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"Advanced Life Support" OR "ALS" OR "ACLS"

Di Liao, Qiao Liao, Cao Huang, Fangfang Bi
To explore the role of the mutations G38R and D40G of Annexin A11 (ANXA11) in the onset of amyotrophic lateral sclerosis (ALS).
 Methods: The plasmids expressing ANXA11 wild type protein, ANXA11 G38R protein and ANXA11 D40G protein were constructed, respectively. The recombinant plasmids were then transfected into HEK293 cells respectively followed by cycloheximide (CHX) treatment for 0, 2, 4 and 8 h. The protein expressions of ANXA11 wild type, ANXA11 G38R and ANXA11 D40G mutations were determined by Western blot...
June 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Makito Hirano, Makoto Samukawa, Chiharu Isono, Kazumasa Saigoh, Yusaku Nakamura, Susumu Kusunoki
Objective: To assess the contribution of noncoding repeat expansions in Japanese patients with amyotrophic lateral sclerosis (ALS). Methods: Sporadic ALS in Western countries is frequently associated with noncoding repeat expansions in the C9ORF72 gene. Spinocerebellar ataxia type 8 (SCA8) is another noncoding repeat disease caused by expanded CTA/CTG repeats in the ATXN8OS gene. Although the involvement of upper and lower motor neurons in SCA8 has been reported, a positive association between SCA8 and ALS remains unestablished...
August 2018: Neurology. Genetics
Mark E Steiner, David Wing, Kempland C Walley, Ohan Manoukian, Miguel Perez-Viloria, Stephen Okajima, Ara Nazarian
Background: In anatomic anterior cruciate ligament (ACL) reconstructions produced with flexible reamers and no knee hyperflexion, it is unknown whether knee hyperflexion is necessary for femoral interference screw insertion. Purpose: To compare femoral screw-graft divergence in anatomic ACL reconstructions with endoscopic interference screws placed without knee hyperflexion and with the use of flexible versus rigid screwdrivers. Study Design: Controlled laboratory study...
August 2018: Orthopaedic Journal of Sports Medicine
Ajay S Padaki, Manish S Noticewala, William N Levine, Christopher S Ahmad, Michael K Popkin, Charles A Popkin
Background: The risk of depression and the fear of reinjury were documented in recent investigations of patients after anterior cruciate ligament (ACL) ruptures. The extent of psychological trauma accompanying these injuries among young athletes, however, has never been assessed. Hypothesis: Posttraumatic stress disorder (PTSD) symptoms after ACL injury are present among young athletes with high athletic identities. Study Design: Case series; Level of evidence, 4...
July 2018: Orthopaedic Journal of Sports Medicine
Jorge E Gómez, Daren D Molina, Shaylon D Rettig, J Herman Kan
Background: Clinical characteristics of uncomplicated bone bruises (ie, not associated with a ligament rupture, meniscal tear, or fracture of the knee) in young athletes have scarcely been reported. Purpose: To identify mechanisms of injury, characterize bone bruise patterns, and identify clinical factors relating to recovery in young patients suffering uncomplicated bone bruises about the knee. Study Design: Case series; Level of evidence, 4...
July 2018: Orthopaedic Journal of Sports Medicine
Alexander Heilinger, Rupert Ortner, Vincenzo La Bella, Zulay R Lugo, Camille Chatelle, Steven Laureys, Rossella Spataro, Christoph Guger
Patients with locked-in syndrome (LIS) are typically unable to move or communicate and can be misdiagnosed as patients with disorders of consciousness (DOC). Behavioral assessment scales are limited in their ability to detect signs of consciousness in this population. Recent research has shown that brain-computer interface (BCI) technology could supplement behavioral scales and allows to establish communication with these severely disabled patients. In this study, we compared the vibro-tactile P300 based BCI performance in two groups of patients with LIS of different etiologies: stroke ( n = 6) and amyotrophic lateral sclerosis (ALS) ( n = 9)...
2018: Frontiers in Neuroscience
Ian Fyfe
No abstract text is available yet for this article.
August 14, 2018: Nature Reviews. Neurology
Chiharu Matsuda, Toshio Shimizu, Yuki Nakayama, Michiko Haraguchi
INTRODUCTION: This study investigated the prognostic significance of the cough peak flow (CPF) decline rate in patients with amyotrophic lateral sclerosis (ALS). METHODS: Thirty-four patients with ALS participated. We examined CPF, forced vital capacity (FVC), body mass index, and the revised ALS Functional Rating Scale (ALSFRS-R), and followed patients to death, tracheostomy or non-invasive ventilator dependency. We analyzed the relationship between the rate of decline of each parameter and survival prognosis...
August 14, 2018: Muscle & Nerve
Whitney A Ratliff, Jessica N Saykally, Michael J Kane, Bruce A Citron
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disease for which there is currently no effective treatment. The progression of ALS includes loss of motor neurons controlling the voluntary muscles, with much of this loss occurring at the neuromuscular junction. In an effort to better understand changes at the neuromuscular junction, we utilized the wobbler mouse model of motor neuron loss. We examined biceps and end plate morphologies and monitored selected factors involved in end plate function...
August 13, 2018: Journal of Molecular Neuroscience: MN
Christian Lattermann, Caitlin E-W Conley, Darren L Johnson, Emily K Reinke, Laura J Huston, Janet L Huebner, Ching-Heng Chou, Virginia B Kraus, Kurt P Spindler, Cale A Jacobs
Background: The majority of patients develop posttraumatic osteoarthritis within 15 years of anterior cruciate ligament (ACL) injury. Inflammatory and chondrodegenerative biomarkers have been associated with both pain and the progression of osteoarthritis; however, it remains unclear if preoperative biomarkers differ for patients with inferior postoperative outcomes. Hypothesis/Purpose: The purpose of this pilot study was to compare biomarkers collected on the day of ACL reconstruction between patients with "good" or "poor" 2-year postoperative outcomes...
2018: BioMed Research International
Anna M Wirth, Andrei Khomenko, Dobri Baldaranov, Ines Kobor, Ohnmar Hsam, Thomas Grimm, Siw Johannesen, Tim-Henrik Bruun, Wilhelm Schulte-Mattler, Mark W Greenlee, Ulrich Bogdahn
Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative process affecting upper and lower motor neurons as well as non-motor systems. In this study, precentral and postcentral cortical thinning detected by structural magnetic resonance imaging (MRI) were combined with clinical (ALS-specific functional rating scale revised, ALSFRS-R) and neurophysiological (motor unit number index, MUNIX) biomarkers in both cross-sectional and longitudinal analyses. Methods: The unicenter sample included 20 limb-onset classical ALS patients compared to 30 age-related healthy controls...
2018: Frontiers in Neurology
Ariel Kiyomi Daoud, Tessa Mandler, Alexia Georgia Gagliardi, Harin Bhavin Parikh, Patrick M Carry, Anusara Carolyn Ice, Jay Albright
Background: Despite advancements in minimally invasive arthroscopic surgical techniques, post-operative pain management following ACL reconstruction remains a concern. This study compares the effectiveness of two common intraoperative pain management strategies - a femoral nerve catheter (FC) versus a combined femoral nerve catheter and single injection sciatic nerve block (FSB) - in pediatric patients undergoing ACL reconstruction. Methods: The medical records of patients age 8 to 18 who underwent ACL reconstruction at our institution were reviewed retrospectively...
2018: Iowa Orthopaedic Journal
Huijuan Shi, Hongshi Huang, Yuanyuan Yu, Zixuan Liang, Si Zhang, Bing Yu, Hui Liu, Yingfang Ao
Individuals who received anterior cruciate ligament (ACL) reconstruction surgeries demonstrated lower extremity movement asymmetries. The purpose of this study was to determine if psychological impairment was a contributor to lower extremity movement asymmetries in walking for individuals who received ACL reconstruction surgeries. Three-dimensional videographic and force plate data were collected for 25 males after unilateral ACL reconstruction performing walking without (single-task condition) and with the concurrent cognitive task (dual-task condition)...
August 13, 2018: Scientific Reports
Amelia S Lanier, Brian A Knarr, Nicholas Stergiou, Thomas S Buchanan
Control of shear ground reaction forces (sGRF) is important in performing running and cutting tasks as poor sGRF control has implications for those with knee injuries, such as anterior cruciate ligament (ACL) ruptures. The goal of this study was to develop a novel and safe task to evaluate control or accurate modulation of shear ground reaction forces related to those generated during cutting. Our approach utilized a force control task using real-time visual feedback of a subject's force production and evaluated control capabilities through accuracy and divergence measurements...
August 11, 2018: Sensors
Qiang Gao, Xuewen Zhao, Xiao Yu, Yu Song, Zhe Wang
BACKGROUND: Brain computer interface (BCI) technology is a communication and control approach. Up to now many studies have attempted to develop an EEG-based BCI system to improve the quality of life of people with severe disabilities, such as amyotrophic lateral sclerosis (ALS), paralysis, brain stroke and so on. The proposed BCIBSHS could help to provide a new way for supporting life of paralyzed people and elderly people. OBJECTIVE: The goal of this paper is to explore how to set up a cost-effective and safe-to-use online BCIBSHS to recognize multi-commands and control smart devices based on SSVEP...
July 27, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Amanda J Foss, Neil Chernoff, Mark T Aubel
β-Methylamino-L-alanine (BMAA) has been identified as the potential cause of the amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) observed in the Chamorro people of Guam. The principal hypothesis for BMAA exposure and intoxication relies on the biomagnification of BMAA in flying fox specimens ingested by the Chamorro people. Although high levels of BMAA were quantitated in flying fox specimens utilizing liquid chromatography-fluorescence (LC-FL), there have not been any confirmatory analyses conducted to date...
August 10, 2018: Toxicon: Official Journal of the International Society on Toxinology
Eric Hamrin Senorski, Eleonor Svantesson, Kurt P Spindler, Eduard Alentorn-Geli, David Sundemo, Olaf Westin, Jon Karlsson, Kristian Samuelsson
BACKGROUND: Factors relating to the patient and anterior cruciate ligament (ACL) reconstruction may help to identify prognostic factors of long-term outcome after reconstruction. PURPOSE: To determine 10-year risk factors for inferior knee function after ACL reconstruction. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: Prospectively collected data from the Swedish National Knee Ligament Register were extracted for patients who underwent ACL reconstruction between January 2005 and December 2006...
August 13, 2018: American Journal of Sports Medicine
Moon Jong Chang, Jin Hwa Jeong, Chong Bum Chang, Young Jun Kim, Bo-Kyung Seo, Min Kyu Song, Taehoon Kang, Seung-Baik Kang
BACKGROUND: Some patients with recurrent symptomatic instability after primary anterior cruciate ligament (ACL) reconstruction have an extension deficiency (ED). This study 1) compared preoperative clinical conditions between the ED and non-ED groups undergoing revision ACL reconstruction, 2) documented clinical and arthroscopic findings in ACL-reconstructed patients with re-instability and ED, and 3) determined whether the ED could be resolved and whether the clinical results of revision surgery differed between the ED and non-ED groups METHODS: This study included 58 patients who underwent revision ACL reconstruction...
August 13, 2018: Scandinavian Journal of Medicine & Science in Sports
Hidemi Misawa, Yuta Morisaki
Different and selective vulnerability among motor neuron subtypes are a fundamental, but unexplained, feature of amyotrophic lateral sclerosis (ALS): fast-fatigable (FF) motor neurons are the most vulnerable, and fast fatigue-resistant/slow (FR/S) motor neurons are relatively resistant. We identified that osteopontin (OPN) can serve as a marker of FR/S motor neurons, whereas matrix metalloproteinase-9 (MMP9) is expressed by FF motor neurons in mice. In SOD1G93A ALS model mice, as the disease progressed, OPN was secreted and accumulated as granular deposits in the extracellular matrix...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
Yumi Matsushita, Naoki Kitamura, Masashi Higuchi, Yoshinao Z Hosaka, Izumi Shibuya
Ten pairs of protrusions, called accessory lobes (ALs), exist at the lateral sides of the avian lumbosacral spinal cord. Histological evidence indicates that neuron-like cells gather in the ALs, and behavioral evidence suggests that the ALs act as a sensory organ of equilibrium during bipedal walking. Recently, using an electrophysiological method, we reported that cells showing Na+ currents and action potentials exist among cells that were dissociated from the ALs. However, it was unclear which isoforms of the voltage-gated sodium channel (VGSC) are expressed in the ALs and whether cells having neuronal morphology in the ALs express VGSCs...
2018: Biomedical Research
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