Philipp Augsburger, Jani Liimatta, Christa E Flück
CONTEXT: Adrenarche marks the timepoint of human adrenal development when the cortex starts secreting androgens in increasing amounts, in healthy children at age 8-9 years, with premature adrenarche (PA) earlier. Because the molecular regulation and significance of adrenarche are unknown, this prepubertal event is characterized descriptively, and PA is a diagnosis by exclusion with unclear consequences at long-term. EVIDENCE ACQUISITION: We searched the literature of the past five years including original articles, reviews, and meta-analyses from PubMed, ScienceDirect, Web of Science, Embase, and Scopus, using search terms "adrenarche", "pubarche", "DHEAS", "steroidogenesis", "adrenal", and "zona reticularis"...
January 5, 2024: Journal of Clinical Endocrinology and Metabolism