospital. Results: Of 181 patients (age range 14-96 years, mean age: 34...
July 2018: Annals of Indian Academy of Neurology
Sadegh Izadi, Afshin Borhani-Haghighi, Kamal Bastani, Bahareh Kardeh, Golnaz Yadollahi-Khales, Mojtaba Neydavoodi
BACKGROUND: Cerebral sinovenous thrombosis (CSVT) is a neurovascular disorder that occurs when a blood clot develops in a vein near the brain. Evaluating the subsequent changes in inflammatory cytokines can better reveal the underlying pathogeneses. OBJECTIVE: To assess the serum levels of interleukin-10 (an anti-inflammatory cytokine) and IL-17 (a pro-inflammatory cytokine) in patients with aseptic non-vasculitic CSVT. METHODS: In this prospective case-control study, 31 patients with aseptic non-vasculitic CSVT (admitted in Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran) were enrolled...
September 2018: Iranian Journal of Immunology: IJI
Prasert Iampreechakul, Wuttipong Tirakotai, Adisak Tanpun, Yodkhwan Wattanasen, Punjama Lertbusayanukul, Somkiet Siriwimonmas
Spontaneous regression of direct carotid-cavernous fistulas (CCFs) is extremely rare. Most of the patients with direct CCFs are usually treated using endovascular techniques. Spontaneous obliteration of the direct fistulas probably results from thrombosis of the venous drainage and/or cavernous sinus. We report spontaneous closure of nine direct CCFs in nine patients. From literature review, we found another 37 patients with 43 fistulas due to spontaneous obliteration of bilateral lesions in six cases. There was no spontaneous closure in large-sized fistula...
September 23, 2018: Interventional Neuroradiology
Małgorzata K Mimier, Dawid T Janczak, Robert D McBane, Damon E Houghton, Waldemar E Wysokinski
Four percent of venous thromboembolism (VTE) involves organ-related venous territories such as: splanchnic, renal, gonadal, cerebral venous segments, and is often called venous thromboembolism of atypical location (VTE-AL). Recommendations regarding anticoagulation method, intensity and duration for VTE-AL are not well established. Direct oral anticoagulants (DOACs) have been a promising alternative to vitamin K antagonists in treatment of acute VTE. However, all major clinical trials with DOACs excluded patients with VTE-AL...
September 20, 2018: Polish Archives of Internal Medicine
Ryo Miyoshi, Shigeto Nishikawa, Shigeyuki Tamari, Misa Noguchi, Kyoko Hijiya, Koji Chihara
Objectives Thrombosis in the pulmonary vein stump after a left upper lobectomy is a rare but potentially life-threatening complication, and the pulmonary vein stump length plays an important role here. We assessed the frequency and risk factors for thrombosis in patients undergoing lobectomy with division of the superior pulmonary vein using ligation. Methods We retrospectively reviewed 425 patients with primary lung cancer who underwent lobectomy or bilobectomy in our institution from 2008 to 2016, with contrast-enhanced chest computed tomography within a year after lobectomy...
September 2018: Asian Cardiovascular & Thoracic Annals
Jafar Mehvari Habibabadi, Mohammad Saadatnia, Nasim Tabrizi
Many conflicting issues exist about seizure in the setting of cerebral venous and sinus thrombosis (CVST). In this article we aimed to address the existing data regarding incidence, characteristics, predictors, treatment, and prognosis of acute and late seizures in patients with CVST and to prepare more practical information for clinicians. PubMed, Embase, Web of science and Cochrane databases were searched within 1966-2016 using relevant keywords. A total of 63 papers met the inclusion criteria. Seizures are classified as acute symptomatic seizures (ASS; first 14 days) and post-CVST epilepsy (PCE; after 14 days)...
September 2018: Epilepsia Open
Hidesaku Asakura
Among all types of myeloproliferative neoplasms (MPNs), polycythemia vera (PV) and essential thrombocythemia (ET) require careful management of both thrombosis and hemostasis. One recent concern associated with MPNs is the JAK2 mutation (V617F). This mutation is essential for MPN pathology, but it has also garnered attention for its association with thrombosis. Several studies have reported the mechanisms underlying the onset of thrombosis in both PV and ET and have also discussed the association between JAK2 mutations and thrombotic tendencies...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Jinrong Zheng, Yuanzhi Shen, Zhiqiang Xu, Zhenwei Yuan, Yuanyuan He, Chen Wei, Murat Er, Jun Yin, Haiyan Chen
Selective and efficient detection and imaging of nitroreductase (NTR) overexpressed in hypoxic tissues is of great importance for better understanding its biological functions. The effective optical probes equipped for NTR detection in vivo is still lacking, so we developed an innovative near infrared (NIR) fluorescent on-off probe (Cy-NO2 ) composed of fluorescence reporting unit (an aminocyaine dye) and recognition unit (p-nitrobenzylcarbamate group). The response and mechanism of the NTR activated reduction of Cy-NO2 were evaluated in vitro through kinetic optical studies, mass spectra analysis and docking calculations...
November 15, 2018: Biosensors & Bioelectronics
Jingwei Li, Shiwei Du, Liyong Sun, Feng Shang, Hongqi Zhang, Guilin Li
As a normal variation of the cerebral venous angioarchitecture, developmental venous anomalies (DVAs) represent a rare cause of intraparenchymal hemorrhage. Different from mixed vascular lesions, such as capillary malformations (CMs), arteriovenous malformations (AVMs), arteriovenous fistulas (AVFs), and thrombosis, here we describe the first case of a ruptured hemodynamic aneurysm associated with a DVA and introduce the first use of hybrid operation for the treatment of a hemorrhagic DVA. A 14-year-old girl suffered from sudden onset of headache, aphasia and left hemiplegia...
August 9, 2018: World Neurosurgery
Wei Wang, Caihou Lin, Jingfang Hong, Shousen Wang, Jianjun Gu
BACKGROUND: Cerebral venous infarction (CVI) is a rare vascular disease most commonly caused by cerebral venous thrombosis that leads to hemorrhage or infarct formation. A rabbit model of CVI was established by placing a recoverable epidural sacculus to research effects of increased pressure on CVI. METHODS: Rabbits were randomly divided into the following groups: A, CVI; B, 0.2-mL epidural sacculus placed on the basis of CVI; C, 0.4-mL epidural sacculus; D, 0.6-mL epidural sacculus; E, sham operation...
August 7, 2018: World Neurosurgery
Raj Nagarkar, Gauri Kokane, Ashvin Wagh, Sirshendu Roy
INTRODUCTION: Neck dissection is a part of the standard surgical procedure in the management of head and neck malignancy. Diplopia following neck dissection is a rare entity; hence, its diagnosis and management strategies needed to be discussed for prevention of its grave consequences. CASE REPORT: A 30-year-old male patient presented with binocular horizontal diplopia following total thyroidectomy and neck dissection. On evaluation, there was internal jugular vein (IJV) thrombosis followed by cerebral venous sinus thrombosis (CVST)...
September 2018: Oral and Maxillofacial Surgery
Bader Al Rawahi, Mosaad Almegren, Marc Carrier
BACKGROUND: Anticoagulation with unfractionated heparin (UFH) or low molecular weight heparin (LMWH) is the mainstay for the treatment of patients with acute cerebral vein thrombosis (CVT) with or without intracranial hemorrhage (ICH). AIM: We conducted a systematic review and meta-analysis to determine the efficacy and safety of LMWH compared to UFH for the treatment of acute CVT. METHODS: An electronic search of MEDLINE, Pubmed, CENTRAL and Google Scholar was performed...
September 2018: Thrombosis Research
Hengwei Jin, Stephanie Lenck, Timo Krings, Ronit Agid, Yibin Fang, Youxiang Li, Alex Kostynskyy, Michael Tymianski, Vitor Mendes Pereira, Ivan Radovanovic
OBJECTIVE The goal of this study was to describe changes in the angioarchitecture of brain arteriovenous malformations (bAVMs) between acute and delayed cerebral digital subtraction angiography (DSA) obtained after hemorrhage, and to examine bAVM characteristics predicting change. METHODS This is a retrospective study of a prospective institutional bAVM database. The authors included all patients with ruptured bAVMs who had DSA in both acute and delayed phases, with no interval treatment of their bAVM, between January 2000 and April 2017...
July 27, 2018: Journal of Neurosurgery
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