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https://www.readbyqxmd.com/read/30098342/important-roles-of-the-ca-2-sensing-receptor-in-vascular-health-and-disease
#1
REVIEW
Yanjun Guo, Xin Yang, Jialin He, Jingjing Liu, Shiming Yang, Hui Dong
Ca2+ -sensing receptor (CaSR), a member of G protein-coupled receptor family, is widely expressed in the vascular system, including perivascular neurons, vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs). When stimulated, CaSR can further increase the cytosolic Ca2+ concentration ([Ca2+ ]cyt ) in two ways: intracellular Ca2+ release from endo/sarcoplasmic reticulum (ER/SR) and extracellular Ca2+ entry through Ca2+ -permeable cation channels. In endothelium, increased Ca2+ subsequently activate nitric oxide synthase (NOS) and intermediate conductance Ca2+ -activated K+ channels (IKCa), resulting in vasodilation through NOS-mediated NO release or membrane hyperpolarization...
August 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/30098230/randomized-clinical-trial-comparing-procedural-amnesia-and-respiratory-depression-between-moderate-versus-deep-sedation-with-propofol-in-the-emergency-department
#2
Lexandra Schick, Brian Driver, Johanna C Moore, Erik Fagerstrom, James R Miner
OBJECTIVES: To determine if there is a difference in procedural amnesia and adverse respiratory events (ARE) between the target sedation levels of moderate (MS) and deep (DS) procedural sedation. METHODS: This was a prospective, randomized clinical trial of consenting adult patients planning to undergo deep procedural sedation with propofol between March 5th , 2015 and May 24th , 2017. Patients were randomized to a target sedation level of moderate or deep sedation using the American Society of Anesthesiologist's definitions...
August 11, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/30098214/yy1-binds-to-the-e3-enhancer-and-inhibits-the-expression-of-the-immunoglobulin-kappa-gene-via-epigenetic-modifications
#3
Xiaorong Zhou, Weiwei Xian, Jie Zhang, Yiqing Zhu, Xiaoyi Shao, Yu Han, Yue Qi, Xiaoling Ding, Xiaoying Wang
The rearrangement and expression of immunoglobulin (Ig) genes is regulated by enhancers and their binding transcriptional factors that activate or suppress the activities of the enhancers. The immunoglobulin kappa (Igκ) gene locus has three important enhancers, i.e. the intrinsic enhancer (Ei), 3' enhancer (E3'), and distal enhancer (Ed). Ei and E3' are both required for Igκ gene rearrangement during early stages of B cell development, whereas optimal expression of the rearranged Igκ gene relies on both E3' and Ed...
August 11, 2018: Immunology
https://www.readbyqxmd.com/read/30098024/intranasal-lidocaine-for-acute-management-of-primary-headaches-a-systematic-review
#4
Renée Dagenais, Peter J Zed
Intranasal lidocaine has been studied and recommended as an alternative in the management of acute headache. The objective of this systematic review was to evaluate the efficacy and safety of intranasal lidocaine in the acute management of primary headaches. The MEDLINE (1946 to May 2018), EMBASE (1974 to May 2018), Cochrane Central Register of Controlled Trials (2008 to May 2018), Cumulative Index to Nursing and Allied Health Literature (CINAHL) (1982 to May 2018), and ClincialTrials. gov online databases were searched...
August 11, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30098003/a-6-month-prospective-randomized-controlled-trial-of-remotely-delivered-group-format-epilepsy-self-management-versus-waitlist-control-for-high-risk-people-with-epilepsy
#5
Martha Sajatovic, Kari Colon-Zimmermann, Mustafa Kahriman, Edna Fuentes-Casiano, Hongyan Liu, Curtis Tatsuoka, Kristin A Cassidy, Samden Lhatoo, Douglas Einstadter, Peijun Chen
OBJECTIVE: Despite advances in care, many people with epilepsy have negative health events (NHEs) such as accidents, emergency department visits, and poor quality of life. "Self-management for people with epilepsy and a history of negative health events" (SMART) is a novel group format epilepsy self-management intervention. A community participatory approach informed the refinement of SMART, which was then tested in a 6-month randomized controlled trial of SMART (n = 60) versus waitlist control (WL, n = 60)...
August 10, 2018: Epilepsia
https://www.readbyqxmd.com/read/30097999/dna-primase-polypeptide-1-prim1-involves-in-estrogen-induced-breast-cancer-formation-through-activation-of-the-g2-m-cell-cycle-checkpoint
#6
Wei-Hwa Lee, Li-Ching Chen, Chia-Jung Lee, Chi-Cheng Huang, Yuan-Soon Ho, Po-Sheng Yang, Chi-Tang Ho, Hang-Lung Chang, I-Hsuan Lin, Hui-Wen Chang, Yun-Ru Liu, Chih-Hsiung Wu, Shih-Hsin Tu
The DNA primase polypeptide 1 (PRIM1) is responsible for synthesizing small RNA primers for Okazaki fragments generated during discontinuous DNA replication. PRIM1 mRNA expression levels in breast tumor samples were detected by real-time PCR analysis. Xenografted tumor model was established to study the carcinogenic role of PRIM1 and its potential therapeutic applications. The average PRIM1 mRNA (copy number x 103 /μg) expression was 4.7-fold higher in tumors than in normal tissue (*p = 0.005, n = 254). PRIM1 was detected preferentially at a higher level (> 40-fold) in poorly differentiated tumor tissues (n = 46) compared with more highly differentiated tumors tissues (n = 10) (*p = 0...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30097978/screening-positive-for-cognitive-impairment-impact-on-healthcare-utilization-and-provider-action-in-primary-and-specialty-care-practices
#7
Michael Rosenbloom, Terry R Barclay, Soo Borson, Ann M Werner, Lauren O Erickson, Jean M Crow, Kamakshi Lakshminarayan, Logan H Stuck, Leah R Hanson
BACKGROUND: Alzheimer's disease, the most common cause of dementia, goes unrecognized in half of patients presenting to healthcare providers and is associated with increased acute care utilization. Routine cognitive screening of older adults in healthcare settings could improve rates of dementia diagnosis and patterns of healthcare utilization. OBJECTIVE: To evaluate the impact of screening positive for cognitive impairment on provider action in primary and specialty care practices and patient healthcare utilization...
August 10, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/30097775/the-lysosome-and-intracellular-signalling
#8
Geoffrey G Hesketh, Lena Wartosch, Luther J Davis, Nicholas A Bright, J Paul Luzio
In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The cytosolic surface of the limiting membrane of the lysosome is the site of activation of the multiprotein complex mammalian target of rapamycin complex 1 (mTORC1), which phosphorylates numerous cell growth-related substrates, including transcription factor EB (TFEB)...
2018: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/30097771/integration-of-the-endocytic-system-into-the-network-of-cellular-functions
#9
Noga Budick-Harmelin, Marta Miaczynska
Maintenance of physiologic cellular functions and homeostasis requires highly coordinated interactions between different cellular compartments. In this regard, the endocytic system, which plays a key role in cargo internalization and trafficking within the cell, participates in upkeep of intracellular dynamics, while communicating with multiple organelles. This chapter will discuss the function of endosomes from a standpoint of cellular integration. We will present examples of different types of interactions between endosomes and other cellular compartments, such as the endoplasmic reticulum (ER), mitochondria, the plasma membrane (PM), and the nuclear envelope...
2018: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/30097770/the-endosomal-network-mediators-and-regulators-of-endosome-maturation
#10
Maria Podinovskaia, Anne Spang
Endocytosis is a means for the cell to sample its environment for nutrients and regulate plasma membrane (PM) composition and area. Whereas the majority of internalized cargo is recycled back to the cell surface, select material is sent to the lysosome for degradation. Endosomes further play major roles in central cell activities as diverse as establishment of cell polarity and signaling, lysosomal storage and immunity. The complexity of endosomal functions is reflected by the extensive changes to endosome properties as they mature...
2018: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/30097750/blunt-traumatic-vascular-injuries-of-the-head-and-neck-in-the-ed
#11
Elizabeth George, Ashish Khandelwal, Christopher Potter, Aaron Sodickson, Srinivasan Mukundan, Diego Nunez, Bharti Khurana
Cerebrovascular injury is increasingly identified in patients presenting after blunt trauma due to the implementation of screening criteria and advances in noninvasive angiographic imaging by CT. The variable latent time before onset of secondary stroke presents a window of opportunity for prevention, reinforcing the importance of detection of asymptomatic patients via screening. Furthermore, the high morbidity and mortality associated with secondary stroke makes it imperative that radiologists recognize these challenging injuries...
August 10, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/30097598/a-superfolder-variant-of-ph-sensitive-phluorin-for-in-vivo-ph-measurements-in-the-endoplasmic-reticulum
#12
Mara Reifenrath, Eckhard Boles
Many cellular processes are regulated via pH, and maintaining the pH of different organelles is crucial for cell survival. A pH-sensitive GFP variant, the so-called pHluorin, has proven to be a valuable tool to study the pH of the cytosol, mitochondria and other organelles in vivo. We found that the fluorescence intensity of Endoplasmic Reticulum (ER)-targeted pHluorin in the yeast Saccharomyces cerevisiae was very low and barely showed pH sensitivity, probably due to misfolding in the oxidative environment of the ER...
August 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30097535/comprehensive-proteomics-identification-of-ifn-%C3%AE-3-regulated-anti-viral-proteins-in-hbv-transfected-cells
#13
Jiradej Makjaroen, Poorichaya Somparn, Kenneth Hodge, Witthaya Poomipak, Nattiya Hirankarn, Trairak Pisitkun
Interferon lambda (IFN-λ) is a relatively unexplored, yet promising anti-viral agent. IFN-λ has recently been tested in clinical trials of chronic hepatitis B virus infection (CHB), with the advantage that side effects may be limited compared with IFN-α, as IFN-λ receptors are found only in epithelial cells. To date, IFN-λ's downstream signaling pathway remains largely unelucidated, particularly via proteomics methods. Here, we report that IFN-λ3 inhibits HBV replication in HepG2.2.15 cells, reducing levels of both HBV transcripts and intracellular HBV DNA...
August 10, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/30097456/could-this-be-whooping-cough
#14
Patrick Nee, Elaine Weir, Madhur Vardhan, Ankita Vaidya
Whooping cough is a notifiable bacterial respiratory infection caused by Bordetella pertussis It may produce serious disease, especially in immunocompromised individuals and very young children. The number of reported cases increases in the winter months and the incidence peaks every 4-5 years. However, this periodicity is variable and is inconsistent between different geographical regions. Bordetella pertussis infection (BPI) may be underdiagnosed because of its seasonality and the fact that clinical features may be indistinguishable from other respiratory disorders in the paediatric ED setting...
August 10, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/30097312/earlyr-a-robust-gene-expression-signature-for-predicting-outcomes-of-estrogen-receptor-positive-breast-cancer
#15
Steven A Buechler, Yesim Gökmen-Polar, Sunil S Badve
INTRODUCTION: Early stage estrogen receptor (ER)-positive breast cancer may be treated with chemotherapy in addition to hormone therapy. Currently available molecular signatures assess the risk of recurrence and the benefit of chemotherapy; however, these tests may have large intermediate risk groups, limiting their usefulness. METHODS: The EarlyR prognostic score was developed using integrative analysis of microarray data sets and formalin-fixed, paraffin-embedded-based quantitative real-time PCR assay and validated in Affymetrix data sets and METABRIC cohort using Cox proportional hazards models and Kaplan-Meier survival analysis...
July 17, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/30097282/endoplasmic-reticulum-stress-mediates-4-5-dichloro-2-n-octyl-4-isothiazolin-3-one-dcoit-induced-toxicity-and-liver-lipid-metabolism-changes-in-nile-tilapia-oreochromis-niloticus
#16
Yujie Su, Huifeng Li, Chang Xu, Xiaodan Wang, Jia Xie, Jian G Qin, Liqiao Chen, Erchao Li
DCOIT (4,5-dichloro-2-n-octyl-4-isothiazolin-3-one) is the main active ingredient in an emerging water environment antifoulant, the toxicity and environmental impacts of which need to be further investigated. Thus, this study examined the toxicity of DCOIT on Nile tilapia (Oreochromis niloticus), including its effects on behavior, respiration and energy metabolism as well as the role of endoplasmic reticulum stress (ER stress) in mediating its toxicity and metabolic changes. The changes in fish behavior, respiration, neuronal signal transmission, energy metabolism, ER stress, and liver histology were examined via acute (4 days) and chronic (28 days) exposures to 0, 3, 15, 30 μg/L DCOIT in vivo...
July 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/30097276/diagnostic-accuracy-of-laboratory-and-ultrasound-findings-in-patients-with-a-non-visualized-appendix
#17
Laurie Malia, Jesse J Sturm, Sharon R Smith, R Timothy Brown, Brendan Campbell, Henry Chicaiza
Ultrasound (US) and laboratory testing are initial diagnostic tests for acute appendicitis. A diagnostic dilemma develops when the appendix is not visualized on US. OBJECTIVE: To determine if specific US findings and/or laboratory results predict acute appendicitis when the appendix is not visualized. METHODS: A prospective study was conducted on children (birth-18 yrs) presenting to the pediatric emergency department with suspected acute appendicitis who underwent right lower quadrant US...
August 7, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30097272/impact-of-an-emergency-medicine-pharmacist-on-empiric-antibiotic-prescribing-for-pneumonia-and-intra-abdominal-infections
#18
Benjamin D Kulwicki, Kasey L Brandt, Lauren M Wolf, Andrew J Weise, Lisa E Dumkow
PURPOSE: It is critical to engage ED providers in antimicrobial stewardship programs (ASP). Emergency medicine pharmacists (EMPs) play an important role in ASP by working with providers to choose empiric antimicrobials. This study aimed to determine the impact of an EMP on appropriate empiric antibiotic prescribing for community-acquired pneumonia (CAP) and intra-abdominal infections (CA-IAI). METHODS: A retrospective cohort study was conducted evaluating adult patients admitted with CAP or CA-IAI...
July 29, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30097208/a-sticky-situation-meconium-aspiration-in-the-emergency-department
#19
Lisa Huang, Elizabeth J Winokur
No abstract text is available yet for this article.
August 7, 2018: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/30097117/aqueous-extracts-of-paeonia-suffruticosa-modulates-mitochondrial-proteostasis-by-reactive-oxygen-species-induced-endoplasmic-reticulum-stress-in-pancreatic-cancer-cells
#20
Yu-Huei Liu, Yui-Ping Weng, Hsin-Ying Tsai, Chao-Jung Chen, Der-Yen Lee, Ching-Liang Hsieh, Yang-Chang Wu, Jung-Yaw Lin
BACKGROUND: Pancreatic cancer (PC) remains the leading cause of cancer mortality, with limited therapeutic targets, and alterations in endoplasmic reticulum (ER)-related proteostasis may be a potential target for therapy. The root bark of Paeonia suffruticosa has been shown to inhibit cancer growth and metastasis, although its impact on PC is unknown. PURPOSE: To ascertain the anti-cancer effects of P. suffruticosa on oncogenic functions of PC and determine the detailed molecular mechanisms...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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