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Histologic Chorioamnionitis

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https://www.readbyqxmd.com/read/30334666/spectrum-of-changes-seen-with-placental-intravascular-organisms
#1
Pawel T Schubert, Deidre Mason, Roosacelis Martines, Marlene Deleon-Carnes, Sherif R Zaki, Drucilla J Roberts
Fetal bacterial infections are a common cause of fetal/neonatal morbidity and mortality. The pathologic correlates of congenital bacterial infection include acute chorioamnionitis, acute villitis, and acute intervillositis. The strength of the association of congenital bacterial infection differs among these pathologies. Acute chorioamnionitis results usually from an ascending infection, and damage to the fetus is thought to be cytokine driven rather than damage secondary to bacteremia. Acute villitis is strongly associated with fetal sepsis due to congenital infections...
October 18, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/30319361/extended-combined-neonatal-treatment-with-erythropoietin-plus-melatonin-prevents-posthemorrhagic-hydrocephalus-of-prematurity-in-rats
#2
Shenandoah Robinson, Fatu S Conteh, Akosua Y Oppong, Tracylyn R Yellowhair, Jessie C Newville, Nagat El Demerdash, Christine L Shrock, Jessie R Maxwell, Stephen Jett, Frances J Northington, Lauren L Jantzie
Posthemorrhagic hydrocephalus of prematurity (PHHP) remains a global challenge. Early preterm infants (<32 weeks gestation), particularly those exposed to chorioamnionitis (CAM), are prone to intraventricular hemorrhage (IVH) and PHHP. We established an age-appropriate, preclinical model of PHHP with progressive macrocephaly and ventriculomegaly to test whether non-surgical neonatal treatment could modulate PHHP. We combined prenatal CAM and postnatal day 1 (P1, equivalent to 30 weeks human gestation) IVH in rats, and administered systemic erythropoietin (EPO) plus melatonin (MLT), or vehicle, from P2 to P10...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/30271352/chorioamnionitis-is-a-risk-factor-for-intraventricular-hemorrhage-in-preterm-infants-a-systematic-review-and-meta-analysis
#3
Eduardo Villamor-Martinez, Monica Fumagalli, Owais Mohammed Rahim, Sofia Passera, Giacomo Cavallaro, Pieter Degraeuwe, Fabio Mosca, Eduardo Villamor
Although chorioamnionitis (CA) is a well-known risk factor for white matter disease of prematurity, the association with intraventricular hemorrhage (IVH) is controversial and has not been yet systematically reviewed. We performed a systematic review and meta-analysis of studies exploring the association between CA and IVH. A comprehensive literature search was conducted using PubMed/MEDLINE and EMBASE, from their inception to 1 July 2017. Studies were included if they examined preterm infants and reported primary data that could be used to measure the association between exposure to CA and the presence of IVH...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30230382/immunohistochemical-demonstration-of-reck-protein-and-interleukin-6-in-fetal-membranes-from-singleton-pregnancies-with-late-preterm-delivery-intact-membranes-and-histological-chorioamnionitis
#4
Z Benzon, S Benzon, S Z Tomaš, I K Prusac, L Vulić, M Vulić, V Stefanovic
We investigated whether chorioamnionitis affects immunohistochemical demonstration of RECK protein and interleukin-6 (IL-6) expression in fetal placental membranes following late preterm delivery with intact membranes. Fetal membranes of 28 women with single pregnancy, preterm delivery and histologically documented chorioamnionitis at gestational age 34-366/7  weeks constituted the chorioamnionitis study group. The control group consisted of 28 fetal membranes from women with preterm deliveries at the same gestational age without histological chorioamnionitis...
September 19, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/30040750/association-between-clinical-chorioamnionitis-and-histological-funisitis-at-term
#5
S Suzuki
To predict the presence of histological funisitis at term, we examined the symptoms of clinical chorioamnionitis in 251 cases of maternal fever of 38 degrees or higher during labor at term. The examined symptoms in this study were clinical maternal findings (uterine fundal tenderness, maternal tachycardia, purulent or foul amniotic fluid or cervical discharge, and maternal white blood cell count) and fetal tachycardia. In these cases, microscopic histopathological analysis of the placenta was performed after delivery...
July 19, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29961407/maternal-and-neonatal-outcomes-following-expectant-management-of-preterm-prelabor-rupture-of-membranes-before-viability
#6
Winnie Huiyan Sim, Hamon Ng, Penelope Sheehan
PURPOSE: To provide center-based outcome data on obstetric and neonatal complications arising from expectantly managed pregnancies affected by preterm prelabor rupture of membranes (PPROM) before viability. MATERIALS AND METHODS: We collected data on 130 consecutive pregnancies complicated by spontaneous rupture of membranes before 24 week's gestation, occurring over a 7-year period. These were women who delivered >24 h after membrane rupture, and had no signs of chorioamnionitis or advanced labor at admission...
August 13, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29941174/subclinical-and-clinical-chorioamnionitis-fetal-vasculitis-and-risk-for-preterm-birth-a-cohort-study
#7
Kristin Palmsten, Katharine K Nelson, Louise C Laurent, Soojin Park, Christina D Chambers, Mana M Parast
OBJECTIVE: To evaluate the association between subclinical and clinical chorioamnionitis and risk of preterm birth (PTB). METHODS: Demographic and clinical characteristics were abstracted from medical records and placental examinations performed (N = 1371 pregnancies including spontaneous and medically-indicated PTBs). Pregnancies were classified as having clinical chorioamnionitis (with or without histologic chorioamnionitis), subclinical chorioamnionitis (histologic, but not clinical, chorioamnionitis), or no chorioamnionitis; pregnancies with histologic chorioamnionitis were further evaluated for fetal vasculitis...
July 2018: Placenta
https://www.readbyqxmd.com/read/29908375/the-change-of-fetal-heart-rate-short-term-variability-during-the-course-of-histological-chorioamnionitis-in-fetal-sheep
#8
Hyo Kyozuka, Syun Yasuda, Tsuyoshi Hiraiwa, Yasuhisa Nomura, Keiya Fujimori
OBJECTIVE: Histological chorioamnionitis (CAM) is related to neonatal mortality and morbidity. However, identifying intrauterine inflammation before delivery is challenging. The aim of this study was to investigate the changes in fetal heart rate (FHR) short-term variability (STV) during the course of histological CAM. STUDY DESIGN: Changes in STV were measured in 7 chronically instrumented fetal sheep at 111-120 days of gestation. Lipopolysaccharide (LPS) was infused into the amniotic cavity for 2 days following the 4th postoperative day to develop histological CAM...
September 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908373/validation-of-diagnostic-tests-for-histologic-chorioamnionitis-systematic-review-and-meta-analysis
#9
Claudia Patricia Cataño Sabogal, Javier Fonseca, Herney Andrés García-Perdomo
INTRODUCTION: The aim of this study was to determine the diagnostic performance of different diagnostic tests for histologic chorioamnionitis in patients at more than 20 weeks of gestation. METHODS: A systematic search was carried out through MEDLINE, EMBASE, LILACS, CENTRAL and unpublished literature. Observational studies included with pregnant women (>20 weeks) with chorioamnionitis. The reference standard was the histopathological study of the placenta, umbilical cord and fetal membranes...
September 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29792096/neonatal-outcome-in-preterm-deliveries-before-34-week-gestation-the-influence-of-the-mechanism-of-labor-onset
#10
Sara Pinto, Maria Filipa Malheiro, Ana Vaz, Teresa Rodrigues, Nuno Montenegro, Hercília Guimarães
PURPOSE: To evaluate neonatal outcomes in preterm infants with less than 34 weeks after spontaneous labor, preterm premature rupture of membranes (PPROM) or iatrogenic delivery and to clarify whether the mechanism of labor onset is a risk factor for adverse short-term neonatal outcome. METHODS: We performed a retrospective case-control study, which included 266 preterm newborns with less than 34-week gestation, between 2011 and 2015. Neonatal outcomes were compared according to the mechanism of labor onset...
June 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29751216/pellino-1-is-a-novel-regulator-of-tnf-and-tlr-signalling-in-human-myometrial-and-amnion-cells
#11
Ratana Lim, Gillian Barker, Martha Lappas
Preterm birth is the primary cause of neonatal deaths and morbidities. Pathological processes causally linked to preterm birth are inflammation and infection. Pellino-1 (Peli1) has previously been found to regulate the inflammatory response in non-gestational tissues in response to toll-like receptor (TLR) ligands and pro-inflammatory cytokines. The aims of this study were to determine the effect of labor on Peli1 expression in myometrium and fetal membranes, and the effect of Peli1 silencing by siRNA (siPELI1) on the production of pro-inflammatory and pro-labor mediators...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29715698/antenatal-vitamin-d-preserves-placental-vascular-and-fetal-growth-in-experimental-chorioamnionitis-due-to-intra-amniotic-endotoxin-exposure
#12
Michael W Cookson, Sharon L Ryan, Gregory J Seedorf, R Blair Dodson, Steve H Abman, Erica W Mandell
BACKGROUND:  Chorioamnionitis (CA) is associated with a high risk for the development of bronchopulmonary dysplasia (BPD) after preterm birth, but mechanisms that increase susceptibility for BPD and strategies to prevent BPD are uncertain. As a model of CA, antenatal intra-amniotic (IA) endotoxin (ETX) exposure alters placental structure, causes fetal growth restriction, increases perinatal mortality, and causes sustained cardiorespiratory abnormalities throughout infancy. Vitamin D (Vit D) has been shown to have both anti-inflammatory and proangiogenic properties...
November 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29682558/dream-is-involved-in-the-genesis-of-inflammation-induced-prolabour-mediators-in-human-myometrial-and-amnion-cells
#13
Priyanka Goradia, Ratana Lim, Martha Lappas
Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leading to preterm birth by activating nuclear factor- κ B (NF- κ B). In nongestational tissues, downstream regulatory element antagonist modulator (DREAM) regulates NF- κ B activity. Our aims were to analyse DREAM expression in myometrium and fetal membranes obtained at term and preterm and to determine the effect of DREAM inhibition on prolabour mediators in primary myometrial and amnion cells...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29610829/association-of-histologic-chorioamnionitis-with-perinatal-brain-injury-and-early-childhood-neurodevelopmental-outcomes-among-preterm-neonates
#14
Daniel Bierstone, Nienke Wagenaar, Dawn L Gano, Ting Guo, Gregory Georgio, Floris Groenendaal, Linda S de Vries, Jojy Varghese, Hannah C Glass, Catherine Chung, Jefferson Terry, Maarten Rijpert, Ruth E Grunau, Anne Synnes, A James Barkovich, Donna M Ferriero, Manon Benders, Vann Chau, Steven P Miller
Importance: Understanding the role of chorioamnionitis, a major factor leading to preterm birth, in the pathogenesis of neonatal brain injury and adverse neurodevelopmental outcomes may help in identifying potentially modifiable perinatal variables affecting brain health and outcomes among children born preterm. Objective: To evaluate whether histologic chorioamnionitis among neonates born very preterm is associated with intraventricular hemorrhage (IVH) and punctate white matter injury (WMI) or with adverse neurodevelopmental outcomes during early childhood...
June 1, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29609190/stillbirth-inflammatory-markers-and-obesity-results-from-the-stillbirth-collaborative-research-network
#15
Margo S Harrison, Vanessa R Thorsten, Donald J Dudley, Corette B Parker, Matthew A Koch, Carol J R Hogue, Barbara J Stoll, Robert M Silver, Michael W Varner, M Halit Pinar, Donald R Coustan, George R Saade, Radek K Bukowski, Deborah L Conway, Marian Willinger, Uma M Reddy, Robert L Goldenberg
BACKGROUND:  Obesity is associated with increased risk of stillbirth, although the mechanisms are unknown. Obesity is also associated with inflammation. Serum ferritin, C-reactive protein, white blood cell count, and histologic chorioamnionitis are all markers of inflammation. OBJECTIVE:  This article determines if inflammatory markers are associated with stillbirth and body mass index (BMI). Additionally, we determined whether inflammatory markers help to explain the known relationship between obesity and stillbirth...
September 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29579759/risk-factors-for-neonatal-hypoxic-ischemic-encephalopathy-in-the-absence-of-sentinel-events
#16
Christopher M Novak, Ahize C Eke, Maide Ozen, Irina Burd, Ernest M Graham
OBJECTIVE:  Hypoxic-ischemic encephalopathy (HIE) may be associated with intrapartum sentinel events or may be unexplained. We sought to identify risk factors for unexplained HIE cases and compare their morbidity and mortality to cases associated with sentinel events. STUDY DESIGN:  Retrospective cohort study of all neonates admitted with suspected HIE treated with whole-body hypothermia from January 2007 through July 2017. Cases of unexplained HIE were compared with those with a sentinel event...
March 26, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29533486/exposure-to-chorioamnionitis-alters-the-monocyte-transcriptional-response-to-the-neonatal-pathogen-staphylococcus-epidermidis
#17
Emma de Jong, David G Hancock, Christine Wells, Peter Richmond, Karen Simmer, David Burgner, Tobias Strunk, Andrew J Currie
Preterm infants are uniquely susceptible to late-onset sepsis that is frequently caused by the skin commensal Staphylococcus epidermidis. Innate immune responses, particularly from monocytes, are a key protective mechanism. Impaired cytokine production by preterm infant monocytes is well described, but few studies have comprehensively assessed the corresponding monocyte transcriptional response. Innate immune responses in preterm infants may be modulated by inflammation such as prenatal exposure to histologic chorioamnionitis which complicates 40-70% of preterm pregnancies...
March 13, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29480140/impact-of-histologic-chorioamnionitis-on-pulmonary-hypertension-and-respiratory-outcomes-in-preterm-infants
#18
Sook Kyung Yum, Min-Sung Kim, Yoojin Kwun, Cheong-Jun Moon, Young-Ah Youn, In Kyung Sung
We aimed to evaluate the association between the presence of histologic chorioamnionitis (HC) and development of pulmonary hypertension (PH) during neonatal intensive care unit (NICU) stay. Data of preterm infants born at 32 weeks of gestation or less were reviewed. The development of PH and other respiratory outcomes were compared according to the presence of HC. Potential risk factors associated with the development of PH during NICU stay were used for multivariable logistic regression analysis. A total of 188 infants were enrolled: 72 in the HC group and 116 in the no HC group...
April 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29453682/persistent-pulmonary-hypertension-and-histologic-chorioamnionitis-in-preterm-infants-controlled-study
#19
N Katz, Y Bar-Or, A Raucher-Sterrnfeld, A Tamir, D Kohelet
Persistent pulmonary hypertension (PPHN) of the newborn is one of the most challenging acute disorders of postnatal transition with substantial morbidity and mortality. The aim of the study was to find if there is an association between persistent pulmonary hypertension and histologic chorioamnionitis in preterm infants. 27 preterm infants with echocardiographic evidence of PPHN within the first 3 days of life were eligible for the study. A matched control group of 27 patients was chosen according to gestational age, date of birth, and gender...
April 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29448926/histologic-chorioamnionitis-in-preterm-infants-correlation-with-brain-magnetic-resonance-imaging-at-term-equivalent-age
#20
Claire Granger, Alicia J Spittle, Jennifer Walsh, Jan Pyman, Peter J Anderson, Deanne K Thompson, Katherine J Lee, Lee Coleman, Charuta Dagia, Lex W Doyle, Jeanie Cheong
BACKGROUND: To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age. METHODS: Preterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation)...
February 15, 2018: BMC Pediatrics
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