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Juan Miguel

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https://www.readbyqxmd.com/read/30535073/the-qualified-presumption-of-safety-assessment-and-its-role-in-efsa-risk-evaluations-fifteen-years-past
#1
Lieve Herman, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Fernandez, Günter Klein, Luisa Peixe, Miguel Prieto, Amparo Querol, Juan Evaristo Suarez, Ingvar Sundh, Just Vlak, Sandra Correia
Microorganisms (food or feed additive, novel food or plant protection product) are intentionally added at different stages of the food and feed chain and are subjected to regulation and safety assessment by the European Food Safety Authority (EFSA). Safety evaluation is based on application dossiers for market authorisation to the European Commission. The qualified presumption of safety (QPS) concept was developed in 2003 to provide a harmonised generic safety pre-appraisal of the above microorganisms. Unambiguously defined biological taxonomic units (TUs) are assessed for their body of knowledge, their safety and their end use...
December 10, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/30534933/-purpura-due-to-strongyloides-stercoralis-in-an-immunocompetent-patient
#2
Raul Herrera, Christian Rojas-Contreras, Gabriel De la Cruz-Ku, Miguel Eduardo Eyzaguirre-Sandoval, Keny Llanos, Carlos Sotelo, Juan Pablo Alcantara, Fabiola Toledo, Milagros Gayoso, Bryan Valcarcel-Valdivia
Infection with Strongyloides stercoralis is a common parasitic infection in tropical and subtropical regions, including the Peruvian Amazon. The clinical manifestations are varied in patients with immunocompromised disease, and the systemic spread of the disease is frequent, compromising different organs and systems. Cutaneous manifestations are infrequent, being described in patients with some degree of immunosuppression. We present the case of an immunocompetent patient who developed a reactive purpura due to chronic Strongyloides stercoralis infection...
August 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/30530897/point-of-care-haemostasis-monitoring-during-liver-transplantation-is-cost-effective
#3
Antonio Leon-Justel, Ana I Alvarez-Rios, Jose A Noval-Padillo, Miguel A Gomez-Bravo, Manuel Porras, Laura Gomez-Sosa, Juan L Lopez-Romero, Juan M Guerrero
Background Optimal haemostasis management in orthotropic liver transplant (OLT) could reduce blood loss and transfusion volume, improve patient outcomes and reduce cost. Methods We performed a study including 336 OLTs to evaluate the clinical and cost effectiveness of a new point-of-care (POC)-based haemostatic management approach in OLT patients. Results In terms of health benefit we found that the new approach showed a significant reduction in transfusion requirements (red blood cell transfusion units were reduced from 5...
December 11, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30529287/efficacy-and-safety-of-a-novel-nitric-oxide-generator-for-the-treatment-of-neonatal-pulmonary-hypertension-experimental-and-clinical-studies
#4
Fernanda Blasina, Lucía Vaamonde, Fernando Silvera, Gonzalo Solla, Juan Andrés Abin-Carriquiry, Carmen Gutiérrez, Pilar Beltramo, Irene García, Miguel Martell
Persistent pulmonary hypertension of the newborn (PPHN) is a complex pathology resulting from a failure of the post-natal reduction in pulmonary vascular resistance leading to hypoxemia. The standard therapy is inhaled Nitric Oxide (NO) improving oxygenation but its availability is limited, especially in hospitals with restricted financial resources. We evaluated the efficacy and safety of a new device generating NO (TAS + PLUS), in an experimental piglet models of pulmonary hypertension (PH), and we later tested its application in a pilot study of newborn patients suffering from PPHN...
December 7, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/30529143/methodological-issues-in-a-prospective-study-on-plasma-concentrations-of-persistent-organic-pollutants-and-pancreatic-cancer-risk-within-the-epic-cohort
#5
Magda Gasull, José Pumarega, Hannu Kiviranta, Panu Rantakokko, Ole Raaschou-Nielsen, Ingvar A Bergdahl, Torkjel Manning Sandanger, Fernando Goñi, Lluís Cirera, Carolina Donat-Vargas, Juan Alguacil, Mar Iglesias, Anne Tjønneland, Kim Overvad, Francesca Romana Mancini, Marie-Christine Boutron-Ruault, Gianluca Severi, Theron Johnson, Tilman Kühn, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Domenico Palli, Valeria Pala, Rosario Tumino, Alessio Naccarati, Salvatore Panico, Monique Verschuren, Roel Vermeulen, Charlotta Rylander, Therese Haugdahl Nøst, Miguel Rodríguez-Barranco, Amaia Molinuevo, María-Dolores Chirlaque, Eva Ardanaz, Malin Sund, Tim Key, Weimin Ye, Mazda Jenab, Dominique Michaud, Giuseppe Matullo, Federico Canzian, Rudolf Kaaks, Alexandra Nieters, Ute Nöthlings, Suzanne Jeurnink, Veronique Chajes, Marco Matejcic, Marc Gunter, Dagfinn Aune, Elio Riboli, Antoni Agudo, Carlos Alberto Gonzalez, Elisabete Weiderpass, Bas Bueno-de-Mesquita, Eric J Duell, Paolo Vineis, Miquel Porta
BACKGROUND: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. OBJECTIVES: First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk...
November 23, 2018: Environmental Research
https://www.readbyqxmd.com/read/30526152/clinical-significance-of-complex-karyotype-at-diagnosis-in-pediatric-and-adult-patients-with-de-novo-acute-promyelocytic-leukemia-treated-with-atra-and-chemotherapy
#6
Jorge Labrador, Elisa Luño, Edo Vellenga, Salut Brunet, José González-Campos, Maria C Chillón, Aleksandra Holowiecka, Jordi Esteve, Juan Bergua, José D González-Sanmiguel, Cristina Gil, Mar Tormo, Olga Salamero, Felix Manso, Isolda Fernández, Javier de laSerna, María-José Moreno, Manuel Pérez-Encinas, Isabel Krsnik, Josep-Maria Ribera, Jose Cervera, María J Calasanz, Blanca Boluda, Marta Sobas, Bob Lowenberg, Miguel A Sanz, Pau Montesinos
Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of ≥2 ACA, and a very CK (CK+) as ≥3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+...
December 11, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/30525864/-home-and-ambulatory-artificial-nutrition-nadya-report-home-parenteral-nutrition-in-spain-2017
#7
Carmina Wanden-Berghe Lozano, José Luis Pereira Cunill, Cristina Cuerda Compes, Esther Ramos Boluda, María Irene Maiz Jiménez, Carmen Gómez Candela, Nuria Virgili Casas, Rosa Burgos Peláez, Antonio Pérez de la Cruz, M ª Ángeles Penacho Lázaro, Eva Ángeles Sánchez Martos, Daniel Antonio De Luis Román, Ceferino Martínez Faedo, María de Los Ángeles Martín Fontalba, Julia Álvarez Hernández, Pilar Matía Martín, Patricia Díaz Guardiola, Fátima Carabaña Pérez, Alejandro Sanz París, Carmen Garde Orbaiz, Olga Sánchez-Vilar Burdiel, Tomás Martín Folgueras, M ª Ángela Martín Palmero, Luis Miguel Luengo Pérez, Ana Zugasti Murillo, Cecilia Martínez Costa, José Pablo Suárez Llanos, Cristina Tejera Pérez, José Antonio Irles Rocamora, Carmen Arraiza Irigoyen, Yaiza García Delgado, Cristina Campos Martín, Miguel Ángel Ponce González, Silvia Mauri Roca, M ª Victoria García Zafra, Jesús M Morán López, Begoña Molina Baeza, Montserrat Gonzalo Marín, Clara Joaquín Ortiz, Begoña Pintor de la Maza, M ª Carmen Gil Martínez, María José Carrera Santaliestra, M ª Del Talló Forga Visa, Antxón Apezetxea Celaya, Rebeca Sánchez Sánchez, Juan Ramón Urgeles Planella
AIM: to communicate HPN data obtained from the HPN registry of the NADYA-SENPE group (www.nadya-senpe.com) for the year 2017. MATERIAL AND METHODS: descriptive analysis of the data collected from adult and pediatric patients with HPN in the NADYA-SENPE group registry from January 1st, 2017 to December 31st, 2017. RESULTS: there were 308 patients from 45 Spanish hospitals (54.5% women), 38 children and 270 adults, with 3,012 episodes, which represent a prevalence rate of 6...
December 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/30525857/-relationship-of-physical-activity-level-and-body-composition-on-postural-control-in-male-adults
#8
José Manuel Delfa-de-la-Morena, Miguel Ángel Rojo Tirado, Eliane Aparecida-de-Castro, Alexander Gil Arias, Juan Carlos Miangolarra-Page, Pedro José Benito Peinado
INTRODUCTION: balance is very important in order to perform daily physical activities as standing or walking. Both physical activity and body composition are some of the most important adjustable intrinsic factors influencing balance. OBJECTIVE: to analyze the influence of physical activity level and different body variables on the postural control of male adults. METHODS: observational, cross-sectional study with 63 men between 25 and 60 years of age, with body mass index (BMI) between 18 and 35 kg/ m2...
December 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/30525856/-analysis-of-the-promoting-actions-of-physical-activity-developed-by-valencian-public-universities
#9
José Miguel Martínez Sanz, Adrián Gómez Arenas, Miguel García-Jaén, Isabel Sospedra, Aurora Norte, Juan Manuel Cortell-Tormo
BACKGROUND: the Valencian Network of Healthy Public Universities (RVUPS) is part of the healthy environments of the World Health Organization (WHO). The aim of the network is to achieve healthier universities through different lines of action, emphasizing the promotion of physical activity and sports. AIM: the purpose of this study was to analyze and review the activities developed by the RVUPS on the promotion of FA and to assess, through key informants, the need to implement an AF service within the university context...
December 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/30525452/discovery-of-in-vivo-chemical-probes-for-treating-alzheimer%C3%A2-s-disease-dual-phosphodiesterase-5-pde5-and-class-i-histone-deacetylases-selective-inhibitors
#10
Obdulia Rabal, Juan A Sánchez-Arias, Mar Cuadrado-Tejedor, Irene De Miguel, Marta Pérez-González, Carolina García-Barroso, Ana Ugarte, Ander Estella, Elena Sáez, Maria Espelosin, Susana Ursua, Haizhong Tan, Wei Wu, Musheng Xu, Ana Garcia-Osta, Julen Oyarzabal
In order to determine the contributions of histone deacetylase (HDAC) isoforms to the beneficial effects of dual PDE5 and pan-HDAC inhibitors on in vivo models of Alzheimer's disease (AD), we have designed, synthesized and tested novel chemical probes with the desired target compound profile of phosphodiesterase 5 (PDE5)- and class I HDAC-selective inhibitors. Compared to previous hydroxamate-based series, these molecules exhibit longer residence times on HDACs. In this scenario, shorter or longer pre-incubation times may have a significant impact on the IC50 values of these compounds and therefore on their corresponding selectivity profiles on the different HDAC isoforms...
December 10, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30522944/spanish-registry-of-recent-onset-psoriatic-arthritis-reapser-study-aims-and-methodology
#11
Rubén Queiro, Ana Laiz, Daniel Seoane-Mato, Eva Galindez Agirregoikoa, Carlos Montilla, Hye Sang Park, Juan José Bethencourt Baute, Sagrario Bustabad, Jose A Pinto Tasende, Patricia Tejón, Beatriz Joven Ibáñez, Julio Ramírez, Andrea Cuervo, Juan D Cañete, Pilar Trenor Larraz, Carmen Ordás, Sara Alonso, Edilia García-Fernández, Elide Toniolo, Manuel José Moreno Ramos, María Dolores Beteta, Leticia Lojo Oliveira, Teresa Navío Marco, Laura Cebrián, Ceferino Barbazán, Francisco Maceiras, Jesús Rodriguez-Moreno, Martina Steiner, Santiago Muñoz-Fernández, Francisco Javier Nóvoa Medina, Manuel León, Esteban Rubio, Julio Medina Luezas, María Dolores Sánchez-González, Marta Arévalo, Jordi Gratacós, José Miguel Senabre, José Carlos Rosas, Gregorio Santos Soler, Juan Carlos Nieto-González, Carlos González, Alejandra López Robles, Carolina Álvarez Castro, María Dolores Ruiz Montesino, Vicenç Torrente-Segarra, Cristina Fernández-Carballido, María Paz Martínez-Vidal, Vega Jovani, Ana Urruticoechea-Arana, Yolanda Cabello Fernández, María Dolores Toledo, Raquel Almodóvar, Miguel Ángel Belmonte-Serrano, Irene Notario Ferreira, Enrique Raya Álvarez
AIMS: To describe the methodology of REAPSER (Spanish Registry of Recent-onset Psoriatic Arthritis), its strengths and limitations. The aim of this study is to identify prognostic factors for the clinical and radiographic course in a cohort of patients with psoriatic arthritis (PsA) diagnosed within 2years of symptom evolution. METHODS: Multicenter, observational and prospective study (with 2-year follow-up including annual visits). Baseline visit intended to reflect patient situation before the disease course was modified by treatments prescribed in rheumatology departments...
December 3, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/30513301/cc2d1b-coordinates-escrt-iii-activity-during-the-mitotic-reformation-of-the-nuclear-envelope
#12
Leandro N Ventimiglia, Miguel Angel Cuesta-Geijo, Nicolas Martinelli, Anna Caballe, Pauline Macheboeuf, Nolwenn Miguet, Ian M Parnham, Yolanda Olmos, Jeremy G Carlton, Winfried Weissenhorn, Juan Martin-Serrano
The coordinated reformation of the nuclear envelope (NE) after mitosis re-establishes the structural integrity and the functionality of the nuclear compartment. The endosomal sorting complex required for transport (ESCRT) machinery, a membrane remodeling pathway that is highly conserved in eukaryotes, has been recently involved in NE resealing by mediating the annular fusion of the nuclear membrane (NM). We show here that CC2D1B, a regulator of ESCRT polymerization, is required to re-establish the nuclear compartmentalization by coordinating endoplasmic reticulum (ER) membrane deposition around chromatin disks with ESCRT-III recruitment to the reforming NE...
December 3, 2018: Developmental Cell
https://www.readbyqxmd.com/read/30511170/how-do-energy-balance-related-behaviors-cluster-in-adolescents
#13
Tatiana Sadalla Collese, Augusto César Ferreira De Moraes, Juan Miguel Fernández-Alvira, Nathalie Michels, Stefaan De Henauw, Yannis Manios, Odysseas Androutsos, Anthony Kafatos, Kurt Widhalm, Myriam Galfo, Laurent Beghin, Michael Sjöström, Raquel Pedrero-Chamizo, Heráclito Barbosa Carvalho, Luis A Moreno
OBJECTIVES: To delineate the clustering of energy balance-related behaviors in adolescents and investigate whether these behaviors are associated with the household socioeconomic status and parental education level. METHODS: Two cross-sectional studies assessed information on sedentary behavior, physical activity, sugar-sweetened beverages and fruit and vegetable consumption, and sleep duration by self-reported questionnaires in adolescents (12.5-17.5 years old) from Maringá/Brazil (BRACAH Study; n = 682) and ten European cities (HELENA Study; n = 1252) from nine different countries...
December 4, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/30509238/degree-of-control-of-patients-with-chronic-obstructive-pulmonary-disease-in-spain-sincon-study
#14
Adolfo Baloira, José Miguel Rodriguez Gonzalez-Moro, Estefanía Sanjuán, Juan Antonio Trigueros, Ricard Casamor
BACKGROUND: Disease control is an important objective of COPD management. The SINCON study evaluated the level of control in terms of respiratory symptoms and exacerbations in Spanish patients with COPD for ≥2 years. METHODS: SINCON was a descriptive, cross-sectional, multicenter study that assessed degree of control using a combined index comprising COPD assessment test (CAT), modified Medical Research Council dyspnea scale (mMRC), and number of moderate/severe exacerbations in the last year...
December 3, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/30506598/invasive-fungal-disease-in-patients-undergoing-umbilical-cord-blood-transplantation-after-myeloablative-conditioning-regimen
#15
Juan Montoro, Jaime Sanz, José Ignacio Lorenzo, Pau Montesinos, Rebeca Rodríguez-Veiga, Miguel Salavert, Eva González, Manuel Guerreiro, Carlos Carretero, Aitana Balaguer, Inés Gómez, Pilar Solves, Guillermo F Sanz, Miguel A Sanz, José Luis Piñana
OBJECTIVE: Characteristics and risk factors (RFs) of invasive fungal disease (IFD) have been little studied in the setting of umbilical cord blood transplantation (UCBT). METHOD: We retrospectively included 205 single-unit myeloablative UCBT recipients with a median follow-up of 64 months. RESULTS: Fifty-six episodes of IFD were observed in 48 patients (23%) at a median time of 123 days after stem cell infusion. Invasive mold disease (IMD) occurred in 42 cases, 38 of them (90%) caused by invasive aspergillosis whereas invasive yeast disease (IYD) occurred in 14 cases, most of them due to candidemia (n= 12, 86%)...
December 1, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/30504932/feasibility-of-treatment-discontinuation-in-chronic-myeloid-leukemia-in-clinical-practice-results-from-a-nationwide-series-of-236-patients
#16
Juan Carlos Hernández-Boluda, Arturo Pereira, Irene Pastor-Galán, Alberto Alvarez-Larrán, Alisa Savchuk, José Manuel Puerta, José María Sánchez-Pina, Rosa Collado, Alvaro Díaz-González, Anna Angona, Miguel Sagüés, Valentín García-Gutiérrez, Concepción Boqué, Santiago Osorio, Rolando Vallansot, Luis Palomera, Arantxa Mendizábal, Luis Felipe Casado, Manuel Pérez-Encinas, Raúl Pérez-López, Francisca Ferrer-Marín, Fermín Sánchez-Guijo, Carmen García, Natalia de Las Heras, José Luis López-Lorenzo, Francisco Cervantes, Juan Luis Steegmann
Over half of chronic myeloid leukemia (CML) patients in deep molecular response do not lose the major molecular response (MMR) after stopping treatment with tyrosine kinase inhibitors (TKI). This strategy is safe in clinical trials, but its applicability in the real-life setting remains unsettled. We describe the outcomes after TKI discontinuation in a nationwide series of 236 CML patients. Median follow-up from treatment discontinuation was 21.5 months and 5 patients died from CML-unrelated causes. TKI therapy was reinitiated due to MMR loss (n = 52), increase ≥ 1 log in BCR-ABL transcript level without losing MMR (n = 12), patient preference (n = 2), and withdrawal syndrome (n = 1)...
December 2, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/30504425/nrf2-through-rps6-activation-is-related-to-anti-her2-drug-resistance-in-her2-amplified-gastric-cancer
#17
Valentina Gambardella, Francisco Gimeno-Valiente, Noelia Tarazona, Carolina Martinez Ciarpaglini, Desamparados Roda, Tania Fleitas, Pablo Tolosa, Juan Miguel Cejalvo, Marisol Huerta, Susana Roselló, Josefa Castillo, Andres Cervantes
PURPOSE: Despite the clinical advantage of the combination of trastuzumab and platinum-based chemotherapy in HER2-amplified tumors, resistance will eventually develop. The identification of molecular mechanisms related to primary and acquired resistance is needed. EXPERIMENTAL DESIGN: We generated lapatinib- and trastuzumab-resistant clones deriving from two different HER2-amplified GC cell lines. Molecular changes such as protein expression and gene expression profile were evaluated to detect alterations which could be related to resistance...
November 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30504116/-percutaneous-balloon-angioplasty-for-treatment-of-chronic-thromboembolic-pulmonary-hypertension
#18
Fernando J Daghero, Juan P Casas, Pablo E Sarmiento, Roberto M A Colque, Miguel A Tibaldi, Eduardo Moreyra, Leandro Martínez Riera, Guillermo Pacheco
Chronic thromboembolic pulmonary hypertension is characterized by the presence of organized thrombotic material in the pulmonary arteries which causes elevation of the pulmonary vascular resistance, right heart failure, and death if not treated. Pulmonary thromboendarterectomy is the treatment of choice and can be curative when the obstruction is proximal. There are cases in which this therapy is not possible, and pulmonary angioplasty is a therapeutic alternative of growing interest. We present our experience with three patients diagnosed with chronic thromboembolic pulmonary hypertension in whom pulmonary endarterectomy was not possible and pulmonary angioplasty was performed...
2018: Medicina
https://www.readbyqxmd.com/read/30502686/synthesis-and-biological-evaluation-as-antiangiogenic-agents-of-ureas-derived-from-3-aminocombretastatin-a-4
#19
Laura Conesa-Milián, Eva Falomir, Juan Murga, Miguel Carda, J Alberto Marco
Twenty-six compounds derived from 3'-aminocombretastatin A-4 (AmCA-4) containing a urea fragment mimicking the structure of Sorafenib, have been synthesized and evaluated as antiangiogenic compounds. Antiproliferative activity of all the synthetic ureas has been measured on tumor cell lines HT-29, MCF-7, HeLa, A-549 and HL-60 as well as on the endothelial cell line HMEC-1 and on the non-tumor cell line HEK-293. Preliminary docking studies were developed in order to predict which ureas show better interactions with the protein VEGFR-2...
November 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30500426/fitness-cortical-thickness-and-surface-area-in-overweight-obese-children-the-mediating-role-of-body-composition-and-relationship-with-intelligence
#20
Irene Esteban-Cornejo, Jose Mora-Gonzalez, Cristina Cadenas-Sanchez, Oren Contreras-Rodriguez, Juan Verdejo-Roman, Pontus Henriksson, Jairo H Migueles, Maria Rodriguez-Ayllon, Pablo Molina-García, Chao Suo, Charles H Hillman, Arthur F Kramer, Kirk I Erickson, Andrés Catena, Antonio Verdejo-García, Francisco B Ortega
Cortical thickness and surface area are thought to be genetically unrelated and shaped by independent neurobiological events suggesting that they should be considered separately in morphometric analyses. Although the developmental trajectories of cortical thickness and surface area may differ across brain regions and ages, there is no consensus regarding the relationships of physical fitness with cortical thickness and surface area as well as for its subsequent influence on intelligence. Thus, this study examine: (i) the associations of physical fitness components (i...
November 27, 2018: NeuroImage
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