keyword
https://read.qxmd.com/read/38522867/endocardial-fibroelastosis-resection-when-it-works-and-when-it-does-not
#1
REVIEW
Gregor Gierlinger, Sitaram M Emani
Endocardial fibroelastosis (EFE) is a thickening of the endocardial layer by accumulation of collagen and elastic fibers. Endothelial to mesenchymal transformation is proposed to be the underlying mechanism of formation. Although EFE can occur in both right and left ventricles, this article will focus on management of left ventricular EFE. Through its fibrous, nonelastic manifestation EFE restricts the myocardium leading to diastolic and systolic ventricular dysfunction and prevents ventricular growth in neonates and infants...
2024: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://read.qxmd.com/read/38338232/neonates-and-infants-with-left-heart-obstruction-and-borderline-left-ventricle-undergoing-biventricular-repair-what-do-we-know-about-long-term-outcomes-a-critical-review
#2
REVIEW
Massimiliano Cantinotti, Vivek Jani, Shelby Kutty, Pietro Marchese, Eliana Franchi, Alessandra Pizzuto, Cecilia Viacava, Nadia Assanta, Giuseppe Santoro, Raffaele Giordano
BACKGROUND: The decision to perform biventricular repair (BVR) in neonates and infants presenting with either single or multiple left ventricle outflow obstructions (LVOTOs) and a borderline left ventricle (BLV) is subject to extensive discussion, and limited information is known regarding the long-term outcomes. As a result, the objective of this study is to critically assess and summarize the available data regarding the prognosis of neonates and infants with LVOTO and BLV who underwent BVR...
January 30, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38310339/impact-of-preoperative-left-pulmonary-artery-stenting-on-the-fontan-procedure-a-retrospective-multicenter-study
#3
JOURNAL ARTICLE
Giuseppe Comentale, Marta Cucchi, Andrea Serrao, Lucio Careddu, C Pace Napoleone, Gaetano Gargiulo, Guido Oppido
OBJECTIVES: Left pulmonary artery (LPA) or bifurcation stenoses at Fontan palliation can be very challenging to treat and may also require cardioplegia and aortic transection. Moreover, the low pressure of Fontan circulation and the bulkiness of the aorta increase the risk of a patch angioplasty collapse. Pre-Fontan LPA stenting of stenotic LPAs overcomes those drawbacks therefore the present study aimed to evaluate its advantageous impact on Fontan surgery. METHODS: A multicentre retrospective analysis was performed on 304 consecutive Fontan patients...
February 3, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38204678/bilateral-pulmonary-artery-banding-in-higher-risk-neonates-with-hypoplastic-left-heart-syndrome
#4
JOURNAL ARTICLE
Harold M Burkhart, Yuki Nakamura, Anas Salkini, Randall M Schwartz, Courtney D Ranallo, Elizabeth S Makil, Matthew Campbell, Suanne M Daves, Emilie D Henry, Arshid Mir
OBJECTIVES: Limited data on performing bilateral pulmonary artery banding (BPAB) before stage 1 Norwood procedure suggest that some patients may benefit through the postponement of the major cardiopulmonary bypass procedure. The objective of this study was to evaluate the effectiveness of BPAB in the surgical management of high-risk patients with hypoplastic left heart syndrome (HLHS). METHODS: A retrospective review of all high-risk neonates with HLHS who underwent BPAB at our institution was performed...
December 2023: JTCVS open
https://read.qxmd.com/read/38105980/cerebral-microhemorrhages-in-children-with-congenital-heart-disease-prevalence-risk-factors-and-impact-on-neurodevelopmental-outcomes
#5
Kristen N Andersen, Sicong Yao, Brian R White, Marin Jacobwitz, Jake Breimann, Jharna Jahnavi, Alexander Schmidt, Wesley B Baker, Tiffany S Ko, J William Gaynor, Arastoo Vossough, Rui Xiao, Daniel J Licht, Evelyn K Shih
BACKGROUND: Infants with complex congenital heart disease (CHD) require life-saving corrective/palliative heart surgery in the first weeks of life. These infants are at risk for brain injury and poor neurodevelopmental outcomes. Cerebral microhemorrhages (CMH) are frequently seen after neonatal bypass heart surgery, but it remains unknown if CMH are a benign finding or constitute injury. Herein, we investigate the risk factors for developing CMH and their clinical significance. METHODS: 192 infants with CHD undergoing corrective cardiac surgery with cardiopulmonary bypass (CPB) at a single institution were prospectively evaluated with pre-(n = 183) and/or postoperative (n = 162) brain magnetic resonance imaging (MRI)...
December 6, 2023: medRxiv
https://read.qxmd.com/read/38065519/cerebral-autoregulation-monitoring-using-cerebral-oximetry-index-after-neonatal-cardiac-surgery-a-single-center-retrospective-cohort-study
#6
JOURNAL ARTICLE
Stefano Pezzato, Rathinaswamy B Govindan, Andrea Moscatelli, Francesca Bagnasco, Eleni Marie Panagopoulos, Chiara Robba, Erta Beqiri, Peter Smielewski, Ricardo A Munoz, Yves d'Udekem, Adre du Plessis
OBJECTIVE: The aims of this study are to investigate whether cerebral autoregulation is impaired after neonatal cardiac surgery and if changes in autoregulation metrics are associated with different congenital heart defects or the incidence of postoperative neurological events. METHODS: This is a retrospective observational study on neonates undergoing monitoring during the first 72 hours after cardiac surgery. Archived data were processed to calculate cerebral oximetry index and derived metrics...
December 6, 2023: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/37880385/higher-cumulative-dose-of-opioids-and-other-sedatives-are-associated-with-extubation-failure-in-norwood-patients
#7
JOURNAL ARTICLE
Sebastian Acosta, Adel M Hassan, Zbigniew Gugala, Zena Karagoli, Jessica Hochstetler, Amy L Kiskaddon, Paul Checchia, David Faraoni, Feng Zheng, Fabio Savorgnan
BACKGROUND: The primary purpose of this study is to evaluate the relationship between sedation usage and extubation failure, and to control for the effects of hemodynamic, oximetric indices, clinical characteristics, ventilatory settings pre- and post-extubation, and echocardiographic (echo) findings in neonates with hypoplastic left heart syndrome (HLHS) post-Norwood procedure. METHODS: Single-center, retrospective analysis of Norwood patients during their first extubation post-surgery from January 2015 to July 2021...
October 25, 2023: Pediatric Cardiology
https://read.qxmd.com/read/37821084/major-congenital-anomalies-in-korean-livebirths-in-2013-2014-based-on-the-national-health-insurance-database
#8
JOURNAL ARTICLE
Jin A Lee, Soon Min Lee, Sung-Hoon Chung, Jang Hoon Lee, Jae Won Shim, Jae Woo Lim, Chang-Ryul Kim, Yun Sil Chang
BACKGROUND: In Korea, there have been no reports comparing the prevalence of major congenital anomalies with other countries and no reports on surgical treatment and long-term mortality. We investigated the prevalence of 67 major congenital anomalies in Korea and compared the prevalence with that of the European network of population-based registries for the epidemiological surveillance of congenital anomalies (EUROCAT). We also investigated the mortality and age at death, the proportion of preterm births, and the surgical rate for the 67 major congenital anomalies...
October 9, 2023: Journal of Korean Medical Science
https://read.qxmd.com/read/37527726/safety-and-feasibility-of-adjunct-autologous-cord-blood-stem-cell-therapy-during-the-norwood-heart-operation
#9
JOURNAL ARTICLE
Christian P Brizard, Ngaire J Elwood, Remi Kowalski, Stephen B Horton, Bryn O Jones, Darren Hutchinson, Diana Zannino, Bennett J Sheridan, Warwick Butt, Michael M H Cheung, Salvatore Pepe
OBJECTIVE: Phase I, open label safety and feasibility trial of autologous cord blood (CB) stem cells (CBSC) therapy via a novel blood cardioplegia-based intracoronary infusion technique during the Norwood procedure in neonates with antenatal diagnosis of hypoplastic left heart syndrome (HLHS). CBSC therapy may support early cardiac remodelling with enhancement of RV function during the critical interstage period. METHODS: Clinical grade CB mononucleated cells (CBMNC) were processed to NetCord-FACT International Standards...
July 30, 2023: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/37434452/pre-operative-enteral-feeding-in-single-ventricle-chd-patients-and-necrotising-enterocolitis-risk
#10
JOURNAL ARTICLE
Lucy B Pappas, Lori A Erickson, Amy M Ricketts, Matthew L Moehlmann, Aaron M Hahn, John M Daniel
INTRODUCTION: Enteral feeding prior to cardiac surgery has benefits in pre-operative and post-operative patient statuses. In 2020, to increase pre-operative feeding for single-ventricle patients prior to stage 1 palliation, an enteral feeding algorithm was created. The aim of this study is to monitor the impact of our practice change with the primary outcome of necrotising enterocolitis incidence from birth to 2 weeks following surgical intervention. METHODS: This is a single-site, retrospective cohort study including patients from 1 March, 2018 to 1 July, 2022...
July 12, 2023: Cardiology in the Young
https://read.qxmd.com/read/37429513/hypoplastic-left-heart-syndrome-with-low-birth-weight-or-prematurity-what-is-the-optimal-approach
#11
JOURNAL ARTICLE
Horacio G Carvajal, Matthew W Canter, Fei Wan, Pirooz Eghtesady
BACKGROUND: Hypoplastic left heart syndrome with low birth weight or prematurity comprises a high-risk population with no optimal treatment pathway. Using the Pediatric Health Information System, we compared management approaches across the United States. METHODS: We analyzed neonates (≤30 days) with birth weight <2500 grams or gestational age <36 weeks between 2012 and 2021. Four strategies were identified: Norwood procedure, ductus arteriosus stent + pulmonary artery banding, pulmonary artery banding + prostaglandin infusion, or comfort care...
July 8, 2023: Annals of Thoracic Surgery
https://read.qxmd.com/read/37425272/the-use-of-novel-diffuse-optical-spectroscopies-for-improved-neuromonitoring-during-neonatal-cardiac-surgery-requiring-antegrade-cerebral-perfusion
#12
JOURNAL ARTICLE
Kalil Shaw, Constantine D Mavroudis, Tiffany S Ko, Jharna Jahnavi, Marin Jacobwitz, Nicolina Ranieri, Rodrigo M Forti, Richard W Melchior, Wesley B Baker, Arjun G Yodh, Daniel J Licht, Susan C Nicolson, Jennifer M Lynch
BACKGROUND: Surgical procedures involving the aortic arch present unique challenges to maintaining cerebral perfusion, and optimal neuroprotective strategies to prevent neurological injury during such high-risk procedures are not completely understood. The use of antegrade cerebral perfusion (ACP) has gained favor as a neuroprotective strategy over deep hypothermic circulatory arrest (DHCA) due to the ability to selectively perfuse the brain. Despite this theoretical advantage over DHCA, there has not been conclusive evidence that ACP is superior to DHCA...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37358116/-perinatal-outcome-and-five-year-survival-in-children-with-prenatal-diagnosis-of-hypoplastic-left-heart-syndrome
#13
JOURNAL ARTICLE
Daniela Cisternas O, Rodrigo Terra V, Susana Aguilera P, Gabriela Enríquez G, Juan Guillermo Rodríguez A
UNLABELLED: Hypoplastic left heart syndrome (HLHS) is a congenital heart disease of low prevalence and high lethality. OBJECTIVE: to determine the perinatal outcome and survival at one and five years of fetuses with a prenatal diagnosis of HLHS. PATIENTS AND METHOD: Prospective cohort study of all the fetuses with HLHS from the Perinatal Reference Center (CERPO) born between January 2008 and December 2017. Demographic and clinical perinatal data were obtained from the CERPO database...
April 2023: Andes pediatrica: revista Chilena de pediatría
https://read.qxmd.com/read/37219966/failed-extubation-in-neonates-after-cardiac-surgery-a-single-center-retrospective-study
#14
JOURNAL ARTICLE
Hunter C Wilson, Megan E Gunsaulus, Gabe E Owens, Stephanie A Goldstein, Sunkyung Yu, Ray E Lowery, Mary K Olive
OBJECTIVES: To describe factors associated with failed extubation (FE) in neonates following cardiovascular surgery, and the relationship with clinical outcomes. DESIGN: Retrospective cohort study. SETTING: Twenty-bed pediatric cardiac ICU (PCICU) in an academic tertiary care children's hospital. PATIENTS: Neonates admitted to the PCICU following cardiac surgery between July 2015 and June 2018. INTERVENTIONS: None...
November 1, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/37219587/medium-term-outcome-of-prenatally-diagnosed-hypoplastic-left-heart-syndrome-and-impact-of-a-restrictive-atrial-septum-diagnosed-in-utero
#15
JOURNAL ARTICLE
Tristan Ramcharan, Diana B Quintero, John Stickley, Esther Poole, Paul Miller, Tarak Desai, Michael Harris, Mark D Kilby, Oliver Stumper, Natasha Khan, David J Barron, Anna N Seale
OBJECTIVE: Surgical outcome data differs from overall outcomes of prenatally diagnosed fetuses with hypoplastic left heart syndrome (HLHS). Our aim was to describe outcome of prenatally diagnosed fetuses with this anomaly. METHODS: Retrospective review of prenatally diagnosed classical HLHS at a tertiary hospital over a 13-year period, estimated due dates 01/08/2006 to 31/12/2019. HLHS-variants and ventricular disproportion were excluded. RESULTS: 203 fetuses were identified with outcome information available for 201...
August 2023: Pediatric Cardiology
https://read.qxmd.com/read/37169122/attributable-mortality-benefit-of-digoxin-treatment-in-hypoplastic-left-heart-syndrome-after-the-norwood-operation-an-instrumental-variable-based-analysis-using-data-from-the-pediatric-health-information-systems-database
#16
JOURNAL ARTICLE
Michael L O'Byrne, Lihai Song, Jing Huang, Bethan Lemley, David Goldberg, Monique M Gardner, Chitra Ravishankar, Jonathan J Rome, Andrew C Glatz
BACKGROUND: Observational studies have demonstrated an association between the use of digoxin and reduced interstage mortality after Norwood operation for hypoplastic left heart syndrome (HLHS). Digoxin use has increased significantly but remains variable between different hospitals, independent of case-mix. Instrumental variable analyses have the potential to overcome unmeasured confounding, the major limitation of previous observational studies and to generate an estimate of the attributable benefit of treatment with digoxin...
September 2023: American Heart Journal
https://read.qxmd.com/read/36967848/stem-cell-therapy-for-single-ventricle-congenital-heart-disease-current-state-and-future-directions
#17
REVIEW
Agata Bilewska, Rachana Mishra, Artur Stefanowicz, Sudhish Sharma, Vivek M Mehta, Sunjay Kaushal
Hypoplastic left heart syndrome (HLHS) is one of the most complex forms of congenital heart disease, characterized by an underdeveloped left ventricle, outflow tract and aorta. Current surgical and medical treatment for this disease remains palliative. As a result of the multi-step surgery, the right ventricle plays the role of the systemic ventricle, which inevitably leads to its failure. There is an urgent need to develop new treatments to ameliorate the right ventricle failure. Stem cell therapy may represent a new approach to single ventricle pathology...
December 2022: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://read.qxmd.com/read/36899964/hypoplastic-left-heart-syndrome-about-a-postnatal-death
#18
JOURNAL ARTICLE
Pasquale Giugliano, Paola Ciamarra, Mariavictoria De Simone, Alessandro Feola, Pierluca Zangani, Carlo Pietro Campobasso, Gelsomina Mansueto
BACKGROUND: Hypoplastic left heart syndrome (HLHS) is a congenital heart disease that is associated with high mortality rates in the early neonatal period and during surgical treatments. This is mainly due to missed prenatal diagnosis, delayed diagnostic suspicion, and consequent unsuccessful therapeutic intervention. CASE REPORT: twenty-six hours after birth, a female newborn died of severe respiratory failure. No cardiac abnormalities and no genetic diseases had been evidenced or documented during intrauterine life...
February 21, 2023: Diagnostics
https://read.qxmd.com/read/36847765/defining-expectations-for-infants-with-hypoplastic-left-heart-syndrome-who-survive-initial-surgical-palliation
#19
JOURNAL ARTICLE
Jason W Greenberg, Farhan Zafar, David S Winlaw, James S Tweddell, David G Lehenbauer, James F Cnota, Haleh C Heydarian, David L S Morales
BACKGROUND: Overall one-year non-mortality outcomes for surgically palliated hypoplastic left heart syndrome (HLHS) patients remain understudied. Using the metric Days Alive and Outside of Hospital (DAOH), the present study sought to characterize expectations for surgically palliated patients' first year of life. METHODS: The Pediatric Health Information System database was used to identify by ICD-10 code all HLHS patients who underwent surgical palliation (Norwood/hybrid and/or heart transplantation [HTx]) during their index neonatal admission and were successfully discharged alive (n  =  2227) and for whom one-year DAOH could be calculated...
January 2023: World Journal for Pediatric & Congenital Heart Surgery
https://read.qxmd.com/read/36842796/support-with-single-ventricle-ventricular-assist-device-svad-in-patients-with-functionally-univentricular-circulation-prior-to-fontan-operation
#20
REVIEW
Mark S Bleiweis, Joseph Philip, James C Fudge, Himesh V Vyas, Giles J Peek, Andrew D Pitkin, Gregory M Janelle, Kevin J Sullivan, Yuriy Stukov, Connie S Nixon, Omar M Sharaf, Dan Neal, Jeffrey P Jacobs
Some patients with functionally univentricular circulation develop cardiac failure refractory to maximal management and are supported with a ventricular assist device (VAD). The purpose of this manuscript is to summarize our previous publications related to single ventricle-ventricular assist device (sVAD) support in patients with functionally univentricular circulation and to describe our current institutional approach at University of Florida to sVAD support in neonates, infants, and children prior to Fontan...
2023: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
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