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https://www.readbyqxmd.com/read/29148959/effect-of-measuring-%C3%AE-glutamyl-transpeptidase-and-using-smoflipid-in-a-parenteral-nutrition-infusion-in-a-patient-with-severe-malabsorption-and-overlapping-primary-sclerosing-cholangitis-and-ulcerative-colitis
#1
Merin Kinikini
Studies discussing inflammation and oxidative stress state that these conditions are known contributors in the pathogenesis of cholestatic diseases and ulcerative colitis, and studies examining patients with liver disease have found decreased antioxidant status and significant elevation of lipid peroxides as compared with healthy subjects. One hypothesis in liver disease is that deficient antioxidant defense mechanisms may lead to excess oxygen free radical formation, which promotes deleterious processes in the liver...
November 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29140838/assessing-specimens-of-devitalized-tissue-in-chronic-sacral-pressure-ulcers-a-pilot-study
#2
Juliany Lino Gomes Silva, Andressa Coope, Eliana Pereira de Araújo, Licio A Velloso, Mário José A Saad, Maria Helena Melo Lima
Pressure ulcers (PrUs)* are chronic wounds caused by a combination of factors, such as repetitive ischemia perfusion injury, bacterial colonization of the wound bed, local tissue hypoxia, or an altered cellular and systemic stress response. The objectives of this study were to analyze fragments of devitalized tissue of Stages III and IV PrUs and compare them with healthy tissue to evaluate the expression of the genes involved in wound inflammation. Samples of healthy skin from patients undergoing plastic surgery (n = 3) were collected, as well as from patients with devitalized tissue from Stages III and IV PrUs (n = 3) by means of sharp debridement...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29128794/baicalin-protects-against-gastroduodenal-ulcers-via-the-modulation-of-nrf2-expression-experimental-biochemical-and-histological-analyses
#3
Tao Zhang, Dong Yang, Xiangyu Meng
BACKGROUND: The present study aimed to determine the mechanisms underlying the gastroprotective effects of baicalin using several animal models of chemically induced gastric ulcers. METHODS: The gastroprotective effects of baicalin against ulcers induced by water immersion stress, alcohol-induced ligation, and indomethacin-induced pylorus ligation were assessed in the present study. Additionally, macroscopic evaluations were performed at the completion of the study and Western blot analyses of Nrf2 were conducted to determine the possible mechanisms of action underlying the effects of baicalin...
July 8, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29126792/in-vivo-cellular-and-molecular-gastroprotective-mechanisms-of-chrysin-emphasis-on-oxidative-stress-inflammation-and-angiogenesis
#4
Mina Y George, Ahmed Esmat, Mariane G Tadros, Ebtehal El-Demerdash
Gastric ulcer is one of the major gastrointestinal disorders affecting people worldwide. Despite medical advances, management of gastric ulcer and its complications remains a challenge facing medicine nowadays. In addition, currently available medicines exhibit limited efficacy and several side effects. In the current study, the potential protective effects of chrysin -naturally occurring flavonoid- were tested against indomethacin-induced gastric ulcer model in rats. It was found that chrysin in both doses; 50 and 100mg/kg were effective in promoting mucus secretion and preventing the rise in ulcer and lesion indices, acid production and histologic changes induced by indomethacin...
November 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29126413/leaves-from-banana-musa-nana-and-maize-zea-mays-have-no-phyto-prophylactic-effects-on-the-susceptibility-of-grass-carp-ctenopharyngodon-idella-to-aeromonas-hydrophila-infection
#5
Richard Mayrhofer, Simon Menanteau-Ledouble, Johannes Pucher, Ulfert Focken, Mansour El-Matbouli
BACKGROUND: The ubiquitous and opportunistic bacterial pathogen Aeromonas hydrophila has been associated with ulcerative dermatitis in fish, especially under stressful conditions. It can cause severe losses in fresh water aquaculture and is particularly prevalent in tropical and subtropical regions. Fresh leaves from maize and bananas have been used as feed supplement by fish farmers in Vietnam and it has been reported that they may have phyto-prophylactic benefits. In the present study, a feeding trial was conducted to investigate the benefits of providing maize and banana leaves as feed supplement: to determine if they were taken up and digested by grass carp (Ctenopharyngodon idella), if this uptake resulted in improved growth performance, and if leaf supplementation protected fish when challenged with A...
November 10, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29120683/unavoidable-pressure-ulcers-at-the-end-of-life-and-nurse-understanding
#6
Maria Carlsson, Lena Gunningberg
OBJECTIVES: prevention of pressure ulcers (PUs) in end-of-life care is often problematic because both PUs and interventions to prevent them can cause suffering. The primary aim of this study was to identify and describe the different ways in which nurses understood unavoidable PUs in late palliative care. A second aim was to explore the expediency of the different levels of understanding. METHODS: a qualitative interview study with a phenomenographic approach was carried out...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29120406/regulation-and-sensing-of-inflammasomes-and-their-impact-on-intestinal-health
#7
REVIEW
Nicole Ranson, Dale Kunde, Rajaraman Eri
Pattern recognition receptors such as nucleotide-binding oligomerization domain (NOD)-containing protein receptors (NLRs) and the pyrin and hematopoitic interferon-inducible nuclear protein (HIN) domain (PYHIN) receptors initiate the inflammatory response following cell stress or pathogenic challenge. When activated, some of these receptors oligomerize to form the structural backbone of a signalling platform known as an inflammasome. Inflammasomes promote the activation of caspase-1 and the maturation of the proinflammatory cytokines, interleukin (IL)-1β and IL-18...
November 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29120271/apple-polyphenol-suppresses-indomethacin-induced-gastric-damage-in-experimental-animals-by-lowering-oxidative-stress-status-and-modulating-the-mapk-signaling-pathway
#8
Yi-Chen Lee, Chun-Wen Cheng, Huei-Jane Lee, Huei-Chuien Chu
Indomethacin is a nonsteroid anti-inflammatory drug (NSAID) that is used to alleviate pain and inflammation in clinical medicine. Previous studies indicated that NSAIDs can cause gastrointestinal mucosal complications, and it is associated with mucosal lipid peroxidation and oxidative damage. Based on the evidences, decreasing oxidative stress may be an ideal therapeutic strategy for preventing gastrointestinal ulcer. Apple (Rosaceae Malus sp.) is one of the most commonly consumed fruits worldwide. The abundant polyphenolic constituents have received increasing attention for decades...
November 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29103205/diagnostic-dilemmas-in-chronic-inflammatory-bowel-disease
#9
Maurice B Loughrey, Neil A Shepherd
Histopathological assessment of biopsy and resection specimens of chronic inflammatory bowel disease (CIBD), or possible CIBD, forms a significant component of the routine workload in most tissue pathology laboratories. In this review, we have chosen selected areas of particular diagnostic difficulty in CIBD pathology, providing key advice for pathology reporting. Those mimics of CIBD which have the greatest potential for misdiagnosis are discussed, particularly the wide range of infectious colitides which represent possible diagnostic pitfalls...
November 4, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29096125/biaxial-mechanical-behavior-of-bovine-saphenous-venous-valve-leaflets
#10
Jiaqi Lu, Hsiao-Ying Shadow Huang
Chronic venous disease is caused by chronic venous insufficiency (CVI), which results in significant symptoms such as venous ulcers, ankle eczema, leg swelling, etc. Venous valve incompetence is a major cause of CVI. When the valves of veins in the leg become incompetent (i.e., do not close properly), blood is able to flow backwards (i.e., reflux), which results in blood pooling in the lower extremities, distal venous hypertension, and CVI. Current clinical therapies, such as surgical venous valve reconstruction and bioprosthetic venous valve replacement, are highly invasive and only moderately successful...
October 24, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29091039/psychosocial-aspects-in-patients-with-chronic-leg-ulcers
#11
Eftychia Platsidaki, Anargyros Kouris, Christos Christodoulou
Chronic leg ulcers persist for > 6 weeks and show no tendency to heal after 3 or more months. They can be distressing to patients, both directly through physical symptoms caused by the disease and indirectly through limitations on work capacity, social activity, and personal hygiene. The quality of life (QoL) of patients with leg ulcers can be impaired by a complex set of aspects. Restrictions in their ability to perform paid employment, handle household duties, and engage in personal hygiene adversely affect patients' QoL...
October 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29084077/accumulation-of-hla-dr4-in-colonic-epithelial-cells-causes-severe-colitis-in-homozygous-hla-dr4-transgenic-mice
#12
Atsushi Irie, Takahisa Imamura, Yayoi Michibata, Ttatsuko Kubo, Naoki Takeda, Isao Shibuya, Shinji Sogo, Kimi Araki, Yasuharu Nishimura
BACKGROUND: Homozygous HLA-DR4/I-E transgenic mice (tgm) spontaneously developed colitis similar to human ulcerative colitis. We explored whether endoplasmic reticulum stress in colonic epithelial cells due to overexpression of HLA-DR4/I-E was involved in the pathogenesis of colitis. METHODS: Major histocompatibility complex class II transactivator-knockout (CIITAKO) background tgm were established to test the involvement of HLA-DR4/I-E expression in the pathogenesis of colitis...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29081776/innate-lymphoid-cells-in-intestinal-inflammation
#13
REVIEW
Alessandra Geremia, Carolina V Arancibia-Cárcamo
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that encompasses Crohn's disease (CD) and ulcerative colitis. The cause of IBD is unknown, but the evidence suggests that an aberrant immune response toward the commensal bacterial flora is responsible for disease in genetically susceptible individuals. Results from animal models of colitis and human studies indicate a role for innate lymphoid cells (ILC) in the pathogenesis of chronic intestinal inflammation in IBD. ILC are a population of lymphocytes that are enriched at mucosal sites, where they play a protective role against pathogens including extracellular bacteria, helminthes, and viruses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29081208/does-proton-pump-inhibitor-increase-the-clostridium-difficile-infection-risk-in-the-treatment-and-prophylaxis-of-stress-ulcers-than-histanime-2-receptor-antagonist
#14
EDITORIAL
https://www.readbyqxmd.com/read/29080461/l-ascorbic-acid-2-glucoside-inhibits-helicobacter-pylori-induced-apoptosis-through-mitochondrial-pathway-in-gastric-epithelial-cells
#15
Xiong Chen, Rui Liu, Xiaoming Liu, Canxia Xu, Xiaoyan Wang
Helicobacter pylori (H. pylori) infection is the major cause for gastritis, peptic ulcer, and gastric cancer. Elevated oxidative stress, mitochondrial dysfunction and apoptotic death of gastric epithelial cells are typical hallmarks of H. pylori infection. Ascorbic Acid 2-Glucoside (AA2G) is a stable version of Vitamin C, that binds glucose to conventional vitamin C. AA2G has free radical scavenging activities and anti-apoptotic abilities. However, the protective effect of AA2G against H. pylori-infection in gastric epithelial cells is yet unknown...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29078713/characterization-of-brusatol-self-microemulsifying-drug-delivery-system-and-its-therapeutic-effect-against-dextran-sodium-sulfate-induced-ulcerative-colitis-in-mice
#16
Jiangtao Zhou, Lihua Tan, Jianhui Xie, Zhengquan Lai, Yanfeng Huang, Chang Qu, Dandan Luo, Zhixiu Lin, Ping Huang, Ziren Su, Youliang Xie
Brusatol (BR) is one of the main bioactive components derived from Brucea javanica, a medicinal herb historically used in the treatment of dysenteric disorders (also known as ulcerative colitis(UC)). Due to its poor aqueous solubility, a novel brusatol self-microemulsifying drug delivery system (BR-SMEDDS) nanoformulation with smaller size, higher negative zeta potential and drug content, and excellent stability was developed. The appearance of BR-SMEDDS remained clear and transparent, and transmission electron microscopy showed microemulsion droplets to be spherical with homogeneous distribution...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29070499/identifying-and-characterizing-preventable-adverse-drug-events-for-prioritizing-pharmacist-intervention-in-hospitals
#17
Nakyung Jeon, Ben Staley, Thomas Johns, Glori Pflugfelder Lipori, Babette Brumback, Richard Segal, Almut G Winterstein
PURPOSE: The approach and results for identifying and characterizing preventable adverse drug events (pADEs) that are key targets for pharmacist medication therapy management (MTM) are summarized. METHODS: This study was part of a larger effort aimed at developing an electronic health record-based prediction model (the complexity score, or C-score) that ranks hospitalized patients according to their risk for pADEs. An environmental scan of published epidemiologic pADE studies and national patient safety priority areas was conducted...
November 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29068994/urinary-incontinence-is-associated-with-the-development-of-peptic-ulcers-in-adult-women-data-from-the-knhanes-iv
#18
Jin Bong Choi, Byung Il Yoon, Kyung-Do Han, Sung-Hoo Hong, U-Syn Ha
The aim of this study was to investigate the association between urinary incontinence (UI) and peptic ulcer (PU) and how this is related to psychological stress in Korean women by analyzing the data from the Korea National Health and Nutrition Examination Survey IV (KNHANES).A nationally representative sample of data on 7475 Korean women ≥19 years of age from the KNHANES 2008 to 2010 was included. Physician-diagnosed UI and PU were assessed using questionnaires and surveys. Psychological stress was assessed through a questionnaire using a 4-point Likert scale...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29064194/-proton-pump-inhibitors-overprescription
#19
Marie Esteves, Victoria Rollason, Olivier Grosgurin
Overutilization of proton pump inhibitors (PPI) is obvious despite available recommendations, with clinical and economical issues. This overuse is due to abusive stress ulcer prophylaxis and to automatic represcription, particularly during transitions from intensive care unit to other inhospital units and at hospital discharge. Withdrawal symptoms may contribute to the difficulty of PPI interruption. It is mandatory to limit initiation of PPI treatment outside of appropriate indications and to regularly reassess the need of this treatment...
October 18, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29060894/the-external-force-associated-with-callus-formation-under-the-first-metatarsal-head-is-reduced-by-wearing-rocker-sole-shoes
#20
Ayumi Amemiya, Rena Okonogi, Hiroki Yamakawa, Kaori Susumu, Tatsuya Jitsuishi, Hisayoshi Sugawara, Yuji L Tanaka, Masatoshi Komiyama, Taketoshi Mori
INTRODUCTION: Callus is one of the main causes of diabetic foot ulcers. Therefore, preventing callus formation is very important. In a previous study, it was clarified that callus formation under the first metatarsal head (MTH) is associated with high shear stress time integral/pressure time integral (SPR-i). another study, it was clarified that rocker sole shoes are effective in reducing peak pressure under the first MTH. Therefore, we hypothesized that rocker sole shoes reduce SPR-i under the first MTH...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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