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Sarcopenia and liver disease

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https://www.readbyqxmd.com/read/30048963/sarcopenia-contributes-to-the-progression-of-nonalcoholic-fatty-liver-disease-related-fibrosis-a-meta-analysis
#1
Xiaoyan Pan, Yijing Han, Tiantian Zou, Guiqi Zhu, Ke Xu, Jina Zheng, Minghua Zheng, Xingbo Cheng
BACKGROUNDS AND AIMS: Previous studies have investigated that sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis, and fibrosis in NAFLD. The study aims to investigate the risk for NAFLD, especially NAFLD-related significant fibrosis among subjects with sarcopenia. METHODS: We searched electronic databases until 30, September 2017 and reviewed literature extensively. Effect estimates were pooled using random effect models regarding the risk for NAFLD and fixed effect models concerning the risk for significant fibrosis among sarcopenia patients...
July 26, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/30037166/age-related-decrease-in-skeletal-muscle-mass-is-an-independent-risk-factor-for-incident-nafld-a-10-year-retrospective-cohort-study
#2
Min Jung Lee, Eun-Hee Kim, Sung-Jin Bae, Gi-Ae Kim, Sung Won Park, JaeWon Choe, Chang Hee Jung, Woo Je Lee, Hong-Kyu Kim
Background/Aims: Sarcopenia has emerged as an important risk factor for non-alcoholic fatty liver disease (NAFLD). Although aging is the main cause of sarcopenia, the longitudinal association between age-related body composition changes and NAFLD development has not been fully investigated. Thus, we evaluated whether age-related increased fat mass or decreased muscle mass is an independent risk factor for incident NAFLD. Methods: We conducted a retrospective cohort study involving 4,398 initially NAFLD-free subjects who underwent routine health examinations during 2004 to 2005 and returned for a follow-up during 2014 to 2015...
July 20, 2018: Gut and Liver
https://www.readbyqxmd.com/read/30014320/sarcopenic-obesity
#3
REVIEW
Stergios A Polyzos, Andrew N Margioris
Sarcopenic obesity, a chronic condition, is today a major public health problem with increasing prevalence worldwide, which is due to progressively aging populations, the increasing prevalence of obesity, and the changes in lifestyle during the last several decades. Patients usually present to healthcare facilities for obesity and related comorbidities (type 2 diabetes mellitus, non-alcoholic fatty liver disease, dyslipidemia, hypertension, and cardiovascular disease) or for non-specific symptoms related to sarcopenia per se (e...
July 16, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30005446/the-ratio-between-estimated-glomerular-filtration-rates-egfr-of-creatinine-and-cystatin-c-predicts-overall-survival-in-patients-with-hepatocellular-carcinoma
#4
Yasuyuki Tamai, Motoh Iwasa, Yuya Kawasaki, Naohiko Yoshizawa, Suguru Ogura, Ryosuke Sugimoto, Akiko Eguchi, Norihiko Yamamoto, Kazushi Sugimoto, Hiroshi Hasegawa, Yoshiyuki Takei
AIM: Hepatocellular carcinoma (HCC) patients with sarcopenia have a poor survival, but there are no predictive markers for survival relating to muscle mass and liver function. Therefore, we investigated whether the ratio between estimated glomerular filtration rates of serum creatinine (Scre) and serum cystain C (Scys) (eGFRcre/eGFRcys) can be used as a predictive marker of survival in HCC patients. METHODS: First, the correlation between Scre/Scys ratio and muscle mass was examined in 50 patients with chronic liver disease...
July 13, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29991895/muscle-fat-infiltration-assessed-by-total-psoas-density-on-computed-tomography-predicts-mortality-in-cirrhosis
#5
Maria Kalafateli, Andreas Karatzas, Georgios Tsiaoussis, Efstratios Koutroumpakis, Paraskevi Tselekouni, Nikolaos Koukias, Christos Konstantakis, Stelios Assimakopoulos, Charalambos Gogos, Konstantinos Thomopoulos, Christina Kalogeropoulou, Christos Triantos
Background: Ongoing evidence suggests that sarcopenia adversely affects outcomes in cirrhosis. The aim of this study was to evaluate muscle fat infiltration as a component of sarcopenia and its prognostic value in this setting. Methods: In 98 consecutive patients with cirrhosis, muscle density was measured during a computed tomography scan at the level of the fourth to fifth lumbar (L4) vertebrae. Univariate and multivariate Cox regression analysis was used to determine predictors of survival...
July 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29964066/exercise-in-cirrhosis-translating-evidence-and-experience-to-practice
#6
REVIEW
Puneeta Tandon, Kathleen Patricia Ismond, Kenneth Riess, Andres Duarte-Rojo, Bandar Al-Judaibi, Michael Andrew Dunn, Jennifer Holman, Nancy Howes, Mark Joseph Franklin Haykowsky, Deborah Ann Josbeno, Margaret McNeely
Physical inactivity, sarcopenia, and frailty are highly prevalent, independent predictors of morbidity and mortality in patients with cirrhosis. Across a range of chronic diseases, exercise training is a key recommendation supported by guidelines and, in some conditions, even by governmental funding of exercise programs. Consistent with the broader chronic disease literature, the evidence for a benefit of exercise in cirrhosis is promising. Several small trials have reported significant improvements in muscle health (mass, strength, functional capacity), quality of life, fatigue, and reductions in the hepatic venous portal gradient, without adverse events...
June 28, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29927763/nutrition-dietary-intake-and-eating-behavior-after-liver-transplantation
#7
Lucilene Rezende Anastácio, Samanta Catherine Ferreira
PURPOSE OF REVIEW: Nutritional status of patients after liver transplantation is affected by dietary intake and this, in turn, is affected by eating behavior. The present review will highlight recent studies on these topics after liver transplantation. RECENT FINDINGS: Malnutrition drops significantly after liver transplantation. Recovery of weight lost during liver disease occurs within 1 year. Liver transplantation recipients gain weight up to the second or third year, often becoming overweight and obese...
September 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29926227/sarcopenia-in-a-mice-model-of-chronic-liver-disease-role-of-the-ubiquitin-proteasome-system-and-oxidative-stress
#8
Fabián Campos, Johanna Abrigo, Francisco Aguirre, Bruno Garcés, Marco Arrese, Saul Karpen, Daniel Cabrera, Marcelo E Andía, Felipe Simon, Claudio Cabello-Verrugio
Sarcopenia is the loss of muscle mass and strength produced by aging or secondary to chronic diseases such as chronic liver disease (CLD). Although not all types of sarcopenia involve the same features, the most common are decreased fiber diameter and myosin heavy chain (MHC) levels, increased activity of ubiquitin-proteasome system (UPS) and reactive oxygen species (ROS). In this study, we aim to characterize the development of sarcopenia secondary to CLD induced by the hepatotoxin 5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)...
June 20, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29920701/sarcopenia-is-associated-with-the-risk-of-significant-liver-fibrosis-in-metabolically-unhealthy-subjects-with-chronic-hepatitis-b
#9
E Han, Y-H Lee, B K Kim, J Y Park, D Y Kim, S H Ahn, B-W Lee, E S Kang, B-S Cha, K-H Han, S U Kim
BACKGROUND: Sarcopenia is significantly associated with the degree of liver fibrosis. This study investigated the influence of sarcopenia on liver fibrosis in individuals with chronic hepatitis B. METHODS: Data from the Korean National Health and Nutrition Examination Surveys 2008-2011 were analysed. The sarcopenia index (total appendicular skeletal muscle mass [kg]/body mass index [kg/m2 ]) was calculated using dual-energy X-ray absorptiometry. Sarcopenia was defined as the lowest quintile sarcopenia index value (cut-offs: 0...
August 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29893704/association-between-low-testosterone-levels-and-sarcopenia-in-cirrhosis-a-cross-sectional-study
#10
Carlos Moctezuma-Velázquez, Gavin Low, Marina Mourtzakis, Mang Ma, Kelly W Burak, Puneeta Tandon, Aldo J Montano-Loza
INTRODUCTION AND AIM: Sarcopenia is an independent predictor of mortality in cirrhosis. Hypogonadism is common in cirrhosis and has been associated with sarcopenia in non-cirrhotic chronic liver disease populations. The aim of this study is to investigate if sarcopenia is associated with low testosterone levels in patients with cirrhosis. MATERIAL AND METHODS: This is a retrospective analysis of prospectively collected data of 211 cirrhotic patients undergoing evaluation for liver transplantation...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29785395/the-relationship-between-nafld-and-sarcopenia-in-elderly-patients
#11
Yu Zhai, Qian Xiao, Jing Miao
Aim: Previous studies have shown that individuals with low muscle mass exhibit an increased risk of nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the association between NAFLD and sarcopenia in elderly patients. Methods: We classified the participants into sarcopenia/nonsarcopenia groups based on dual-energy X-ray absorptiometry (DXA), muscle strength (grip strength), or/and physical performance (6 m usual gait speed). We diagnosed NAFLD by ultrasonography combined with the history of alcohol intake...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29743452/-treatment-for-sarcopenia-in-patients-with-chronic-liver-disease
#12
Takumi Kawaguchi, Dan Nakano, Takuji Torimura
No abstract text is available yet for this article.
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29743450/-epidemiology-and-clinical-significance-of-sarcopenia-in-liver-disease
#13
Makoto Shiraki, Tatsunori Hanai
No abstract text is available yet for this article.
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29743449/-sarcopenia-in-liver-disease
#14
Shuhei Nishiguchi, Hiroki Nishikawa, Hirayuki Enomoto
No abstract text is available yet for this article.
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29734510/association-between-sarcopenia-and-osteoporosis-in-chronic-liver-disease
#15
Manabu Hayashi, Kazumichi Abe, Masashi Fujita, Ken Okai, Atsushi Takahashi, Hiromasa Ohira
AIM: Sarcopenia and osteoporosis are important complications in chronic liver disease (CLD). The aim of this study was to investigate the relationship between sarcopenia and osteoporosis in patients with CLD. METHODS: We retrospectively investigated the relationship between sarcopenia and osteoporosis in 112 CLD patients (57 men and 55 women), including 40 cirrhotic patients (36%), by measuring the appendicular skeletal muscle mass index (ASMI) using bio-impedance analysis...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29724029/somatotropic-axis-dysfunction-in-non-alcoholic-fatty-liver-disease-beneficial-hepatic-and-systemic-effects-of-hormone-supplementation
#16
Daniel Cabrera, Claudio Cabello-Verrugio, Nancy Solís, Diego San Martín, Catalina Cofré, Margarita Pizarro, Juan Pablo Arab, Johanna Abrigo, Fabián Campos, Betzabé Irigoyen, Gonzalo Carrasco-Avino, Katiuska Bezares, Valentina Riquelme, Arnoldo Riquelme, Marco Arrese, Francisco Barrera
BACKGROUND: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin -like growth factor-1 (IGF-1) supplementation on liver histology, adipokine profile and muscle function in an NAFLD model. METHODS: C57BL/6 mice were fed with a high fat diet (HFD) for 12 weeks and were separated into three groups treated for 4 weeks with: (1) High fat diet (HFD) ( n = 10); (2) HFD + GH 9 μg/g/d ( n = 10); (3) HFD + IGF-1 0...
May 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29719446/ursolic-acid-in-health-and-disease
#17
REVIEW
Dae Yun Seo, Sung Ryul Lee, Jun-Won Heo, Mi-Hyun No, Byoung Doo Rhee, Kyung Soo Ko, Hyo-Bum Kwak, Jin Han
Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. There is a growing interest in UA because of its beneficial effects, which include anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects. It exerts these effects in various tissues and organs: by suppressing nuclear factor-kappa B signaling in cancer cells, improving insulin signaling in adipose tissues, reducing the expression of markers of cardiac damage in the heart, decreasing inflammation and increasing the level of anti-oxidants in the brain, reducing apoptotic signaling and the level of oxidants in the liver, and reducing atrophy and increasing the expression levels of adenosine monophosphate-activated protein kinase and irisin in skeletal muscles...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29684966/-nutritional-assessment-and-management-for-patients-with-chronic-liver-disease
#18
REVIEW
Tae Hee Lee
When liver disease is severe, the prognosis can be worse if the patient is malnourished. Adequate nutritional support for patients with liver diseases can improve the patient's condition and prognosis. In the case of liver cirrhosis, malnutrition can occur due to a variety of causes, including poor oral intake, maldigestion, malabsorption, associated renal disease, and metabolic abnormalities. For a nutritional assessment, it is important to check the dietary intake, change in body composition, including anthropometry, and a functional assessment of muscle...
April 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29673321/relationship-of-sarcopenia-with-steatohepatitis-and-advanced-liver-fibrosis-in-non-alcoholic-fatty-liver-disease-a-meta-analysis
#19
Rui Yu, Qiangwei Shi, Lei Liu, Lidong Chen
BACKGROUND: Several studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histological severity of nonalcoholic fatty liver disease. METHODS: Pubmed, the Cochrane Library and EMBASE were searched (until August 2017) for studies examining the relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in nonalcoholic fatty liver disease...
April 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29603630/frailty-after-liver-transplantation-the-strong-survive-but-may-not-prosper
#20
EDITORIAL
Haripriya Maddur, Josh Levitsky
No abstract text is available yet for this article.
March 30, 2018: American Journal of Transplantation
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