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Juan Miguel

Alfonso Santiago, Miguel Zavala-Aké, Jazmín Aguado-Sierra, Ruben Doste, Samuel Gómez, Ruth Arís, Juan C Cajas, Eva Casoni, Mariano Vázquez
In this work we present a fully coupled fluid-electro-mechanical model of a 50th percentile human heart. The model is implemented on Alya, the BSC multi-physics parallel code, capable of running efficiently in supercomputers. Blood in the cardiac cavities is modelled by the incompressible Navier-Stokes equations and an Arbitrary Lagrangian-Eulerian (ALE) scheme. Electrophysiology is modelled with a monodomain scheme and the O'Hara-Rudy cell model. Solid mechanics is modelled with a total-Lagrangian formulation for discrete strains using the Holzapfel-Ogden cardiac tissue material model...
August 16, 2018: International Journal for Numerical Methods in Biomedical Engineering
Miguel Balado, Marta A Lages, Juan C Fuentes-Monteverde, Diana Martínez-Matamoros, Jaime Rodríguez, Carlos Jiménez, Manuel L Lemos
Vibrio anguillarum causes vibriosis, a hemorrhagic septicaemia that affects many cultured marine fish species worldwide. Two catechol siderophores, vanchrobactin and anguibactin, were previously identified in this bacterium. While vanchrobactin is a chromosomally encoded system widespread in all pathogenic and environmental strains, anguibactin is a plasmid-encoded system restricted to serotype O1 strains. In this work, we have characterized, from a serotype O2 strain producing vanchrobactin, a novel genomic island containing a cluster of genes that would encode the synthesis of piscibactin, a siderophore firstly described in the fish pathogen Photobacterium damselae subsp...
2018: Frontiers in Microbiology
Francisco O'Valle, Juan G de Buitrago, Pedro Hernández-Cortés, Miguel Padial-Molina, Vicente Crespo-Lora, Marien Cobo, David Aguilar, Pablo Galindo-Moreno
This study aimed to analyze the expression of Musashi-1 (MSI1) in maxillary native bone and grafted bone after maxillary sinus floor elevation. To do so, fifty-seven bone biopsies from 45 participants were studied. Eighteen samples were collected from native bone while 39 were obtained 6 months after maxillary sinus grafting procedures. Musashi-1 was analyzed by immunohistochemistry and RT-PCR. MSI1 was detected in osteoblasts and osteocytes in 97.4% (38/39) of grafted areas. In native bone, MSI1 was detected in only 66...
August 16, 2018: Scientific Reports
Rocio L Espinosa, María Fe Laguna, Fátima Fernández, Beatriz Santamaria, Francisco Javier Sanza, Maria Victoria Maigler, Juan J Álvarez-Millán, Víctor Canalejas-Tejero, Miguel Holgado
Food allergy is a common disease worldwide with over 6% of the population (200⁻250 million people) suffering from any food allergy nowadays. The most dramatic increase seems to be happening in children and young people. Therefore, improvements in the diagnosis efficiency of these diseases are needed. Immunoglobulin type E (IgE) biomarker determination in human serum is a typical in vitro test for allergy identification. In this work, we used a novel biosensor based on label-free photonic transducers called BICELLs (Biophotonic Sensing Cells) for IgE detection...
August 15, 2018: Sensors
Ángel Borque-Fernando, José Rubio-Briones, Luis M Esteban, Yan Dong, Ana Calatrava, Álvaro Gómez-Ferrer, Enrique Gómez-Gómez, Jesús M Gil Fabra, Nuria Rodríguez-García, Pedro Á López González, Jorge García-Rodríguez, Miguel Rodrigo-Aliaga, Bernardo Herrera-Imbroda, Juan Soto-Villalba, Sara Martínez-Breijo, Virginia Hernández-Cañas, Ana M Soto-Poveda, Carlos Sánchez-Rodríguez, Carlos Carrillo-George, Yumaira E Hernández-Martínez, David Okrongly
BACKGROUND: Management of active surveillance (AS) in low-risk prostate cancer (PCa) patients could be improved with new biomarkers, such as the 4Kscore test. We analyze its ability to predict tumor reclassification by upgrading at the confirmatory biopsy at 6 months. METHODS: Observational, prospective, blinded, and non-randomized study, within the Spanish National Registry on AS (AEU/PIEM/2014/0001; NCT02865330) with 181 patients included after initial Bx and inclusion criteria: PSA ≤10 ng/mL, cT1c-T2a, Grade group 1, ≤2 cores, and ≤5 mm/50% length core involved...
August 14, 2018: Prostate Cancer and Prostatic Diseases
Alejandro Alvaro-Meca, Pablo Ryan, Dariela Micheloud, Angel De Miguel, Juan Berenguer, Salvador Resino
Chronic infections are a major factor in the development of pulmonary embolism (PE). We aimed to evaluate the trends of PE-related hospitalizations and PE-related deaths in people living with HIV (PLWH) during the era of combination antiretroviral therapy (cART) through a retrospective study in Spain. Data were collected from the Minimum Basic Data Set (MBDS) between 1997 and 2013. The study period was fragmented into four calendar periods (1997-1999, 2000-2003, 2004-2007, and 2008-2013). The rate of PE-related hospitalizations remained stable in PLWH (P = 0...
August 14, 2018: Scientific Reports
Nuria Tormo, Eliseo Albert, Emilio Borrajo, Monserrat Bosque, Juan José Camarena, Victoria Domínguez, Encarnación Fuentes, Isabel Gascón, Bárbara Gomila, Nieves Gonzalo, Marta Jiménez, Olalla Martínez, José Miguel Nogueira, Nieves Orta, Josep Prat, Juan Carlos Rodríguez, Concepción Gimeno, David Navarro
A questionnaire-based cross-sectional study was conducted to gather information on current microbiological practices for active surveillance of carriage of multidrug-resistant (MDR) bacteria in hospitals from 14 health departments of the Autonomous Community of Valencia (ACV), Spain, which together provided medical attention to 3,271,077 inhabitants in 2017, approximately 70% of the population of the ACV. The survey consisted of 35 questions on MDR bacteria screening policies, surveillance approach chosen (universal vs...
August 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Sonia Rodríguez-Fernández, Encarnación Castillo-Lorente, Francisco Guerrero-Lopez, David Rodríguez-Rubio, Eduardo Aguilar-Alonso, Jesús Lafuente-Baraza, Francisco Javier Gómez-Jiménez, Juan Mora-Ordóñez, Ricardo Rivera-López, María Dolores Arias-Verdú, Guillermo Quesada-García, Miguel Ángel Arráez-Sánchez, Ricardo Rivera-Fernández
OBJECTIVE: Validation of the intracerebral haemorrhage (ICH) score in patients with a diagnosis of spontaneous ICH admitted to the intensive care unit (ICU). METHODS: A multicentre cohort study was conducted in all consecutive patients with ICH admitted to the ICUs of three hospitals with a neurosurgery department between 2009 and 2012 in Andalusia, Spain. Data collected included ICH, Glasgow Coma Scale (GCS) and Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores...
August 13, 2018: BMJ Open
Patricia Seoane-Collazo, Juan Roa, Eva Rial-Pensado, Laura Liñares-Pose, Daniel Beiroa, Francisco Ruíz-Pino, Tania López-González, Donald A Morgan, José Ángel Pardavila, María Jesús Sánchez-Tapia, Noelia Martínez-Sánchez, Cristina Contreras, Miguel Fidalgo, Carlos Diéguez, Roberto Coppari, Kamal Rahmouni, Rubén Nogueiras, Manuel Tena-Sempere, Miguel López
AMP-activated protein kinase (AMPK) is a cellular gauge that is activated under conditions of low energy, increasing energy production and reducing energy waste. Current evidence links hypothalamic AMPK with the central regulation of energy balance. However, it is unclear whether targeting hypothalamic AMPK has beneficial effects in obesity. Here, we show that genetic inhibition of AMPK in the ventromedial nucleus of the hypothalamus (VMH) protects against high fat diet (HFD)-induced obesity by increasing brown adipose tissue (BAT) thermogenesis and subsequently energy expenditure...
August 13, 2018: Diabetes
Jose Luis Lopez-Campos, Bernardino Alcázar Navarrete, Joan B Soriano, Juan J Soler-Cataluña, José Miguel Rodríguez González-Moro, Manuel E Fuentes Ferrer, Myriam Calle Rubio
Purpose: Current COPD management recommendations indicate that pharmacological treatment can be stepped up or down, but there are no recommendations on how to make this adjustment. We aimed to describe pharmacological prescriptions during a routine clinical visit for COPD and study the determinants of changing therapy. Methods: EPOCONSUL is a Spanish nationwide observational cross-sectional clinical audit with prospective case recruitment including 4,508 COPD patients from outpatient respiratory clinics for a period of 12 months (May 2014-May 2015)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Francesca Gay, Graham Jackson, Laura Rosiñol, Sarah A Holstein, Philippe Moreau, Stefano Spada, Faith Davies, Juan José Lahuerta, Xavier Leleu, Sara Bringhen, Andrea Evangelista, Cyrille Hulin, Ugo Panzani, David A Cairns, Francesco Di Raimondo, Margaret Macro, Anna Marina Liberati, Charlotte Pawlyn, Massimo Offidani, Andrew Spencer, Roman Hájek, Evangelos Terpos, Gareth J Morgan, Joan Bladé, Pieter Sonneveld, Jesús San-Miguel, Philip L McCarthy, Heinz Ludwig, Mario Boccadoro, Maria-Victoria Mateos, Michel Attal
Importance: Several trials demonstrated the impact of novel agent-based maintenance in newly diagnosed multiple myeloma (NDMM), but there is no current evidence demonstrating the superiority of one regimen over the other, owing to the lack of direct/indirect comparisons. Objective: To analyze and compare the effectiveness of different maintenance regimens in NDMM via a network meta-analysis. Data Sources: We performed 2 independent searches in PubMed and Cochrane databases, and then we identified all the records registered after 1999 and on or before November 20, 2017...
August 9, 2018: JAMA Oncology
Miguel Angel Ruiz Ibán, Juan Sarasquete, Mario Gil de Rozas, Pedro Costa, Juan Daniel Tovío, Eduardo Carpinteiro, Abdul Ilah Hachem, Manuel Perez España, Cristina Asenjo Gismero, Jorge Diaz Heredia, Miguel García Navlet
PURPOSE: To define the prevalence of associated articular injuries in patients with severe (Rockwood's III-VI) acute acromioclavicular joint injuries and to find out how many of these were associated with the traumatic event and required surgical treatment. METHODS: Retrospective observational multicentric study performed in ten centres included patients who required surgery for acute acromioclavicular joint injuries between 2010 and 2017. The inclusion criteria were: presence of an acute acromioclavicular joint injury (grades III-IV-V-VI) and surgical treatment within 3 weeks of injury that included a full arthroscopic evaluation of the shoulder...
August 10, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Edgardo Cristiano, Juan Ignacio Rojas, Patricio Abad, Tarso Adoni, Jorge Barahona, Jefferson Becker, Adriana Carrá, José Flores, Manuel Fruns, Nora Fernández Liguori, Orlando Garcea, Juan García Bónito, Diego Giunta, Fernando Gracia, Fernando Hamuy, Miguel A Macias Islas, Cárlos Navas, Liliana Ordoñez Boschetti, Liliana Patrucco, Douglas K Sato, Jorge Correale
Despite the availability of a large amount of information regarding the management and care of relapsing remitting multiple sclerosis (RRMS) patients, there is scant information about recommendations on how to care for primary progressive MS (PPMS) patients. The objective of this study was to review how PPMS patients should be assessed and cared for in Latin America (LATAM). METHODS: A panel of neurology experts from LATAM dedicated to the diagnosis and care of MS patients gathered virtually during 2017 and 2018 to carry out a consensus recommendation on the diagnosis and treatment of PPMS patients in LATAM...
July 31, 2018: Journal of the Neurological Sciences
Pablo Garrido-Abad, Miguel Ángel Rodríguez-Cabello, Arturo Platas Sancho, Mairena Coronado Ruiz, Juan José Ortiz Zapata
No abstract text is available yet for this article.
August 5, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Diego Bejarano, Rodrigo Martínez, Carlos Manrique, Luis Miguel Parra, Juan Felipe Rocha, Yolanda Gómez, Yesid Abuabara, Jaime Gallego
The linkage disequilibrium (LD) between molecular markers affects the accuracy of genome-wide association studies and genomic selection application. High-density genotyping platforms allow identifying the genotype of thousands of single nucleotide polymorphisms (SNPs) distributed throughout the animal genomes, which increases the resolution of LD evaluations. This study evaluated the distribution of minor allele frequencies (MAF) and the level of LD in the Colombian Creole cattle breeds Blanco Orejinegro (BON) and Romosinuano (ROMO) using a medium density SNP panel (BovineSNP50K_v2)...
April 2018: Genetics and Molecular Biology
Juan Miguel Arrazola, Thomas R Bromley
Boson sampling devices are a prime candidate for exhibiting quantum supremacy, yet their application for solving problems of practical interest is less well understood. Here we show that Gaussian boson sampling (GBS) can be used for dense subgraph identification. Focusing on the NP-hard densest k-subgraph problem, we find that stochastic algorithms are enhanced through GBS, which selects dense subgraphs with high probability. These findings rely on a link between graph density and the number of perfect matchings-enumerated by the Hafnian-which is the relevant quantity determining sampling probabilities in GBS...
July 20, 2018: Physical Review Letters
Juan Carlos Hurtado, Carla Carrilho, Inacio Mandomando, Miguel J Martínez
No abstract text is available yet for this article.
August 3, 2018: Enfermedades Infecciosas y Microbiología Clínica
Alexandre Bolze, Bertrand Boisson, Barbara Bosch, Alexander Antipenko, Matthieu Bouaziz, Paul Sackstein, Malik Chaker-Margot, Vincent Barlogis, Tracy Briggs, Elena Colino, Aurora C Elmore, Alain Fischer, Ferah Genel, Angela Hewlett, Maher Jedidi, Jadranka Kelecic, Renate Krüger, Cheng-Lung Ku, Dinakantha Kumararatne, Alain Lefevre-Utile, Sam Loughlin, Nizar Mahlaoui, Susanne Markus, Juan-Miguel Garcia, Mathilde Nizon, Matias Oleastro, Malgorzata Pac, Capucine Picard, Andrew J Pollard, Carlos Rodriguez-Gallego, Caroline Thomas, Horst Von Bernuth, Austen Worth, Isabelle Meyts, Maurizio Risolino, Licia Selleri, Anne Puel, Sebastian Klinge, Laurent Abel, Jean-Laurent Casanova
Isolated congenital asplenia (ICA) is the only known human developmental defect exclusively affecting a lymphoid organ. In 2013, we showed that private deleterious mutations in the protein-coding region of RPSA , encoding ribosomal protein SA, caused ICA by haploinsufficiency with complete penetrance. We reported seven heterozygous protein-coding mutations in 8 of the 23 kindreds studied, including 6 of the 8 multiplex kindreds. We have since enrolled 33 new kindreds, 5 of which are multiplex. We describe here 11 new heterozygous ICA-causing RPSA protein-coding mutations, and the first two mutations in the 5'-UTR of this gene, which disrupt mRNA splicing...
August 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
Antonio Rivero Juárez, Antonio Aguilera, Ana Avellón, Miguel García Deltoro, Federico García, Christian Gortazar, Rafael Granados, Juan Macías, Nicolás Merchante, José Antonio Oteo, María Teresa Pérez Gracia, Juan Antonio Pineda, Antonio Rivero, David Rodriguez-Lazaro, Francisco Téllez, Luis E Morano Amado
Hepatitis E virus (HEV) infection is one of the main causes of acute hepatitis in both developed and developing countries. This infectious disease has a high prevalence and incidence in Europe. HEV infection has a greater clinical impact in vulnerable populations, such as immunosuppressed patients, pregnant women and patients with underlying liver disease. Therefore, the Study Group for Viral Hepatitis (Grupo de Estudio de Hepatitis Víricas, GEHEP) of the Spanish Society of Infectious Diseases and Clinical Microbiology (Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, SEIMC) believed it very important to prepare a consensus document to help in decision-making regarding diagnosis, clinical and therapeutic management, and prevention of HEV infection...
July 30, 2018: Enfermedades Infecciosas y Microbiología Clínica
Juan Fd Montero, Humberto Cm de Souza, Mariana S Martins, Miguel N Oliveira, César Am Benfatti, Ricardo de Souza Magini
INTRODUCTION: The knowledge of the anatomy surrounding Bichat's fat pad, as well as its clinical applications, is essential to indicate and to safely perform its removal. This surgery is indicated not only for esthetic purposes, but also for functional reasons. When used properly, Bichat's fat pad is composed of stem cells that have a similar phenotype to adipose stem cells, useful in the treatment of pathologies and/or complications, such as maxillary sinus membrane perforation, oroantral/oronasal communications, peri-implantitis, ulcers, fibrosis of the oral mucosa, soft tissue reconstruction, among others...
July 1, 2018: Journal of Contemporary Dental Practice
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