keyword
https://read.qxmd.com/read/38311355/%C3%AF-neuromuscular-monitoring-of-a-patient-with-charcot-marie-tooth-disease-which-monitoring-technique-is-adequate-a-case-report-and-literature-review
#21
Seung Un Kim, Seora Kim, Ki Tae Jung
BACKGROUND: Charcot-Marie-Tooth disease (CMTD) is a hereditary polyneuropathy associated with a life-threatening risk of pulmonary complications. CASE: A 61-year-old male with CMTD for 40 years was admitted for the drainage of an abscess in his left ankle. Total intravenous anesthesia was administered, and an electromyography device was attached to the hand for neuromuscular monitoring; however, the response was not measured. Kinemyography and acceleromyography devices were attached to both hands, and responses were obtained...
January 2024: Anesthesia and pain medicine
https://read.qxmd.com/read/38302078/effects-of-a-single-dose-of-rocuronium-in-patients-with-different-body-fat-percentages-a-randomised-controlled-trial
#22
RANDOMIZED CONTROLLED TRIAL
Guanghui An, Yan Qiu, Zheliang Zhou, Xueying Ding, Cheng Li
The pharmacodynamics in patients with high body fat percentage might be similar to those in obese patients. This randomised controlled clinical trial observed the effects of rocuronium in patients with different percent body fats (PBFs). Fifty-four patients who underwent elective urological or pelvic surgery under general anaesthesia at Shanghai General Hospital were included in the present study; 51 patients were included for data analysis. Patients with normal PBF (<25%) were given a single dose of rocuronium calculated based on total body weight (N-TBW, control group)...
March 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38284525/macrocycles-and-acyclic-cucurbit-n-urils-as-pseudo-2-catenane-partners-for-long-acting-neuromuscular-blocks-and-rapid-reversal-in-vivo
#23
JOURNAL ARTICLE
Yan Wu, Jingyu Yang, Sheng-Yi Zhuang, Shang-Bo Yu, Yang Zong, Yue-Yang Liu, Gang Wu, Qiao-Yan Qi, Hui Wang, Jia Tian, Wei Zhou, Da Ma, Dan-Wei Zhang, Zhan-Ting Li
Long-acting neuromuscular blocks followed by rapid reversal may provide prolonged surgeries with improved conditions by omitting repetitive or continuous administration of the neuromuscular blocking agent (NMBA), eliminating residual neuromuscular block and minimizing postoperative recovery, which, however, is not clinically available. Here, we demonstrate that imidazolium-based macrocycles (IMCs) and acyclic cucurbit[ n ]urils (ACBs) can form such partners by functioning as long-acting NMBAs and rapid reversal agents through a pseudo[2]catenation mechanism based on stable complexation with K a values of over 109 M-1 ...
January 29, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38281489/low-dose-sugammadex-reverses-moderate-rocuronium-induced-neuromuscular-block-in-horses
#24
JOURNAL ARTICLE
Manuel Martin-Flores, Daniel M Sakai, Joaquin Araos, Luis Campoy
BACKGROUND: Neuromuscular block (NMB) during general anaesthesia has an implicit risk of inadvertent residual NMB during recovery. Reversal of NMB is commonly encouraged to decrease this risk, and has historically been performed with neostigmine/atropine, two agents with important cardiac and gastrointestinal side effects. Sugammadex is a new selective relaxant binding agent that can reverse rocuronium-induced NMB efficiently and without these complications. Recommended doses are possibly cost-prohibitive...
January 28, 2024: Equine Veterinary Journal
https://read.qxmd.com/read/38278354/are-changes-in-antibiotic-prophylaxis-recommendations-responsible-for-an-increased-risk-of-cefazolin-allergy
#25
JOURNAL ARTICLE
Nicolas Chéron, Luc de Chaisemartin, Simon Aubert, Philippe Montravers, Catherine Neukirch, Aurélie Gouel-Chéron
BACKGROUND: The first line of prevention of surgical site infection relies on the timely administration of antibiotic prophylaxis. First- and second-generation cephalosporins are the most recommended antibiotics in elective surgery. The incidence of cefazolin allergy has increased worldwide over the years. The sensitization mechanism of cefazolin is currently unknown, and data supporting cross-reactivity between penicillins and cephalosporins are lacking. Sensitization could occur through previous exposure either to cefazolin or to structurally related chemical agents...
January 24, 2024: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/38266059/efficacy-and-safety-of-adamgammadex-for-reversing-rocuronium-induced-deep-neuromuscular-blockade-a%C3%A2-multicenter-randomized-phase-iib-study
#26
JOURNAL ARTICLE
Yanhua Zhao, Sifan Chen, Wenqin Xie, Xiaoqing Zhang, Guozhong Chen, Fuhai Ji, Dongxin Wang, Youmao Qi, Qing Jie, Diansan Su, Weifeng Yu
The rapid reversal of deep neuromuscular blockade (NMB) is important but remains challenging. This study aimed to evaluate the efficacy and safety of adamgammadex versus sugammadex in reversing deep rocuronium-induced NMB. This multicenter, randomized, phase IIb study included 80 patients aged 18-64 years, American Society of Anesthesiologists (ASA) grade 1-2, undergoing elective surgery under general anesthesia with rocuronium. Patients were randomized to the adamgammadex 7, 8, and 9 mg/kg group or the sugammadex 4 mg/kg group...
January 2024: Clinical and Translational Science
https://read.qxmd.com/read/38259183/factors-associated-with-decision-to-use-and-dosing-of-sugammadex-in-children-a-retrospective-cross-sectional-observational-study
#27
JOURNAL ARTICLE
Sydney E S Brown, Graciela Mentz, Ruth Cassidy, Meridith Wade, Xinyue Liu, Wenjun Zhong, Julia DiBello, Rebecca Nause-Osthoff, Sachin Kheterpal, Douglas A Colquhoun
BACKGROUND: Sugammadex was initially approved for reversal of neuromuscular blockade in adults in the United States in 2015. Limited data suggest sugammadex is widely used in pediatric anesthesia practice however the factors influencing use are not known. We explore patient, surgical, and institutional factors associated with the decision to use sugammadex versus neostigmine or no reversal, and the decision to use 2 mg/kg vs 4 mg/kg dosing. METHODS: Using data from the Multicenter Perioperative Outcomes Group (MPOG) database, an EHR-derived registry, we conducted a retrospective cross-sectional study...
January 19, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38250051/comment-on-potential-interaction-between-exogenous-anabolic-steroids-and-sugammadex-failed-reversal-of-rocuronium-in-a-patient-taking-testosterone-and-trestolone-acetate
#28
JOURNAL ARTICLE
https://read.qxmd.com/read/38233786/effects-of-propofol-versus-sevoflurane-on-surgical-field-visibility-during-arthroscopic-rotator-cuff-repair-a-randomized-trial
#29
RANDOMIZED CONTROLLED TRIAL
Wenchao Yin, Chenzhu Yin, Wencan Wang, Rao Peng, Li Su, Peiyu Li
BACKGROUND: During arthroscopic rotator cuff repair (ARCR), clear surgical field visibility (SFV) is the basis of successful surgery, but the choice of anesthesia maintenance drugs may have different effects on SFV. In this study, we aimed to compare the effects of propofol- and sevoflurane-based general anesthesia on SFV in patients undergoing ARCR. METHODS: Patients (n = 130) undergoing elective ARCR in the lateral decubitus position were randomized into either the propofol group or sevoflurane group (65 per group)...
January 17, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38231204/morphine-concentrations-in-fatalities-after-palliative-treatment-of-acute-burn-injury
#30
JOURNAL ARTICLE
Julian Bickel, Nadine Aboutara, Hilke Jungen, Anne Szewczyk, Alexander Müller, Benjamin Ondruschka, Stefanie Iwersen-Bergmann
The evaluation of a morphine concentration in postmortem blood is routine for a forensic toxicologist. We here report three fatal cases where we found high morphine concentrations with 7.96, 4.30, and 5.82 mg/l in femoral blood that have to be estimated as unusually high. All these individuals died due to severe burn injuries and obtained morphine in the context of their palliative care in the last hours of their lives. According to the autopsy results, the cause of death in case 1 was burn disease with burns of about 90% of the body surface area (BSA), case 2 burn trauma, and case 3 burn shock...
January 17, 2024: International Journal of Legal Medicine
https://read.qxmd.com/read/38221696/anesthetic-management-of-a-patient-with-spinocerebellar-ataxia-type-1
#31
JOURNAL ARTICLE
Sakura Takeda, Sumire Idzuchi, Kentaro Mizuta
Spinocerebellar ataxia type 1 (SCA1) is one of the autosomal dominant spinocerebellar degeneration (SCD) diseases characterized by progressive cerebellar ataxia, muscle atrophy, and peripheral neuropathy. We report the management of a 43-year-old man with SCA1 who underwent general anesthesia for open reduction and internal fixation of a mandibular fracture. Although anesthesia-induced vocal cord paralysis has been reported in patients with SCD, nasotracheal intubation was performed uneventfully with video laryngoscope...
December 1, 2023: Anesthesia Progress
https://read.qxmd.com/read/38205981/rocuronium-dosing-by-ideal-vs-total-body-weight-in-obesity-a-prospective-observational-non-inferiority-study
#32
JOURNAL ARTICLE
Marc McDowell, Amanda Lewandowski, Dharati Desai, Stephany Nunez Cruz, Nicole Glowacki, Alaa Sulh, Michael Cirone, Nadine Lomotan, Mary Hormese
BACKGROUND: Providing adequate paralysis and appropriate sedation is challenging in patients with obesity during rapid sequence intubation (RSI). Pharmacokinetic parameters play an important role in dosing of rocuronium due to low lipophilicity. Rocuronium may be dosed based on ideal body weight (IBW). Current guidelines do not offer recommendations for dosing in the setting of obesity. Dosing depends on clinician preference based on total body weight (TBW) or IBW. OBJECTIVE: In this study we performed non-inferiority analysis to compare the intubation conditions, duration of paralysis, and incidence of new-onset tachycardia or hypertension after intubation in obese patients requiring RSI in the emergency department (ED)...
January 2024: Western Journal of Emergency Medicine
https://read.qxmd.com/read/38192096/delayed-emergence-from-total-intravenous-anesthesia-following-posterior-spinal-correction-and-fusion-for-scoliosis-a-case-report
#33
JOURNAL ARTICLE
Osamu Hisatomi, Tetsuhiro Fujiyoshi, Sho Shinotsuka, Hirokazu Saiwai, Midoriko Higashi, Ken Yamaura
BACKGROUND Postoperative acute liver failure, a complication following spine surgery, can cause delayed emergence from total intravenous anesthesia. Here, we report a case of acute severe postoperative liver failure following posterior spinal correction and fusion in a patient with congenital scoliosis. CASE REPORT A girl's congenital scoliosis worsened, and posterior spinal correction and fusion was scheduled. General anesthesia was induced with sevoflurane, fentanyl, target-controlled-infusion with propofol, and rocuronium...
January 9, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38190344/sugammadex-versus-neostigmine-for-reversal-of-neuromuscular-blockade-in-patients-with-severe-renal-impairment-a-randomized-double-blinded-study
#34
JOURNAL ARTICLE
Matthew W Oh, Shweta G Mohapatra, Taylor Pak, Aundree Hermawan, Chieh-An Chen, Bhavana Thota, Joy Chen, Eric Siu, Jenny Park, Tiffany S Moon
BACKGROUND: Sugammadex is not advised for patients with severe renal impairment, but has been shown in a variety of other populations to be superior to neostigmine for reversal of neuromuscular blockade. The objective of this study was to determine if reversal of rocuronium-induced neuromuscular blockade with sugammadex versus reversal of cisatracurium-induced neuromuscular blockade with neostigmine results in a faster return to a train-of-four ratio (TOFR) ≥90% in patients with severe renal impairment...
January 8, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38178960/lessons-learned-from-a-cluster-of-immunization-errors-in-newborns
#35
JOURNAL ARTICLE
Loubna Alj, Amina Tebaa, Ismail Talibi, Sofia Moubarik, Mohammed Benazzouz, Rachida Soulaymani Bencheikh
BACKGROUND: Vaccines are safe and effective, but adverse reactions can occur. Immunization errors (IEs) are one of the types of adverse events following immunization. The Moroccan Pharmacovigilance Centre (MPC) received a cluster of IEs from a maternity university hospital (MUH) regarding six newborns who were inadvertently administered rocuronium instead of hepatitis B (HepB) vaccine. The newborns experienced respiratory distress and one had a fatal outcome. OBJECTIVES: The study aimed to describe the investigation findings, the underlying causes, and contributing factors of the IEs cluster, and proposed risk minimization actions...
2024: Therapeutic Advances in Vaccines and Immunotherapy
https://read.qxmd.com/read/38173689/emergency-care-drugs-chemical-stability-after-eight-weeks-deployment-in-the-prehospital-setting
#36
JOURNAL ARTICLE
Simpiwe Sobuwa, Thishana Singh, Kerusha Kalicharan
UNLABELLED: Temperature conditions vary in emergency service vehicles, which may pose a risk to the integrity of the drugs on board, possibly rendering them ineffective and increasing morbidity and mortality in patients. AIM: This study assessed the stability of four emergency care drugs (adrenaline, etomidate, ketamine, and rocuronium) after eight weeks of deployment in the prehospital context. METHODS: The study adopted a longitudinal quantitative design to evaluate the chemical stability of emergency care drugs...
March 2024: African Journal of Emergency Medicine Revue
https://read.qxmd.com/read/38172775/carotid-blood-flow-changes-following-a-simulated-end-inspiratory-occlusion-maneuver-measured-by-ultrasound-can-predict-hypotension-after-the-induction-of-general-anesthesia-an-observational-study
#37
JOURNAL ARTICLE
Guangshan Jin, Fuqiang Liu, Yiwen Yang, Jiahui Chen, Qian Wen, Yudong Wang, Ling Yu, Jianhua He
BACKGROUND: The primary purpose of this study was to investigate the predictive value of alterations in cervical artery hemodynamic parameters induced by a simulated end-inspiratory occlusion test (sEIOT) measured by ultrasound for predicting postinduction hypotension (PIH) during general anesthesia. METHODS: Patients undergoing gastrointestinal tumor resection under general anesthesia were selected for this study. Ultrasound has been utilized to assess hemodynamic parameters in carotid artery blood flow before induction, specifically focusing on variations in corrected flow time (ΔFTc) and peak blood flow velocity (ΔCDPV), both before and after sEIOT...
January 3, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38171649/is-adamgammadex-the-brother-of-sugammadex-or-the-next-generation-of-reversal-agent
#38
EDITORIAL
Jennifer M Hunter, J Robert Sneyd
Sugammadex is now in widespread use to reverse the neuromuscular blocking effects of rocuronium. Adverse effects from sugammadex are rare, but anaphylactic and cardiovascular reactions to the drug have been reported. In an attempt to reduce such side-effects, a modified gamma-cyclodextrin, adamgammadex, has been developed. Phase 3 clinical trials suggest that it is slightly less potent than sugammadex and has a non-inferior speed of onset. In a multicentre trial of 310 patients, there was a suggestion of a lower incidence of allergic responses and recurarisation after adamgammadex compared with sugammadex...
January 2024: British Journal of Anaesthesia
https://read.qxmd.com/read/38166027/quantitative-evaluation-of-the-biomechanical-and-viscoelastic-properties-of-the-dog-patellar-tendon-in-response-to-neuromuscular-blockade-at-different-stifle-angles
#39
JOURNAL ARTICLE
Dito Anggoro, Melpa Susanti Purba, Norihiro Nishida, Harumichi Itoh, Kazuhito Itamoto, Yuki Nemoto, Munekazu Nakaichi, Hiroshi Sunahara, Kenji Tani
The patellar tendon (PT) is crucial for maintaining stability and facilitating movement in the stifle joint. Elastography has been recognized as a prominent method for evaluating PT properties in humans and dogs. The utilization of oscillation methods in canine studies remains limited despite their extensive documentation in human studies. Our study represents the first effort to quantitatively assess and compare the effects of muscle relaxant on the biomechanical and viscoelastic characteristics of the PT at varying stifle angles in living dogs...
2024: PloS One
https://read.qxmd.com/read/38149896/rocuronium-induced-anaphylaxis-in-the-perioperative-period-a-clinical-review
#40
REVIEW
David E Harris
Rocuronium, a nondepolarizing neuromuscular blocking agent used for muscle relaxation especially during endotracheal intubation, can cause hypersensitivity reactions. This article provides an overview of anaphylactic reactions; risk factors; and the pathophysiology, presentation, diagnosis, treatment, and nursing implications associated with rocuronium-induced anaphylaxis. Life-threatening anaphylaxis can be immunoglobulin E-mediated or non-immunoglobulin E-mediated and usually occurs after the first dose. Anaphylaxis can present with hypotension and bronchospasm; cutaneal symptoms, such as erythema, may not be obvious...
January 2024: AORN Journal
keyword
keyword
15831
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.