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Juan Miguel

Marta Sobas, Pau Montesinos, Blanca Boluda, Teresa Bernal, Edo Vellenga, Josep Nomdedeu, Jose González-Campos, Maria Chillón, Aleksandra Holowiecka, Jordi Esteve, Juan Bergua, José David González-Sanmiguel, Cristina Gil-Cortes, Mar Tormo, Olga Salamero, Felix Manso, Isolda Fernández, Javier de la Serna, María-José Moreno, Manuel Pérez-Encinas, Isabel Krsnik, Josep-Maria Ribera, Lourdes Escoda, Bob Lowenberg, Miguel Angel Sanz
Out of 956, there were 95 (10%) CD56+ APL patients treated with PETHEMA ATRA and chemotherapy. CD56+ expression was associated with high WBC, BCR3 isoform, and co-expression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. CD56+ vs CD56- APL presented higher induction death rate (16% vs 8%, p = .02) and 5-years cumulative incidence of relapse (33% versus 10%, p = .006), irrespectively of the Sanz score (low-risk 47% versus 5%, p < .001; intermediate 23% versus 7%, p < .001; and high-risk 42% versus 21%, p = ...
October 15, 2018: Leukemia & Lymphoma
Maria Joao Baptista, Gustavo Tapia, Mireia Morgades, Josep Muncunill, Ana-María Muñoz-Marmol, Silvia Montoto, John G Gribben, Maria Calaminici, Antonio Martinez, Blanca Gonzalez-Farre, Ivan Dlouhy, Eva González-Barca, María-José Terol, Pilar Miralles, Miguel Alcoceba, Ferran Vall-Llovera, Javier Briones, Pau Abrisqueta, Eugenia Abella, Mariano Provencio, Carlos García-Ballesteros, José-María Moraleda, Juan-Manuel Sancho, Josep-Maria Ribera, José-Luis Mate, José-Tomas Navarro
No abstract text is available yet for this article.
October 15, 2018: Leukemia & Lymphoma
Gerard Hoek, Andrea Ranzi, Ilir Alimehmeti, Elena-Roxana Ardeleanu, Juan P Arrebola, Paula Ávila, Carla Candeias, Ann Colles, Gloria Cerasela Crișan, Sarah Dack, Zoltán Demeter, Lucia Fazzo, Tine Fierens, Benjamin Flückiger, Stephanie Gaengler, Otto Hänninen, Hedi Harzia, Rupert Hough, Barna Laszlo Iantovics, Olga-Ioanna Kalantzi, Spyros P Karakitsios, Konstantinos C Markis, Piedad Martin-Olmedo, Elena Nechita, Thomai Nicoli, Hans Orru, Roberto Pasetto, Francisco Miguel Pérez-Carrascosa, Diogo Pestana, Fernando Rocha, Dimosthenis A Sarigiannis, João Paulo Teixeira, Christos Tsadilas, Visa Tasic, Lorenzo Vaccari, Ivano Iavarone, Kees de Hoogh
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Health risks related to living close to industrially contaminated sites (ICSs) are a public concern. Toxicology-based risk assessment of single contaminants is the main approach to assess health risks, but epidemiological studies which investigate the relationships between exposure and health directly in the affected population have contributed important evidence. Limitations in exposure assessment have substantially contributed to uncertainty about associations found in epidemiological studies...
September 2018: Epidemiologia e Prevenzione
Stephen M Okajima, M Belen Cubria, Sharri J Mortensen, Juan C Villa-Camacho, Philip Hanna, Aron Lechtig, Miguel Perez-Viloria, Patrick Williamson, Mark W Grinstaff, Edward K Rodriguez, Ara Nazarian
This proposal aims to create an in vivo rat model of adhesive capsulitis for researching potential treatment options for this condition and other etiologies of comparable arthrofibrosis. The model includes extra-articular fixation of the shoulder in rats via scapular to humeral suturing, resulting in a secondary contracture without invading the intra-articular space and resulting in decreased rotational ROM and increased joint stiffness. We used 10 Sprague-Dawley rats for the purpose of this study. Baseline ROM measurements were taken before glenohumeral immobilization...
September 28, 2018: Journal of Visualized Experiments: JoVE
Edgar Guevara, Juan Carlos Torres-Galván, Miguel G Ramírez-Elías, Claudia Luevano-Contreras, Francisco Javier González
Type 2 diabetes mellitus (DM2) is one of the most widely prevalent diseases worldwide and is currently screened by invasive techniques based on enzymatic assays that measure plasma glucose concentration in a laboratory setting. A promising plan of action for screening DM2 is to identify molecular signatures in a non-invasive fashion. This work describes the application of portable Raman spectroscopy coupled with several supervised machine-learning techniques, to discern between diabetic patients and healthy controls (Ctrl), with a high degree of accuracy...
October 1, 2018: Biomedical Optics Express
Manuel Almendro-Delia, Iván J Núñez-Gil, Manuel Lobo, Mireia Andrés, Oscar Vedia, Alessandro Sionis, Ana Martin-García, María Cruz Aguilera, Eduardo Pereyra, Irene Martín de Miguel, José A Linares Vicente, Miguel Corbí-Pascual, Xavier Bosch, Oscar Fabregat Andrés, Alejandro Sánchez Grande Flecha, Alberto Pérez-Castellanos, Javier López Pais, Manuel De Mora Martín, Juan María Escudier Villa, Roberto Martín Asenjo, Marta Guillen Marzo, Ferrán Rueda Sobella, Álvaro Aceña, José María García Acuña, Juan C García-Rubira
OBJECTIVES: This study sought to describe the incidence, determinants, and prognostic impact of cardiogenic shock (CS) in takotsubo syndrome (TTS). BACKGROUND: TTS can be associated with severe hemodynamic instability. The prognostic implication of CS has not been well characterized in large studies of TTS. METHODS: We analyzed patients with a definitive TTS diagnosis (modified Mayo criteria) who were recruited for the National RETAKO (Registry on Takotsubo Syndrome) trial from 2003 to 2016...
October 4, 2018: JACC. Heart Failure
Carlos Ortiz-Bautista, Laura Morán-Fernández, Marta Díaz-García, Miguel Ángel Delgado-Nicolás, Inés Ponz-de Antonio, Adriana Rodríguez-Chaverri, Mª Dolores García-Cosio, Javier de Juan-Bagudá, David Lora-Pablos, Violeta Sánchez-Sánchez, Pilar Escribano-Subías, Héctor Bueno, Fernando Arribas-Ynsaurriaga, Juan F Delgado-Jiménez
BACKGROUND AND OBJECTIVE: Several trials have evaluated the effect of disease management programs in heart failure (HF) with diverse results. The aim of this study was to develop a simple nurse-led clinic intervention program for patients with HF and assess whether this intervention positively affects the prognosis of patients, their care costs and perceived quality of life (QoL). METHODS: Between 2011 and 2013, 127 patients with reduced ejection fraction were prospectively randomly allocated (1:2) to standard care or intervention program...
October 9, 2018: Medicina Clínica
María Díaz, Lucía Guadamuro, Irene Espinosa-Martos, Leonardo Mancabelli, Santiago Jiménez, Cristina Molinos-Norniella, David Pérez-Solis, Christian Milani, Juan Miguel Rodríguez, Marco Ventura, Carlos Bousoño, Miguel Gueimonde, Abelardo Margolles, Juan José Díaz, Susana Delgado
Cow's milk protein allergy (CMPA) is the most common food allergy in infancy. Non-IgE mediated (NIM) forms are little studied and the responsible mechanisms of tolerance acquisition remain obscure. Our aim was to study the intestinal microbiota and related parameters in the fecal samples of infants with NIM-CMPA, to establish potential links between type of formula substitutes, microbiota, and desensitization. Seventeen infants between one and two years old, diagnosed with NIM-CMPA, were recruited. They were all on an exclusion diet for six months, consuming different therapeutic protein hydrolysates...
October 11, 2018: Nutrients
Benjamín Gaya-Sancho, Inmaculada Alemán Aguilera, Juan Jesús Navarro-Muñoz, Miguel Botella López
Sex determination is one of the essential steps when it comes to establishing an individual's biological profile. It is important in both archaeology and forensic studies. The sacrum is not generally conserved, but in cases where it is, it can be used for determination of the sex of skeletal remains. Furthermore, the sacrum is not a commonly studied bone and has not been studied in a Spanish population. For this study, measurements of 170 sacra of individuals from the contemporary osteological collection of San José from Granada including only the adults were taken...
October 6, 2018: Journal of Forensic and Legal Medicine
Esther Rivas, Jose Luis Santiago, Yolanda Lechón, Fernando Martín, Arturo Ariño, Juan José Pons, Jesús Miguel Santamaría
A methodology based on CFD-RANS simulations (WA CFD-RANS, Weighted Averaged Computational Fluid Dynamic-Reynolds-Averaged Navier-Stokes simulations) which includes appropriate modifications, has been applied to compute the annual, seasonal, and hourly average concentration of NO2 and NOX throughout the city of Pamplona (Spain) at pedestrian level during 2016. The results have been evaluated using measurements provided both by the city's network of air quality monitoring stations and by a network of mobile microsensors carried around by cyclists during their daily commutes, obtaining a maximum relative error lower than 30% when computing NO2 annual average concentrations...
February 1, 2019: Science of the Total Environment
Alberto Parafita-Fernández, Montserrat García-Gonzalez, Andreas Katsanos, Juan Gros-Otero, Miguel Teus
PURPOSE: To compare postoperative evolution of visual acuity, flap thickness, and stromal optical density during the first 3 months after femtosecond (FS) laser in situ keratomileusis surgery for correction of myopia using the iFS 150-kHz FS laser and LenSx FS laser platforms. METHODS: This was a prospective case series. Thirty-nine eyes treated with the iFS 150-kHz FS laser versus 38 refraction-matched eyes treated with the LenSx FS laser platform were included...
October 10, 2018: Cornea
José Manuel Moreno Villares, Miguel Sáenz de Pipaón, Ángel Carrasco Sanz, Juan José Díaz Martín, Susana Redecillas Ferreiro, Ana Moráis López, Félix Sánchez Valverde, Víctor Navas López, Miguel Ángel San José González, Rosaura Leis Trabazo, Mercedes Gil-Campos, Luis Carlos Blesa Baviera, Cristina Campoy Folgoso
INTRODUCTION: the recent economic and financial crisis has affected most Western countries, especially families of low socioeconomic classes. We speculate that worsening of socioeconomic condition associated with the crisis would increase obesity, mainly in disadvantaged families. MATERIAL AND METHODS: cross-sectional study of the 290,111 children aged three to 12 years old attending public school during the term 2014-2015 in Madrid City, by means of a stratified weighted sample randomly chosen, taking into account age (grade), city district and schools...
October 5, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Marta Toral, Rosario Jimenez, Sebastián Montoro-Molina, Miguel Romero, Rosemary Wangensteen, Juan Duarte, Félix Vargas
Thyroid hormone activity is associated with L-arginine metabolism and nitric oxide (NO) production, which participate in the cardiovascular manifestations of thyroid disorders. L-arginine transporters play an important role in activating L-arginine uptake and NO production. However, the effects of thyroid hormones on L-arginine transporters in endothelial cells have not yet been evaluated. The following methods were used. We measured L-arginine uptake, mRNA expression of L-arginine transporters, endothelial nitric oxide synthase (eNOS) mRNA and NO generation after the administration of T3, T4 and the T3 analog, 3,3′,5-triiodothyroacetic acid TRIAC in human umbilical vein endothelial cells (HUVECs)...
October 1, 2018: Journal of Endocrinology
Regina Juanbeltz, Iván Martínez-Baz, Ramón San Miguel, Silvia Goñi-Esarte, Juan Manuel Cabasés, Jesús Castilla
BACKGROUND: Direct-acting antivirals (DAA) have demonstrated high efficacy to achieve sustained virological response (SVR) in chronic hepatitis C patients. We aim to assess the change in health-related quality of life (HRQoL) among patients successfully treated, and to identify predictors of this variation. METHODS: In a prospective observational study, patients with chronic hepatitis C who started DAA therapy between May 2016 and April 2017 completed the EQ-5D-5L questionnaire at baseline and 12 weeks after the end of therapy before knowing the virological result...
2018: PloS One
José Pérez-Navarro, Pedro Miguel Izquierdo-Cañas, Adela Mena-Morales, Jesús Martínez-Gascueña, Juan Luis Chacón-Vozmediano, Esteban García-Romero, Sergio Gómez-Alonso, Isidro Hermosín-Gutiérrez
BACKGROUND: Due to the currently dominance of a few grape varieties in the wine market, the aim of this work was to study the detailed phenolic and volatile composition, chromatic characteristics and sensorial properties of red wines elaborated with new Vitis vinifera grapes identified (Moribel and Tinto Fragoso) using HPLC-DAD-ESI-MS/MS, GC-MS, CIELab colour space and Napping ® technique. RESULTS: Tinto Fragoso wine showed higher phenolic content than Moribel, with more anthocyanins, flavonols and stilbenes...
October 9, 2018: Journal of the Science of Food and Agriculture
Luis M Real, Juan Macías, Ana B Pérez, Dolores Merino, Rafael Granados, Luis Morano, Marcial Delgado, María J Ríos, Carlos Galera, Miguel G Deltoro, Nicolás Merchante, Federico García, Juan A Pineda
Hepatitis C virus (HCV) response to direct-acting antivirals (DAAs) may be influenced by the presence of resistance-associated substitutions (RASs). This study aimed to assess if NS5A baseline RAS-guided treatment enhances the rate of sustained viral response (SVR) in naïve HCV-infected patients in clinical practice. All HCV-infected patients who initiated treatment with interferon (IFN)-free DAA-based regimens between March 2016 and May 2017 in 17 Spanish hospitals and who had evaluable SVR 12 weeks (SVR12) after the end of therapy were included...
October 8, 2018: Scientific Reports
Marina Suhorutshenko, Viktorija Kukushkina, Agne Velthut-Meikas, Signe Altmäe, Maire Peters, Reedik Mägi, Kaarel Krjutškov, Mariann Koel, Francisco M Codoñer, Juan Fco Martinez-Blanch, Felipe Vilella, Carlos Simón, Andres Salumets, Triin Laisk
STUDY QUESTION: Does cellular composition of the endometrial biopsy affect the gene expression profile of endometrial whole-tissue samples? SUMMARY ANSWER: The differences in epithelial and stromal cell proportions in endometrial biopsies modify the whole-tissue gene expression profiles and affect the results of differential expression analyses. WHAT IS ALREADY KNOWN: Each cell type has its unique gene expression profile. The proportions of epithelial and stromal cells vary in endometrial tissue during the menstrual cycle, along with individual and technical variation due to the method and tools used to obtain the tissue biopsy...
October 8, 2018: Human Reproduction
Maria Luisa Mandelli, Ariane E Welch, Eduard Vilaplana, Christa Watson, Giovanni Battistella, Jesse A Brown, Katherine L Possin, Honey I Hubbard, Zachary A Miller, Maya L Henry, Gabe A Marx, Miguel A Santos-Santos, Lynn P Bajorek, Juan Fortea, Adam Boxer, Gil Rabinovici, Suzee Lee, Jessica Deleon, Howard J Rosen, Bruce L Miller, William W Seeley, Maria Luisa Gorno-Tempini
Non-fluent/agrammatic primary progressive aphasia (nfvPPA) is caused by neurodegeneration within the left fronto-insular speech and language production network (SPN). Graph theory is a branch of mathematics that studies network architecture (topology) by quantifying features based on its elements (nodes and connections). This approach has been recently applied to neuroimaging data to explore the complex architecture of the brain connectome, though few studies have exploited this technique in PPA. Here, we used graph theory on functional MRI resting state data from a group of 20 nfvPPA patients and 20 matched controls to investigate topological changes in response to focal neurodegeneration...
August 11, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Luz M Canet, Jose M Sánchez-Maldonado, Rafael Cáliz, Ana Rodríguez Ramos, Carmen B Lupiañez, Helena Canhão, Manuel Martínez-Bueno, Alejandro Escudero, Juana Segura-Catena, Signe B Sorensen, Merete L Hetland, María José Soto-Pino, Miguel A Ferrer, Antonio García, Bente Glintborg, Ileana Filipescu, Eva Pérez-Pampin, Alfonso González-Utrilla, Miguel Ángel López Nevot, Pablo Conesa-Zamora, Alfons den Broeder, Salvatore De Vita, Sven Erik Hobe Jacobsen, Eduardo Collantes-Estevez, Luca Quartuccio, Federico Canzian, João E Fonseca, Marieke J H Coenen, Vibeke Andersen, Juan Sainz
The aim of this case-control study was to evaluate whether 47 single-nucleotide polymorphisms (SNPs) in steroid hormone-related genes are associated with the risk of RA and anti-TNF drug response. We conducted a case-control study in 3 European populations including 2936 RA patients and 2197 healthy controls. Of those, a total of 1985 RA patients were treated with anti-TNF blockers. The association of potentially interesting markers in the discovery population was validated through meta-analysis with data from DREAM and DANBIO registries...
October 5, 2018: Pharmacogenomics Journal
Ismael Álvarez-Álvarez, Miguel Á Martínez-González, Ana Sánchez-Tainta, Dolores Corella, Andrés Díaz-López, Montserrat Fitó, Jesús Vioque, Dora Romaguera, J Alfredo Martínez, Julia Wärnberg, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Fernando Arós, Josep A Tur, Francisco J Tinahones, Lluís Serra-Majem, Vicente Martín, José Lapetra, Sebastián Más Fontao, Xavier Pintó, Josep Vidal, Lidia Daimiel, José Juan Gaforio, Pilar Matía, Emilio Ros, Miguel Ruiz-Canela, José V Sorlí, Nerea Becerra-Tomás, Olga Castañer, Helmut Schröder, Eva M Navarrete-Muñoz, M Ángeles Zulet, Antonio García-Ríos, Jordi Salas-Salvadó, Javier Díez-Espino, Estefanía Toledo
INTRODUCTION AND OBJECTIVES: The cardiovascular benefits of the Mediterranean diet have usually been assessed under assumptions of ad libitum total energy intake (ie, no energy restriction). In the recently launched PREDIMED-Plus, we conducted exploratory analyses to study the baseline associations between adherence to an energy-restricted Mediterranean diet (MedDiet) and the prevalence of cardiovascular risk factors (CVRF). METHODS: Cross-sectional assessment of all PREDIMED-Plus participants (6874 older adults with overweight/obesity and metabolic syndrome) at baseline...
October 1, 2018: Revista Española de Cardiología
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