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Histologic Chorioamnionitis

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https://www.readbyqxmd.com/read/30040750/association-between-clinical-chorioamnionitis-and-histological-funisitis-at-term
#1
S Suzuki
To predict the presence of histological funisitis at term, we examined the symptoms of clinical chorioamnionitis in 251 cases of maternal fever of 38 degrees or higher during labor at term. The examined symptoms in this study were clinical maternal findings (uterine fundal tenderness, maternal tachycardia, purulent or foul amniotic fluid or cervical discharge, and maternal white blood cell count) and fetal tachycardia. In these cases, microscopic histopathological analysis of the placenta was performed after delivery...
July 19, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29961407/maternal-and-neonatal-outcomes-following-expectant-management-of-preterm-prelabour-rupture-of-membranes-before-viability
#2
Winnie Huiyan Sim, Hamon Ng, Penelope Sheehan
PURPOSE: To provide centre-based outcome data on obstetric and neonatal complications arising from expectantly managed pregnancies affected by preterm prelabour rupture of membranes (PPROM) before viability. MATERIALS AND METHODS: We collected data on 130 consecutive pregnancies complicated by spontaneous rupture of membranes before 24 weeks gestation, occurring over a 7-year period. These were women who delivered > 24 hours after membrane rupture, and had no signs of chorioamnionitis or advanced labour at admission...
July 1, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29941174/subclinical-and-clinical-chorioamnionitis-fetal-vasculitis-and-risk-for-preterm-birth-a-cohort-study
#3
Kristin Palmsten, Katharine K Nelson, Louise C Laurent, Soojin Park, Christina D Chambers, Mana M Parast
OBJECTIVE: To evaluate the association between subclinical and clinical chorioamnionitis and risk of preterm birth (PTB). METHODS: Demographic and clinical characteristics were abstracted from medical records and placental examinations performed (N = 1371 pregnancies including spontaneous and medically-indicated PTBs). Pregnancies were classified as having clinical chorioamnionitis (with or without histologic chorioamnionitis), subclinical chorioamnionitis (histologic, but not clinical, chorioamnionitis), or no chorioamnionitis; pregnancies with histologic chorioamnionitis were further evaluated for fetal vasculitis...
July 2018: Placenta
https://www.readbyqxmd.com/read/29908375/the-change-of-fetal-heart-rate-short-term-variability-during-the-course-of-histological-chorioamnionitis-in-fetal-sheep
#4
Hyo Kyozuka, Syun Yasuda, Tsuyoshi Hiraiwa, Yasuhisa Nomura, Keiya Fujimori
OBJECTIVE: Histological chorioamnionitis (CAM) is related to neonatal mortality and morbidity. However, identifying intrauterine inflammation before delivery is challenging. The aim of this study was to investigate the changes in fetal heart rate (FHR) short-term variability (STV) during the course of histological CAM. STUDY DESIGN: Changes in STV were measured in 7 chronically instrumented fetal sheep at 111-120 days of gestation. Lipopolysaccharide (LPS) was infused into the amniotic cavity for 2 days following the 4th postoperative day to develop histological CAM...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908373/validation-of-diagnostic-tests-for-histologic-chorioamnionitis-systematic-review-and-meta-analysis
#5
Claudia Patricia Cataño Sabogal, Javier Fonseca, Herney Andrés García-Perdomo
INTRODUCTION: The aim of this study was to determine the diagnostic performance of different diagnostic tests for histologic chorioamnionitis in patients at more than 20 weeks of gestation. METHODS: A systematic search was carried out through MEDLINE, EMBASE, LILACS, CENTRAL and unpublished literature. Observational studies included with pregnant women (>20 weeks) with chorioamnionitis. The reference standard was the histopathological study of the placenta, umbilical cord and fetal membranes...
June 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29792096/neonatal-outcome-in-preterm-deliveries-before-34-week-gestation-the-influence-of-the-mechanism-of-labor-onset
#6
Sara Pinto, Maria Filipa Malheiro, Ana Vaz, Teresa Rodrigues, Nuno Montenegro, Hercília Guimarães
PURPOSE: To evaluate neonatal outcomes in preterm infants with less than 34 weeks after spontaneous labor, preterm premature rupture of membranes (PPROM) or iatrogenic delivery and to clarify whether the mechanism of labor onset is a risk factor for adverse short-term neonatal outcome. METHODS: We performed a retrospective case-control study, which included 266 preterm newborns with less than 34-week gestation, between 2011 and 2015. Neonatal outcomes were compared according to the mechanism of labor onset...
June 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29751216/pellino-1-is-a-novel-regulator-of-tnf-and-tlr-signalling-in-human-myometrial-and-amnion-cells
#7
Ratana Lim, Gillian Barker, Martha Lappas
Preterm birth is the primary cause of neonatal deaths and morbidities. Pathological processes causally linked to preterm birth are inflammation and infection. Pellino-1 (Peli1) has previously been found to regulate the inflammatory response in non-gestational tissues in response to toll-like receptor (TLR) ligands and pro-inflammatory cytokines. The aims of this study were to determine the effect of labor on Peli1 expression in myometrium and fetal membranes, and the effect of Peli1 silencing by siRNA (siPELI1) on the production of pro-inflammatory and pro-labor mediators...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29715698/antenatal-vitamin-d-preserves-placental-vascular-and-fetal-growth-in-experimental-chorioamnionitis-due-to-intra-amniotic-endotoxin-exposure
#8
Michael W Cookson, Sharon L Ryan, Gregory J Seedorf, R Blair Dodson, Steve H Abman, Erica W Mandell
BACKGROUND:  Chorioamnionitis (CA) is associated with a high risk for the development of bronchopulmonary dysplasia (BPD) after preterm birth, but mechanisms that increase susceptibility for BPD and strategies to prevent BPD are uncertain. As a model of CA, antenatal intra-amniotic (IA) endotoxin (ETX) exposure alters placental structure, causes fetal growth restriction, increases perinatal mortality, and causes sustained cardiorespiratory abnormalities throughout infancy. Vitamin D (Vit D) has been shown to have both anti-inflammatory and proangiogenic properties...
May 1, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29682558/dream-is-involved-in-the-genesis-of-inflammation-induced-prolabour-mediators-in-human-myometrial-and-amnion-cells
#9
Priyanka Goradia, Ratana Lim, Martha Lappas
Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leading to preterm birth by activating nuclear factor- κ B (NF- κ B). In nongestational tissues, downstream regulatory element antagonist modulator (DREAM) regulates NF- κ B activity. Our aims were to analyse DREAM expression in myometrium and fetal membranes obtained at term and preterm and to determine the effect of DREAM inhibition on prolabour mediators in primary myometrial and amnion cells...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29610829/association-of-histologic-chorioamnionitis-with-perinatal-brain-injury-and-early-childhood-neurodevelopmental-outcomes-among-preterm-neonates
#10
Daniel Bierstone, Nienke Wagenaar, Dawn L Gano, Ting Guo, Gregory Georgio, Floris Groenendaal, Linda S de Vries, Jojy Varghese, Hannah C Glass, Catherine Chung, Jefferson Terry, Maarten Rijpert, Ruth E Grunau, Anne Synnes, A James Barkovich, Donna M Ferriero, Manon Benders, Vann Chau, Steven P Miller
Importance: Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. Objective: To evaluate whether histologic chorioamnionitis among neonates born very preterm is associated with intraventricular hemorrhage (IVH) and punctate white matter injury (WMI) or with adverse neurodevelopmental outcomes during early childhood...
June 1, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29609190/stillbirth-inflammatory-markers-and-obesity-results-from-the-stillbirth-collaborative-research-network
#11
Margo S Harrison, Vanessa R Thorsten, Donald J Dudley, Corette B Parker, Matthew A Koch, Carol J R Hogue, Barbara J Stoll, Robert M Silver, Michael W Varner, M Halit Pinar, Donald R Coustan, George R Saade, Radek K Bukowski, Deborah L Conway, Marian Willinger, Uma M Reddy, Robert L Goldenberg
BACKGROUND:  Obesity is associated with increased risk of stillbirth, although the mechanisms are unknown. Obesity is also associated with inflammation. Serum ferritin, C-reactive protein, white blood cell count, and histologic chorioamnionitis are all markers of inflammation. OBJECTIVE:  This article determines if inflammatory markers are associated with stillbirth and body mass index (BMI). Additionally, we determined whether inflammatory markers help to explain the known relationship between obesity and stillbirth...
April 2, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29579759/risk-factors-for-neonatal-hypoxic-ischemic-encephalopathy-in-the-absence-of-sentinel-events
#12
Christopher M Novak, Ahize C Eke, Maide Ozen, Irina Burd, Ernest M Graham
OBJECTIVE:  Hypoxic-ischemic encephalopathy (HIE) may be associated with intrapartum sentinel events or may be unexplained. We sought to identify risk factors for unexplained HIE cases and compare their morbidity and mortality to cases associated with sentinel events. STUDY DESIGN:  Retrospective cohort study of all neonates admitted with suspected HIE treated with whole-body hypothermia from January 2007 through July 2017. Cases of unexplained HIE were compared with those with a sentinel event...
March 26, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29533486/exposure-to-chorioamnionitis-alters-the-monocyte-transcriptional-response-to-the-neonatal-pathogen-staphylococcus-epidermidis
#13
Emma de Jong, David G Hancock, Christine Wells, Peter Richmond, Karen Simmer, David Burgner, Tobias Strunk, Andrew J Currie
Preterm infants are uniquely susceptible to late-onset sepsis that is frequently caused by the skin commensal Staphylococcus epidermidis. Innate immune responses, particularly from monocytes, are a key protective mechanism. Impaired cytokine production by preterm infant monocytes is well described, but few studies have comprehensively assessed the corresponding monocyte transcriptional response. Innate immune responses in preterm infants may be modulated by inflammation such as prenatal exposure to histologic chorioamnionitis which complicates 40-70% of preterm pregnancies...
March 13, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29480140/impact-of-histologic-chorioamnionitis-on-pulmonary-hypertension-and-respiratory-outcomes-in-preterm-infants
#14
Sook Kyung Yum, Min-Sung Kim, Yoojin Kwun, Cheong-Jun Moon, Young-Ah Youn, In Kyung Sung
We aimed to evaluate the association between the presence of histologic chorioamnionitis (HC) and development of pulmonary hypertension (PH) during neonatal intensive care unit (NICU) stay. Data of preterm infants born at 32 weeks of gestation or less were reviewed. The development of PH and other respiratory outcomes were compared according to the presence of HC. Potential risk factors associated with the development of PH during NICU stay were used for multivariable logistic regression analysis. A total of 188 infants were enrolled: 72 in the HC group and 116 in the no HC group...
April 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29453682/persistent-pulmonary-hypertension-and-histologic-chorioamnionitis-in-preterm-infants-controlled-study
#15
N Katz, Y Bar-Or, A Raucher-Sterrnfeld, A Tamir, D Kohelet
Persistent pulmonary hypertension (PPHN) of the newborn is one of the most challenging acute disorders of postnatal transition with substantial morbidity and mortality. The aim of the study was to find if there is an association between persistent pulmonary hypertension and histologic chorioamnionitis in preterm infants. 27 preterm infants with echocardiographic evidence of PPHN within the first 3 days of life were eligible for the study. A matched control group of 27 patients was chosen according to gestational age, date of birth, and gender...
April 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29448926/histologic-chorioamnionitis-in-preterm-infants-correlation-with-brain-magnetic-resonance-imaging-at-term-equivalent-age
#16
Claire Granger, Alicia J Spittle, Jennifer Walsh, Jan Pyman, Peter J Anderson, Deanne K Thompson, Katherine J Lee, Lee Coleman, Charuta Dagia, Lex W Doyle, Jeanie Cheong
BACKGROUND: To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age. METHODS: Preterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation)...
February 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29447339/integrated-microrna-and-mrna-network-analysis-of-the-human-myometrial-transcriptome-in-the-transition-from-quiescence-to-labor
#17
William E Ackerman, Irina A Buhimschi, Douglas Brubaker, Sean Maxwell, Kara M Rood, Mark R Chance, Hongwu Jing, Sam Mesiano, Catalin S Buhimschi
We conducted integrated transcriptomics network analyses of miRNA and mRNA interactions in human myometrium to identify novel molecular candidates potentially involved in human parturition. Myometrial biopsies were collected from women undergoing primary Cesarean deliveries in well-characterized clinical scenarios: (1) spontaneous term labor (TL, n = 5); (2) term nonlabor (TNL, n = 5); (3) spontaneous preterm birth (PTB) with histologic chorioamnionitis (PTB-HCA, n = 5); and (4) indicated PTB nonlabor (PTB-NL, n = 5)...
June 1, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29405967/identification-of-haptoglobin-switch-on-status-in-archived-placental-specimens-indicates-antenatal-exposure-to-inflammation-and-potential-participation-of-the-fetus-in-triggering-preterm-birth
#18
Megan E McCarthy, Catalin S Buhimschi, John T Hardy, Antonette T Dulay, Christine A Laky, Mert-Ozan Bahtyiar, Ramesha Papanna, Guomao Zhao, Irina A Buhimschi
OBJECTIVE: Haptoglobin (Hp) has key immunoregulatory roles that vary with phenotype (Hp1-1, Hp2-1, Hp2-2). Cord blood Hp expression is switched-off in the normal fetus. We hypothesized that in the setting of fetal inflammation placenta becomes inundated with Hp of fetal origin that in turn modulates the output of PGE2 and MMP-9 in a phenotype dependent manner. METHODS: Placentas from 40 pregnancies complicated by preterm birth (PTB) (<37 weeks), without (n = 15) or with (n = 25) intra-amniotic infection and histological chorioamnionitis (HCA) were scored for intensity of Hp immunostaining...
February 2018: Placenta
https://www.readbyqxmd.com/read/29402780/chorioamnionitis-induces-a-specific-signature-of-placental-abc-transporters-associated-with-an-increase-of-mir-331-5p-in-the-human-preterm-placenta
#19
Guinever Eustaquio do Imperio, Enrrico Bloise, Mohsen Javam, Phetcharawan Lye, Andrea Constantinof, Caroline Dunk, Fernando Marcos Dos Reis, Stephen James Lye, William Gibb, Tania M Ortiga-Carvalho, Stephen Giles Matthews
BACKGROUND/AIMS: The ATP-binding cassette (ABC) transporters mediate drug biodisposition and immunological responses in the placental barrier. In vitro infective challenges alter expression of specific placental ABC transporters. We hypothesized that chorioamnionitis induces a distinct pattern of ABC transporter expression. METHODS: Gene expression of 50 ABC transporters was assessed using TaqMan® Human ABC Transporter Array, in preterm human placentas without (PTD; n=6) or with histological chorioamnionitis (PTDC; n=6)...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29395186/antecedents-and-outcomes-of-abnormal-cranial-imaging-in-moderately-preterm-infants
#20
Girija Natarajan, Seetha Shankaran, Shampa Saha, Abbot Laptook, Abhik Das, Rosemary Higgins, Barbara J Stoll, Edward F Bell, Waldemar A Carlo, Carl D'Angio, Sara B DeMauro, Pablo Sanchez, Krisa Van Meurs, Betty Vohr, Nancy Newman, Ellen Hale, Michele Walsh
OBJECTIVES: To describe the frequency and findings of cranial imaging in moderately preterm infants (born at 290/7 -336/7 weeks of gestation) across centers, and to examine the association between abnormal imaging and clinical characteristics. STUDY DESIGN: We used data from the Neonatal Research Network Moderately Preterm Registry, including the most severe early (≤28 days) and late (>28 days) cranial imaging. Stepwise logistic regression and CART analysis were performed after adjustment for gestational age, antenatal steroid use, and center...
April 2018: Journal of Pediatrics
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