keyword
https://read.qxmd.com/read/38541084/caesarean-delivery-a-narrative-review-on-the-choice-of-neuraxially-administered-opioid-and-its-implications-for-the-multimodal-peripartum-pain-concept
#1
REVIEW
Mark Ulrich Gerbershagen, Hanaa Baagil
Nowadays, obstetrical anesthesia-related mortality is a very rare complication in industrialized countries. The recommended choice of intrathecal opioid for spinal anesthesia in the context of a multimodal peripartum pain management concept is discussed in this narrative review. Nowadays, there is a consensus that a perioperative multimodal pain concept should be used for caesarean delivery. This pain concept should include neuraxial opioids for spinal anesthesia, acetaminophen, NSAIDs, intravenous dexamethasone, and postoperative local or regional anesthetic procedures...
February 21, 2024: Medicina
https://read.qxmd.com/read/38528479/effect-of-pretreatment-with-a-small-dose-of-esketamine-on-sufentanil-induced-cough-during-anesthesia-induction-a-randomized-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Liangliang Gao, Zhuoliang Zhang, Yi Zhu, Xinyu Lu, Yue Tian, Lei Wei
BACKGROUND: Sufentanil-induced cough is common during the induction of anesthesia. The objective of this study was to determine whether pretreatment with a small dose of esketamine is effective in treating sufentanil-induced cough. METHODS: 220 patients were screened, and 200 patients who had scheduled elective surgery and were between 18 and 70 years old were randomly divided into two groups. Before sufentanil was administered, esketamine group (group K) was injected with 0...
March 26, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38525317/risk-factors-for-postoperative-cognitive-decline-after-orthopedic-surgery-in-elderly-chinese-patients-a-retrospective-cohort-study
#3
JOURNAL ARTICLE
Xian Li, Hong Lai, Peng Wang, Shuai Feng, Xuexin Feng, Chao Kong, Dewei Wu, Chunlin Yin, Jianghua Shen, Suying Yan, Rui Han, Jia Liu, Xiaoyi Ren, Ying Li, Lu Tang, Dong Xue, Ying Zhao, Hao Huang, Xiaoying Li, Yanhong Zhang, Xue Wang, Chunxiu Wang, Ping Jin, Shibao Lu, Tianlong Wang, Guoguang Zhao, Chaodong Wang
PURPOSE: We aimed to identify the risk factors for postoperative cognitive decline (POCD) by evaluating the outcomes from preoperative comprehensive geriatric assessment (CGA) and intraoperative anesthetic interventions. PATIENTS AND METHODS: Data used in the study were obtained from the Aged Patient Perioperative Longitudinal Evaluation-Multidisciplinary Trial (APPLE-MDT) cohort recruited from the Department of Orthopedics in Xuanwu Hospital, Capital Medical University between March, 2019 and June, 2022...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38524538/impact-of-the-addition-of-dexmedetomidine-to-patient-controlled-intravenous-analgesia-on-postoperative-pain-sleep-interaction-cycle-and-delirium-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
JOURNAL ARTICLE
Wenjie Xu, Yuxiang Zheng, Qing Wang, Zizheng Suo, Lingling Fang, Jing Yang, Shuai Li, Peng Li, Xixi Jia, Xiaoyan Liu, Hui Zheng, Cheng Ni
BACKGROUND: The reciprocal nexus between sleep and pain is well-documented, with the deleterious impact of operative trauma potentially playing a pivotal role in the dysregulation of this interplay, which could significantly contribute to the manifestation of postoperative delirium (POD). Studies have investigated the effect of adding dexmedetomidine (DEX) to patient-controlled intravenous analgesia (PCIA) pumps on postoperative pain-sleep interaction cycle and POD, but conclusions remained uncertain...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38518033/efficacy-and-safety-of-nalbuphine-for-epidural-labor-analgesia-at-high-altitude-an-observational-study
#5
JOURNAL ARTICLE
Pengxia Wang, Ping Yu, Sen Cheng, Xinting Wu, Xuemei Li, Yinying Zeng, Shanshan Liu
Xining is located at the eastern edge of the Qinghai-Tibet Plateau, with an average altitude of >7000 feet (>2000 m). Nalbuphine is a kappa-opioid receptor agonist that can provide analgesia with fewer side effects than other opioid analgesics. This study aimed to evaluate pain control, side effects, and neonatal outcomes from combining nalbuphine with sufentanil and ropivacaine in 600 women during epidural anesthesia while giving birth at a high altitude in Xining, China. A total of 600 parturients receiving epidural labor analgesia were randomly divided into 2 groups, each group 300 parturients...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38509745/randomized-clinical-trial-of-continuous-transversus-thoracis-muscle-plane-block-for-patients-undergoing-open-heart-valve-replacement-surgery
#6
JOURNAL ARTICLE
Yanping Zhan, Lei Li, Shibiao Chen, Yongbao Peng, Yang Zhang
The optimal analgesia regimen after open cardiac surgery is unclear. The aim of this study was to investigate the beneficial effects of continuous transversus thoracis muscle plane (TTMP) blocks initiated before surgery on open cardiac surgery outcomes. A group of 110 patients were randomly allocated to either receive bilateral continuous TTMP blocks (TTP group) or no nerve block (SAL group). The primary endpoint was post-operative pain at 4, 8, 16, 24, 48 and 72 h after extubation at rest and exercise...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38503889/ethno-entomotherapeutic-and-metabolite-profiling-of-coridius-chinensis-dallas-a-traditional-edible-insect-species-of-north-east-india
#7
JOURNAL ARTICLE
Rajkumari Bonysana, Kabrambam Dasanta Singh, Wahengbam Deepanita Devi, Arunkumar Singh Koijam, Kokho Kapesa, Jatin Kalita, Pulok Kumar Mukherjee, Yallappa Rajashekar
Edible insects possess several health enhancing properties and play an important role in human nutrition. Coridius chinensis is an edible insect that is considered food and claimed as traditional medicine. In the present study, nutritional contents, chemical composition, antioxidant, and anti-inflammatory properties of C. chinensis were analyzed. It was found that the insect sample contains 50.46% moisture, 44.65% protein, 4.45% carbohydrate, 39.42% crude fats, 3.53% ash and 576.11 (Kcal/100 g) energy...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38485177/comparison-of-ultrasound-guided-subtransverse-process-interligamentary-plane-block-with-paravertebral-block-for-postoperative-analgesia-in-thoracic-surgery-protocol-for-a-randomised-non-inferiority-trial
#8
JOURNAL ARTICLE
Wei Wu, Danyang Wang, Yang Liu, Tianyi Zhu, Wenxin He, Hong Shi
INTRODUCTION: The subtransverse process interligamentary (STIL) plane block is an emerging interfascial plane block that has garnered attention for its potential to provide effective postoperative analgesia for breast and thoracic surgeries. However, a direct comparative assessment between the STIL plane block and the paravertebral block is currently lacking. Consequently, our study aims to assess the analgesic efficacy of the STIL block in comparison to paravertebral block for patients undergoing video-assisted thoracoscopic surgery (VATS)...
March 13, 2024: BMJ Open
https://read.qxmd.com/read/38470557/sufentanil-suppresses-cell-carcinogenesis-via-targeting-mir-186-5p-hmgb1-axis-and-wnt-%C3%AE-catenin-pathway-in-non-small-cell-lung-cancer
#9
JOURNAL ARTICLE
Di Liu, Ye Huang, You Shang
Sufentanil is a common opioid anesthetic agent, which exerts anti-cancer properties in several cancer types. However, its action mechanisms in non-small cell lung cancer (NSCLC) are unclear. Therefore, the present study investigated the pharmacological effect of sufentanil on miRNAs in NSCLC treatment. In this study, after treatment with sufentanil, the proliferation, migration, invasion and apoptosis of A549 and H1299 NSCLC cell lines were measured by cell counting kit-8 (CCK-8) assay, colony formation assay, transwell assays and flow cytometry...
March 12, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38444044/effect-of-intravenous-lidocaine-on-the-ed50-of-propofol-induction-dose-in-elderly-patients-undergoing-painless-gastroscopy-a-prospective-randomized-double-blinded-controlled-study
#10
JOURNAL ARTICLE
Lili Tang, Wenhui Lv, Jingjing Sun, Lijian Chen
BACKGROUND: Intravenous lidocaine could be a potential alternative adjuvant to propofol-based sedation for gastroscopy in elderly patients. This study aimed to evaluate the effect of intravenous lidocaine on the median effective dose (ED50) of propofol induction dose in elderly patients undergoing painless gastroscopy. METHODS: The study included 70 patients aged ≥ 60 years undergoing painless gastroscopy with 64 randomly assigned to either group L (2% lidocaine 1...
March 5, 2024: Perioperative Medicine
https://read.qxmd.com/read/38441505/catheter-tip-associated-mass-with-continuous-infusion-of-sufentanil-for-persistent-spinal-pain-syndrome-type-2-a-case-report-including-histopathologic-examination-and-review-of-the-associated-basic-and-clinical-research
#11
REVIEW
Andrew J B Pisansky, Benjamin J MacDougall, Edgar L Ross, John H Chi, Grace Neville, Tony L Yaksh
OBJECTIVES: Intrathecal opioids delivered by implanted pumps are used to treat malignant or nonmalignant chronic pain. In this study, we 1) review a case in which intrathecal infusions of sufentanil along with other adjuvants were used and after an extended period led to an intrathecal mass and 2) compared and contrasted the potential mechanisms for these phenomena. MATERIALS AND METHODS: A woman aged 66 years with a history of scoliosis and multiple spine surgeries was treated with an implantable drug delivery system for treating persistent pain after laminectomy...
March 5, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38434013/ultrasound-guided-erector-spinae-plane-block-for-perioperative-analgesia-in-patients-undergoing-laparoscopic-nephrectomy-surgery-a-randomized-controlled-trial
#12
JOURNAL ARTICLE
Ming Yang, Lei Cao, Tong Lu, Cheng Xiao, Zhuoxi Wu, Xuetao Jiang, Wei Wang, Hong Li
STUDY OBJECTIVE: Kidney neoplasms have a high incidence, and radical nephrectomy or partial nephrectomy are the main treatment options. Our study aims to investigate the use of ultrasound-guided erector spinae plane block for perioperative analgesia in patients undergoing laparoscopic nephrectomy surgery. DESIGN: Prospective, randomized, double-blind. SETTING: University hospital. PATIENTS: Our study included 50 patients (ASA I-III) who underwent laparoscopic nephrectomy at the hospital of Second Affiliated Hospital of Army Medical University...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38425386/effect-of-different-anesthetic-modalities-with-multimodal-analgesia-on-postoperative-pain-level-in-colorectal-tumor-patients
#13
JOURNAL ARTICLE
Ji-Chun Tang, Jia-Wei Ma, Jin-Jin Jian, Jie Shen, Liang-Liang Cao
BACKGROUND: According to clinical data, a significant percentage of patients experience pain after surgery, highlighting the importance of alleviating postoperative pain. The current approach involves intravenous self-control analgesia, often utilizing opioid analgesics such as morphine, sufentanil, and fentanyl. Surgery for colorectal cancer typically involves general anesthesia. Therefore, optimizing anesthetic management and postoperative analgesic programs can effectively reduce perioperative stress and enhance postoperative recovery...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38415195/the-effects-of-different-doses-of-sufentanil-on-intraoperative-cardiovascular-response-and-postoperative-recovery-in-patients-undergoing-cardiac-surgery-a-retrospective-cohort-study
#14
JOURNAL ARTICLE
Meng Li, Xue Li, Yong Wu, Tianyu Zhang, Mengya Li, Ying Chen
OBJECTIVE: To investigate the correlation between the amount of sufentanil used during anesthesia and intraoperative hemodynamic fluctuation and postoperative recovery in patients undergoing cardiopulmonary bypass (CPB). MATERIALS AND METHODS: A retrospective analysis was performed on 454 patients undergoing elective heart surgery under CPB. Patients were divided into two groups according to the amount of sufentanil used during anesthesia: Group L (induced sufentanil 0...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38412109/effect-of-remimazolam-supplementation-on-propofol-requirements-during-hysteroscopy-a-double-blind-dose-response-study
#15
JOURNAL ARTICLE
Yan-Hong Zhou, Shu-Xi Li, Lin Li, Chun-Mei Deng, Jian-Jun Shen, Dong-Xin Wang, Xin-Zhong Chen, Li-Li Xu
BACKGROUND: Propofol is commonly used for procedural sedation but may increase side effects in a dose-dependent manner. Remimazolam, an ultrashort-acting benzodiazepine, has been approved for procedural sedation but may delay awakening. This study tested the hypothesis that remimazolam as a supplement reduces effect-site propofol concentration (Ceprop) required to suppress response to cervical dilation in patients undergoing hysteroscopy. METHODS: One hundred and fifty patients who were scheduled for hysteroscopy were randomized to receive 0, 0...
February 27, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38411763/oxygen-vacancy-rich-fe-2-moo-4-3-combined-with-mwcnts-for-electrochemical-sensors-of-fentanyl-and-its-analogs
#16
JOURNAL ARTICLE
Zhidong Zhao, Xingrui Qi, Yuan He, Nian Li, Huajie Lai, Bo Liu, Yufang Chen, Tao Jin
Hundreds of thousands of people dying from the abuse of fentanyl and its analogs. Hence, the development of an efficient and highly accurate detection method is extremely relevant and challenging. Therefore, we proposed the introduction of oxygen defects into Fe2 (MoO4 )3 nanoparticles for improving the catalyst performance and combining it with multi-walled carbon nanotubes (MWCNTs) for electrochemical detection of fentanyl and its analogs. Oxygen vacancy-rich Fe2 (MoO4 )3 (called r-Fe2 (MoO4 )3 ) nanoparticles were successfully synthesized and characterized in detail by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive spectrometry (EDS), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), Raman spectra, BET, X-ray photoelectron spectroscopy (XPS), and electron paramagnetic resonance (EPR) and investigated by comparison with oxygen vacancy-poor Fe2 (MoO4 )3 (called p-Fe2 (MoO4 )3 )...
February 27, 2024: Mikrochimica Acta
https://read.qxmd.com/read/38408904/mass-intraoperative-endothelial-glycocalyx-shedding-affects-postoperative-systemic-inflammation-response
#17
JOURNAL ARTICLE
JiaWan Wang, Yan Wu
BACGROUND: Off-pump coronary artery bypass graft (OPCABG) has a high incidence of postoperative systemic inflammation response syndrome (SIRS), and perioperative endothelial glycocalyx layer (EGL) disruption can be one of the predisposing factors. We hypothesized that EGL shedding happened earlier in OPCABG which can influence on postoperative SIRS, and sevoflurane might preserve EGL better than propofol. METHODS: We randomly allocated 50 patients undergoing OPCABG to receive either sevoflurane-sufentanil or propofol-sufentanil anesthesia...
February 26, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38384750/efficacy-of-intravenous-administration-of-esketamine-in-preventing-and-treating-rebound-pain-after-thoracic-paravertebral-nerve-block-a-prospective-randomized-double-blind-placebo-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Xu Zeng, Xianjie Zhang, Wencai Jiang, Xinyu Zhou
PURPOSE: Investigating the efficacy of intraoperative fractionated intravenous esketamine in the prevention of rebound pain after cessation of thoracic paravertebral nerve blockade. METHODS: One hundred and twenty patients who underwent elective thoracoscopic lobectomy were selected for the study and were randomly divided into two groups, the esketamine group was given 0.5 mg/kg and 0.3 mg/kg of esketamine at the induction of anaesthesia and 30 minutes before the end of the operation, respectively, and the control group was given an equal amount of saline...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38384296/esketamine-combined-with-sufentanil-versus-sufentanil-in-patient-controlled-intravenous-analgesia-a-meta-analysis
#19
REVIEW
Manman Yao, Baoxia Fang, Jinguo Yang, Peng Chen, Fuchao Chen
Objective: Patient-controlled intravenous analgesia (PCIA) can alleviate pain to some extent, and several randomized controlled trials (RCTs) have examined the efficacy of esketamine-assisted sufentanil in postoperative PCIA. In this research, we conducted a meta-analysis of relevant RCTs to compare the effect and safety of esketamine-sufentanil versus sufentanil alone for postoperative PCIA. Methods: We systematically searched the Cochrane Library, PubMed, Embase, Web of Science, CNKI, and other libraries up to December 2023 to screen out RCTs examining the use of esketamine combined with sufentanil for PCIA...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38378447/the-effect-of-esketamine-combined-with-propofol-induced-general-anesthesia-on-cerebral-blood-flow-velocity-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Shuang Yan, Qiying Li, Kaihua He
BACKGROUND: Esketamine is increasingly used in clinical anesthesia. The effect of esketamine on the blood flow velocity of the middle cerebral artery has a clinical guiding effect. To investigate the effect of esketamine combined with propofol-induced general anesthesia for endotracheal intubation on the blood flow velocity of middle cerebral artery and hemodynamics during the induction period. METHODS: The randomized clinical trial included 80 patients aged 20-65 years who would undergo non-intracranial elective surgery under general anesthesia in our hospital from May 2022 to May 2023...
February 20, 2024: BMC Anesthesiology
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