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Ahmed Mohamed El Ghoneimy, Magdy El Sherbiny, Nehal Kamal
BACKGROUND:  Most reports on skeletal reconstruction using vascularized fibular free flap include patients with varying age groups and anatomic locations. This study has limited the inclusion criteria to pediatric and adolescent patients diagnosed with bone sarcoma of the femoral shaft. METHODS:  Forty-one patients, diagnosed with a malignant bone tumor of the femoral shaft (21 Ewing's sarcomas and 20 osteosarcomas), were locally treated by joint sparing wide resection and reconstruction using a vascularized fibular free flap...
August 18, 2018: Journal of Reconstructive Microsurgery
Preeti Prajapati, Jaya Pandey, Poonam Tandon, Kirti Sinha
Molecular structure, chemical and physical reactivity, spectroscopic behavior, intermolecular interactions play an important role in understanding the biological nature of pharmaceutical drugs. The objective of the study is to combine the spectroscopic and computational methodology for the investigation of structural behavior of ezetimibe (EZT). Computational study was done on monomeric, dimeric and trimeric models of EZT using B3LYP/6-311G(d,p). Hydrogen bond interactions were taken into consideration to validate the theoretical results with the experimental one...
August 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Neha J Pagidipati, Anne S Hellkamp, Puza P Sharma, Tracy Y Wang, Gregg C Fonarow, Michael Pencina
IMPORTANCE: The extent to which levels of high-sensitivity C-reactive protein (hs-CRP), a known marker of increased cardiovascular risk, are elevated and are associated with standard cardiovascular risk factors in patients with a history of myocardial infarction (MI) is unknown. OBJECTIVES: To determine the pattern and determinants of the distribution of hs-CRP in those with a prior MI in the United States using a nationally representative sample. DESIGN AND PARTICIPANTS: Adults with hs-CRP data in the National Health and Nutrition Examination Surveys from 1999-2010...
July 27, 2018: American Heart Journal
Amanda C Kentner, Stephanie Scalia, Junyoung Shin, Mattia M Migliore, Alejandro N Rondón-Ortiz
Both basic and clinical research support the use of tactile stimulation to rescue several neurobiobehavioral consequences that follow early life stress including. Here, using a translational rodent model of the neonatal intensive care unit (NICU), we tested the individual prophylactic potential of a variety of sensory interventions including tactile (brushing pups with a paint brush to mimic maternal licking), auditory (a simulated lactating rat dam heart beat), and olfactory (a series of aroma therapy scents) stimulation...
July 30, 2018: Psychoneuroendocrinology
M Efthymiou, D R J Arachchillage, P J Lane, A G O'Keeffe, T McDonnell, H Cohen, I J Mackie
BACKGROUND: Tissue factor pathway inhibitor (TFPI) antibodies, which have been reported in patients with antiphospholipid syndrome (APS), may impair TFPI activity and contribute to hypercoagulability, but their role in APS and in thrombosis remains undefined. OBJECTIVE/METHODS: We assessed the presence and avidity of TFPI IgG antibodies, associations with protein C IgG antibodies and associations with clinical disease severity, in 50 patients with thrombotic APS and 50 thrombotic control patients, on long term anticoagulation with warfarin...
August 7, 2018: Thrombosis Research
Stephen Wahlig, Matthew Lovatt, Jodhbir S Mehta
Peroxiredoxin 6 (Prdx6) is the only mammalian 1-Cys member of the Prdx family, a group of enzymes which share the ability to reduce peroxides. In addition to its peroxidase function, Prdx6 also demonstrates phospholipase A2 and lysophosphatidylcholine acyl transferase (LPCAT) activities. These enzymatic activities play an important role in regenerating oxidized membrane phospholipids and maintaining an appropriate balance of intracellular reactive oxygen species. Development of clinical pathologies, including those within the eye, have been linked to dysregulation of Prdx6 function...
August 15, 2018: Free Radical Biology & Medicine
Afsane Bahrami, Negin Parsamanesh, Stephen L Atkin, Maciej Banach, Amirhossein Sahbekar
The toll-like receptors (TLRs) are a class of transmembrane-spanning receptors that are sentinels of both innate and adaptive immunity. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the most commonly prescribed therapeutic agents for treating hypercholesterolemia globally. However, statin therapy appears to have pleiotropic effects including attenuation of chronic low-grade inflammation and modulation of TLR activity. Statins through abolition of TLR4 expression and regulation of the TLR4/Myd88/NF-κB signaling pathway may slow the progression of atherosclerosis and other inflammatory diseases...
August 15, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Tang Li, Haiyun Wang, Jinxin Wang, Yimeng Chen, Chenyi Yang, Mingshu Zhao, Guolin Wang, Zhuo Yang
Chemokines related neuroinflammation and N-methyl-D-aspartate receptor (NMDAR) mediated nociceptive transmission are pivotal determinants in the pathogenesis of opioid-induced hyperalgesia (OIH), but little is known about specific mechanism and treatment. Chemokine CXCL12 with its receptor CXCR4 is implicated in different pathological pain, moreover, neurotoxicity of CXCL12 is associated with NMDAR activation. Recent studies recapitulate the anti-nociception of Annexin 1 (ANXA1) in inflammatory pain. This study examined whether ANXA1 prevented remifentanil-caused OIH through modulating CXCL12 and NMDAR pathway in rats...
August 15, 2018: Neuroscience Research
Wankun Xie, Min Zhao, Shu-Huai Tsai, William L Burkes, Luke B Potts, Wenjuan Xu, H Ross Payne, Travis W Hein, Lih Kuo, Robert H Rosa
Spectral domain optical coherence tomography (SD-OCT) is used as a non-invasive tool for retinal morphological assessment in vivo. Information on the correlation of SD-OCT with retinal histology in the porcine retina, a model resembling the human retina, is limited. Herein, we correlated the hypo- and hyper-reflective bands on SD-OCT with histology of the lamellar architecture and cellular constituents of the porcine retina. SD-OCT images were acquired with the Heidelberg Spectralis HRA + OCT. Histological analysis was performed using epoxy resin embedded tissue and transmission electron microscopy...
August 15, 2018: Experimental Eye Research
Baizhuo Dong, Zhigang Sun, Bin Zhou, Shengming Huang, Liang Han, Honghua Nie, Guohui Chen, Shibing Liu, Yanna Zhang, Ning Bao, Xiaolong Yang, Hongwei Feng
BACKGROUND: LncRNA-FENDRR is a kind of endothelial genes critical for vascular development. Moreover, miR-126 and vascular endothelial growth factor A (VEGFA) are also involved in the physiological process of vascular endothelial cells. This study aimed to the underlying mechanism of FENDRR involving miR-126 and VEGFA in hypertensive intracerebral hemorrhage (HICH). METHODS: C57BL/6 mice were chosen to establish HICH model. The expression of FENDRR, miR-126 and VEGFA at mRNA level were determined by qRT-PCR...
August 18, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Wei Feng, Rui Shi, Chao Zhang, Shaojun Liu, Tingting Yu, Dan Zhu
To realize visualization of the skin microvascular dysfunction of type 1 diabetic mice, we combined laser speckle contrast imaging and hyperspectral imaging to simultaneously monitor the noradrenaline (NE)-induced responses of vascular blood flow and blood oxygen with the development of diabetes through optical clearing skin window. The main results showed that venous and arterious blood flow decreased without recovery after injection of NE; furthermore, the decrease of arterious blood oxygen induced by NE greatly weakened, especially for 2- and 4-week diabetic mice...
August 2018: Journal of Biomedical Optics
P Verze, D Arcaniolo, C Imbimbo, T Cai, L Venturino, L Spirito, G Califano, R La Rocca, V Mirone
BACKGROUND: Couple distress is a crucial point in premature ejaculation (PE). PE has been associated with significant bother, interpersonal problems, and dissatisfaction with sexual intercourse for both men and their partners. OBJECTIVES: The primary objective of this study was to assess the effect of PE on female sexuality in female partners of men affected from PE. Secondary objectives were to assess the impact of PE on female sexual quality of life, to assess the presence of sexual problems of the male partner, and to evaluate the prevalence and characteristics of comorbidities...
August 17, 2018: Andrology
Mariusz Klopotowski, Aleksandra Kwapiszewska, Krzysztof Kukula, Jacek Jamiolkowski, Maciej Dabrowski, Pawel Derejko, Artur Oreziak, Rafal Baranowski, Mateusz Spiewak, Magdalena Marczak, Anna Klisiewicz, Barbara Szepietowska, Zbigniew Chmielak, Adam Witkowski
BACKGROUND: Atrial fibrillation is a common complication in patients with hypertrophic cardiomyopathy (HCM) and may contribute to high cardiovascular morbidity and mortality. Therefore it is important to assess parameters associated with AF in HCM patients. OBJECTIVES: The aim of the study was to evaluate AF prevalence in patients with HCM and to investigate risk factors for AF. METHODS: 546 HCM patients age below 65 were included into analysis...
August 18, 2018: Clinical Cardiology
Raphaëlle Beau-Lejdstrom, Julie Magno Zito
Attention-deficit hyperactivity disorder (ADHD) medication use has dramatically increased in youth worldwide. Recent prevalence data in some European countries show expanded use with one country now matching US usage. Still, substantial geographic differences by country remain regarding the extent to which children receive ADHD medications. These geographic differences by country raise research questions about which country's prevalence data represents appropriate medication use. We urgently need country level studies to contribute to our understanding of an appropriate prevalence of ADHD medication use...
August 17, 2018: Clinical Pharmacology and Therapeutics
Wen-Zhi Li, Xiang Wan, Long Li, Bin Xu, Zhong Wang
We encountered 2 patients (a 33-year-old woman and a 66-year-old man) with an aldosterone-producing adenoma (APA) and a left accessory spleen. The patients' primary symptoms were hypertension and hypokalemia, and both had elevated serum aldosterone levels. Preoperative computed tomography a left suprarenal retroperitoneal mass and laparoscopic left adrenalectomy was performed in both cases. The postoperative microscopic examination revealed splenic tissue. Both patients experienced relief of their hypertension and hypokalemia, with an uneventful recovery...
August 16, 2018: Urology Journal
Ercan Yuvanc, Mehmet Tolga Dogru, Vedat Simsek, Hüseyin Kandemir, Devrim Tuglu
PURPOSE: Hypertension (HT) is known to be of the main risk factors for erectile dysfunction (ED). But non-dipping (<%10 drop in the night) of HT is not investigated truly. The aim of this study was to test the hypothesis that the non-dipper hypertensive patients are more prone to develop erectile dysfunction. MATERIALS AND METHODS: This was a cross-sectional clinical study. 70 HT patients diagnosed by Ambulatory blood pressure monitoring (ABPM) were classified into 3 groups (No ED, mild to moderate and severe) according to their International Index of Erectile Function (IIEF) scores...
August 18, 2018: Urology Journal
Yasemin Eren, Naciye Kabatas, Hayat Guven, Selcuk Comoglu, Canan Gurdal
In the case of mild papilledema, fundoscopy findings may sometimes be insufficient, leading to false and misleading indices in the diagnosis of early-stage idiopathic intracranial hypertension (IIH). This study aims to evaluate these patients through optic coherence tomography (OCT). The study included 54 individuals diagnosed with IIH and 48 healthy individuals in the control group. All patients underwent neurological and ophthalmologic examinations. Opening pressure values of patients' cerebrospinal fluid (CSF) were recorded...
August 17, 2018: Acta Neurologica Belgica
Jorge L Medina, Eliza A Sebastian, Andrea B Fourcaudot, Rossella Dorati, Kai P Leung
An inflammatory response is the normal response to a burn-induced injury. The burn-associated inflammation can lead to further tissue damage as the tissue tries to repair the damage. Prolonged or excessive inflammation is associated with increased fibrosis of burn wounds and the development of hypertrophic scars. The high incidence of hypertrophic scar formation is one of the many challenges to treating deep partial-thickness burns. Prophylactic treatment to improve burn-induced hypertrophic scarring is lacking...
August 17, 2018: Inflammation
Jason Graham Skinner, Luca Menichetti, Alessandra Flori, Anna Dost, Andreas Benjamin Schmidt, Markus Plaumann, Ferdia Aiden Gallagher, Jan-Bernd Hövener
Since reaching the clinic, magnetic resonance imaging (MRI) has become an irreplaceable radiological tool because of the macroscopic information it provides across almost all organs and soft tissues within the human body, all without the need for ionising radiation. The sensitivity of MR, however, is too low to take full advantage of the rich chemical information contained in the MR signal. Hyperpolarisation techniques have recently emerged as methods to overcome the sensitivity limitations by enhancing the MR signal by many orders of magnitude compared to the thermal equilibrium, enabling a new class of metabolic and molecular X-nuclei based MR tracers capable of reporting on metabolic processes at the cellular level...
August 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Natasa Mijailovic, Dragica Selakovic, Jovana Joksimovic, Vladimir Mihailovic, Jelena Katanic, Vladimir Jakovljevic, Tamara Nikolic, Sergey Bolevich, Vladimir Zivkovic, Milica Pantic, Gvozden Rosic
The aim of this study was to evaluate the effects of atorvastatin and simvastatin on behavioral manifestations that followed hyperhomocysteinemia induced by special dietary protocols enriched in methionine and deficient in B vitamins (B6, B9, B12) by means of alterations in anxiety levels in rats. Simultaneously, we investigated the alterations of oxidative stress markers in rat hippocampus induced by applied dietary protocols. Furthermore, considering the well-known antioxidant properties of statins, we attempted to assess their impact on major markers of oxidative stress and their possible beneficial role on anxiety-like behavior effect in rats...
August 17, 2018: Molecular and Cellular Biochemistry
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