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https://www.readbyqxmd.com/read/30336432/evaluation-of-the-estrogen-receptor-alpha-as-a-possible-target-of-bifenthrin-effects-in-the-estrogenic-and-dopaminergic-signaling-pathways-in-zebrafish-embryos
#1
Luísa Becker Bertotto, Subham Dasgupta, Sara Vliet, Stacia Dudley, Jay Gan, David C Volz, Daniel Schlenk
Bifenthrin (BF) is a pyrethroid insecticide widely used in urban and agricultural applications. Previous studies in embryos of zebrafish have shown that BF can affect estradiol biosynthesis and the dopaminergic system. To examine the role of the estrogen receptor (ER) in the endocrine effects of BF, embryos were exposed for 96 h to a mixture of 0.15 and 1.5 μg/L BF and an ER agonist (17α-ethynylestradiol - EE2) at 0.09 μg/L. Transcripts related to estrogenic (vitellogenin VTG) and dopaminergic (tyrosine hydroxylase (TH), dopamine receptor 1 (DR1), monoamine oxidase (MAO), and catechol-O-methyltransferase b (COMTb)) signaling pathways were investigated by qRT-PCR...
October 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30336414/sustainability-of-construction-materials-electrodialytic-technology-as-a-tool-for-mortars-production
#2
C Magro, J M Paz-Garcia, L M Ottosen, E P Mateus, A B Ribeiro
The reduction of tap water consumption in all activity sectors, including the building industry, is crucial to the sustainability of water resources. Effluents from wastewater treatment plants have the potential to replace freshwater in the construction sector but they contain a critical mixture of impurities, which hampers their use in mortars production. In this work, the viability of using effluent as an alternative to potable water for the production of mortars, after electrodialytic treatment, was assessed...
October 4, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/30336249/the-involvement-of-autophagic-flux-in-the-development-and-recovery-of-doxorubicin-induced-neurotoxicity
#3
Xueyuan Zhou, Pengfei Xu, Ruili Dang, Yujin Guo, Gongying Li, Yi Qiao, Ruining Xie, Yuanyuan Liu, Pei Jiang
Doxorubicin (Dox) is an effective anti-cancer agent, whose clinical use is limited by the cytotoxicity in non-target tissues, especially the heart and brain. The drug-induced neuronal damage is primarily mediated by oxidative stress, in which autophagy plays a central role. Although numerous studies indicate the involvement of autophagy in neurodegenerative diseases and brain injury, the evidence concerning autophagic process in Dox-induced neuronal death is limited. We found that repeated Dox administration induced the protein expression of LC3II and P62 and impaired autophagic flux with enhanced autophagasome accumulation in rat hippocampus, whereas two weeks after the cessation of Dox treatment, the autophagic process was restored, even stimulated, with normalized protein levels of LC3II and P62 and enhanced expression of Becline-1, indicating a compensatory response in the recovery state...
October 15, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30336233/extracorporeal-life-support-in-the-emergency-department-a-narrative-review-for-the-emergency-physician
#4
REVIEW
Justyna Swol, Jan Belohlávek, Daniel Brodie, Joseph Bellezzo, Scott D Weingart, Zachary Shinar, Andreas Schober, Matthew Bachetta, Jonathan W Haft, Shingo Ichiba, Tetsuya Sakamoto, Giles J Peek, Roberto Lorusso, Steven A Conrad
BACKGROUND: Extracorporeal life support (ECLS) describes the use of blood perfusion devices to provide advanced cardiac or respiratory support. Advances in percutaneous vascular cannula insertion, centrifugal pump technologies, and the miniaturization of extracorporeal devices have simplified ECLS. The intention of this discussion is to review the role of ECLS as a potential rescue method for emergency department (ED) clinicians in critical clinical scenarios and to focus on the prerequisites for managing an ECLS program in an ED setting...
October 15, 2018: Resuscitation
https://www.readbyqxmd.com/read/30335991/synthetic-control-on-structure-dimensionality-and-photophysical-properties-of-low-dimensional-organic-lead-bromide-perovskite
#5
Muhammed P U Haris, Rangarajan Bakthavatsalam, Samir Shaikh, Bhushan P Kore, Dhanashree Moghe, Rajesh G Gonnade, D D Sarma, Dinesh Kabra, Janardan Kundu
Low dimensional lead halide perovskites have attracted huge research interest due to their structural diversity and remarkable photophysical properties. The ability to controllably change dimensionality/structure of perovskites remains highly challenging. Here, we report synthetic control on structure/dimensionality of ethylenediammonium (ED) lead bromide perovskite from a two dimensionally networked (2DN) sheet to a one dimensionally networked (1DN) chain structure. Intercalation of solvent molecules into the perovskite plays a crucial role in directing the final dimensionality/structure...
October 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/30335924/diagnosis-and-treatment-of-posttraumatic-arteriovenous-fistula-in-the-lower-leg-a-case-report
#6
Jan Sobstyl, Maryla Kuczyńska, Ewa Kuklik, Łukasz Światłowski, Maria Tsitskari, Tomasz Jargiełło
External injuries are one of the common reasons for reporting to hospital emergency departments. Peripheral vascular injuries occur in up to about 25% of upper and lower extremity injury cases. Arteriovenous fistula is a type of arterial injury. Doppler ultrasound is currently the primary diagnostic method for vascular injuries as it allows for the implementation of appropriately targeted treatment, indicating the potential need for extended diagnosis or patient qualification for endovascular or classical surgery...
2018: Journal of Ultrasonography
https://www.readbyqxmd.com/read/30335857/confounding-factors-in-algal-phosphorus-limitation-experiments
#7
Whitney S Beck, Ed K Hall
Assessing algal nutrient limitation is critical for understanding the interaction of primary production and nutrient cycling in streams, and nutrient diffusing substrate (NDS) experiments are often used to determine limiting nutrients such as nitrogen (N) and phosphorus (P). Unexpectedly, many experiments have also shown decreased algal biomass on NDS P treatments compared to controls. To address whether inhibition of algal growth results from direct P toxicity, NDS preparation artifacts, or environmental covariates, we first quantified the frequency of nutrient inhibition in published experiments...
2018: PloS One
https://www.readbyqxmd.com/read/30335691/attitudes-and-opinions-of-adolescent-females-regarding-2-methods-of-bladder-filling-for-transabdominal-ultrasound-a-q-sort-study
#8
Marie R Waterhouse, Phung K Pham, Todd P Chang
OBJECTIVES: Adolescent female patients who are not sexually active and who present to a pediatric emergency department with abdominal pain require a full bladder prior to transabdominal ultrasound. Procedures to fill the bladder are largely institution or provider dependent. We examined adolescent females' attitudes and opinions toward 2 common methods of bladder filling, intravenous fluid administration and transurethral Foley catheter placement, by means of a Q-sort study. METHODS: Two convenience samples of adolescent female patients in the pediatric emergency department at an academic children's hospital participated in the study...
October 17, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30335689/seizures-meds-and-vtach-a-journey-to-a-brugada-diagnosis
#9
David P Fitzgerald, Srikant Das, Matthew P Malone, B Shane Holland, Stephen M Schexnayder
Sudden cardiac arrest of cardiac etiology is rare in children and adolescents and most often occurs with exertion. Conversely, syncope is a common pediatric emergency department complaint but rarely is associated with a serious underlying cardiac disorder. This report describes a case of the channelopathy Brugada syndrome (BrS) as a cause of sudden cardiac arrest in a febrile preadolescent child taking medications known to affect cardiac conduction. The patient received cardiopulmonary resuscitation and was successfully defibrillated...
October 17, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30335688/vascular-endothelial-growth-factor-and-soluble-vascular-endothelial-growth-factor-receptor-as-novel-biomarkers-for-poor-outcomes-in-children-with-severe-sepsis-and-septic-shock
#10
Jane E Whitney, Melanie Silverman, Jackson S Norton, Richard G Bachur, Elliot Melendez
Vascular endothelial growth factor (VEGF) and its receptor, soluble fms-like tyrosine kinase (sFLT), are biomarkers of endothelial activation. Vascular endothelial growth factor and sFLT have been associated with sepsis severity among adults, but pediatric data are lacking. The goal of this study was to assess VEGF and sFLT as predictors of outcome for children with sepsis. METHODS: Biomarkers measured for each patient at time of presentation to the emergency department were compared in children with septic shock versus children with sepsis without shock...
October 17, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30335687/practice-pattern-variation-in-test-ordering-for-low-acuity-pediatric-emergency-department-patients
#11
Kaynan Doctor, Kristen Breslin, James M Chamberlain, Deena Berkowitz
OBJECTIVES: Rising costs in healthcare have focused attention on interventions to optimize efficiency of patient care, including decreasing unnecessary diagnostic testing. The primary objective of this study was to determine the variability of laboratory and radiology testing among licensed independent providers (LIPs) with different training backgrounds treating low-acuity patients in a pediatric emergency department (PED). METHODS: We performed a retrospective review of the electronic health records of all encounters with patients 21 years or younger, triaged as low-acuity, visiting 2 urban, academic PEDs from January 2012 to December 2013...
October 17, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30335685/a-7-day-old-male-infant-with-carbon-monoxide-poisoning-treated-with-hyperbaric-oxygen
#12
Caner Turan, Eylem Ulas Saz
OBJECTIVE: Children are presented with an unknown intoxication at emergency department (ED) after carbon monoxide (CO) poisoning. Although CO poisoning is well defined in the adult literature, little information exists regarding CO poisoning in childhood, especially in infants. The only diagnostic test for CO poisoning is elevation of the carboxyhemoglobin level in the blood. CASE: We report the second youngest neonate in literature who was severely poisoned by CO and treated with hyperbaric oxygen at the ED...
October 17, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30335674/dc-sign-expression-in-intestinal-epithelial-cells-regulates-sepsis-associated-acute-intestinal-injury-via-activating-erk1-2-nf-%C3%AE%C2%BAb-p65-signaling
#13
Weiwei Chen, Li Ma, Ranran Li, Shunwei Huang, Rongli Xie, Ying Chen, Bing Zhao, Jian Fei, Hongping Qu, Hao Chen, Enqiang Mao, Er-Zhen Chen
OBJECTIVE: The aim of the study was to investigate the role of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) in intestinal epithelial cells (IECs) in regulating sepsis-induced acute intestinal injury and systemic inflammatory response. METHODS: To induce sepsis condition, Male C57BL/6 mice were exposed to cecal ligation and puncture (CLP) in vivo, whereas a normal human IECs line (FHs74Int) was stimulated with lipopolysaccharide (LPS) in vitro...
October 17, 2018: Shock
https://www.readbyqxmd.com/read/30335617/the-patient-centered-oncology-care-on-health-care-utilization-and-cost-a-systematic-review-and-meta-analysis
#14
Hailun Liang, Lei Tao, Eric W Ford, May A Beydoun, Shaker M Eid
BACKGROUND: Optimal cancer care entails coordination among multiple providers and continued follow-up and surveillance over time. The patient-centered care brings opportunities to improve the delivery of cancer care. The adoption of patient-centered oncology care (PCOC) is in its infancy. Evidence synthesis on the model's effectiveness is scant. PURPOSES: This is the first systemic review and meta-analysis on associations of PCOC with cancer patients' adverse health care utilization, cost, patient satisfaction, and quality of care...
October 17, 2018: Health Care Management Review
https://www.readbyqxmd.com/read/30335496/ace-2-ang1-7-ameliorates-er-stress-induced-apoptosis-in-seawater-aspiration-induced-acute-lung-injury
#15
MinLong Zhang, Yongheng Gao, Gaole Yu, Weiguo Zhao, Faguang Jin
Previous studies have shown that apoptosis of alveolar cells can be regulated by autocrine of ANGII and its counter regulatory ACE-2/ANG1-7 axis. Our earlier study has shown that ER stress in response to seawater aspiration eventually led to apoptosis in lung tissue. In this study, we examined the hypothesis that ER stress induced apoptosis in seawater aspiration-induced ALI might also be regulated by ANGII/ANG1-7 system. ER stress was induced by seawater stimulation and proteasome inhibitor MG132 (an ER stress inductor) ...
October 18, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/30335213/scanning-fluorescence-correlation-spectroscopy-for-quantification-of-the-dynamics-and-interactions-in-tube-organelles-of-living-cells
#16
Joseph D Unsay, Fabronia Murad, Eduard Hermann, Jonas Ries, Ana J García-Sáez
Single-molecule spectroscopic quantification of protein-protein interactions directly in the organelles of living cells is highly desirable but remains challenging. Bulk methods, such as Förster resonance energy transfer (FRET), currently only give a relative quantification of the strength of protein-protein interactions. Here, we introduce tube scanning fluorescence cross-correlation spectroscopy (tubeSFCCS) for the absolute quantification of diffusion and complex formation of fluorescently labeled molecules in the mitochondrial compartments...
October 18, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/30334869/where-do-people-go-for-gonorrhea-and-chlamydia-tests-a-cross-sectional-view-of-the-central-indiana-population-2003-2014
#17
Teresa A Batteiger, Brian E Dixon, Jane Wang, Zuoyi Zhang, Guoyu Tao, Yan Tong, Wanzhu Tu, Sarah A Hoover, Janet N Arno
BACKGROUND: Despite major efforts to control their spread, reported sexually transmitted infections (STI) are increasing. Using data from a mid-sized Midwest metropolitan area, we examined the settings in which individuals are tested for gonorrhea and chlamydia in relation to demographics and test result to determine where interventions may best be focused. METHODS: A de-identified and integrated registry, containing records from all patients tested for an STI from 2003-2014, was created by combining data from a large health information exchange and the reporting district's STI Program located in Indianapolis, IN...
October 16, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/30334649/is-cybervictimization-associated-with-body-dissatisfaction-depression-and-eating-disorder-psychopathology
#18
José H Marco, Maria Pilar Tormo-Irun, Alba Galán-Escalante, Carmen Gonzalez-García
Studies carried out in nonclinical samples have found an association between cyberbullying victimization and eating disorder (ED) psychopathology (negative emotions, low self-esteem, unhealthy eating behaviors, and body dissatisfaction); however, these previous studies were carried out with participants without an ED diagnosis. To extend the knowledge in this area of research, we aim to confirm these associations in two different samples: on the one hand, a sample composed of participants with ED diagnoses and, on the other hand, a sample composed of participants at high risk of ED...
October 2018: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/30334555/variable-coordination-of-carbazolyl-bis-tetrazole-ligands-in-lanthanide-chemistry
#19
Leah Gajecki, David J Berg, Josh Hoenisch, Allen G Oliver
The synthesis of the protioligand 1,8-bis(2'-isopropyltetrazo-5'-yl)-3,6-di-tert-butylcarbazole, HCzTiPr 2, is described. The acid-base reaction of 2 with various Ln[N(SiMe3)2]3 (Ln = Ce, Sm, Er, Yb, Y) precursors leads to products displaying a variety of different bonding modes for the CzTiPr- ligand as revealed by X-ray crystallographic studies. The smaller lanthanides form Ln(CzTiPr)[N(SiMe3)2]2 complexes (Ln = Er (3), Yb(4)) with a near planar, tridentate coordination mode for the CzTiPr- ligand. In contrast, the larger lanthanides form Ln(CzTiPr)2[N(SiMe3)2] complexes (Ln = Ce (5), Sm (6)) at room temperature that feature a sandwich structure with a highly distorted tridentate mode where tetrazole canting allows the metal to sit well out of the carbazole plane...
October 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30334551/thioredoxin-silencing-induced-cardiac-supercontraction-occurs-through-endoplasmic-reticulum-stress-and-calcium-overload-in-chicken
#20
Jie Yang, Yafan Gong, Qi Liu, Jingzeng Cai, Bo Zhang, Ziwei Zhang
The thioredoxin (Txn) system is the most crucial antioxidant defense mechanism in the myocardium, and hampering the Txn system may compromise cell survival. Calcium (Ca) imbalance is associated with a variety of cardiomyopathies, and dysregulation of Ca2+ homeostasis is often considered a critical starting point for heart disease. However, the roles of Txn and the Txn system in maintaining Ca2+ homeostasis in cardiomyocytes have been infrequently reported. Here, we examined the expression of genes associated with Ca2+ channels using a model of Txn suppression in cardiomyocyte cultures (siRNA and Txn inhibitor) and report that Txn knockdown can cause Ca2+ overload in the myocardial cytoplasm and release of endoplasmic reticulum (ER) Ca2+, which induces ER stress...
October 18, 2018: Metallomics: Integrated Biometal Science
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