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https://www.readbyqxmd.com/read/30557883/platelet-dense-granules-worsen-pre-infection-thrombocytopenia-during-gram-negative-pneumonia-derived-sepsis
#1
Theodora A M Claushuis, Alex F de Vos, Joris J T H Roelofs, Onno J de Boer, Cornelis van 't Veer, Tom van der Poll
Platelet-dense (δ) granules are important for platelet function. Platelets contribute to host defense and vascular integrity during pneumonia and sepsis, and δ granule products, including adenosine diphosphate (ADP), can influence inflammatory responses. We therefore aimed to study the role of platelet δ granules in the host response during sepsis. Hermansky-Pudlak syndrome (Hps)3coa mice (with reduced δ granule content), mice treated with the platelet ADP receptor inhibitor clopidogrel, and appropriate control mice were infected with the human sepsis pathogen Klebsiella pneumoniae via the airways to induce pneumonia and sepsis...
December 17, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/30557322/acanthamoeba-profilin-elicits-allergic-airway-inflammation-in-mice
#2
So Myung Song, Shin Ae Kang, Hye Kyung Park, Dong Hee Kim, So Young Park, Se Bok Jang, Hak Sun Yu
BACKGROUND: In previous studies, we suggested that Acanthamoeba is a new aero-allergen and that patients who showed positive results for the skin-prick test response to Acanthamoeba cross-reacted with several pollen allergens. Additionally, patients with common antibodies reacted to the 13-15 kDa Acanthamoeba unknown allergen. OBJECTIVE: We examined whether profilin of Acanthamoeba is a human airway allergic agent because of its molecular weight. METHODS: We expressed recombinant Ac-PF (rAc-PF) protein using an Escherichia coli expression system and evaluated whether Ac-PF is an airway allergic agent using an allergic airway inflammation animal model...
December 17, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30557318/exposure-to-phthalates-aggravates-pulmonary-function-and-airway-inflammation-in-asthmatic-children
#3
Young-Min Kim, Jihyun Kim, Hae-Kwan Cheong, Byoung-Hak Jeon, Kangmo Ahn
INTRODUCTION: Studies on the associations between phthalate exposures and respiratory outcomes are limited. We investigated the association of phthalates exposure with pulmonary function and airway inflammation in asthmatic children. METHODS: Fifty-six children with asthma living in Seoul Metropolitan Area, Korea aged 6-16 years were enrolled. Their pulmonary function including forced expiratory volume in 1 sec (FEV1) and peak expiratory flow rate (PEFR) were measured, and the fractional exhaled nitric oxide (FeNO) as a marker of airway inflammation was examined repeatedly up to four times during the study period...
2018: PloS One
https://www.readbyqxmd.com/read/30557236/laryngeal-mask-airway-as-a-rescue-device-for-failed-endotracheal-intubation-during-scene-to-hospital-air-transport-of-combat-casualties
#4
Itai Shavit
No abstract text is available yet for this article.
February 2019: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/30557235/laryngeal-mask-airway-as-a-rescue-device-for-failed-endotracheal-intubation
#5
Mark C Kendall
No abstract text is available yet for this article.
February 2019: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/30556777/high-efficiency-nose-to-lung-aerosol-delivery-in-an-infant-development-of-a-validated-computational-fluid-dynamics-method
#6
Karl Bass, Susan Boc, Michael Hindle, Kelley Dodson, Worth Longest
BACKGROUND: Computational fluid dynamics (CFD) provides a powerful tool for developing new high-efficiency aerosol delivery strategies, such as nose-to-lung (N2L) aerosol administration to infants and children using correctly sized aerosols. The objective of this study was to establish numerically efficient CFD solution methods and guidelines for simulating N2L aerosol administration to an infant based on comparisons with concurrent in vitro experiments. MATERIALS AND METHODS: N2L administration of a micrometer-sized aerosol (mass median aerodynamic diameter [MMAD] = 1...
December 15, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/30556457/insertion-depth-of-nasotracheal-tubes-sized-to-fit-the-nostril-an-observational-study
#7
Bora Lee, Wyun Kon Park, Soon Young Yun, Soojeong Kang, Hyun Joo Kim
OBJECTIVE: Nasotracheal (NT) intubation is commonly applied during head and neck surgery. However, improper tube size and depth may cause complications. In the current study, we investigated whether NT tubes are being appropriately used in terms of size and depth in adult patients. METHODS: Nares were sized in 40 patients using standard nasopharyngeal airways (6.0-8.0) before elective surgery under general anesthesia. The largest sized airway that passed easily into the nasopharynx without resistance was considered as a proper size...
December 16, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30556411/-foreign-body-aspiration-of-the-lower-airways-in-children-diagnosis-in-clinical-practice
#8
Dániel Hajnal, Tamás Kovács
INTRODUCTION AND AIM: Rigid bronchoscopic foreign body removal is the gold standard procedure for foreign body aspiration. We have analysed our results of bronchoscopies and the accuracy of diagnosis among the paediatric population in Southeast Hungary. METHOD: A retrospective study of children admitted because of suspected solid foreign body aspiration between 2006 and 2017 was performed. RESULTS: From among 220 admitted patients, 86 were suspected of solid particle aspiration...
December 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/30556399/intralesional-cidofovir-for-treatment-of-acyclovir-resistant-laryngeal-herpes-manifesting-as-supraglottic-mass
#9
Charles Q Yang, Anisha Mathur, Princy N Kumar, Vaninder K Dhillon
INTRODUCTION: Laryngopharyngeal herpes simplex virus infection is rare and presents typically in the supraglottis. Findings on presentation can range from small mucosal lesions to fungating obstructive masses mimicking neoplasm. Laryngopharyngeal herpes is a medically treated disease. OBJECTIVES: Identify potential treatment in cases that are refractory to antiviral medications. METHODS: Individual case with treatment adapted from other case report...
December 17, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/30556048/voice-outcomes-in-laryngotracheal-stenosis-impact-of-the-montgomery-t-tube
#10
Vaninder K Dhillon, Lee M Akst, Simon R Best, Alexander T Hillel
Objectives: Montgomery T-tubes enable patients with laryngotracheal stenosis to maintain airway patency. They also restore the ability to phonate in many patients. The primary objective is to compare voice quality of life outcomes in patients before and after Montgomery T-tube placement. The secondary objective is evaluating complications associated with T-tube placement. Methods: Retrospective chart review of patients with T-tubes for laryngotracheal stenosis from 2012-2016...
January 2018: Clinics in Surgery
https://www.readbyqxmd.com/read/30555782/sleeve-pneumonectomy-and-carinal-resection-for-management-of-primary-adenoid-cystic-tumor-of-the-lung-with-carinal-extension-report-of-two-cases
#11
Liliana Fernández, Nathalia Salazar, Luz F Sua, Mauricio Velásquez
Adenoid cystic carcinoma is a rare tumor of low frequency, low grade malignancy and slow growth originating from the major and minor salivary glands. Its primary pulmonary presentation is very rare, it can manifest with central airway obstruction and extensive lung involvement. Although it is slow growing, it has a tendency to local recurrence and late hematogenous metastases. The cornerstone of management consists in the complete resection of the tumor. Radiotherapy and adjuvant chemotherapy have been used in a limited number of patients with unsatisfactory results...
2019: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/30555703/management-of-malignant-carinal-involvement-using-side-by-side-method-of-bilateral-self-expandable-metallic-stents
#12
Takayuki Takeda, Hideki Itano, Ryo Wakasa, Masahiko Saitoh, Sorou Takeda
Central airway obstruction caused by cancer requires urgent interventional pulmonology. Malignant main carinal involvement is one of the most challenging situations, usually treated by rigid bronchoscopic intervention under general anaesthesia. However, these patients tend to be in poor condition due to underlying malignancy. Therefore, less-invasive strategies are needed. Six patients with lung cancer exhibiting malignant carinal involvement treated using the 'side-by-side' method of bilateral self-expandable metallic stents using fibre-optic bronchoscopy under topical anaesthesia were retrospectively investigated...
February 2019: Respirology Case Reports
https://www.readbyqxmd.com/read/30555555/exosomal-microrna-21-derived-from-bronchial-epithelial-cells-is-involved-in-aberrant-epithelium-fibroblast-cross-talk-in-copd-induced-by-cigarette-smoking
#13
Hui Xu, Min Ling, Junchao Xue, Xiangyu Dai, Qian Sun, Chao Chen, Yi Liu, Liang Zhou, Jianping Liu, Fei Luo, Qian Bian, Qizhan Liu
Rationale: Aberrant bronchial epithelium-fibroblast communication is essential for the airway remodeling that contributes to chronic obstructive pulmonary disease (COPD). Exosomes have emerged as novel mediators of intercellular communication, but their role in cigarette smoke (CS)-induced COPD is unknown. Here, we investigated the role of exosomal miR-21 in the dysfunctional epithelium-fibroblast cross-talk caused by CS. Methods: Normal or CS extract (CSE)-treated human bronchial epithelial (HBE) cells were co-cultured with bronchial fibroblasts (MRC-5 cells)...
2018: Theranostics
https://www.readbyqxmd.com/read/30555487/chac1-is-differentially-expressed-in-normal-and-cystic-fibrosis-bronchial-epithelial-cells-and-regulates-the-inflammatory-response-induced-by-pseudomonas-aeruginosa
#14
Léa Perra, Viviane Balloy, Tobias Foussignière, Didier Moissenet, Hortense Petat, Imran N Mungrue, Lhousseine Touqui, Harriet Corvol, Michel Chignard, Loic Guillot
In cystic fibrosis (CF), Pseudomonas aeruginosa ( Pa ) colonizes the lungs, leading to chronic inflammation of the bronchial epithelium. ChaC glutathione-specific γ-glutamylcyclotransferase 1 ( CHAC1 ) mRNA is differentially expressed in primary human airway epithelial cells from bronchi (hAECBs) from patients with CF and healthy patients at baseline and upon infection with Pa . CHAC1 degrades glutathione and is associated with ER stress and apoptosis pathways. In this study, we examined the roles of CHAC1 in the inflammatory response and apoptosis in lung epithelial cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30555416/the-clinical-impact-of-systematic-screening-for-obstructive-sleep-apnea-in-a-type-2-diabetes-population-adherence-to-the-screening-diagnostic-process-and-the-acceptance-and-adherence-to-the-cpap-therapy-compared-to-regular-sleep-clinic-patients
#15
Katerina Westlake, Veronika Dostalova, Andrea Plihalova, Martin Pretl, Jan Polak
Obstructive sleep apnea (OSA) is a common disorder in Type 2 diabetes (T2D) patients further increasing their already high cardiovascular risk. As T2D patients typically not report OSA symptoms, systematic screening for OSA in this population is warranted. We aimed to determine the readiness of T2D patients to undergo screening and to compare their adherence to continuous positive airway pressure (CPAP) therapy with "regular" sleep clinic patients who typically seek medical advice on their own initiative...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30555398/no-effect-of-a-self-help-book-for-insomnia-in-patients-with-obstructive-sleep-apnea-and-comorbid-chronic-insomnia-a-randomized-controlled-trial
#16
Bjørn Bjorvatn, Thomas Berge, Sverre Lehmann, Ståle Pallesen, Ingvild W Saxvig
Objective: To compare the effects of a self-help book for insomnia to that of sleep hygiene advice in a randomized controlled trial with follow-up after about 3 months among patients who were diagnosed with obstructive sleep apnea (OSA) and comorbid chronic insomnia, and who were concurrently initiating treatment with continuous positive airway pressure (CPAP). Methods: In all, 164 patients were included. OSA was diagnosed and categorized based on a standard respiratory polygraphic sleep study using a type 3 portable monitor...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30555195/where-has-all-the-power-gone-energy-production-and-loss-in-vocalization
#17
Ingo R Titze
Human voice production for speech is an inefficient process in terms of energy expended to produce acoustic output. A traditional measure of vocal efficiency relates acoustic power radiated from the mouth to aerodynamic power produced in the trachea. This efficiency ranges between 0.001 % and 1.0 % in speech-like vocalization. Simplified Navier-Stokes equations for non-steady compressible airflow from trachea to lips were used to calculate steady aerodynamic power, acoustic power, and combined total power at seven strategic locations along the airway...
July 2018: Speech Communication
https://www.readbyqxmd.com/read/30554710/clinical-validation-and-reproducibility-of-endoscopic-airway-measurement-in-pediatric-aerodigestive-evaluation
#18
Christian R Francom, Cameron A Best, Ryan G Eaton, Victoria Pepper, Amanda J Onwuka, Christopher K Breuer, Meredith N Merz Lind, Jonathan M Grischkan, Tendy Chiang
BACKGROUND: Endoscopic airway measurement (EAM) combines optical endoscopic instruments with open source image processing to accurately obtain airway dimensions. Preclinical models have demonstrated EAM as an accurate technique of airway measurement with the added advantage of characterizing multilevel stenosis, non-circular lesions, and distal obstruction. The aim of this prospective clinical study was to compare EAM to airway measurements obtained from endotracheal tube approximation (ETTA) during pediatric aerodigestive evaluation and to evaluate reproducibility of EAM across practitioners...
January 2019: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30554649/effect-of-adaptive-servo-ventilation-on-periodic-limb-movements-in-sleep-in-patients-with-heart-failure
#19
Jiang Xie, Naima Covassin, Anwar A Chahal, Phillip J Schulte, Prachi Singh, Virend K Somers, Sean M Caples
Periodic limb movements in sleep (PLMS) are associated with adverse outcomes in patients with heart failure (HF). The aim of this study was to investigate whether PLMS change in response to adaptive servo-ventilation (ASV) for central sleep apnea (CSA) in patients with HF. We examined polysomnographic studies conducted between 2010 and 2014 at Mayo Clinic, Rochester, Minnesota (n = 14,444). In those, 314 of 579 patients with CSA completed the sleep study with a protocol that began with diagnostic polysomnography, followed by continuous positive airway pressure, and, for persistent CSA, by ASV titration...
November 24, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30554520/single-cell-transcriptomic-analysis-of-human-lung-provides-insights-into-the-pathobiology-of-pulmonary-fibrosis
#20
Paul A Reyfman, James M Walter, Nikita Joshi, Kishore R Anekalla, Alexandra C McQuattie-Pimentel, Stephen Chiu, Ramiro Fernandez, Mahzad Akbarpour, Ching-I Chen, Ziyou Ren, Rohan Verma, Hiam Abdala-Valencia, Kiwon Nam, Monica Chi, SeungHye Han, Francisco J Gonzalez-Gonzalez, Saul Soberanes, Satoshi Watanabe, Kinola J N Williams, Annette S Flozak, Trevor T Nicholson, Vince K Morgan, Deborah R Winter, Monique Hinchcliff, Cara L Hrusch, Robert D Guzy, Catherine A Bonham, Anne I Sperling, Remzi Bag, Robert B Hamanaka, Gökhan M Mutlu, Anjana V Yeldandi, Stacy A Marshall, Ali Shilatifard, Luis A N Amaral, Harris Perlman, Jacob I Sznajder, A Christine Argento, Colin T Gillespie, Jane Dematte, Manu Jain, Benjamin D Singer, Karen M Ridge, Anna P Lam, Ankit Bharat, Sangeeta M Bhorade, Cara J Gottardi, G R Scott Budinger, Alexander V Misharin
RATIONALE: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are important for disease pathogenesis. OBJECTIVES: To determine whether single-cell RNA sequencing can reveal disease-related heterogeneity within alveolar macrophages, epithelial cells or other cell types in lung tissue from subjects with pulmonary fibrosis compared with controls...
December 15, 2018: American Journal of Respiratory and Critical Care Medicine
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