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Symptom clusters

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https://www.readbyqxmd.com/read/29049938/dietary-patterns-in-french-home-living-older-adults-results-from-the-prause-study
#1
C Ferrand, C Féart, G Martinent, C Albinet, N André, M Audiffren
The aim of the present study was to provide descriptive dietary patterns of home-living older adults, and to examine their association with sociodemographic and 'diet-related' variables, and health and psychological factors. Dietary patterns were analyzed using separately cluster analysis for men (N=151,Mage=72.72, SD=8.80, range=56-97) and women (N=251, Mage=76.74, SD=9.95, range=55-97) in 402 older adults aged 55 years and over. Cluster analyses showed four distinct dietary profiles for each gender. In older men, the four distinct dietary clusters were associated with any differences in sociodemographic and 'diet-related' variables, cognitive function, and health and psychological factors...
October 12, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29049464/clustering-of-neuropsychiatric-disease-in-first-degree-and-second-degree-relatives-of-patients-with-amyotrophic-lateral-sclerosis
#2
Margaret O'Brien, Tom Burke, Mark Heverin, Alice Vajda, Russell McLaughlin, John Gibbons, Susan Byrne, Marta Pinto-Grau, Marwa Elamin, Niall Pender, Orla Hardiman
Importance: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition primarily involving the motor system. There is increasing epidemiologic evidence of an association between ALS and a wider spectrum of neurodegenerative and neuropsychiatric disorders among family members, including schizophrenia and psychotic illness and suicidal behavior. Objective: To examine the frequency and range of neuropsychiatric conditions that occur within individual first-degree and second-degree relatives of patients with ALS...
October 16, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29048949/discovering-pediatric-asthma-phenotypes-based-on-response-to-controller-medication-using-machine-learning
#3
Mindy K Ross, Jinsung Yoon, Auke van der Schaar, Mihaela van der Schaar
RATIONALE: Pediatric asthma has variable underlying inflammation and symptom control. Approaches to address this heterogeneity such as clustering methods to find phenotypes and predicting outcomes have been investigated. However, clustering based upon the relationship between treatment and clinical outcome has not been performed. Also, machine learning approaches for long-term outcome prediction in pediatric asthma have not been studied in depth. OBJECTIVES: Our objectives were to use our novel machine learning algorithm, Predictor Pursuit (PP) to discover pediatric asthma phenotypes based on treatment response to different asthma controller medications, to predict outcomes of children with asthma over time, and to identify the most indicative features of asthma control for the discovered pediatric phenotypes...
October 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29046347/investigating-immune-gene-signatures-in-peripheral-blood-from-subjects-with-allergic-rhinitis-undergoing-nasal-allergen-challenge
#4
Young Woong Kim, Amrit Singh, Casey P Shannon, Jenny Thiele, Lisa M Steacy, Anne K Ellis, Helen Neighbour, Daniel R Gliddon, Pascal L C Hickey, Mark Larché, Scott J Tebbutt
Nasal allergen challenge (NAC) is a human model of allergic rhinitis (AR) that delivers standardized allergens locally to the nasal mucosa allowing clinical symptoms and biospecimens such as peripheral blood to be collected. Although many studies have focused on local inflammatory sites, peripheral blood, an important mediator and a component of the systemic immune response, has not been well studied in the setting of AR. We sought to investigate immune gene signatures in peripheral blood collected after NAC under the setting of AR...
October 18, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29045582/strategies-to-reduce-injuries-and-develop-confidence-in-elders-stride-a-cluster-randomized-pragmatic-trial-of-a-multifactorial-fall-injury-prevention-strategy-design-and-methods
#5
Shalender Bhasin, Thomas M Gill, David B Reuben, Nancy K Latham, Jerry H Gurwitz, Patricia Dykes, Siobhan McMahon, Thomas W Storer, Pamela W Duncan, David A Ganz, Shehzad Basaria, Michael E Miller, Thomas G Travison, Erich J Greene, James Dziura, Denise Esserman, Heather Allore, Martha B Carnie, Maureen Fagan, Catherine Hanson, Dorothy Baker, Susan L Greenspan, Neil Alexander, Fred Ko, Albert L Siu, Elena Volpi, Albert W Wu, Jeremy Rich, Stephen C Waring, Robert Wallace, Carri Casteel, Jay Magaziner, Peter Charpentier, Charles Lu, Katy Araujo, Haseena Rajeevan, Scott Margolis, Richard Eder, Joanne M McGloin, Eleni Skokos, Jocelyn Wiggins, Lawrence Garber, Steven B Clauser, Rosaly Correa-De-Araujo, Peter Peduzzi
Background: Fall injuries are a major cause of morbidity and mortality among older adults. We describe the design of a pragmatic trial to compare the effectiveness of an evidence-based, patient-centered multifactorial fall injury prevention strategy to an enhanced usual care. Methods: Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) is a 40-month cluster-randomized, parallel-group, superiority, pragmatic trial being conducted at 86 primary care practices in 10 healthcare systems across USA...
October 14, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29045430/the-association-between-herpes-virus-infections-and-functional-somatic-symptoms-in-a-general-population-of-adolescents-the-trails-study
#6
Iris Jonker, Robert Schoevers, Hans Klein, Judith Rosmalen
BACKGROUND: FSS have been suggested to follow activation of the immune system, triggered by herpes virus infections. The aim of this study was to find out whether herpes virus infections were associated with the experience of FSS in adolescents, and whether this association was mediated by hsCRP, as a general marker of immune activation. METHODS: This study was performed in TRAILS, a large prospective population cohort of 2230 adolescents (mean age: 16.1 years, SD = ...
2017: PloS One
https://www.readbyqxmd.com/read/29045422/cluster-analysis-identifies-three-urodynamic-patterns-in-patients-with-orthotopic-neobladder-reconstruction
#7
Kwang Hyun Kim, Hyun Suk Yoon, Wan Song, Hee Jung Choo, Hana Yoon, Woo Sik Chung, Bong Suk Sim, Dong Hyeon Lee
PURPOSE: To classify patients with orthotopic neobladder based on urodynamic parameters using cluster analysis and to characterize the voiding function of each group. MATERIALS AND METHODS: From January 2012 to November 2015, 142 patients with bladder cancer underwent radical cystectomy and Studer neobladder reconstruction at our institute. Of the 142 patients, 103 with complete urodynamic data and information on urinary functional outcomes were included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29043929/a-survey-based-study-identifies-common-but-unrecognized-symptoms-in-a-large-series-of-juvenile-huntington-s-disease
#8
Amelia D Moser, Eric Epping, Patricia Espe-Pfeifer, Erin Martin, Leah Zhorne, Katherine Mathews, Martha Nance, Denise Hudgell, Oliver Quarrell, Peg Nopoulos
AIM: The symptoms of Huntington's disease are well known, yet the symptoms of juvenile Huntington's disease (JHD) are less established due to its rarity. The study examined a cluster of symptoms considered to be common, but under-recognized in JHD: pain, itching, sleeping difficulties, psychosis and tics. MATERIALS & METHODS: A symptom survey was constructed using the online tool Qualtrics and dispersed to JHD caregivers through websites. RESULTS: A total of 33 surveys were completed...
October 18, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29042390/effect-of-point-of-care-susceptibility-testing-in-general-practice-on-appropriate-prescription-of-antibiotics-for-patients-with-uncomplicated-urinary-tract-infection-a-diagnostic-randomised-controlled-trial
#9
Anne Holm, Gloria Cordoba, Tina Møller Sørensen, Lisbeth Rem Jessen, Niels Frimodt-Møller, Volkert Siersma, Lars Bjerrum
OBJECTIVES: To investigate the effect of adding point-of-care (POC) susceptibility testing to POC culture on appropriate use of antibiotics as well as clinical and microbiological cure for patients with suspected uncomplicated urinary tract infection (UTI) in general practice. DESIGN: Open, individually randomised controlled trial. SETTING: General practice. PARTICIPANTS: Women with suspected uncomplicated UTI, including elderly patients above 65, patients with recurrent UTI and patients with diabetes...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042266/development-and-validation-of-the-symptom-assessment-to-improve-symptom-control-for-institutionalized-elderly-scale
#10
Maaike L De Roo, Marc F Tanghe, Nele J Van Den Noortgate, Ruth D Piers
OBJECTIVES: To validate a newly developed multiple symptom self-assessment tool in nursing homes. DESIGN: Thirty prevalent symptoms identified in the literature were classified by a 2-round Delphi procedure to a top 10 of the most relevant, burdensome symptoms. Because no existing symptom scale fully covered this top 10, we developed a new scale, consisting of a horizontal numerical scale for the top 10 symptoms, with the possibility to add and rate 3 other symptoms...
October 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29041995/reproducibility-of-cognitive-profiles-in-psychosis-using-cluster-analysis
#11
Kathryn E Lewandowski, Justin T Baker, Julie M McCarthy, Lesley A Norris, Dost Öngür
OBJECTIVES: Cognitive dysfunction is a core symptom dimension that cuts across the psychoses. Recent findings support classification of patients along the cognitive dimension using cluster analysis; however, data-derived groupings may be highly determined by sampling characteristics and the measures used to derive the clusters, and so their interpretability must be established. We examined cognitive clusters in a cross-diagnostic sample of patients with psychosis and associations with clinical and functional outcomes...
October 18, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29040947/a-6-week-multicenter-double-blind-double-dummy-chlorpromazine-controlled-non-inferiorityrandomized-phase-iiitrial-to-evaluate-the-efficacy-and-safety-of-quetiapine-fumarate-seroquel-extended-release-xr-in-the-treatment-of-patients-with-schizophrenia-and-acute
#12
Huafang Li, Yifeng Shen, Gang Wang, Jianguo Shi, Cui Ma, Shiping Xie, Honggeng Zhang, Xiaoping Wang, Keqing Li, Xiufeng Xu, Niufan Gu
This study aimed to evaluate the efficacy and safety of quetiapine fumarate extended-release (XR) in the treatment of Chinese patients with acute schizophrenia. Multicenter, double-blind, double-dummy, active-controlled non-inferiority randomized study in Chinese patients (n = 388) with schizophrenia randomly assigned to quetiapine XR or chlorpromazine for 6 weeks. Primary outcome was the change from baseline in Positive and Negative Syndrome Scale (PANSS) total score at the end of treatment. Safety objectives included adverse event (AE) monitoring, laboratory test results, and electrocardiograms...
July 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29038979/decreased-metabolism-in-the-posterior-medial-network-with-concomitantly-increased-metabolism-in-the-anterior-temporal-network-during-transient-global-amnesia
#13
SangHak Yi, Young Ho Park, Jae-Won Jang, Jae-Sung Lim, In Kook Chun, SangYun Kim
Perturbation of corticohippocampal circuits is a key step in the pathogenesis of transient global amnesia. We evaluated the spatial distribution of altered cerebral metabolism to determine the location of the corticohippocampal circuits perturbed during the acute stage of transient global amnesia. A consecutive series of 12 patients with transient global amnesia who underwent (18)F-fluorodeoxyglucose positron emission tomography within 3 days after symptom onset was identified. We used statistical parametric mapping with two contrasts to identify regions of decreased and increased brain metabolism in transient global amnesia patients compared with 25 age-matched controls...
October 16, 2017: Brain Topography
https://www.readbyqxmd.com/read/29037303/prevalence-and-impact-of-asthma-among-school-aged-students-in-lima-peru
#14
M Martin, T Sauer, J A Alarcon, J Vinoles, E C Walter, T G Ton, J Zunt
SETTING AND OBJECTIVE: The International Study of Asthma and Allergies in Childhood (ISAAC) reported asthma prevalence in Peru to be among the highest in the world. We assessed the prevalence and morbidity of self-reported asthma in an underserved, peri-urban area of Lima, Peru, with limited medical access. DESIGN: The study was conducted in the outskirts of Lima from March to May 2011. Five hundred children aged 6-18 years were selected through cluster sampling...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29037244/prediction-of-microbe-disease-association-from-the-integration-of-neighbor-and-graph-with-collaborative-recommendation-model
#15
Yu-An Huang, Zhu-Hong You, Xing Chen, Zhi-An Huang, Shanwen Zhang, Gui-Ying Yan
BACKGROUND: Accumulating clinical researches have shown that specific microbes with abnormal levels are closely associated with the development of various human diseases. Knowledge of microbe-disease associations can provide valuable insights for complex disease mechanism understanding as well as the prevention, diagnosis and treatment of various diseases. However, little effort has been made to predict microbial candidates for human complex diseases on a large scale. METHODS: In this work, we developed a new computational model for predicting microbe-disease associations by combining two single recommendation methods...
October 16, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29036587/latent-profile-analysis-and-conversion-to-psychosis-characterizing-subgroups-to-enhance-risk-prediction
#16
Kristin M Healey, David L Penn, Diana Perkins, Scott W Woods, Richard S E Keefe, Jean Addington
BACKGROUND: Groups at clinical high risk (CHR) of developing psychosis are heterogeneous, composed of individuals with different clusters of symptoms. It is likely that there exist subgroups, each associated with different symptom constellations and probabilities of conversion. METHOD: Present study used latent profile analysis (LPA) to ascertain subgroups in a combined sample of CHR (n = 171) and help-seeking controls (HSCs; n = 100; PREDICT study). Indicators in the LPA model included baseline Scale of Prodromal Symptoms (SOPS), Calgary Depression Scale for Schizophrenia (CDSS), and neurocognitive performance as measured by multiple instruments, including category instances (CAT)...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29034611/epidemiology-and-spatio-temporal-analysis-of-west-nile-virus-in-horses-in-spain-between-2010-and-2016
#17
I García-Bocanegra, J Belkhiria, S Napp, D Cano-Terriza, S Jiménez-Ruiz, B Martínez-López
During the last decade, West Nile virus (WNV) outbreaks have increased sharply in both horses and human in Europe. The aims of this study were to evaluate characteristics and spatio-temporal distribution of WNV outbreaks in horses in Spain between 2010 and 2016 in order to identify the environmental variables most associated with WNV occurrence and to generate high-resolution WNV suitability maps to inform risk-based surveillance strategies in this country. Between August 2010 and November 2016, a total of 403 WNV suspected cases were investigated, of which, 177 (43...
October 16, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29033282/character-strengths-of-individuals-with-first-episode-psychosis-in-individual-resiliency-training
#18
Julia Browne, Sue E Estroff, Kelsey Ludwig, Carrington Merritt, Piper Meyer-Kalos, Kim T Mueser, Jennifer D Gottlieb, David L Penn
Positive psychology interventions that integrate a person's strengths into treatment result in improvements in life satisfaction and well-being. Character strengths classified within six core virtues (wisdom/knowledge, courage, humanity, justice, temperance, and transcendence) have been the subject of substantial research. Though a number of studies have been conducted in the general population, little is known about the character strengths of individuals with first episode psychosis (FEP). Moreover, positive psychology principles, in particular a focus on personal strengths, have been increasingly integrated into FEP treatment and was a core component of Individual Resiliency Training (IRT), the individual therapy component of NAVIGATE tested in the Recovery After an Initial Schizophrenia Episode Early Treatment Program...
October 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29033063/factor-analysis-of-symptom-profile-in-early-onset-and-late-onset-ocd
#19
Sandeep Grover, Siddharth Sarkar, Gourav Gupta, Natasha Kate, Abhishek Ghosh, Subho Chakrabarti, Ajit Avasthi
This study aimed to assess the factor structure of early and late onset OCD. Additionally, cluster analysis was conducted in the same sample to assess the applicability of the factors. 345 participants were assessed with Yale Brown Obsessive Compulsive Scale symptom checklist. Patients were classified as early onset (onset of symptoms at age ≤ 18 years) and late onset (onset at age > 18 years) OCD depending upon the age of onset of the symptoms. Factor analysis and cluster analysis of early-onset and late-onset OCD was conducted...
October 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29031318/symptom-clustering-and-quality-of-life-in-patients-with-ovarian-cancer-undergoing-chemotherapy
#20
Ju-Hee Nho, Sung Reul Kim, Joo-Hyun Nam
PURPOSE: The symptom clusters in patients with ovarian cancer undergoing chemotherapy have not been well evaluated. We investigated the symptom clusters and effects of symptom clusters on the quality of life of patients with ovarian cancer. METHOD: We recruited 210 ovarian cancer patients being treated with chemotherapy and used a descriptive cross-sectional study design to collect information on their symptoms. To determine inter-relationships among symptoms, a principal component analysis with varimax rotation was performed based on the patient's symptoms (fatigue, pain, sleep disturbance, chemotherapy-induced peripheral neuropathy, anxiety, depression, and sexual dysfunction)...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
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