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Diabetes glucose control

Cindy Park, Quang A Le
BACKGROUND: Continuous glucose monitoring (CGM) provides glucose trend information that can be used to guide treatment and motivate patients with diabetes. Currently, the evidence on effectiveness of CGM in patients with type 2 diabetes is debatable. We aim to provide a systematic review and meta-analysis to synthesize current evidence of effectiveness of CGM in adults with type 2 diabetes. MATERIALS AND METHODS: Cochrane, Embase, PubMed, and Web of Science were searched to include all studies that reported effectiveness of CGM in terms of HbA1c in adults aged 18 and older, with type 2 diabetes, on any treatment for diabetes...
August 10, 2018: Diabetes Technology & Therapeutics
Shao-Jun Li, Dan Feng
Few treatments are effective to manage herpes-zoster (HZ)-related pain. This retrospective study focused on the efficacy of 2% lidocaine continuous epidural infusion on pain control and quality of life in patients with thoracic or lumbar HZ.A total of 256 patients with thoracic or lumbar HZ were reviewed for this study. Patients included in the study were divided into continuous epidural infusion (70 mL 2% lidocaine + 180 mL 0.9% normal saline) and medical therapy group (group1) and only medical therapy group (group2)...
August 2018: Medicine (Baltimore)
Hao Li, Fang-Hong Shi, Shi-Ying Huang, Shun-Guo Zhang, Zhi-Chun Gu
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel class of oral antidiabetic drugs, which mainly increase urinary glucose excretion through reducing renal glucose reabsorption. There is still a concern about the overall safety profile of SGLT2 inhibitors. In this systematic review and meta-analysis, we will assess the clinical adverse effects of SGLT2 inhibitors in type 2 diabetes mellitus. METHODS: This systemic review and meta-analysis described in this protocol will be conducted to follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline...
August 2018: Medicine (Baltimore)
Jose Garcia-Tirado, Christian Zuluaga-Bedoya, Marc D Breton
OBJECTIVE: Our aim is to analyze the identifiability of three commonly used control-oriented models for glucose control in patients with type 1 diabetes (T1D). METHODS: Structural and practical identifiability analysis were performed on three published control-oriented models for glucose control in patients with type 1 diabetes (T1D): the subcutaneous oral glucose minimal model (SOGMM), the intensive control insulin-nutrition-glucose (ICING) model, and the minimal model control-oriented (MMC)...
August 10, 2018: Journal of Diabetes Science and Technology
Andjela T Drincic
Self-monitoring of blood glucose is a part of integral care of patients with diabetes mellitus. Understanding and appropriately responding to glucose levels is a fundamental part of self-management. Grady et al's work, published in the current issue of Journal of Diabetes Science and Technology, investigated whether switching people with diabetes from their usual meter to a meter featuring color range indicator (CRI) could improve glycemic control, by facilitating improved understanding of blood glucose targets...
August 10, 2018: Journal of Diabetes Science and Technology
Annika Rosengren, Jon Edqvist, Araz Rawshani, Naveed Sattar, Stefan Franzén, Martin Adiels, Ann-Marie Svensson, Marcus Lind, Soffia Gudbjörnsdottir
AIMS/HYPOTHESIS: Type 2 diabetes is an established risk factor for heart failure, but age-specific data are sparse. We aimed to determine excess risk of heart failure, based on age, glycaemic control and kidney function in comparison with age- and sex-matched control individuals from the general population. METHODS: Individuals with type 2 diabetes registered in the Swedish National Diabetes Registry 1998-2012 (n = 266,305) were compared with age-, sex- and county-matched control individuals without diabetes (n = 1,323,504), and followed over a median of 5...
August 9, 2018: Diabetologia
Hiroaki Tanaka, Takenori Yamashita, Misao Yoneda, Satoshi Takagi, Toshihiro Miura
Objective: Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia, hyperinsulinemia, and complications such as obesity and osteoporosis. The Tsumura, Suzuki, Obese Diabetes (TSOD) mouse is an animal model of spontaneous obese T2DM. However, bone metabolism in TSOD mice is yet to be investigated. The objective of the present study was to investigate the effects of T2DM on bone mass, metabolism, microstructure, and strength in TSOD mice. Methods: We determined the following parameters in TSOD mice and Tsumura, Suzuki, Non-obesity (TSNO) mice (as controls): serum glucose levels; serum insulin levels; bone mass; bone microstructure; bone metabolic markers; and bone strength...
December 2018: Bone Reports
Valentina Guarnotta, Giulia Di Bella, Giuseppe Pillitteri, Alessandro Ciresi, Carla Giordano
Background: Cardiovascular disease is a frequent complication of type 1 diabetes (T1D). We evaluated the effectiveness of switching from glargine to degludec in reducing the cardiovascular risk factors, the Framingham risk score (FRS) and visceral adiposity index (VAI) in patients with T1D and autoimmune polyglandular syndrome (APS). Methods: We selected 66 T1D outpatients who had been on stable treatment with glargine for at least 5 years. Among them, 30 patients maintained glargine (group A), while 36 were switched to degludec (group B) for 12 months...
2018: Frontiers in Endocrinology
Vijay Chathoth, Parthasarathy Ramamurthy, Susan Solomon
Clozapine is superior to all other antipsychotics in treatment-resistant schizophrenia. However, metabolic side effects are common while treating patients with clozapine. Administering clozapine in a patient who already is diabetic involves careful weighing of risks and benefits. Here, we report our experience of starting clozapine in a known diabetic patient. Clozapine was started in a patient with treatment-resistant psychosis in view of suicidal risk. Her diabetes mellitus was under good control with oral medications...
July 2018: Indian Journal of Psychological Medicine
Susanne Rospleszcz, Anina Schafnitzel, Wolfgang Koenig, Roberto Lorbeer, Sigrid Auweter, Cornelia Huth, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Holger Hetterich, Fabian Bamberg, Annette Peters
BACKGROUND: Left ventricular (LV) hypertrophy and changes in LV geometry are associated with increased cardiovascular mortality. Subjects with type 2 diabetes have an increased risk of such alterations in cardiac morphology. We sought to assess the association of glycemic status and LV wall thickness measured by cardiac magnetic resonance (CMR), and potential interactions of hypertension and diabetes. METHODS: CMR was performed on 359 participants from a cross-sectional study nested in a population-based cohort (KORA FF4) free of overt cardiovascular disease...
August 9, 2018: BMC Cardiovascular Disorders
A Abdulrazak, Y Tanko, A Mohammed, K A Mohammed, N M Sada, A Au Dikko
The aimed of this research is to evaluate the effects of clove and fermented ginger supplements on blood glucose,serum insulin, insulin receptor and Leptin levels of high fat diet-induced type 2 diabetes mellitus in rabbits. Clove and gingerare spices with records of medicinal value over decades. Thirty males rabbits weighing, 1-1.5kg were used for the research.Type 2 diabetes was induced by feeding the animals with a high fat diet for a period of eight weeks. Blood glucose levelswere determined after the induction period and rabbits having 140 mg/dL and above were selected for the study...
June 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
Hazem M El-Ashmawy, Azza M Ahmed
BACKGROUND: The aim of the study was to evaluate the relationship between serum cathelicidin level and diabetic nephropathy (DN) in patients with type 1 diabetes mellitus (T1DM). METHODS: The study group consisted of 76 patients with T1DM (47 men), aged 36 ± 7 years and with duration of T1DM 14 (7-18) years. Serum cathelicidin was measured by ELISA kit test in healthy controls (n = 20) and in 76 T1DM patients grouped as follows: G1= patients with normal urinary albumin excretion (n = 20); G2= patients with microalbumin excretion (n = 19); G 3= patients with macroalbumin excretion but normal serum creatinine level (n = 19), G4 = patients with macroalbumin excretion with increased serum creatinine (n = 18)...
August 9, 2018: Diabetes/metabolism Research and Reviews
R Herring, D Russell-Jones
Despite advances in insulin analogues and monitoring, and changes in insulin delivery, Type 1 diabetes is still difficult to control. It can result in significant short- and long-term adverse health effects including renal failure, blindness, early cardiovascular disease and foot ulceration. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have potential benefit as an adjunct treatment in people not achieving adequate glycaemic control with insulin alone. This article is protected by copyright. All rights reserved...
August 8, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Joachim Tillner, Maximilian G Posch, Frank Wagner, Lenore Teichert, Youssef Hijazi, Christine Einig, Stefanie Keil, Torsten Haack, Michael Wagner, Martin Bossart, Philip J Larsen
AIMS: To evaluate the safety, pharmacokinetics, and pharmacodynamics of SAR425899, a novel polypeptide active as an agonist at both the glucagon-like peptide-1 receptor (GLP-1 R) and the glucagon receptor, in healthy volunteers and in patients with overweight/obesity and type 2 diabetes. METHODS: Subcutaneous administrations of SAR425899 were tested in two randomized, placebo-controlled, double-blind clinical trials. In the first trial, healthy overweight volunteers (BMI: 25─30 kg/m2 ; n = 32) received single-ascending doses (0...
August 8, 2018: Diabetes, Obesity & Metabolism
Kohei Kaku, Masakazu Haneda, Yuko Tanaka, Ganghyuck Lee, Kosuke Shiki, Yuki Miyamoto, Fernando Solimando, Jisoo Lee, Christopher Lee, Jyothis George
AIMS: This two-part, double-blind, double-dummy, randomized, placebo-controlled trial (83 sites) evaluated efficacy and safety of empagliflozin (Empa) 10 or 25 mg and linagliptin (Lina) 5 mg fixed-dose combinations (FDCs) in Japanese patients with type 2 diabetes mellitus (T2DM) poorly controlled with Empa. MATERIALS AND METHODS: Patients (previously drug-naive or on 1 oral antidiabetic drug for ≥12 weeks) entered an open-label stabilization period (16-week, Empa 10 mg [Part A] or Empa 25 mg [Part B])...
August 9, 2018: Diabetes, Obesity & Metabolism
Clifford J Bailey, Nikolaus Marx
This review examines recent randomised controlled cardiovascular (CV) outcome trials with glucose-lowering therapies in type 2 diabetes and their impact on the treatment of patients with type 2 diabetes. The trials were designed to comply with regulatory requirements to confirm that major adverse cardiac events (MACE) are not detrimrntally affected by such therapies. Trials involving dipeptidyl peptidase-4 (DPP4) inhibitors did not alter a composite MACE comprising CV deaths, nonfatal myocardial infarction (MI) and non-fatal stroke...
August 8, 2018: Diabetes, Obesity & Metabolism
E Leibovitz, J Wainstein, M Boaz
AIM: To study the association between serum albumin and cholesterol levels at hospital admission and incident hypoglycaemia among people admitted to internal medicine units. METHODS: In this cross-sectional analysis, we examined the electronic medical records of people hospitalized in internal medicine departments. Data extracted included all glucose measurements as well as serum albumin and cholesterol, which were measured upon admission. A hypoglycaemia event was recorded for a given person if at least one glucose measurement of ≤ 3...
August 8, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Ewelina Król, Paweł Bogdański, Joanna Suliburska, Zbigniew Krejpcio
The aim of this study was to assess the levels of Zn, Fe and Cu in the serum and hair, and dietary intake of type 2 diabetic patients and their association with glucose and lipid indices. The study was conducted on 62 people aged 40-78 years (31 diabetic patients and 31 healthy subjects, who were the control group). The content of trace elements in the hair and serum was analysed with the AAS method. The serum insulin, HbA1c, glucose, total cholesterol and triacylglycerol concentrations were measured by means of RIA, HPLC and colorimetric methods, respectively...
August 8, 2018: Biological Trace Element Research
Matthew J Magee, Argita D Salindri, Nang Thu Thu Kyaw, Sara C Auld, J Sonya Haw, Guillermo E Umpierrez
PURPOSE OF REVIEW: The intersection of tuberculosis (TB) disease and type 2 diabetes mellitus is severely hindering global efforts to reduce TB burdens. Diabetes increases the risk of developing TB disease and negatively impacts TB treatment outcomes including culture conversion time, mortality risk, and TB relapse. Recent evidence also indicates plausible mechanisms by which TB disease may influence the pathogenesis and incidence of diabetes. We review the epidemiology of stress hyperglycemia in patients with TB and the pathophysiologic responses to TB disease that are related to established mechanisms of stress hyperglycemia...
August 9, 2018: Current Diabetes Reports
Jasmin Steudle, Christiane Schön, Manfred Wargenau, Lioba Pauly, Susann Schwejda-Güttes, Barbara Gaigg, Angelika Kuchinka-Koch, John F Stover
AIM: To investigate possible changes of blood glucose levels after oral intake of lactulose in healthy subjects. METHODS: The study was performed as prospective, randomized, two-part study with 4-way cross-over design with n = 12 in each study arm. Capillary blood glucose levels were determined over a time period of 180 min after intake of a single dose of 10 g or 20 g lactulose provided as crystal or liquid formulation. During the manufacturing process of lactulose, impurities with sugars ( e...
August 7, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
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