Yan Wu, Jingyu Yang, Sheng-Yi Zhuang, Shang-Bo Yu, Yang Zong, Yue-Yang Liu, Gang Wu, Qiao-Yan Qi, Hui Wang, Jia Tian, Wei Zhou, Da Ma, Dan-Wei Zhang, Zhan-Ting Li
Long-acting neuromuscular blocks followed by rapid reversal may provide prolonged surgeries with improved conditions by omitting repetitive or continuous administration of the neuromuscular blocking agent (NMBA), eliminating residual neuromuscular block and minimizing postoperative recovery, which, however, is not clinically available. Here, we demonstrate that imidazolium-based macrocycles (IMCs) and acyclic cucurbit[ n ]urils (ACBs) can form such partners by functioning as long-acting NMBAs and rapid reversal agents through a pseudo[2]catenation mechanism based on stable complexation with K a values of over 109 M-1 ...
January 29, 2024: Journal of Medicinal Chemistry