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https://www.readbyqxmd.com/read/28821789/isolation-characterization-and-toxicological-potential-of-alternaria-mycotoxins-tea-aoh-and-ame-in-different-alternaria-species-from-various-regions-of-india
#1
Mukesh Meena, Prashant Swapnil, R S Upadhyay
Alternaria species produce various sorts of toxic metabolites during their active growth and causes severe diseases in many plants by limiting their productivity. These toxic metabolites incorporate various mycotoxins comprising of dibenzo-α-pyrone and some tetramic acid derivatives. In this study, we have screened out total 48 isolates of Alternaria from different plants belonging to different locations in India, on the basis of their pathogenic nature. Pathogenicity testing of these 48 strains on susceptible tomato variety (CO-3) showed 27...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821528/post-traumatic-stress-disorder-in-adult-victims-of-cluster-munitions-in-lebanon-a-10-year-longitudinal-study
#2
Jawad Fares, Souheil Gebeily, Mohamad Saad, Hayat Harati, Sanaa Nabha, Najwane Said, Mohamad Kanso, Ronza Abdel Rassoul, Youssef Fares
OBJECTIVE: This study aims to explore the short-term and long-term prevalence and effects of post-traumatic stress disorder (PTSD) among victims of cluster munitions. DESIGN AND SETTING: A prospective 10-year longitudinal study that took place in Lebanon. PARTICIPANTS: Two-hundred-and-forty-four Lebanese civilian victims of submunition blasts, who were injured in 2006 and were over 18 years old, were interviewed. Included were participants who had been diagnosed with PTSD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) and the PTSD Checklist - Civilian Version in 2006...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28818717/the-effect-of-post-traumatic-stress-disorder-on-the-risk-of-developing-prescription-opioid-use-disorder-results-from-the-national-epidemiologic-survey-on-alcohol-and-related-conditions-iii
#3
Ahmed N Hassan, Bernard Le Foll, Sameer Imtiaz, Jürgen Rehm
OBJECTIVE: To evaluate the effect of baseline post-traumatic stress disorder (PTSD) and each symptoms cluster on the risk of developing opioid use disorder (OUD) in those exposed to opioid painkillers and to assess the effect of comorbid PTSD and OUD on functioning, OUD severity, and treatment seeking compared with individuals with OUD only. METHODS: We obtained data from 4025 individuals exposed to opioid painkillers from the National Epidemiologic Survey on Alcohol and Related Conditions III...
August 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28818038/role-of-the-type-vi-secretion-systems-during-disease-interactions-of-erwinia-amylovora-with-its-plant-host
#4
Tim Kamber, Joël F Pothier, Cosima Pelludat, Fabio Rezzonico, Brion Duffy, Theo H M Smits
BACKGROUND: Type VI secretion systems (T6SS) are widespread among Gram-negative bacteria and have a potential role as essential virulence factors or to maintain symbiotic interactions. Three T6SS gene clusters were identified in the genome of E. amylovora CFBP 1430, of which T6SS-1 and T6SS-3 represent complete T6SS machineries, while T6SS-2 is reduced in its gene content. RESULTS: To assess the contribution of T6SSs to virulence and potential transcriptomic changes of E...
August 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28817186/a-prognostic-11genes-expression-model-for-ovarian-cancer
#5
Chuan-Di Men, Qiong-Na Liu, Qing Ren
The symptoms of ovarian cancer at early stages are usually absent which makes the diagnosis in its early stages exceedingly difficult. Previous research has proven that ovarian cancer is a genetic disease, which depends on the alteration of multi-cancer related genes and anti-cancer genes, multi-stages and multi-pathways, involving a variety of oncogene activation and anti-oncogene inactivation. For a better understanding of the prognostic classification of ovarian cancer, gene expression profiles were used to analyse the prognostic factors of ovarian cancer, and the prognostic model was used to classify the ovarian cancer samples...
August 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28816505/pre-attack-signs-and-symptoms-in-cluster-headache-characteristics-and-time-profile
#6
Agneta Snoer, Nunu Lund, Rasmus Beske, Rigmor Jensen, Mads Barloese
Introduction In contrast to the premonitory phase of migraine, little is known about the pre-attack (prodromal) phase of a cluster headache. We aimed to describe the nature, prevalence, and duration of pre-attack symptoms in cluster headache. Methods Eighty patients with episodic cluster headache or chronic cluster headache, according to ICHD-3 beta criteria, were invited to participate. In this observational study, patients underwent a semi-structured interview where they were asked about the presence of 31 symptoms/signs in relation to a typical cluster headache attack...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28815853/changes-to-white-matter-microstructure-in-transient-ischemic-attack-a-longitudinal-diffusion-tensor-imaging-study
#7
Jennifer K Ferris, Jodi D Edwards, Jennifer A Ma, Lara A Boyd
Transient ischemic attack (TIA) is associated with localized ischemic changes, identifiable by diffusion-weighted imaging. Past research has not considered whether TIA is also associated with diffuse changes to white matter microstructure; further past work has not tracked changes longitudinally. Here we examine whole-brain changes in fractional anisotropy (FA) in individuals with TIA presenting with sensorimotor symptoms. Twenty individuals with a recent (within 30 days) TIA and 12 healthy older adults were recruited...
August 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28814899/irritable-bowel-symptoms-and-the-development-of-common-mental-disorders-and-functional-somatic-syndromes-identified-in-secondary-care-a-long-term-population-based-study
#8
Chalotte Heinsvig Poulsen, Lene Falgaard Eplov, Carsten Hjorthøj, Marie Eliasen, Sine Skovbjerg, Thomas Meinertz Dantoft, Andreas Schröder, Torben Jørgensen
OBJECTIVE: Irritable bowel syndrome (IBS) is associated with mental vulnerability, and half of patients report comorbid somatic and mental symptoms. We aimed to investigate the relationship between an IBS symptom continuum and the subsequent development of common mental disorders (CMDs) and functional somatic syndromes (FSSs). METHODS AND STUDY DESIGN: A longitudinal population-based study comprising two 5-year follow-up studies, Dan-MONICA 1 (1982-1987) and Inter99 (1999-2004), recruited from the western part of Copenhagen County...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28814317/collaborative-care-for-panic-disorder-generalised-anxiety-disorder-and-social-phobia-in-general-practice-study-protocol-for-three-cluster-randomised-superiority-trials
#9
Nadja Kehler Curth, Ursula Ødum Brinck-Claussen, Annette Sofie Davidsen, Marianne Engelbrecht Lau, Merete Lundsteen, John Hagel Mikkelsen, Claudio Csillag, Carsten Hjorthøj, Merete Nordentoft, Lene Falgaard Eplov
BACKGROUND: People with anxiety disorders represent a significant part of a general practitioner's patient population. However, there are organisational obstacles for optimal treatment, such as a lack of coordination of illness management and limited access to evidence-based treatment such as cognitive behavioral therapy. A limited number of studies suggest that collaborative care has a positive effect on symptoms for people with anxiety disorders. However, most studies are carried out in the USA and none have reported results for social phobia or generalised anxiety disorder separately...
August 16, 2017: Trials
https://www.readbyqxmd.com/read/28811752/occurrence-and-epidemics-of-bacterial-canker-of-kiwifruit-in-korea
#10
REVIEW
Gyoung Hee Kim, Jae Sung Jung, Young Jin Koh
Bacterial canker is the largest limiting factor in the cultivation and production of kiwifruit worldwide. Typical symptoms comprise necrotic spots on leaves, canker and dieback on canes and trunks, twig wilting, and blossom necrosis. Pseudomonas syringae pv. actinidiae (Psa), which is the causal agent of kiwifruit bacterial canker, is divided into four biovars based on multilocus sequence analysis of different genes, additional PCR testing of pathogenic genes (argKtox cluster, cfl, and various effector genes), and biochemical and physiological characterization...
August 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28811733/community-partners-in-care-6-month-outcomes-of-two-quality-improvement-depression-care-interventions-in-male-participants
#11
Pratik Mehta, Anthony Brown, Bowen Chung, Felica Jones, Lingqi Tang, James Gilmore, Jeanne Miranda, Kenneth Wells
OBJECTIVE: Limited data exist on approaches to improve depression services for men in under-resourced communities. This article explores this issue using a sub-analysis of male participants in Community Partners in Care (CPIC). DESIGN: Community partnered, cluster, randomized trial. SETTING: Hollywood-Metropolitan and South Los Angeles, California. PARTICIPANTS: 423 adult male clients with modified depression (PHQ-8 score≥10)...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28811213/hemodynamic-characteristics-of-suspected-stroke-in-the-emergency-department
#12
Joseph B Miller, Richard M Nowak, Brian P Reed, Salvatore DiSomma, Prabath Nanayakkara, Michele Moyer, Scott Millis, Harish Kinni, Phillip Levy
BACKGROUND: Systemic hemodynamic characteristics of patients with suspected acute ischemic stroke are poorly described. The objective of this study was to identify baseline hemodynamic characteristics of emergency department (ED) patients with suspected acute stroke. METHODS: This was a planned analysis of the stroke cohort from a multicenter registry of hemodynamic profiling of ED patients. The registry prospectively collected non-invasive hemodynamic measurements of patients with suspicion for acute stroke within 12h of symptom onset...
August 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28808897/should-posttraumatic-stress-be-a-disorder-or-a-specifier-towards-improved-nosology-within-the-dsm-categorical-classification-system
#13
REVIEW
Jeffrey Guina, Matthew Baker, Kelly Stinson, Jon Maust, Joseph Coles, Pamela Broderick
PURPOSE OF REVIEW: Since 1980, posttraumatic stress (PTS) disorder has been controversial because of its origin as a social construct, its discriminating trauma definition, and the Procrustean array of symptoms/clusters chosen for inclusion/exclusion. This review summarizes the history of trauma-related nosology and proposed changes, within current categorical models (trauma definitions, symptoms/clusters, subtypes/specifiers, disorders) and new models. RECENT FINDINGS: Considering that trauma is a risk factor for virtually all mental disorders (particularly depressive, anxiety, dissociative, personality), the multi-finality of trauma (some survivors are resilient, and some develop PTS and/or non-PTS symptoms), and the various symptoms that trauma survivors express (mood, cognitive, perceptual, somatic), it is difficult to classify PTS...
August 15, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28807628/vertebral-alveolar-echinococcosis-a-case-report-systematic-analysis-and-review-of-the-literature
#14
REVIEW
Thomas Raphael Meinel, Bruno Gottstein, Vanessa Geib, Marius Johann Keel, Ruggero Biral, Markus Mohaupt, Jan Brügger
Alveolar echinococcosis caused by Echinococcus multilocularis is an infrequent zoonosis with a high degree of disability, morbidity, and mortality, especially in disease clusters of the northern hemisphere. The diagnosis is complicated by extended incubation time, diverse clinical manifestations, and mimicking of differential diagnoses. The primary organ affected is the liver, but extrahepatic disease is possible, with vertebral involvement in only a few dozen cases described worldwide. Although vertebral alveolar echinococcosis seems to be rare, it might be under diagnosed, and it might be seen more often as the number of people with immunocompromised conditions increases...
August 11, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28807133/the-tense-the-hostile-and-the-distressed-multidimensional-psychosocial-risk-profiles-based-on-the-esc-interview-in-coronary-artery-disease-patients-the-thoresci-study
#15
Eveline van Montfort, Johan Denollet, Jeroen K Vermunt, Jos Widdershoven, Nina Kupper
BACKGROUND: While single psychosocial factors have been associated with cardiovascular outcomes, it is still unclear how they cluster. Therefore, we examined whether latent multidimensional psychosocial risk profiles could be identified in the European Society of Cardiology (ESC) psychosocial screening interview. Additionally we examined whether these profiles were associated with specific sociodemographic, clinical, and psychosocial characteristics. METHOD: 681 coronary artery disease patients (age=64...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28806607/dissociation-in-patients-with-borderline-personality-disorder-in-acute-inpatient-care-a-latent-profile-analysis
#16
Susanne Jaeger, Tilman Steinert, Carmen Uhlmann, Erich Flammer, Dana Bichescu-Burian, Stefan Tschöke
PURPOSE: Dissociation is a common symptom in Borderline Personality disorder (BPD) and its consideration is important for the therapeutic outcome. The aim of this cross-sectional study was to scrutinize the co-occurrence of BPD symptoms and dissociative experiences. In particular, we were interested in the occurrence of specific symptom clusters characterizing qualitatively different patient groups in a clinical sample of BPD patients. BASIC PROCEDURES: We analyzed the data of 103 patients in a specialized acute inpatient care crisis intervention unit...
July 20, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28806143/whose-preferences-matter-a-patient-centered-approach-for-eliciting-treatment-goals
#17
Nananda F Col, Andrew J Solomon, Vicky Springmann, Calvin P Garbin, Carolina Ionete, Lori Pbert, Enrique Alvarez, Brenda Tierman, Ashli Hopson, Christen Kutz, Idanis Berrios Morales, Carolyn Griffin, Glenn Phillips, Long H Ngo
BACKGROUND: Patients facing a high-stakes clinical decision are often confronted with an overwhelming array of options. High-quality decisions about treatment should reflect patients' preferences as well as their clinical characteristics. Preference-assessment instruments typically focus on pre-selected clinical outcomes and attributes chosen by the investigator. OBJECTIVE: We sought to develop a patient-centered approach to elicit and compare the treatment goals of patients with multiple sclerosis (MS) and healthcare providers (HCPs)...
August 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28803783/impact-of-mutations-within-the-fe-s-cluster-or-the-lipoic-acid-biosynthesis-pathways-on-mitochondrial-protein-expression-profiles-in-fibroblasts-from-patients
#18
E Lebigot, P Gaignard, I Dorboz, A Slama, M Rio, P de Lonlay, B Héron, F Sabourdy, O Boespflug-Tanguy, A Cardoso, F Habarou, C Ottolenghi, P Thérond, C Bouton, M P Golinelli-Cohen, A Boutron
Lipoic acid (LA) is the cofactor of the E2 subunit of mitochondrial ketoacid dehydrogenases and plays a major role in oxidative decarboxylation. De novo LA biosynthesis is dependent on LIAS activity together with LIPT1 and LIPT2. LIAS is an iron‑sulfur (Fe-S) cluster-containing mitochondrial protein, like mitochondrial aconitase (mt-aco) and some subunits of respiratory chain (RC) complexes I, II and III. All of them harbor at least one [Fe-S] cluster and their activity is dependent on the mitochondrial [Fe-S] cluster (ISC) assembly machinery...
August 3, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28802928/nonmotor-subtyping-in-parkinson-s-disease
#19
Anna Sauerbier, Miguel Rosa-Grilo, Mubasher A Qamar, K Ray Chaudhuri
Nonmotor symptoms are integral to Parkinson's disease. Several subtypes dominated by specific nonmotor symptoms have emerged. In this chapter, the rationale behind nonmotor subtyping and currently proposed nonmotor subgroups within Parkinson's disease based on data-driven cluster analysis and clinical observations will be summarized. Furthermore, the concept of seven clinical nonmotor subtypes will be discussed in detail including the clinical presentation, potential biomarkers, and the clinical relevance. In future, nonmotor subtypes will possibly play a major role within the aim to achieve personalized medicine...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28797869/association-of-inflammatory-cytokines-with-the-symptom-cluster-of-pain-fatigue-depression-and-sleep-disturbance-in-chinese-patients-with-cancer
#20
Yan-Bo Ji, Chun-Lu Bo, Xiu-Juan Xue, En-Ming Weng, Guang-Chao Gao, Bei-Bei Dai, Kai-Wen Ding, Cui-Ping Xu
CONTEXT: Pain, fatigue, depression, and sleep disturbance are common in patients with cancer and usually co-occur as a symptom cluster. However, the mechanism underlying this symptom cluster is unclear. OBJECTIVES: This study aimed to identify subgroups of cluster symptoms, compare demographic and clinical characteristics between subgroups, and examine the associations between inflammatory cytokines and cluster symptoms. METHODS: Participants were 170 Chinese inpatients with cancer from two tertiary hospitals...
August 7, 2017: Journal of Pain and Symptom Management
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