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Symptom clusters

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https://www.readbyqxmd.com/read/28550741/exploring-syndrome-differentiation-using-non-negative-matrix-factorization-and-cluster-analysis-in-patients-with-atopic-dermatitis
#1
Younghee Yun, Wonmo Jung, Hyunho Kim, Bo-Hyoung Jang, Min-Hee Kim, Jiseong Noh, Seong-Gyu Ko, Inhwa Choi
Syndrome differentiation (SD) results in a diagnostic conclusion based on a cluster of concurrent symptoms and signs, including pulse form and tongue color. In Korea, there is a strong interest in the standardization of Traditional Medicine (TM). In order to standardize TM treatment, standardization of SD should be given priority. The aim of this study was to explore the SD, or symptom clusters, of patients with atopic dermatitis (AD) using non-negative factorization methods and k-means clustering analysis...
May 22, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28550433/the-biological-features-and-genetic-diversity-of-novel-fish-rhabdovirus-isolates-in-china
#2
Xiaozhe Fu, Qiang Lin, Hongru Liang, Lihui Liu, Zhibin Huang, Ningqiu Li, Jianguo Su
The Rhabdoviridae is a diverse family of negative-sense single-stranded RNA viruses which infects mammals, birds, reptiles, fish, insects and plants. Herein, we reported the isolation and characterization of 6 novel viruses from diseased fish collected from China including SCRV-QY, SCRV-SS, SCRV-GM, CmRV-FS, MsRV-SS, OmbRV-JM. The typical clinical symptom of diseased fish was hemorrhaging. Efficient propagation of these isolates in a Chinese perch brain cell line was determined by means of observation of cytopathic effect, RT-PCR and electron microscopy...
May 26, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28549263/prevalence-reasons-perceived-effects-and-correlates-of-medical-marijuana-use-a-review
#3
REVIEW
Ji-Yeun Park, Li-Tzy Wu
BACKGROUND: The use of marijuana for medical purposes is now legal in some U.S. states and other jurisdictions, such as Canada, and Israel. Despite the widespread legalization of medical marijuana globally, there is limited information on patterns and correlates of medical marijuana use (MMU). We conducted a literature review to assess prevalence, reasons, perceived effects, and correlates of MMU among adolescents and adults. METHODS: We searched peer-reviewed articles in English between January 1996 and August 2016 from several databases (PubMed, Google Scholar, Embase, CINAHL, and PsycINFO) using different combinations of keywords...
May 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28549077/clinical-criteria-for-subtyping-parkinson-s-disease-biomarkers-and-longitudinal-progression
#4
Seyed-Mohammad Fereshtehnejad, Yashar Zeighami, Alain Dagher, Ronald B Postuma
Parkinson's disease varies widely in clinical manifestations, course of progression and biomarker profiles from person to person. Identification of distinct Parkinson's disease subtypes is of great priority to illuminate underlying pathophysiology, predict progression and develop more efficient personalized care approaches. There is currently no clear way to define and divide subtypes in Parkinson's disease. Using data from the Parkinson's Progression Markers Initiative, we aimed to identify distinct subgroups via cluster analysis of a comprehensive dataset at baseline (i...
May 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28544134/depression-and-cognitive-impairment-among-newly-admitted-nursing-home-residents-in-the-usa
#5
Christine M Ulbricht, Anthony J Rothschild, Jacob N Hunnicutt, Kate L Lapane
OBJECTIVE: The objective of this study is to describe the prevalence of depression and cognitive impairment among newly admitted nursing home residents in the USA and to describe the treatment of depression by level of cognitive impairment. METHODS: We identified 1,088,619 newly admitted older residents between 2011 and 2013 with an active diagnosis of depression documented on the Minimum Data Set 3.0. The prevalence of receiving psychiatric treatment was estimated by cognitive impairment status and depression symptoms...
May 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28544009/a-cluster-randomised-controlled-trial-evaluating-the-effects-of-delaying-onset-of-adolescent-substance-abuse-on-cognitive-development-and-addiction-following-a-selective-personality-targeted-intervention-program-the-co-venture-trial
#6
Maeve O'Leary-Barrett, Benoit Mâsse, Robert Pihl, Sherry Stewart, Jean R Séguin, Patricia Conrod
AIMS: Substance use and binge drinking during early adolescence are associated with neurocognitive abnormalities, mental health problems and an increased risk for future addiction. The trial aims to evaluate the protective effects of an evidence-based substance use prevention program on the onset of alcohol and drug use in adolescence, as well as on cognitive, mental health and addiction outcomes over 5 years. DESIGN: Thirty-eight high schools will be recruited, with a final sample of 31 schools assigned to intervention or control conditions (approximately 3800 youth)...
May 21, 2017: Addiction
https://www.readbyqxmd.com/read/28542742/exercise-or-social-intervention-for-nursing-home-residents-with-dementia-a-pilot-randomized-controlled-trial
#7
Philipe de Souto Barreto, Matteo Cesari, Philippe Denormandie, Didier Armaingaud, Bruno Vellas, Yves Rolland
OBJECTIVES: To compare the effects of exercise with those of a structured nonphysical intervention on ability to perform activities of daily living (ADLs) and physical and cognitive function of persons with dementia (PWDs) living in nursing homes (NH). DESIGN: Cluster-randomized pilot-controlled trial. SETTING: Seven French NHs. PARTICIPANTS: PWDs living in NHs. MEASUREMENTS: NHs were randomized to an exercise group (4 NHs, n = 47) or structured social activity group (3 NHs, n = 50) for a 24-week intervention performed twice per week for 60 minutes per session...
May 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28540017/cluster-headache-associated-with-secondary-unilateral-blepharospasm-a-case-report-and-review-of-the-literature
#8
Abbas Bagheri, Minoo Mohammadi, Ghader Harooni, Keyvan Khosravifard, Mohadeseh Feizi, Shahin Yazdani
PURPOSE: Cluster headache is one of the most serious types of headache that is accompanied by autonomic parasympathetic symptoms. Its association with hemifacial spasm in the same side had been rarely reported. The aim of this report is describing a case with this association and treatment strategies. CASE REPORT: Here we report a 37-year-old female with cluster headache associated with secondary unilateral blepharospasm that was successfully treated with combination therapy including botulinum toxin injection...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28539654/quasispecies-composition-and-evolution-of-a-typical-zika-virus-clinical-isolate-from-suriname
#9
Sander van Boheemen, Ali Tas, S Yahya Anvar, Rebecca van Grootveld, Irina C Albulescu, Martijn P Bauer, Mariet C Feltkamp, Peter J Bredenbeek, Martijn J van Hemert
The arthropod-borne Zika virus (ZIKV) is currently causing a major international public health threat in the Americas. This study describes the isolation of ZIKV from the plasma of a 29-year-old female traveler that developed typical symptoms, like rash, fever and headache upon return from Suriname. The complete genome sequence including the 5' and 3' untranslated regions was determined and phylogenetic analysis showed the isolate clustering within the Asian lineage, close to other viruses that have recently been isolated in the Americas...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28536961/emotional-clarity-anxiety-sensitivity-and-ptsd-symptoms-among-trauma-exposed-inpatient-adolescents
#10
Andres G Viana, Abigail E Hanna, Emma C Woodward, Elizabeth M Raines, Daniel J Paulus, Erin C Berenz, Michael J Zvolensky
Although several investigations-on primarily adult samples-demonstrate a potential role of emotion dysregulation in the etiology and maintenance of posttraumatic stress disorder (PTSD), investigations into the mechanisms that may underlie these associations in general and among adolescents in particular are lacking. The present study examined associations among emotional clarity (i.e., the extent to which individuals are confused about the specific emotions they are experiencing), (Gratz, Journal of Psychopathology Behavioral Assessment 26(1):41-54, 2004) anxiety sensitivity, and DSM-IV PTSD symptom cluster severity (i...
May 23, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28536884/an-update-in-symptom-clusters-using-the-edmonton-symptom-assessment-system-in-a-palliative-radiotherapy-clinic
#11
Vithusha Ganesh, Liying Zhang, Stephanie Chan, Bo Angela Wan, Leah Drost, May Tsao, Cyril Danjoux, Elizabeth Barnes, Rachel McDonald, Leigha Rowbottom, Pearl Zaki, Ronald Chow, Matthew K Hwang, Carlo DeAngelis, Nicholas Lao, Edward Chow
PURPOSE: To identify symptom clusters in advanced cancer patients attending a palliative radiotherapy clinic using the Edmonton Symptom Assessment System (ESAS). METHODS: Principal component analysis (PCA), exploratory factor analysis (EFA), and hierarchical cluster analysis (HCA) were used to identify symptom clusters among the nine ESAS items using scores from each patient's first visit. RESULTS: ESAS scores from 182 patients were analyzed...
May 23, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28535078/complementation-of-ctb7-in-the-maize-pathogen-cercospora-zeina-overcomes-the-lack-of-in-vitro-cercosporin-production
#12
Velushka Swart, Bridget Genevieve Crampton, John Ridenour, Burton Bluhm, Nicholas Olivier, Marion Meyer, Dave Kenneth Berger
Gray leaf spot (GLS), caused by the sibling species Cercospora zeina or Cercospora zeae-maydis, is cited as one of the most important diseases threatening global maize production. C. zeina fails to produce cercosporin in vitro, and in most cases causes large coalescing lesions during maize infection; a symptom generally absent from cercosporin-deficient mutants in other Cercospora spp. Here we describe the C. zeina cercosporin toxin biosynthetic gene cluster. The oxidoreductase gene CTB7 contained several insertions and deletions as compared to the C...
May 23, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28533265/antibiotic-prescription-strategies-and-adverse-outcome-for-uncomplicated-lower-respiratory-tract-infections-prospective-cough-complication-cohort-3c-study
#13
Paul Little, Beth Stuart, Sue Smith, Matthew J Thompson, Kyle Knox, Ann van den Bruel, Mark Lown, Michael Moore, David Mant
Objective To assess the impact on adverse outcomes of different antibiotic prescribing strategies for lower respiratory tract infections in people aged 16 years or more.Design Prospective cohort study.Setting UK general practice.Participants 28 883 patients with lower respiratory tract infection; symptoms, signs, and antibiotic prescribing strategies were recorded at the index consultation.Main outcome measures The main outcomes were reconsultation with symptoms of lower respiratory tract infection in the 30 days after the index consultation, hospital admission, or death...
May 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28533161/differences-in-symptom-clusters-identified-using-ratings-of-symptom-occurrence-versus-severity-in-lung-cancer-patients-receiving-chemotherapy
#14
Melisa L Wong, Bruce A Cooper, Steven M Paul, Jon D Levine, Yvette P Conley, Fay Wright, Marilyn Hammer, Christine Miaskowski
CONTEXT: An important question in symptom clusters research is whether the number and types of symptom clusters vary based on the specific dimension of the symptom experience used to create the clusters. OBJECTIVES: Given that lung cancer patients undergoing chemotherapy (CTX) report an average of 14 co-occurring symptoms and studies of symptom clusters in these patients are limited, the purpose of this study, in lung cancer patients undergoing CTX (n=145), was to identify whether the number and types of symptom clusters differed based on whether symptom occurrence rates or symptom severity ratings were used to create the clusters...
May 19, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28532290/midlife-women-s-cardiovascular-symptoms-a-cluster-analysis
#15
Eun-Ok Im, Young Ko, Eunice Chee, Wonshik Chee, Jun James Mao
Menopausal transition, in which biological and psychosocial changes are caused due to estrogen fluctuations, has been reported to increase cardiovascular risk among midlife women. Our purpose of this study was to identify the clusters of midlife women by cardiovascular symptoms and to examine racial/ethnic differences in the clusters. This was a secondary analysis, in which hierarchical cluster and multinomial logistic analyses were conducted with the data (N = 966) collected in two previous studies. Three-clusters were adopted: Cluster 1 (high vasomotor and low cardiorespiratory), Cluster 2 (low vasomotor and high cardiorespiratory and high discomfort/pain), and Cluster 3 (high discomfort/pain and high indigestion)...
May 22, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28531764/disrupted-resting-brain-graph-measures-in-individuals-at-high-risk-for-alcoholism
#16
Bharath Holla, Rajanikant Panda, Ganesan Venkatasubramanian, Bharat Biswal, Rose Dawn Bharath, Vivek Benegal
Familial susceptibility to alcoholism is likely to be linked to the externalizing diathesis seen in high-risk offspring from high-density alcohol use disorder (AUD) families. The present study aimed at comparing resting brain functional connectivity and their association with externalizing symptoms and alcoholism familial density in 40 substance-naive high-risk (HR) male offspring from high-density AUD families and 30 matched healthy low-risk (LR) males without a family history of substance dependence using graph theory-based network analysis...
May 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28531552/the-role-of-next-generation-sequencing-in-infection-prevention-in-human-parainfluenza-virus-3-infections-in-immunocompromised-patients
#17
Atul Kothari, Mary J Burgess, Juan Carlos Rico Crescencio, Joshua L Kennedy, Jesse L Denson, Kurt C Schwalm, Ashley N Stoner, John C Kincaid, Faith E Davies, Darrell L Dinwiddie
BACKGROUND: Respiratory viral infections are a significant problem in patients with hematologic malignancies. We report a cluster of HPIV 3 infections in our myeloma patients, and describe the utility of next generation sequencing (NGS) to identify transmission linkages which can assist in infection prevention. OBJECTIVES: To evaluate the utility of NGS to track respiratory viral infection outbreaks and delineate between community acquired and nosocomial infections in our cancer units...
May 12, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28528930/clinical-and-psychosocial-predictors-of-urologic-chronic-pelvic-pain-symptom-change-over-one-year-a-prospective-study-from-the-mapp-research-network
#18
Bruce D Naliboff, Alisa J Stephens, H Henry Lai, James W Griffith, J Quentin Clemens, Susan Lutgendorf, Larissa V Rodriguez, Craig Newcomb, Siobhan Sutcliffe, Wensheng Guo, John W Kusek, J Richard Landis
OBJECTIVE: To examine baseline clinical and psychosocial characteristics that predict 12- month symptom change in men and women with urologic chronic pelvic pain syndromes (UCPPS). METHODS: 221 female and 176 male UCPPS patients were recruited from 6 academic medical centers in the United States and evaluated at baseline with a comprehensive battery of symptom, psychosocial, and illness-impact measures. Based on biweekly symptom reports, a functional clustering procedure classified participant's outcome as worse, stable, or improved on pain and urinary symptom severity...
May 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28528203/changes-in-resting-state-functional-brain-connectivity-and-withdrawal-symptoms-are-associated-with-acute-electronic-cigarette-use
#19
Andréa L Hobkirk, Travis T Nichols, Jonathan Foulds, Jessica M Yingst, Susan Veldheer, Shari Hrabovsky, John Richie, Thomas Eissenberg, Stephen J Wilson
Resting state functional brain connectivity (rsFC) may be an important neuromarker of smoking behavior. Prior research has shown, among cigarette smokers, that nicotine administration alters rsFC within frontal and parietal cortices involved in executive control, as well as striatal regions that drive reward processing. These changes in rsFC have been associated with reductions in withdrawal symptom severity. We currently have a limited understanding of how rsFC is affected by the use of electronic cigarettes (ecigs), an increasingly popular class of products, the members of which deliver nicotine with varying effectiveness...
May 17, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28527117/non-viral-and-viral-delivery-systems-for-crispr-cas9-technology-in-the-biomedical-field
#20
REVIEW
Zhi-Yao He, Ke Men, Zhou Qin, Yang Yang, Ting Xu, Yu-Quan Wei
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR-Cas9) system provides a novel genome editing technology that can precisely target a genomic site to disrupt or repair a specific gene. Some CRISPR-Cas9 systems from different bacteria or artificial variants have been discovered or constructed by biologists, and Cas9 nucleases and single guide RNAs (sgRNA) are the major components of the CRISPR-Cas9 system. These Cas9 systems have been extensively applied for identifying therapeutic targets, identifying gene functions, generating animal models, and developing gene therapies...
May 2, 2017: Science China. Life Sciences
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