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Stress ulcer

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https://www.readbyqxmd.com/read/28932080/comparison-between-tocotrienol-and-omeprazole-on-gastric-growth-factors-in-stress-exposed-rats
#1
Mohd Fahami Nur Azlina, Hj Mohd Saad Qodriyah, Kien Hui Chua, Yusof Kamisah
AIM: To investigate and compare the effects of tocotrienol and omeprazole on gastric growth factors in rats exposed to water-immersion restraint stress (WIRS). METHODS: Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered vitamin-free palm oil (vehicle) and the two treatment groups were given omeprazole (20 mg/kg) or tocotrienol (60 mg/kg) by oral gavage. After 28 d of treatment, rats from one control group and both treated groups were subjected to WIRS one time for 3...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28929324/stress-ulcer-prophylaxis-in-neurocritical-care
#2
Jeffrey F Barletta, Alicia J Mangram, Joseph F Sucher, Victor Zach
Stress ulcer prophylaxis (SUP) with acid-suppressive drug therapy is widely utilized in critically ill patients following neurologic injury for the prevention of clinically important stress-related gastrointestinal bleeding (CIB). Data supporting SUP, however, largely originates from studies conducted during an era where practices were vastly different than what is considered routine by today's standard. This is particularly true in neurocritical care patients. In fact, the routine provision of SUP has been challenged due to an increasing prevalence of adverse drug events with acid-suppressive therapy and the perception that CIB rates are sparse...
September 19, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28928660/-1-h-nmr-based-metabolomics-study-of-the-toxicological-effects-in-rats-induced-by-renqing-mangjue-pill-a-traditional-tibetan-medicine
#3
Can Xu, Caidan Rezeng, Jian Li, Lan Zhang, Yujing Yan, Jian Gao, Yingfeng Wang, Zhongfeng Li, Jianxin Chen
"RenqingMangjue" pill (RMP), as an effective prescription of Traditional Tibetan Medicine (TTM), has been widely used in treating digestive diseases and ulcerative colitis for over a thousand years. In certain classical Tibetan Medicine, heavy metal may add as an active ingredient, but it may cause contamination unintentionally in some cases. Therefore, the toxicity and adverse effects of TTM became to draw public attention. In this study, 48 male Wistar rats were orally administrated with different dosages of RMP once a day for 15 consecutive days, then half of the rats were euthanized on the 15th day and the remaining were euthanized on the 30th day...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28926923/involvement-of-mapk-nf-%C3%AE%C2%BAb-signal-transduction-pathways-camellia-japonica-mitigates-inflammation-and-gastric-ulcer
#4
Md Rashedunnabi Akanda, Byung-Yong Park
Gastric ulcer is an important risk factor for human health globally. Camellia japonica (CJ) is a plant of which the fruits are used as traditional phytomedicine for inflammatory and immunomodulatory diseases; however, the underlying molecular mechanism has not been clarified. The present study aimed to investigate the immunopharmacological activities of Camellia japonica and validate its pharmacological targets. To evaluate the protective roles of Camellia japonica on LPS-induced inflammation in RAW 264.7 cells and HCl/EtOH-induced gastric ulcer in mice; we applied 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nitric oxide (NO), reactive oxygen species (ROS), histopathology, malondialdehyde (MDA), quantitative real-time polymerase chain reaction (qPCR), immunohistochemistry (IHC), and western blot analyses...
September 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28924528/near-fatal-gastrointestinal-hemorrhage-in-a-child-with-medulloblastoma-on-high-dose-dexamethasone
#5
Derek Yecies, Daniel Tawfik, Jennifer Damman, Chad Thorson, David S Hong, Gerald A Grant, Rachel Bensen, Mihaela Damian
A four-year-old female was admitted to a university-based children's hospital with a newly-diagnosed posterior fossa tumor. She was started on famotidine and high-dose dexamethasone and underwent gross total resection of a medulloblastoma. She was continued on dexamethasone and famotidine. She exhibited postoperative posterior fossa syndrome and was started on enteral feeds via the nasoduodenal tube. She had small gastrointestinal bleeds on postoperative days eight, 11, and 18, and was found to have a well-circumscribed posterior duodenal ulcer...
July 7, 2017: Curēus
https://www.readbyqxmd.com/read/28919395/gastroprotective-effect-of-aucubin-against-ethanol-induced-gastric-mucosal-injury-in-mice
#6
Yang Yang, Bing Yin, Le Lv, Ziye Wang, Jiao He, Ziyang Chen, Xin Wen, Yongmin Zhang, Wenji Sun, Yang Li, Ye Zhao
AIMS: Aucubin, an iridoid glycoside, was isolated from seeds of Eucommia ulmoides Oliver. This study was aimed to evaluate the protective effect of aucubin against ethanol-induced gastric mucosal injury in mice. MATERIALS AND METHODS: Mice were orally administrated with aucubin (20, 40 and 80mg/kg) for 3 consecutive days. On the 3rd day, the mice of gastric mucosal injury were induced with 70% ethanol after the last administration of aucubin. Gastric tissue of mice were submitted for evaluating the severity of gastric mucosal injury...
September 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28905321/network-analysis-of-mpo-and-other-relevant-proteins-involved-in-diabetic-foot-ulcer-and-other-diabetic-complications
#7
Mathew Saumya, E K Subin, T V Suchithra
Network analysis and visualization of genes are very important to understand large complex biological data in a better manner. Large data on genes and proteins in the biological systems are analyzed on the occurrence, interactions, co-expression, and co-regulations of various genes. Here we have visualized the genes involved in type 1 diabetes (T1D), type 2 diabetes (T2D), and foot ulcer condition to put light on the corrective measures to the problem of impaired healing. The goal of this study was to identify the important genes involved in the pathogenesis of diabetes complications and foot ulcer and its association with the free radical-producing enzyme, the myeloperoxidase (MPO)...
September 13, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28905242/poly-n-acetyl-glucosamine-snag-enhances-early-rotator-cuff-tendon-healing-in-a-rat-model
#8
C A Nuss, J Huegel, J F Boorman-Padgett, D S Choi, S N Weiss, J Vournakis, L J Soslowsky
Rotator cuff injuries frequently require surgical repairs which have a high failure rate. Biological augmentation has been utilized in an attempt to improve tendon repair. Poly-N-acetyl glucosamine (sNAG) polymer containing nanofibers has been shown to increase the rate for healing of venous leg ulcers. The purpose of this study was to investigate the healing and analgesic properties of sNAG in a rat rotator cuff injury and repair model. 144 adult male Sprague-Dawley rats underwent a transection and repair of their left supraspinatus tendons...
September 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28894319/should-we-continue-to-use-stress-ulcer-prophylaxis-for-critically-ill-patients
#9
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28894313/need-for-a-randomized-controlled-trial-of-stress-ulcer-prophylaxis-in-critically-ill-children-a-canadian-survey
#10
Mark Duffett, Karen Choong, Jennifer Foster, Elaine Gilfoyle, Jacques Lacroix, Deborah J Cook
BACKGROUND: Stress ulcer prophylaxis is commonly used in pediatric critical care, to prevent upper gastrointestinal bleeding. The most frequently used agents are histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs). The risk-benefit ratio for stress ulcer prophylaxis is uncertain, because data from randomized clinical trials (RCTs) on the effectiveness and harms of prophylaxis in children are limited. OBJECTIVE: To describe the views of Canadian pediatric intensivists about a future RCT of stress ulcer prophylaxis...
July 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28867427/prevalence-and-effectiveness-of-psychiatric-treatments-for-patients-with-ibd-a-systematic-literature-review
#11
REVIEW
Ilaria Tarricone, Maria Giulia Regazzi, Giulia Bonucci, Fernando Rizzello, Giovanni Carini, Roberto Muratori, Gilberto Poggioli, Massimo Campieri
OBJECTIVES: Higher prevalence of psychiatric disorders, such as anxiety and depression, has been found in people with Crohn's disease and Ulcerative Colitis compared to the general population. Nowadays, international guidelines advocate psychotherapy and psycho-pharmacological treatments as playing an important role in IBD care. The main goal of this systematic literature review was summarize the evidence on the utilization and effectiveness of treatments for depression and anxiety in persons with IBD...
October 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28865339/enteral-nutrition-as-stress-ulcer-prophylaxis-in-critically-ill-patients-a-randomized-controlled-exploratory-study
#12
Karim El-Kersh, Bilal Jalil, Stephen A McClave, Rodrigo Cavallazzi, Juan Guardiola, Karen Guilkey, Annuradha K Persaud, Stephen P Furmanek, Brian E Guinn, Timothy L Wiemken, Mohamed Saad
PURPOSE: We investigated whether early enteral nutrition alone may be sufficient prophylaxis against stress-related gastrointestinal (GI) bleeding in mechanically ventilated patients. MATERIALS AND METHODS: Prospective, double blind, randomized, placebo-controlled, exploratory study that included mechanically ventilated patients in medical ICUs of two academic hospitals. Intravenous pantoprazole and early enteral nutrition were compared to placebo and early enteral nutrition as stress-ulcer prophylaxis...
August 26, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28851369/evaluation-of-the-effect-of-different-sitting-assistive-devices-in-reclining-wheelchair-on-interface-pressure
#13
Chun-Ting Li, Kuo-Yuan Huang, Chien-Feng Kung, Yen-Nien Chen, Yen-Ting Tseng, Kuen-Horng Tsai
BACKGROUND: Reclining wheelchair users often add one or more sitting assistive devices to their wheelchairs, but the effect of these additional sitting assistive devices on the risk of pressure ulcers has rarely been investigated. This study examined the four modes of reclining wheelchair without and with different sitting assistive devices, namely the back reclined mode, the lumbar support with back reclined mode, the femur upward with back reclined mode, and the lumbar support with femur upward with back reclined mode, in terms of their effects on human-wheelchair interface pressure...
August 29, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28846960/impact-of-obesity-and-mood-disorders-on-physical-comorbidities-psychological-well-being-health-behaviours-and-use-of-health-services
#14
Ahmed Jérôme Romain, Jacques Marleau, Aurélie Baillot
BACKGROUND: Albeit obesity and mood disorders frequently co-occur, few studies examined the impacts of this co-occurrence. The aim was to compare individuals with obesity and mood disorders (ObMD) to those with obesity without mood disorder in terms of physical comorbidities, psychological well-being, health behaviours and use of health services. METHODS: Cross-sectional study using the Canadian Community Health Survey including a weighted sample of individuals with obesity (n = 1298) representing inhabitants from the province of Quebec (Canada)...
August 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28837515/dietary-polyphenols-in-the-aetiology-of-crohn-s-disease-and-ulcerative-colitis-a-multicenter-european-prospective-cohort-study-epic
#15
Yunxia Lu, Raul Zamora-Ros, Simon Chan, Amanda J Cross, Heather Ward, Paula Jakszyn, Robert Luben, Jorrit L Opstelten, Bas Oldenburg, Göran Hallmans, Pontus Karling, Olof Grip, Timothy Key, Manuela M Bergmann, Heiner Boeing, Kim Overvad, Domenico Palli, Giovanna Masala, Kay-Tee Khaw, Antoine Racine, Franck Carbonnel, Marie-Christine Boutron-Ruault, Vibeke Andersen, Anja Olsen, Anne Tjonneland, Rudolf Kaaks, Rosario Tumino, Antonia Trichopoulou, Augustin Scalbert, Elio Riboli, Andrew R Hart
BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols...
August 22, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28836746/review-of-biosimilars-of-adalimumab
#16
V V Kaushik
A first fully humanized monoclonal antibody approved by US Food and Drug Administration (FDA) in 2002 was Adalimumab. Clinical efficacy and safety of adalimumab has been assessed in various trials in rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, Crohn's Disease, and ulcerative colitis. It is one of the major sales success among biological and still one of the greatest blockbuster amongst monoclonal antibodies. With the advent of patent expiry of the parent drug HUMIRA, several potential biosimilars have debuted in various markets worldwide...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28834889/the-association-between-peptic-ulcer-diseases-and-mental-health-problems-a-population-based-study-a-strobe-compliant-article
#17
Young Bok Lee, Jihan Yu, Hyun Ho Choi, Bu Seok Jeon, Hyung-Keun Kim, Sang-Woo Kim, Sung Soo Kim, Yong Gyu Park, Hiun Suk Chae
This study aimed to investigate the association between the prevalence of peptic ulcer disease (PUD) and mental health problems, such as severe stress, depressive mood, and suicidal ideation.The population-based cross-sectional study was comprised of 14,266 subjects participating in the fourth annual Korea National Health and Nutrition Examination survey from 2007 to 2009. The participants were divided into 2 groups according to the self-reported questionnaires: the PUD group and the non-PUD group. The association between PUD and mental health problems, such as severe stress, depressed mood, suicidal ideation, and psychological counseling history, were evaluated by using multivariate analysis and logistic regression...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28832517/therapeutic-potential-of-amino-acids-in-inflammatory-bowel-disease
#18
REVIEW
Yulan Liu, Xiuying Wang, Chien-An Andy Hu
Inflammatory bowel disease (IBD), which includes both ulcerative colitis and Crohn's disease, is a chronic relapsing inflammation of the gastrointestinal tract, and is difficult to treat. The pathophysiology of IBD is multifactorial and not completely understood, but genetic components, dysregulated immune responses, oxidative stress, and inflammatory mediators are known to be involved. Animal models of IBD can be chemically induced, and are used to study etiology and to evaluate potential treatments of IBD...
August 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28828176/erratum-to-pediatric-intensive-care-stress-ulcer-prevention-pic-up-a-protocol-for-a-pilot-randomized-trial
#19
Mark Duffett, Karen Choong, Jennifer Foster, Elaine Gilfoyle, Jacques Lacroix, Nikhil Pai, Lehana Thabane, Deborah J Cook
[This corrects the article DOI: 10.1186/s40814-017-0142-y.].
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28821163/metformin-maintains-mucosal-integrity-in-experimental-model-of-colitis-by-inhibiting-oxidative-stress-and-pro-inflammatory-signaling
#20
Abhimanu Pandey, Sneh Verma, Vijay L Kumar
Metformin, an antidiabetic drug, is well known for its multifarious properties and its ability to modulate inflammatory cascade. Ulcerative colitis (UC) is an inflammatory condition of the colon where drugs exhibiting anti-inflammatory property have been shown to induce and maintain remission. The objective of the present study was to evaluate the efficacy of metformin against acetic-acid induced colitis in rat. The study included five groups of rats namely normal control, experimental control, drug treated groups (50 and 500mg/kg of metformin, MET50, MET500 and 300mg/kg of mesalazine, MSZ300)...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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