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breast cancer pathology

Penglong Cao, Shuai Zhao, Zhigang Sun, Nan Jiang, Yuhong Shang, Yingxin Wang, Juebin Gu, Shijun Li
A low level of breast cancer metastasis suppressor 1-like (BRMS1L) has been implicated in tumour metastasis involving breast cancer and other cancers. It remains unclear whether BRMS1L is involved in epithelial ovarian cancer (EOC) metastasis and what the molecular mechanism of BRMS1L is in suppressing EOC metastasis. In this study, we examined the mRNA expression and protein level of BRMS1L by screening EOC patients. Our results show that BRMS1L expression is downregulated in EOC patients compared to that in normal people and negatively correlated to pathological stages of EOC...
August 14, 2018: Experimental Cell Research
Xueling Ge, Xiaohui Sui, Xiaosheng Fang, Yujie Jiang, Mei Ding, Xin Liu, Xin Wang
AIMS: To determine if Metadherin (MTDH) expression levels are positively correlated with the clinical stage of diffuse large B-cell lymphoma (DLBCL) based on MTDH being highly expressed in other type of tumors including melanoma, malignant glioma, breast cancer, and hepatocellular carcinoma. In this study, we investigated the pathologic significance of MTDH and its potential in predicting DLBCL outcomes. MATERIALS AND METHODS: Tissue samples from 50 patients with DLBCL and 22 patients with lymph node reactive hyperplasia were collected and evaluated using immunohistochemical staining, microscopy, and western blotting...
August 2018: Genetic Testing and Molecular Biomarkers
Kumar Bhaskar Pal, Mukul Mahanti, Xiaoli Huang, Stella Persson, Anders P Sundin, Fredrik R Zetterberg, Stina Oredsson, Hakon Leffler, Ulf J Nilsson
Quinolines, indolizines, and coumarins are well known structural elements in many biologically active molecules. In this report, we have developed straightforward methods to incorporate quinoline, indolizine, and coumarin structures into galactoside derivatives under robust reaction conditions for the discovery of glycomimetic inhibitors of the galectin family of proteins that are involved in immunological and tumor-promoting biological processes. Evaluation of the quinoline, indolizine and coumarin-derivatised galactosides as inhibitors of the human galectin-1, 2, 3, 4N (N-terminal domain), 4C (C-terminal domain), 7, 8N, 8C, 9N, and 9C revealed quinoline derivatives that selectively bound galectin-8N, a galectin with key roles in lymphangiogenesis, tumor progression, and autophagy, with up to nearly 60-fold affinity improvements relative to methyl β-d-galactopyranoside...
August 17, 2018: Organic & Biomolecular Chemistry
Florentina Pascale, Laurent Bédouet, Afchine Fazel, Julien Namur, Saida Homayra Ghegediban, Isabelle Schwartz Cornil, Michel Wassef, Laurence Moine, Alexandre Laurent
PURPOSE: To assess the lymphatic transport of microparticles of 100 nm, 1 μm and 10 μm subcutaneously injected into the breast area of healthy and tumor-bearing rabbits, and to analyze their location in lymph node (LN) in relation to malignant cells. METHODS: Female rabbits (n = 9) bearing a VX2 tumor in one thoracic mammary gland were subcutaneously injected at D15 with polystyrene fluorescent particles around the nipple, on the tumor and on the healthy sides...
August 15, 2018: Pharmaceutical Research
Nilgun Yildirim, Aykut Bahceci
Trastuzumab and pertuzumab are monoclonal antibodies used for the treatment of breast cancer. Until now, there have been no reports on the use of pertuzumab during pregnancy and on its potential effects on the fetus. Herein, we present a breast cancer patient who received trastuzumab and pertuzumab treatment during the first 20 weeks of pregnancy. This 22-year-old patient initially diagnosed with invasive ductal carcinoma of the breast was found to be negative for estrogen receptor and progesterone receptor and positive for human epidermal growth factor receptor in the immunohistochemical examination...
September 2018: Anti-cancer Drugs
Tima Davidson, Michal M Ravid, Ella Nissan, Mirriam Sklair-Levy, Johnatan Nissan, Bar Chikman
BACKGROUND: When a breast lesion is suspected based on a physical exam, mammography, or ultrasound, a stereotactic core needle biopsy (CNB) is usually performed to help establish a definitive diagnosis. CNBs are far less invasive than excisional biopsies, with no need for general anesthetics or hospitalization, and no recovery period. However, since only samples of the mass are removed in a CNB and not the whole mass, sampling errors can occur. OBJECTIVES: To compare the degree of agreement between the pathological data from CNBs and excisional biopsies from a single tertiary referral hospital...
July 2018: Israel Medical Association Journal: IMAJ
Takeshi Urade, Shigeteru Oka, Shinya Iimori, Mariko Man-I, Tomoki Abe, Hidehiro Sawa, Yoshiteru Iwatani, Yukiko Morinaga, Daisuke Kuroda
Gallbladder metastasis from breast cancer, especially from ductal carcinoma, is rare. Herein, we report a rare case of gallbladder metastasis from ductal carcinoma of the breast that was diagnosed after laparoscopic cholecystectomy (LC) for acute cholecystitis. A 78-year-old woman presented with right upper abdominal tenderness and positive Murphy's sign during chemotherapy for advanced multiple metastases of the breast cancer. Abdominal ultrasonography and computed tomography showed a slightly thickened gallbladder wall and two calculi...
August 14, 2018: Clinical Journal of Gastroenterology
Arpita Ghosh, Natalya Degyatoreva, Casey Kukielski, Sandra Story, Sayantan Bhaduri, Krishnagopal Maiti, Smita Nahar, Arjun Ray, Dev P Arya, Souvik Maiti
Epithelial to mesenchymal transition (EMT) is a process in which epithelial cells lose cell polarity and cell-cell adhesion and gain migratory and invasive properties to become mesenchymal cells that are very vital for development, wound healing and stem cell behavior and contribute pathologically to fibrosis and cancer progression. miR21, a potent regulator of the tumor suppressor gene PTEN, can be silenced to reverse EMT, thereby providing an attractive target for abrogating the malignant behavior of breast cancer...
July 1, 2018: MedChemComm
Sadia Anwar, Aamna Hassan
Increased F18-FDG uptake is on PET-CT images should always be assessed carefully for physiological and pathological causes. Breast uptake may be focal or diffuse. Although propensity of tumours increase in focal uptake; diffuse involvement may be seen in lymphoma and some types of breast cancer. Frequently, diffuse breast uptake is non-pathologic due to infection, physiological uptake or lactation. We describe the case of a 27-years old female who underwent 18F FDGPET-CT scan for staging workup of diffuse large B-cell lymphoma (DLBCL)...
August 2018: JPMA. the Journal of the Pakistan Medical Association
Z G Du, L Y Wang, Y Zhou, H Y Wan, F Q Liang, Q Lyu
Objective: The aim of this study was to investigate the association of the CYP19A1 rs7176005 single nucleotide polymorphism (SNP) with breast cancer risk and with clinicopathologic features of tumors. Methods: This study was conducted by including 138 patients with breast cancer (cancer group), those who diagnosed as primary breast cancer after operation by pathology. There were 293 cases in the group of benign breast disease which was presented as a solid mass by the color ultrasound and pathologically diagnosed as "fibroadenoma or adenosis" (benign breast disease group), the cases were paired with breast cancer patients by age±5 in the same period, and there were 259 cases in the group of healthy control who received routine physical examination during the same period and were paired with breast cancer patients by age±5 without any detection of breast related diseases (healthy control group) at West China hospital between September 2012 and November 2016...
August 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Michael Co, Ava Kwong
INTRODUCTION: Long-term survival is excellent in ductal Carcinoma in situ (DCIS); whether or not we are over-treating DCIS has been a major public concern. This study aims at reviewing the long-term survival outcome of DCIS and identifying adverse prognosticators for DCIS. PATIENTS AND METHODS: Patients treated for DCIS between 1st January 1997 and 31st December 2016 were identified from a prospectively maintained database. Multivariate analysis was performed to evaluate the adverse factors for surgical margin involvement and local recurrence RESULTS: 3042 female patients were treated for breast cancer over the 20-year study period, of which 203 (6...
2018: Cancer Treatment and Research Communications
Ziyad M Mohaidat, Abed-Allah A Saleh, Salah Al-Gharaibeh, Ibrahim R Yousef
BACKGROUND: Synovial sarcoma is a rare soft tissue sarcoma which most commonly affects the extremities of young adults. Axilla involvement by this sarcoma is very rare especially with involvement of the brachial plexus. This combination adds to the challenge in approaching such tumors which might significantly affect survival and function. CASE PRESENTATION: Herein, we present a 48-year-old female patient who presented with an isolated painless lump in her right axilla...
August 13, 2018: World Journal of Surgical Oncology
Bo Wang, Dongping Li, Rocio Rodriguez-Juarez, Allison Farfus, Quinn Storozynsky, Megan Malach, Emily Carpenter, Jody Filkowski, Anne E Lykkesfeldt, Olga Kovalchuk
BACKGROUND: Breast cancer is the most common malignancy in women worldwide. Although the endocrine therapy that targets estrogen receptor α (ERα) signaling has been well established as an effective adjuvant treatment for patients with ERα-positive breast cancers, long-term exposure may eventually lead to the development of acquired resistance to the anti-estrogen drugs, such as fulvestrant and tamoxifen. A better understanding of the mechanisms underlying antiestrogen resistance and identification of the key molecules involved may help in overcoming antiestrogen resistance in breast cancer...
August 13, 2018: BMC Cancer
Hang Sun, Hong Li, Shuang Si, Shouliang Qi, Wei Zhang, He Ma, Siqi Liu, Li Yingxue, Wei Qian
OBJECTIVE: Various imaging modalities have been used to diagnose suspicious breast lesions. Purpose of this study is to compare the diagnostic accuracy for breast cancer using mammography, ultrasonography and magnetic resonance imaging (MRI). METHODS: Total 107 patients aged from 19 to 62 years are included in this retrospective study. Mammography, ultrasonography and MRI scans were performed for each patient detected with suspected breast tumor within a month. In addition, the tumor diversity (10 types of benign and 5 types of malignant) was confirmed by pathological findings of tumor biopsy...
July 31, 2018: Journal of X-ray Science and Technology
Margarita L Zuley, Robert M Nishikawa, Cindy S Lee, Elizabeth Burnside, Robert Rosenberg, Edward A Sickles, Wendie Berg, Jessica Leung, Jennifer Harvey, Debapriya Sengupta, David Gur
PURPOSE: The National Mammography Database (NMD) contains nearly 20 million examinations from 693 facilities; it is the largest information source for use and effectiveness of breast imaging in the United States. NMD collects demographic, imaging, interpretation, biopsy, and basic pathology results, enabling facility and physician comparison for quality improvement. However, NMD lacks treatment and clinical outcomes data. The network of state cancer registries (CRs) contains detailed pathologic, treatment, and clinical outcomes data...
August 8, 2018: Journal of the American College of Radiology: JACR
Wafaa S El-Sherbeny, Nesreen M Sabry, Radwa M Sharbay
BACKGROUND: Adjuvant trastuzumab improved overall survival and reduced the risk for disease recurrence in women with breast cancers, because of its potential cardiotoxicity, careful monitoring of left ventricular (LV) function during treatment is required. METHODS: This study investigates, whether myocardial strain imaging and level of N-terminal pro-brain natriuretic peptide (NT-pro BNP) could predict subsequent reduction in LVEF in breast cancer patients received adjuvant trastuzumab...
August 11, 2018: Journal of Echocardiography
Loïc Lelièvre, Philippe Clézardin, Laurent Magaud, Laurent Roche, Nicole Tubiana-Mathieu, Jean-Dominique Tigaud, Delphine Topart, Nadia Raban, Marie-Ange Mouret-Reynier, Patrice Mathevet
INTRODUCTION: Neoadjuvant chemotherapy has become the treatment of choice for locally advanced breast cancer. Zoledronic acid (ZA) is a bisphosphonate initially used in the treatment of bone metastases because of its antibone resorption effect. Antitumor effects of ZA, including the inhibition of cell adhesion to mineralized bone or the antiangiogenic effect, have been demonstrated. However, the clinical significance of these effects remains to be determined. MATERIALS AND METHODS: We undertook a multicenter open-label randomized trial to analyze the value of adding ZA to neoadjuvant chemotherapy for TNM clinical stage T2/T3 breast cancer...
July 10, 2018: Clinical Breast Cancer
John Brodersen, Volkert Siersma, Hanne Thorsen
BACKGROUND: Cervical cancer screening will inevitably lead to unintentional harmful effects e.g. detection of indolent pathological conditions defined as overdetection or overdiagnosis. Overdiagnosis often leads to overutilisation, overtreatment, labelling and thereby negative psychosocial consequences. There is a lack of adequate psychosocial measures when it comes to measurement of the harms of medical screening. However, the Consequences of Screening questionnaire (COS) has been found relevant and comprehensive with adequate psychometric properties in breast and lung cancer screening...
August 10, 2018: BMC Psychology
Santanu Roy, Alok Kumar Jain, Shyam Lal, Jyoti Kini
Histopathology images are used for the diagnosis of the cancerous disease by the examination of tissue with the help of Whole Slide Imaging (WSI) scanner. A decision support system works well by the analysis of the histopathology images but a lot of problems arise in its decision. Color variation in the histopathology images is occurring due to use of the different scanner, use of various equipments, different stain coloring and reactivity from a different manufacturer. In this paper, detailed study and performance evaluation of color normalization methods on histopathology image datasets are presented...
August 1, 2018: Micron: the International Research and Review Journal for Microscopy
Adam Gyedu, Cameron E Gaskill, Kwabena Agbedinu, Daniela Rebollo Salazar, T Peter Kingham
BACKGROUND AND OBJECTIVES: Outcome data after surgery for cancer in Sub-Saharan Africa are insufficient. We aimed to describe the presentation and outcomes of patients with solid cancers managed at a tertiary hospital in Ghana. METHODS: Records of cancer patients admitted to Komfo Anokye Teaching Hospital general surgery wards from 2013 to 2016 were reviewed for data on presentation, staging, management, and mortality. Patients discharged alive were followed-up by biannual telephone calls to establish their postdischarge status...
August 10, 2018: Journal of Surgical Oncology
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