keyword
https://read.qxmd.com/read/38493055/epidemiology-of-perioperative-anaphylaxis-in-france-in-2017-2018-the-11th-gerap-survey
#1
JOURNAL ARTICLE
Charles Tacquard, Julien Serrier, Simon Viville, Anca-Mirela Chiriac, Sébastien Franchina, Aurélie Gouel-Cheron, Antoine Giraudon, Morgan Le Guen, Diane Le Quang, Jean-Marc Malinovsky, Nadine Petitpain, Pascal Demoly, Paul M Mertes
BACKGROUND: Perioperative anaphylaxis is rare but is associated with significant morbidity. This complication has been well described in France by the GERAP (Groupe d'Etude des Réactions Anaphylactiques Périopératoires), a network focused on its study. The epidemiology of perioperative anaphylaxis is evolving, influenced by environmental factors and clinical practice. The aim of this study was to update the epidemiology of perioperative anaphylaxis in France. METHODS: This multicentre retrospective study was performed in 26 allergy clinics of the GERAP network in 2017-8...
March 15, 2024: British Journal of Anaesthesia
https://read.qxmd.com/read/38460887/relationship-between-muscle-mass-ratio-and-rocuronium-dose-required-for-maintaining-deep-neuromuscular-blockade-a-prospective-observational-study
#2
JOURNAL ARTICLE
Jiwon Han, Ah-Young Oh, Jung-Won Hwang, Sun Woo Nam
BACKGROUND: Deep neuromuscular blockade (NMB) has benefits in various surgical procedures, however, precise quantitative neuromuscular monitoring is crucial for its proper maintenance and recovery. Neuromuscular blocking agent dosage relies on actual body weight (ABW), but this varies among individuals. Therefore, this study hypothesizes that there is a correlation between the rocuronium requirement for deep NMB and muscle mass ratio measured by bioelectric impedance analysis. METHODS: Ninety adult female patients undergoing laparoscopic operation were enrolled in this study...
March 7, 2024: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/38444477/the-feasibility-of-dexmedetomidine-led-anesthesia-maintenance-strategy-during-major-abdominal-surgery
#3
JOURNAL ARTICLE
Cheng Ni, Wenjie Xu, Bing Mu, Hongyi Li, Jiao Geng, Yinyin Qu, Yi Tian, Jie Yu, Naiyuan Tian, Xiaoxiao Wang, Chan Chen, Xu Jin, Hui Zheng
BACKGROUND: Dexmedetomidine is known for its selective action on α2-adrenoceptor sites and is recognized for its neuroprotective capabilities. It can improve postoperative cognitive function. Commonly used anesthetics, such as sevoflurane and propofol, have been reported to affect postoperative cognitive function. Therefore, it could be valuable to explore dexmedetomidine-led anesthesia strategy. This study was designed to assess the performance, safety, and effective infusion rate in anesthesia maintenance, to explore a feasible dexmedetomidine-led anesthesia maintenance protocol, and to provide a foundation for potential combined anesthesia...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38430156/reducing-remifentanil-usage-in-laparoscopic-rectal-cancer-surgery-for-elderly-patients-by-optimizing-dosing
#4
JOURNAL ARTICLE
Jing Li, Liye Yang, Feifei Wu, Xiang Li, Xuan Guo
BACKGROUND: Colorectal cancer is a prevalent and serious health concern globally, particularly among the elderly population. Laparoscopic surgery is a commonly used approach for colorectal cancer treatment. However, the use of appropriate anesthesia and muscle relaxants is essential to ensure optimal surgical outcomes. Elderly patients undergoing surgery often have unique physiological characteristics and comorbidities, such as hypertension, diabetes, and coronary heart disease. These factors can affect treatment efficiency and patient outcomes...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38410855/extravascular-injection-of-neuromuscular-blocking-drugs-a-systematic-review-of-current-evidence-and-management
#5
JOURNAL ARTICLE
Frederik Nietvelt, Imré Van Herreweghe, Vincent Godschalx, Filiep Soetens
Extravascular injection of neuromuscular blocking drugs (NMBDs) can cause a neuromuscular block because of systemic absorption. Currently, there are no guidelines available on managing extravasation of NMBDs. This article reviews the available literature on extravasation of NMBDs. Medline and Embase databases were searched for studies concerning the paravenous or subcutaneous injection of NMBDs. Nine articles were included consisting of seven case reports, one case series and one clinical trial. Rocuronium was used as primary NMBD in nine cases, vecuronium in two cases and pancuronium in one case...
February 26, 2024: European Journal of Anaesthesiology
https://read.qxmd.com/read/38409359/opioid-free-anesthesia-with-ultrasound-guided-quadratus-lumborum-block-in-the-supine-position-for-lower-abdominal-or-pelvic-surgery-a-randomized-controlled-trial
#6
JOURNAL ARTICLE
Jingwei Dai, Shanliang Li, Qijun Weng, Jinxiong Long, Duozhi Wu
In the past, quadratus lumborum block (QLB) was mostly used for postoperative analgesia in patients, and few anesthesiologists applied it during surgery with opioid-free anesthesia (OFA). Consequently, it is still unclear whether QLB in the supine position can provide perfect analgesia and inhibit anesthetic stress during surgery under the OFA strategy. To observe the clinical efficacy of ultrasound-guided quadratus lumborum block (US-QLB) in the supine position with OFA for lower abdominal and pelvic surgery...
February 26, 2024: Scientific Reports
https://read.qxmd.com/read/38405120/innovative-in-vivo-rat-model-for-global-cerebral-hypoxia-a-new-approach-to-investigate-therapeutic-and-preventive-drugs
#7
JOURNAL ARTICLE
Sarah Stahlke, Jonas Frai, Johanna Franziska Busse, Veronika Matschke, Carsten Theiss, Thomas Weber, Jennifer Herzog-Niescery
Introduction: Severe acute global cerebral hypoxia can lead to significant disability in humans. Although different animal models have been described to study hypoxia, there is no endogenous model that considers hypoxia and its effect on the brain as an independent factor. Thus, we developed a minimally invasive rat model, which is based on the non-depolarizing muscle blocking agent rocuronium in anesthetized animals. This drug causes respiratory insufficiency by paralysis of the striated muscles. Methods: In this study, 14 rats underwent 12 min of hypoxemia with an oxygen saturation of approximately 60% measured by pulse oximetry; thereafter, animals obtained sugammadex to antagonize rocuronium immediately...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38399560/the-relationship-between-pre-anesthetic-analgesia-and-nociception-ani-and-propofol-injection-pain-among-patients-receiving-remifentanil-a-prospective-randomized-controlled-study
#8
JOURNAL ARTICLE
Cheolhyeong Lee, Cheol Lee, Junsung Lim, Jeongki Park, Jaehak Jung, Hayoung Lee, Myeongjong Lee
Background and Objectives : The analgesia/nociception index (ANI) potentially monitors nociceptive status during anesthesia, but its link to preoperative pain sensitivity is unclear. We investigated the relationship between pre-anesthetic ANI scores and propofol injection pain (PIP) in patients receiving remifentanil. Materials and Methods : This study included 124 male patients aged 19-60 undergoing general anesthesia (ASA class I or II). Patients were randomized to group R ( n = 62, remifentanil 4 ng/mL) or group C ( n = 62, saline)...
February 5, 2024: Medicina
https://read.qxmd.com/read/38389166/sugammadex-use-outside-of-the-postoperative-setting
#9
JOURNAL ARTICLE
Hayley T Gartner, Megan A Rech
BACKGROUND: Sugammadex rapidly reverses the nondepolarizing neuromuscular blocking agents (NMBAs) rocuronium and vecuronium. The role of sugammadex is not well-defined outside of the postoperative setting. OBJECTIVE: This study aims to describe sugammadex use outside the postoperative setting for the reversal of nondepolarizing NMBAs. METHODS: This was a single-center, retrospective cohort study conducted in patients who received sugammadex outside of the postoperative setting at an academic medical center between June 2016 and November 2022...
February 22, 2024: Annals of Pharmacotherapy
https://read.qxmd.com/read/38383307/effect-of-esketamine-on-the-ec50-of-remifentanil-for-blunting-cardiovascular-responses-to-endotracheal-intubation-in-female-patients-under-general-anesthesia-a-sequential-allocation-dose-finding-study
#10
JOURNAL ARTICLE
Fan Ziqiang, He Keyu, Xue Yun, Liu Li, Bai Yiping
BACKGROUND: This study aimed to investigate the effect of esketamine on the dose-effect relationship between remifentanil and the cardiovascular response to endotracheal intubation during target-controlled infusion (TCI) of propofol. METHODS: Patients underwent elective gynecological laparoscopic surgery under general anesthesia with endotracheal intubation, aged 18-65 years, American Society of Anesthesiologists class I or II, 18 kg/m2  ≤ body mass index ≤ 30 kg/m2 , were randomly divided into the control (group C) and esketamine groups (group E)...
February 21, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38380199/cardiac-arrest-in-the-post-anesthesia-care-unit-pacu-postoperative-recurrence-of-neuromuscular-block-after-sugammadex-reversal
#11
Vasyl Katerenchuk, Alexandre Calçada, Raquel Louzada, Daniela Rosinha, Ana C Batista, Andreia Capelão, Lisbete Cordeiro
Sugammadex has transformed clinical practice by enabling the rapid reversal of rocuronium-induced neuromuscular block (NMB) at any depth. We present a case of cardiac arrest following postoperative recurarization despite the sugammadex-induced transient reversal of NMB. Despite its proven clinical reliability, this case highlights the often overlooked aspects that must be considered when using this drug. An 84-year-old male patient was scheduled for a laparoscopic partial gastrectomy for gastric cancer...
January 2024: Curēus
https://read.qxmd.com/read/38376589/effect-of-remifentanil-on-three-effect-site-concentrations-of-propofol-and-their-relationship-during-electroencephalography-at-loss-of-response-at-maximum-alpha-power-and-at-onset-of-burst-suppression-a-prospective-randomized-trial
#12
JOURNAL ARTICLE
Satoshi Aihara, Satoshi Hagihira, Rieko Uno, Takahiko Kamibayashi
PURPOSE: The effect-site concentration (Ce) at loss of response (Ce-LOR) to propofol closely correlates both with Ce as electroencephalographic alpha power becomes highest (Ce-alpha) and with Ce at onset of burst suppression (BS) (Ce-OBS), when no opioids are administered. Co-administration of opioids dose-dependently decreases Ce-LOR. We investigated the influence of remifentanil on the relationship between these three Ces. METHODS: After receiving approval from our local ethical committee, with written informed consent, we enrolled 90 participants (ASA-PS I or II) who were scheduled for elective surgery...
February 20, 2024: Journal of Anesthesia
https://read.qxmd.com/read/38373229/remimazolam-and-remifentanil-anesthetics-for-an-adolescent-patient-with-stiff-person-syndrome-a-case-report
#13
JOURNAL ARTICLE
Hironobu Morita, Hirotaka Kinoshita, Masayo Kiyokawa, Tetsuya Kushikata, Kazuyoshi Hirota
Stiff-person syndrome (SPS) is a rare autoimmune disease characterized by fluctuating rigidity and stiffness of the axial muscles. There are no reports on the use of remimazolam in a patient with SPS. A 16-year-old Japanese woman with SPS was scheduled to undergo intrathecal baclofen pump exchange. General anesthesia was induced and maintained using remimazolam, remifentanil, and intermittent rocuronium bromide. No intraoperative mobility or significant autonomic symptoms were observed. Additionally, electroencephalographic signature showed sufficient anesthetic depth...
February 1, 2024: A&A Practice
https://read.qxmd.com/read/38371001/anesthetic-management-of-a-patient-with-central-core-disease-undergoing-thoracoscopic-lung-resection-the-importance-of-neuromuscular-monitoring-at-the-masseter-muscle
#14
Hiroko Baba, Ryo Wakabayashi, Hiroki Ichiyanagi, Aki Suzuki, Nobukazu Sato
Central core disease is a rare muscular disorder in which anesthetic considerations for the prevention of malignant hyperthermia and for avoidance of residual neuromuscular block are required. A 63-year-old woman with central core disease underwent thoracoscopic sublobar lung resection under total IV anesthesia with a prepared anesthetic workstation. The rocuronium-induced neuromuscular block was monitored by using acceleromyography at the left adductor pollicis muscle and the right masseter muscle. The recovery of neuromuscular block at the masseter was slower than that at the adductor pollicis...
January 2024: Curēus
https://read.qxmd.com/read/38368167/effect-of-optimizing-the-induction-regimen-in-preventing-cough-reactions-in-patients-undergoing-general-anesthesia-a-prospective-randomized-controlled-study
#15
JOURNAL ARTICLE
Lei Wang, Xing Lu, Yi Cheng, You-Chuan Zhang, De-Xiang Zhao, Yan-Hong Zhu
PURPOSE: During the induction of general anesthesia, opioids and endotracheal intubation may cause coughing. This study aimed to investigate the safety and effectiveness of an optimized drug induction scheme for general anesthesia to prevent coughing in patients. METHODS: A total of 220 patients aged 18 to 65 years who underwent surgery under general anesthesia with endotracheal intubation were randomly assigned to two groups, each with 110 patients. One group was administered a divided sufentanil bolus (group A) and the other with a single sufentanil bolus (group B)...
February 16, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38357323/effect-of-sugammadex-rocuronium-and-sevoflurane-on-oxidative-stress-and-apoptosis-in-cerebral-ischemia-reperfusion-model-in-rats
#16
JOURNAL ARTICLE
Hakan Ciftci, Nilay Tas, Zubeyir Cebeci, Sibel Kokturk, Selma Cirrik, Tevfik Noyan
OBJECTIVE: Cerebral ischemia-reperfusion (I/R) injury causes neurological dysfunction and cell death. Sugammadex, as a large molecule, is normally difficult to pass through the blood-brain barrier (BBB). In ischemia, molecules can pass into the brain tissue. In this study, we aimed to evaluate the effect of sugammadex in the presence of cerebral I/R damage in rats with a general anesthesia model with sevoflurane and rocuronium. METHODS: Rats were divided into 7 groups; Group 1 (Control), Group 2 (Sham), Group 3 (Sevoflurane), Group 4 (Sugammadex), Group 5 (Sevoflurane + Rocuronium), Group 6 (Sevoflurane + Sugammadex), Group 7 (Sevoflurane + Rocuronium + Sugammadex)...
2024: Northern Clinics of Istanbul
https://read.qxmd.com/read/38347604/cardiorespiratory-consequences-of-attenuated-fentanyl-and-augmented-rocuronium-dosing-during-protocolised-prehospital-emergency-anaesthesia-at-a-regional-air-ambulance-service-a-retrospective-study
#17
JOURNAL ARTICLE
Sarah Morton, Zoey Spurgeon, Charlotte Ashworth, James Samouelle, Peter B Sherren
BACKGROUND: Pre-Hospital Emergency Anaesthesia (PHEA) has undergone significant developments since its inception. However, optimal drug dosing remains a challenge for both medical and trauma patients. Many prehospital teams have adopted a drug regimen of 3 mcg/kg fentanyl, 2 mg/kg ketamine and 1 mg/kg rocuronium ('3:2:1'). At Essex and Herts Air Ambulance Trust (EHAAT) a new standard dosing regimen was introduced in August 2021: 1 mcg/kg fentanyl, 2 mg/kg ketamine and 2 mg/kg rocuronium (up to a maximum dose of 150 mg) ('1:2:2')...
February 12, 2024: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/38345929/effect-of-changing-estimated-glomerular-filtration-rate-formula-on-sugammadex-use-and-pulmonary-complications-for-african-american-and-non-african-american-patients
#18
JOURNAL ARTICLE
Milo Engoren, Michael Heung
BACKGROUND: Sugammadex is associated with fewer postoperative pulmonary complications than is neostigmine reversal of neuromuscular blockade. However, the Food and Drug Administration-approved package insert states that its use is "not recommended" in severe renal impairment, separately defined as creatinine clearance <30 mL/min. Recently, the formula for estimating glomerular filtration rate (GFR) was updated to remove the race variable. Compared to the prior formula, the new consensus equation lowers the estimated GFR for African American patients and raises it for everyone else...
February 12, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38344478/compliance-with-world-health-organization-who-world-federation-of-societies-of-anesthesiologists-wfas-standards-for-general-anesthesia-at-ibn-sina-university-hospital-center-morocco
#19
JOURNAL ARTICLE
Wafaa Harfaoui, Hicham Ziani, Zakaria Slaihi, Manal Arfaoui, Bouchra Armel, Hamza Elhamzaoui, Lahcen Belyamani, Mustapha Alilou, Majdouline Obtel
INTRODUCTION: Patient safety in anaesthesia has significantly improved over the past decades, largely due to pharmacological and technological advancements, as well as the widespread adoption of guidelines and standards recommended by international organisations. This study aimed to evaluate the practice of anaesthesia and its compliance with the international standards for safe anaesthesia practice recommended by the World Federation of Societies of Anaesthesiologists (WFSA) and the World Health Organization (WHO)...
January 2024: Curēus
https://read.qxmd.com/read/38332961/current-practices-and-safety-of-medication-use-during-pediatric-rapid-sequence-intubation
#20
JOURNAL ARTICLE
Sarah A Bisesi, Sierra D Stauber, David J Hutchinson, Nicole M Acquisto
OBJECTIVES: This study aimed to characterize medication-related practices during and immediately -following rapid sequence intubation (RSI) in pediatric care units across the United States and to evaluate adverse drug events. METHODS: This was a multicenter, observational study of medication practices surrounding intubation in pediatric and neonatal intensive care unit (NICU) and emergency department patients across the United States. RESULTS: A total of 172 patients from 13 geographically diverse institutions were included...
2024: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
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