Irene Suárez-Pereira, Carolina López-Martín, Carmen Camarena-Delgado, Meritxell Llorca-Torralba, Francisco González-Saiz, Rocío Ruiz, Martiniano Santiago, Esther Berrocoso
BACKGROUND: Dynamic changes in neuronal activity and in noradrenergic locus coeruleus (LC) projections have been proposed during the transition from acute to chronic pain. Thus, we explored the cellular cFos activity of the LC and its projections, in conjunction with spontaneous pain-like behavior in neuropathic rats. METHODS: Tyrosine hydroxylase:Cre and wild-type Long-Evans rats, males and females, were subjected to chronic constriction injury (CCI) for 2 (short-term, CCI-ST) or 30 days (long-term, CCI-LT), evaluating cFos and Fluoro-Gold expression in the LC, and its projections to the spinal cord (SC) and rostral anterior cingulate cortex (rACC)...
April 10, 2024: Anesthesiology