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https://www.readbyqxmd.com/read/30554433/sog1-dependent-nac103-modulates-the-dna-damage-response-as-a-transcriptional-regulator-in-arabidopsis
#1
Tae Ho Ryu, Young Sam Go, Seung Hee Choi, Jeong-Il Kim, Byung Yeoup Chung, Jin-Hong Kim
The plant-specific transcription factor (TF) NAC103 was previously reported to modulate the unfolded protein response in Arabidopsis under endoplasmic reticulum (ER) stress. Alternatively, we here report that the NAC103 is involved in the downstream signaling of SOG1, a master regulator for expression of DNA damage response (DDR) genes induced by genotoxic stress. Arabidopsis NAC103 expression was strongly induced by genotoxic stress and nac103 mutants displayed substantial inhibition of DDR gene expression after gamma radiation or radiomimetic zeocin treatment...
December 15, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/30554079/lipid-exchange-at-er-mitochondria-contact-sites-a-puzzle-falling-into-place-with-quite-a-few-pieces-missing
#2
REVIEW
Carmelina Petrungaro, Benoît Kornmann
Over the last years, the importance of inter-organelle communication has become more and more evident, attested by the fast growing number of newly-identified membrane contact sites (MCS). At MCSs two organelles are connected via protein tethers that bring them in close proximity to facilitate metabolite exchange. In this review, we will focus on the MCSs connecting the ER and mitochondria, which have been implicated in phospholipid transport. While we already know the molecular identity of some tethers, we are still far from understanding the mechanisms underlying the phospholipid transport processes...
December 13, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/30553987/clinical-tests-to-determine-femoral-version-category-in-people-with-chronic-hip-joint-pain-and-asymptomatic-controls
#3
Alexandria Uding, Nancy J Bloom, Paul K Commean, Travis J Hillen, Jacqueline D Patterson, John C Clohisy, Marcie Harris-Hayes
STUDY DESIGN: Controlled laboratory cross-sectional. OBJECTIVES: To investigate the relationship between femoral version (FV), measured by MRI (FVMRI), Craig's test and hip rotation range of motion (ROM). To determine rotation ROM values associated with FVMRI categories: excessive anteversion, normal version and retroversion. BACKGROUND: Abnormal FV values are associated with hip disorders, such as osteoarthritis, structural instability, acetabular labral tears and femoroacetabular impingement...
December 10, 2018: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/30553973/egr-mediated-control-of-stim-expression-and-function
#4
REVIEW
Christina K Go, Scott Gross, Robert Hooper, Jonathan Soboloff
Ca2+ is a ubiquitous, dynamic and pluripotent second messenger with highly context-dependent roles in complex cellular processes such as differentiation, proliferation, and cell death. These Ca2+ signals are generated by Ca2+ -permeable channels located on the plasma membrane (PM) and endoplasmic reticulum (ER) and shaped by PM- and ER-localized pumps and transporters. Differences in the expression of these Ca2+ homeostasis proteins contribute to cell and context-dependent differences in the spatiotemporal organization of Ca2+ signals and, ultimately, cell fate...
December 6, 2018: Cell Calcium
https://www.readbyqxmd.com/read/30553876/comparative-estrogenicity-of-endogenous-environmental-and-dietary-estrogens-in-pregnant-women-ii-total-estrogenicity-calculations-accounting-for-competitive-protein-and-receptor-binding-and-potency
#5
Paritosh Pande, Stefanie C Fleck, Nathan C Twaddle, Mona I Churchwell, Daniel R Doerge, Justin G Teeguarden
Evaluating the biological significance of human-relevant exposures to environmental estrogens involves assessing the individual and total estrogenicity of endogenous and exogenous estrogens found in serum, for example from biomonitoring studies. We developed a method for this assessment by integrating approaches for (i) measuring total hormone concentrations by mass spectrometry (Fleck et al., 2017), (ii) calculating hormone bioavailable concentrations in serum and, (iii) solving multiple equilibria between estrogenic ligands and receptors, and (iv) quantitatively describing key elements of estrogen potency...
December 13, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30553871/endoplasmic-reticulum-stress-triggered-by-soyasapogenol-b-promotes-apoptosis-and-autophagy-in-colorectal-cancer
#6
Luping Wang, Lu Yun, Xiaojun Wang, Liying Sha, Luning Wang, Yingying Sui, Hui Zhang
AIM: Colorectal cancer (CRC) is a common human malignancy which accounts for 600,000 deaths annually at the global level. Soyasapogenol B (Soy B), an ingredient of soybean, has been found to exert anti-proliferative activities in vitro in human breast cancer cells. The current study aimed to evaluate the efficacy of Soy B in suppressing CRC. METHODS AND MATERIALS: The effect of Soy B on cell viability was assessed using the Cell Counting Kit-8 (CCK-8) assay. The effect of Soy B on cell proliferation was determined using colony formation assay...
December 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/30553844/inhibition-of-protein-tyrosine-phosphatase-1b-protects-against-sevoflurane-induced-neurotoxicity-mediated-by-er-stress-in-developing-brain
#7
Bin Liu, Guoyao Ou, Yali Chen, Jun Zhang
BACKGROUND: ER stress is involved in sevoflurane-induced neurotoxicity. Protein tyrosine phosphatase 1B (PTP1B) resided in the ER membrane is known to regulate ER stress. However, the role of PTP1B in sevoflurane-induced neurotoxicity is unknown. METHOD: Seven-day-old mice treated with 2.3% sevoflurane for 6 hours as animal model. The hippocampal tissues were harvested following sevoflurane exposure for evaluation of ER stress markers with Western blot, ER morphology with transmission electron microscopy and density of dendrite spine with Golgi staining...
December 13, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/30553640/-autochthonous-hydatid-cyst-of-the-lung
#8
Morgan Tourne, Clairelyne Dupin, Pierre Mordant, Mathilde Neuville, Camille Taillé, Claire Danel
Cystic echinococcosis, or hydatidosis, also known as hydatid cyst, is a cosmopolitan parasitosis mainly present in breeding areas. This anthropozoonosis is related to the tissue development of an hydatid of an echinococcus tænia, Echinococcus granulosus, found in the digestive tract of canids, at the adult state. In France, this larval cestosis is essentially an import disease developed by patients from endemic areas such as East and North Africa, South America or Asia. However, autochtonous forms, although rare, still persist...
December 12, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/30553561/amyloid-cardiomyopathy-in-the-emergency-department
#9
Mauricio Baca, Mark Newberry
BACKGROUND: Cardiac amyloidosis is an underdiagnosed cause of restrictive cardiomyopathy resulting from the infiltration of the myocardium by amyloid proteins. CASE REPORT: We report the case of an 83-year-old woman who presented with increasing dyspnea and lower-extremity swelling. She reported a medical history of unspecified heart failure. Evaluation in the Emergency Department (ED) revealed evidence of heart failure on physical examination, low-voltage electrocardiogram, chest x-ray study with mild pulmonary edema, and laboratory evaluation with elevated brain natriuretic peptide and troponin...
December 12, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30553437/novel-mtorc1-mechanism-suggests-therapeutic-targets-for-compopathies
#10
Karen L Posey, Francoise Coustry, Alka C Veerisetty, Mohammad G Hossain, Michael J Gambello, Jacqueline T Hecht
Cartilage oligomeric matrix protein (COMP) is a large, multifunctional extracellular protein that, when mutated, is retained in the rough endoplasmic reticulum (ER). This retention elicits ER stress, inflammation, and oxidative stress, resulting in dysfunction and death of growth plate chondrocytes. While identifying the cellular pathologic mechanisms underlying the murine mutant (MT)-COMP model of pseudoachondroplasia, increased midline-1 (MID1) expression and mammalian target of rapamycin complex 1 (mTORC1) signaling was found...
December 7, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/30553283/discharge-materials-provided-to-patients-with-kidney-stones-in-the-emergency-department-may-be-a-source-of-misinformation
#11
Kevan M Sternberg, Andrew Pham, Theodore Cisu, Marissa L Kildow, Kristina L Penniston
INTRODUCTION: Renal colic is commonly seen in the emergency department (ED), where the focus is on diagnosis and symptom control. Educational materials are sometimes provided upon discharge, however, no standard content has been established. We characterized the educational materials given to patients reporting to EDs in different regions across the U.S. for symptomatic kidney stones, specifically evaluating disease-specific information, symptom management, prevention strategies including dietary recommendations (DRs), and patient follow up plans...
December 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/30553188/clinicopathological-characteristics-of-metaplastic-breast-cancer-analysis-of-the-basic-immunohistochemical-profile-and-comparison-with-other-invasive-breast-cancer-types
#12
M P Budzik, J Patera, M Sobol, A I Czerw, A Deptała, A M Badowska-Kozakiewicz
INTRODUCTION: Metaplastic breast cancer (MpBC) is a rare but aggressive type of breast cancer accounting for 0.25-1% of all diagnosed invasive breast cancers. Morphologically, it is characterized by differentiation of the neoplastic epithelium into squamous cells and/or mesenchymal-looking tissue. MATERIAL AND METHODS: We analyzed 13 MpBCs selected from the group of 1122 invasive breast cancers. Histopathological examination and analysis of estrogen (ER), progesterone (PR) and HER2 receptors expression in MpBC patients and their comparison to other types of invasive breast cancer has been performed...
December 7, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30553132/cladophora-glomerata-methanolic-extract-decreases-oxidative-stress-and-improves-viability-and-mitochondrial-potential-in-equine-adipose-derived-mesenchymal-stem-cells-ascs
#13
Lynda Bourebaba, Izabela Michalak, Michael Röcken, Krzysztof Marycz
Reactive oxygen species (ROS) are key mediators of several cellular damage and thus associated with equine diseases such as inflammation and metabolic syndrome. This study aimed to evaluate the protective and antioxidant activities of methanolic extract prepared from Cladophora glomerata (C. glomerata) biomass, on equine adipose derived mesenchymal stem cells (EqASCs), under experimental oxidative stress induced by H2 O2 . Pre-treatment of EqASCs cells with different concentrations of C. glomerata methanolic extract (1% and 5%) provided a clear protection against cellular damage triggered by H2 O2 ...
December 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30553125/predictors-of-self-harm-emergency-department-visits-in-adolescents-a-statewide-longitudinal-study
#14
Sidra Goldman-Mellor, Kevin Kwan, Jonathan Boyajian, Paul Gruenewald, Paul Brown, Deborah Wiebe, Magdalena Cerdá
OBJECTIVE: This study investigated patient- and area-level characteristics associated with adolescent emergency department (ED) patients' risk of subsequent ED visits for self-harm. METHOD: Retrospective analysis of adolescent patients presenting to a California ED in 2010 (n = 480,706) was conducted using statewide, all-payer, individually linkable administrative data. We examined associations between multiple predictors of interest (patient sociodemographic factors, prior ED utilization, and residential mobility; and area-level characteristics) and odds of a self-harm ED visit in 2010...
December 8, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/30553077/telephone-delivered-cognitive-behavioral-therapy-for-veterans-with-chronic-pain-following-traumatic-brain-injury-rationale-and-study-protocol-for-a-randomized-controlled-trial-study
#15
Jeanne M Hoffman, Dawn M Ehde, Sureyya Dikmen, Tiara Dillworth, Kevin Gertz, Carrie Kincaid, Sylvia Lucas, Nancy Temkin, Kate Sawyer, Rhonda Williams
BACKGROUND AND OBJECTIVES: Chronic pain is a highly prevalent and potentially disabling condition in Veterans who have had a traumatic brain injury (TBI) and access to non-pharmacological pain treatments such as cognitive behavioral therapy is limited and variable. The purpose of this randomized controlled trial (RCT) is to evaluate the efficacy of a telephone-delivered cognitive behavioral therapy (T-CBT) for pain in Veterans with a history of TBI. METHODS: Veterans with a history of TBI and chronic pain of at least six months duration (N = 160) will be randomized to either T-CBT or a telephone-delivered pain psychoeducational active control condition (T-Ed)...
December 12, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/30553056/ergosterol-reduction-impairs-mitochondrial-dna-maintenance-in-s-cerevisiae
#16
Angela Cirigliano, Alberto Macone, Michele Maria Bianchi, Simonetta Oliaro-Bosso, Gianni Balliano, Rodolfo Negri, Teresa Rinaldi
Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments. With the aim of studying organelle interactions, we discovered that Erg27p resides mainly in Lipid Droplets (LDs) in respiratory competent cells, while in absence of respiration, is found mostly in the ER. The results presented in this paper demonstrate an interplay between the mitochondrial respiration and ergosterol production: on the one hand, rho° cells show lower ergosterol content when compared with wild type respiratory competent cells, on the other hand, the ergosterol biosynthetic pathway influences the mitochondrial status, since treatment with ketoconazole, which blocks the ergosterol pathway, or the absence of the ERG27 gene, induced rho° production in S...
December 12, 2018: Biochimica et biophysica acta. Molecular and cell biology of lipids
https://www.readbyqxmd.com/read/30553054/high-fat-diet-induces-aberrant-hepatic-lipid-secretion-in-blunt-snout-bream-by-activating-endoplasmic-reticulum-stress-associated-ire1-xbp1-pathway
#17
Xiu-Fei Cao, Yong-Jun Dai, Ming-Yang Liu, Xiang-Yang Yuan, Cong-Cong Wang, Yang-Yang Huang, Wen-Bin Liu, Guang-Zhen Jiang
This study was conducted to understand the effect of high-fat diet challenge on lipid transport and endoplasmic reticulum stress in blunt snout bream. Ninety fish (average weight: 41.84 ± 0.07 g) were randomly fed a control diet (6% fat) or a high-fat diet (11% fat) for 9 weeks. The growth performance and feed utilization efficiency were evaluated at the end of the trial. The liver samples of both groups were harvested for molecular analysis and histological evaluation. Compared to the Control group, the high-fat diet group showed no effects on either growth performance or energy intake in blunt snout bream...
December 12, 2018: Biochimica et biophysica acta. Molecular and cell biology of lipids
https://www.readbyqxmd.com/read/30552934/an-isolated-ureteropelvic-junction-injury-following-a-low-impact-mechanical-fall
#18
Timothy Baloda, Scott Greenberg, Paula Bellin
OBJECTIVE: To describe the presentation of a rare isolated ureteropelvic junction injury resulting from a mechanical fall on ice. MATERIALS AND METHODS: A 71-year-old previously healthy man presented to the emergency department at the University of Massachusetts Medical School three hours following falling on ice with complaints of gross hematuria and flank pain. Patient records were accessed via the institution's electronic medical records system between March 22, 2018 and April 22, 2018...
December 12, 2018: Urology
https://www.readbyqxmd.com/read/30552812/factors-predicting-early-dropout-from-dialectical-behaviour-therapy-in-individuals-with-borderline-personality-disorder
#19
Cristina Carmona I Farrés, Juan C Pascual, Matilde Elices, Helena Navarro, Ana Martin Blanco, Joaquim Soler
BACKGROUND: Dialectical behaviour therapy skills training (DBT-ST) has proven effective to treat individuals with borderline personality disorder (BPD). However, therapy still faces the problem of early dropout. The aim of the present study is to examine which factors are associated with early dropout from DBT-ST in a sample of subjects with BPD. METHOD: 118 subjects with BPD diagnosis were included in the study. Apart from socio-demographic and clinical variables, childhood trauma history, personality dimensions, and comorbidities with other psychiatric disorders were collected...
November 2018: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/30552763/vagus-nerve-stimulation-reduces-ventricular-arrhythmias-and-increases-ventricular-electrical-stability
#20
Nasi-Er Buajieer-Guli, Zhang Wenhui, Sun HuaXin, Zhou Xianhui, Li Yaodong, Lu Yanmei, Wang Hongli, TuEr-Hong ZuKe-la, Zhou Qina, Tang BaoPeng
BACKGROUND: Transcutaneous stimulation of the auricular branch of the vagus nerve (AB-VNS) is a potentially non-invasive, inexpensive and safe approach for vagus nerve stimulation that suppresses the induction and duration of atrial fibrillation and reduces sympathetic nerve outflow in healthyhumans. Researchers have not determined whether AB-VNS affects ventricular arrhythmias. OBJECTIVE: To evaluate the antiarrhythmic effects of noninvasive AB-VNS on ventricular arrhythmias induced by myocardial infarction (MI)...
December 15, 2018: Pacing and Clinical Electrophysiology: PACE
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