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https://www.readbyqxmd.com/read/30341960/impact-of-ige-sensitization-and-rhinitis-on-inflammatory-biomarkers-and-lung-function-in-adolescents-with-and-without-asthma
#1
Jenny Hallberg, Natalia Ballardini, Catarina Almqvist, Marit Westman, Marianne van Hage, Gunnar Lilja, Anna Bergström, Inger Kull, Erik Melén
BACKGROUND: Both allergic and non-allergic rhinitis are associated with worse asthma control. However, it is unclear how IgE sensitization and/or rhinitis are associated to lung function. We therefore evaluated the effect of rhinitis and sensitization on lung function, including the periphery of the airway system, and inflammatory biomarkers in individuals with and without asthma. METHODS: Participants in the BAMSE longitudinal birth cohort study underwent measures of spirometry, impulse oscillometry and FeNO at age 16 years...
October 20, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/30341485/petiveria-alliacea-suppresses-airway-inflammation-and-allergen-specific-th2-responses-in-ovalbumin-sensitized-murine-model-of-asthma
#2
Rosa Martha Perez Gutierrez, Jose Maria Mota Flores
OBJECTIVE: To examine the effect of metanol extract of Petiveria alliacea (PM) on airway inflammation in a murine model of chronic asthma. METHODS: Two-month-old male BALB/c mice (n=6-8/group) were sensitized on days 0 and 14 by intraperitoneal injection of 20 μg ovalbumin (OVA). On day 25, the mice received an airway challenge with OVA (3%, w/v, in phosphate buffered saline). PM was administered orally by oral gavage to mice at doses of 100, 200 and 400 mg/kg body weight once daily from days 18 to 23...
October 19, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/30341405/can-nasal-continuous-positive-airway-pressure-be-used-as-primary-respiratory-support-for-infants-with-meconium-aspiration-syndrome
#3
Kelsey A Montgomery, Rebecca S Rose
No abstract text is available yet for this article.
October 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30341388/up-regulated-mir-133a-orchestrates-epithelial-mesenchymal-transition-of-airway-epithelial-cells
#4
Linjie Chen, Xiaobai He, Yan Xie, Yapei Huang, Dennis W Wolff, Peter W Abel, Yaping Tu
Dysregulation of microRNAs (miRNAs) contributes to epithelial-mesenchymal transition (EMT) of cancer, but the pathological roles of miRNAs in airway EMT of lung diseases remains largely unknown. We performed sequencing and real-time PCR analysis of the miRNA expression profile of human airway epithelial cells undergoing EMT, and revealed miR-133a to be one of the most common up-regulated miRNAs. MiR-133a was previously reported to be persistently up-regulated in airway epithelial cells of smokers. We found that mice exposed to cigarette smoke (CS) showed airway hyper-responsiveness, a typical symptom occurring in CS-related lung diseases, up-regulation of miR-133a and EMT marker protein N-cadherin in airway epithelium...
October 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30340955/the-epithelial-sodium-channel-enac-as-a-therapeutic-target-for-cystic-fibrosis
#5
REVIEW
Ren-Jay Shei, Jacelyn E Peabody, Niroop Kaza, Steven M Rowe
Cystic fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR dysfunction is characterized by abnormal mucociliary transport due to a dehydrated airway surface liquid (ASL) and hyperviscous mucus, among other pathologies of host defense. ASL depletion is caused by the absence of CFTR mediated chloride secretion along with continued activity of the epithelial sodium channel (ENaC) activity, which can also be affected by CFTR mediated anion conductance...
October 16, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/30340932/pda-tolerate-trial-an-exploratory-randomized-controlled-trial-of-treatment-of-moderate-to-large-patent-ductus-arteriosus-at-1-week-of-age
#6
Ronald I Clyman, Melissa Liebowitz, Joseph Kaempf, Omer Erdeve, Ali Bulbul, Stellan Håkansson, Johanna Lindqvist, Aijaz Farooqi, Anup Katheria, Jason Sauberan, Jaideep Singh, Kelly Nelson, Andrea Wickremasinghe, Lawrence Dong, Denise C Hassinger, Susan W Aucott, Madoka Hayashi, Anne Marie Heuchan, William A Carey, Matthew Derrick, Erika Fernandez, Meera Sankar, Tina Leone, Jorge Perez, Arturo Serize
OBJECTIVE: To compare early routine pharmacologic treatment of moderate-to-large patent ductus arteriosus (PDA) at the end of week 1 with a conservative approach that requires prespecified respiratory and hemodynamic criteria before treatment can be given. STUDY DESIGN: A total of 202 neonates of <28 weeks of gestation age (mean, 25.8 ± 1.1 weeks) with moderate-to-large PDA shunts were enrolled between age 6 and 14 days (mean, 8.1 ± 2.2 days) into an exploratory randomized controlled trial...
October 16, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30339768/increased-iga-expression-in-lung-lymphoid-follicles-in-severe-copd
#7
Maha Zohra Ladjemi, Clémence Martin, Marylène Lecocq, Bruno Detry, Frank Aboubakar Nana, Charlotte Moulin, Birgit Weynand, Chantal Fregimilicka, Caroline Bouzin, Pascal Thurion, François Carlier, Jef Serré, Ghislaine Gayan-Ramirez, Monique Delos, Sebahat Ocak, Pierre Régis Burgel, Charles Pilette
RATIONALE: Accumulation of B cells and lymphoid follicles (LF) has been described in chronic obstructive pulmonary disease (COPD) airways, but the functional status of lung B cells remains poorly known. OBJECTIVES: The aim of this study was to characterize LF for expression of IgA, the main mucosal antibody. METHODS: The presence of B cells and LF, including intra-follicular IgA expression, were determined in the lung from COPD patients (n=37) versus controls (n=34) by immunohistochemistry...
October 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30339709/pneumococcal-colonization-among-tracheostomy-tube-dependent-children
#8
Guliz Erdem, Anirudh K Singh, Anthony J Brusnahan, Amber N Moore, William J Barson, Amy Leber, Jorge E Vidal, Serkan Atici, Samantha J King
Streptococcus pneumoniae colonization is a precursor to pneumococcal disease. Although children with a tracheostomy have an increased risk of pneumococcal pneumonia, the pneumococci colonizing their lower airways remain largely uncharacterized. We sought to compare lower respiratory tract isolates colonizing tracheostomy patients and a convenience sample of isolates from individuals intubated for acute conditions. We collected pneumococcal isolates from the lower respiratory tract of 27 patients with a tracheostomy and 42 patients intubated for acute conditions...
2018: PloS One
https://www.readbyqxmd.com/read/30339593/genial-tubercle-fracture
#9
Ryo Sasaki, Toshihiro Okamoto, Noriko Sangu, Yorikatsu Watanabe, Tomohiro Ando
Genial tubercle fracture is a rare mandibular fracture. It is classified into 2 different types based on the mechanism of injury, including type I, associated with an atrophied edentulous mandible or denture, and type II, associated with mandibular fracture. Although type I usually can be treated by only observation, type II may cause obstruction of the pharyngeal airway due to hematoma and edema of the floor of the mouth. In this report, genial tubercle fracture associated with mandibular fracture caused by a traffic accident was reported...
October 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30339588/nasal-airway-clearance-for-bronchiolitis
#10
(no author information available yet)
No abstract text is available yet for this article.
November 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/30339587/airway-clearance-of-the-term-newborn
#11
(no author information available yet)
No abstract text is available yet for this article.
November 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/30339577/airway-clearance-for-newborns-and-infants
#12
(no author information available yet)
No abstract text is available yet for this article.
November 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/30339479/occupational-exposures-influence-ct-imaging-characteristics-in-the-spiromics-cohort
#13
Laura M Paulin, Benjamin M Smith, Abby Koch, MeiLan Han, Eric A Hoffman, Carlos Martinez, Chinedu Ejike, Paul D Blanc, Jennifer Rous, R Graham Barr, Stephen P Peters, Robert Paine, Cheryl Pirozzi, Christopher B Cooper, Mark T Dransfield, Alejandro P Comellas, Richard E Kanner, M Brad Drummond, Nirupama Putcha, Nadia N Hansel
RATIONALE: Quantitative computed tomography (CT) imaging can aid in COPD phenotyping. Few studies have identified whether occupational exposures are associated with distinct CT imaging characteristics. OBJECTIVE: To examine the association between occupational exposures and CT-measured patterns of disease in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). METHODS: Participants underwent whole-lung multidetector helical CT at full inspiration and expiration...
October 19, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/30339463/marcks-myristoylated-alanine-rich-c-kinase-substrate-and-lung-disease
#14
Mary K Sheats, Qi Yin, Shijing Fang, Joungjoa Park, Anne L Crews, Indu Parikh, Brian Dickson, Kenneth B Adler
MARCKS (Myristoylated Alanine Rich C Kinase Substrate) is a prominent Protein Kinase C (PKC) substrate expressed in all eukaryotic cells. It is known to bind to and cross-link actin filaments, to serve as a bridge between Ca++/Calmodulin (CaM) and PKC signaling, and to sequester the signaling molecule phosphatidylinositol 4,5-bisphosphate PI(4,5)P2 (PIP2) in the plasma membrane (1-6). Since the mid 1980's, this evolutionarily - conserved and ubiquitously - expressed protein has been associated with regulating cellular events that require dynamic actin reorganization, including cellular adhesion, migration and exocytosis (7-21)...
October 19, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/30339304/asthma-related-outcomes-associated-with-indoor-air-pollutants-among-schoolchildren-from-four-informal-settlements-in-two-municipalities-in-the-western-cape-province-of-south-africa
#15
Toyib Olaniyan, Mohamed Aqiel Dalvie, Martin Röösli, Rajen Naidoo, Nino Künzil, Kees de Hoogh, Bhawoodien Parker, Joy Leaner, Mohamed Jeebhay
The health impact of indoor air pollution in informal settlement households has not been extensively studied in South Africa. This cross-sectional study investigated the association between asthma and common indoor exposures among schoolchildren from four informal settlements located in two municipalities in the Western Cape Province. A total of 590 children, aged 9 - 11 years, were recruited. The International Study of Asthma and Allergies in Children (ISAAC) questionnaire, was administered to caregivers. Pulmonary function assessment included spirometry and fractional-exhaled nitric oxide (FeNO)...
October 19, 2018: Indoor Air
https://www.readbyqxmd.com/read/30339061/natural-derived-surfactant-preparation-as-a-carrier-of-polymyxin-e-for-treatment-of-pseudomonas-aeruginosa-pneumonia-in-a-near-term-rabbit-model
#16
Oihana Basabe-Burgos, Jakub Zebialowicz, Guido Stichtenoth, Tore Curstedt, Peter Bergman, Jan Johansson, Anna Rising
BACKGROUND: Pulmonary surfactant spreads rapidly over the airway epithelium, a property that could be harnessed to transport drugs into the lungs. For efficient drug delivery, an interaction between pulmonary surfactant and the drug to be administered is likely needed. On the other hand, the interaction should not compromise the activity of surfactant or the drug once delivered in vivo. The antibiotics gentamicin (an aminoglycoside) and polymyxin E represent drugs that could benefit from being delivered directly to the lung, thereby increasing local concentrations and reducing systemic side effects...
October 19, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/30338816/changes-in-surface-tension-of-saliva-in-down-syndrome
#17
M Kawai, N Ito, T Ayuse
OBJECTIVE: Surface tension in saliva might contribute to the maintenance of upper airway patency. The present study aimed to determine whether salivary surface tension is altered in patients with Down syndrome who are predisposed to upper airway collapse. PATIENTS AND METHODS: We used the pull-off force technique to measure surface tension in samples (100 μL) of saliva collected from twenty-three male patients with Down syndrome and twenty-three healthy males (controls)...
October 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30338742/ventricular-arrhythmias-in-patients-with-obstructive-sleep-apnea
#18
Rita Marinheiro, Leonor Parreira, Pedro Amador, Dinis Mesquita, José Farinha, Marta Fonseca, Tatiana Duarte, Andreia Fernandes, Claudia Lopes, Rui Caria
Obstrutive sleep apnea (OSA) is a prevalent condition thought to increase in the future. Being mostly undiagnosed, the most serious complications are cardiovascular diseases, among which arrhythmias. Controversy remains as to whether OSA is a primary etiologic factor for ventricular arrhythmias, because of the high incidence of cardiovascular comorbidities in OSA patients. However, there is mostly a strong evidence of a relation between OSA and ventricular arrhythmias. A few mechanisms have been proposed to be responsible for this association and some electrocardiographic changes have also been demonstrated to be more frequent in OSA patients...
October 12, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/30338441/drug-induced-sleep-endoscopy-the-effect-of-different-passive-maneuvers-on-the-distribution-of-collapse-patterns-of-the-upper-airway-in-obstructive-sleep-apnea-patients
#19
A M E H Beelen, P E Vonk, N de Vries
PURPOSE: To evaluate the effect of different passive maneuvers (lateral head rotation and jaw thrust) during drug-induced sleep endoscopy (DISE) on distribution of collapse patterns at the level of velum, oropharynx, tongue base, and epiglottis (VOTE). METHODS: Retrospective, single-center cohort study. Patients diagnosed with OSA who underwent DISE between August 2016 and February 2017 were included. During DISE procedure lateral head rotation, jaw thrust and a combination of both were applied and scored by VOTE obstruction level...
October 18, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30338440/drug-induced-sleep-endoscopy-dise-as-a-guide-towards-upper-airway-behavior-and-treatment-outcome-the-quest-for-a-vigorous-standardization-of-dise
#20
EDITORIAL
Olivier M Vanderveken
No abstract text is available yet for this article.
October 18, 2018: Sleep & Breathing, Schlaf & Atmung
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