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https://www.readbyqxmd.com/read/30518007/-multicenter-investigation-of-extracorporeal-membrane-oxygenation-application-in-pediatric-intensive-care-unit-in-china
#1
G F Yan, X D Cai, C B Zhou, X Y Hong, Y Wang, C M Zhang, Z H Yang, Y C Zhang, Y Cui, Y Q Cui, Y B Cheng, S Y Qian, P F Zhang, Y P Jin, X D Zhu, H Gao, Z P Li, X L Lu, H J Miao, Q Y Zhang, Y M Li, W G Yang, C Y Liu, B Li, Y Li, Z J Bo, J P Chu, X Wang, G P Lu
Objective: To survey the conduction and evaluate the effectiveness of extracorporeal membrane oxygenation (ECMO) therapy in pediatric intensive care unit (PICU) in China mainland. Methods: In a questionnaire-based survey, we retrospectively reviewed the application of ECMO in children's hospital and general hospital in China mainland to summarize and analyze the categories of diseases and prognosis of children treated with ECMO therapy. Results: By December 31, 2017, a total of 23 hospitals using ECMO, including 22 tertiary referral hospitals and 1 secondary hospital, among which 16 were children's hospitals and 7 were general hospitals...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/30517978/glucose-homeostasis-in-statin-users-the-lifestat-study
#2
Thomas Morville, Tine Dohlmann, Anja B Kuhlman, Tine Monberg, Mimmi Torp, Bolette Hartmann, Jens J Holst, Steen Larsen, Jørn W Helge, Flemming Dela
Background Statins are widely used to lower cholesterol concentrations in both primary and secondary prevention of cardiovascular disease. The treatment increases the risk of muscle pain (myalgia) and of type 2 diabetes. However, the underlying mechanisms remain disputed. Methods We investigated whether statin induced myalgia is coupled to impaired glucose homeostasis using oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IVGTT) and the hyperinsulinemic euglycemic clamp. We performed a cross-sectional study of statin users without CVD (primary prevention) stratified into a statin myalgic (M; n=25) and a non-myalgic (NM; n=39) group as well as a control group (C; n=20) consisting of non-statin users...
December 5, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30517959/a-diver-with-immersion-pulmonary-oedema-and-prolonged-respiratory-symptoms
#3
Ryo Morishima, Kei Nakashima, Shinya Suzuki, Nobuo Yamami, Masahiro Aoshima
Immersion pulmonary oedema (IPE) is particularly associated with an excessive reaction to exercise and/or cold stress. IPE usually resolves without recompression therapy within a day or two. Herein we report a diver diagnosed with IPE, in whom symptoms persisted for five days. A 58-year-old man presented with sudden onset of dyspnoea, cough and haemoptysis after surfacing. He was an experienced diving instructor with a history of moderate mitral valve regurgitation. While IPE was diagnosed and oxygen administered, respiratory symptoms deteriorated, and serum C-reactive protein elevated...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/30517956/preventive-effects-of-ketone-ester-bd-acac-2-on-central-nervous-system-oxygen-toxicity-and-concomitant-acute-lung-injury
#4
Hongjie Yi, Shichong Yu, Yanan Zhang, Runping Li, Dazhi Zhang, Dazhi Zhang, Weigang Xu
BACKGROUND: Recent studies indicated that ketone ester R,S-1,3-butanediol acetoacetate diester (BD-AcAc2 ) may be effective in preventing central nervous system oxygen toxicity (CNS-OT) and concomitant acute lung injury, a serious medical problem to be faced when breathing hyperbaric oxygen (HBO). This study aimed to further investigate the protective effects of BD-AcAc2 against CNS-OT and concomitant acute lung injury (ALI) in mice. METHODS: Mice were treated with BD-AcAc2 in peanut oil vehicle (2...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/30517955/assessment-of-hyperbaric-patients-at-risk-of-malnutrition-using-the-malnutrition-screening-tool-a-pilot-study
#5
Hooi Geok See, Yan Ru Tan, Kwan Leong Au-Yeung, Michael H Bennett
BACKGROUND: Nutritional assessment and support is essential for wound management. The hyperbaric oxygen clinic is a unique outpatient service where chronically unwell patients present daily for hyperbaric oxygen treatment (HBOT) over several weeks, allowing time for effective nutritional intervention. This is the first study to examine the prevalence of those at risk of malnutrition in a cohort of hyperbaric medical patients. METHODS: A prospective study was undertaken over six months...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/30517953/decompression-illness-and-other-injuries-in-a-recreational-dive-charter-operation
#6
Marion Hubbard, F Michael Davis, Kate Malcolm, Scott J Mitchell
INTRODUCTION: Health and safety within the recreational diving industry are poorly described. We aimed to obtain the true prevalence of decompression illness (DCI) and other diving and non-diving injuries, including occupational injuries, in a large recreational diving charter operation. METHODS: A New Zealand recreational diving operator keeps detailed records of diving activity and event/incident reports. We extracted passenger and crew numbers, dive numbers and incident statistics from all boat trips and associated work-related injuries between 01 January 2008 and 31 December 2014...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/30517951/malnutrition-screening-in-outpatients-receiving-hyperbaric-oxygen-therapy-an-opportunity-for-improvement
#7
EDITORIAL
Oana A Tatucu-Babet, Emma J Ridley
Outpatients who receive hyperbaric oxygen treatment (HBOT) may represent a group at significant risk of malnutrition owing to the underlying conditions that are often treated with HBOT (e.g., non-healing diabetic wounds and radiation-induced skin injury). In this issue, See and colleagues provide new, preliminary evidence of the prevalence of malnutrition in a small group of HBOT outpatients treated in an Australian hospital, reporting that approximately one-third of patients receiving HBOT were at risk of malnutrition...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/30517949/over-the-counter-weight-loss-herbal-supplements-in-egypt-label-claim-microbiological-pharmaceutical-quality-and-safety-assessments
#8
Nada Ahmed, Mohamed Ismail Nounou, Alaa Abouelfetouh, Amal El-Kamel
OBJECTIVES: Nutraceuticals are advertised and sold with the label claim of being natural and safe herbal products. Due to the absence of clear regulations and guidelines for safety assessments of these products, nutraceuticals are commonly adulterated in order to increase sales. The objective of the current study was to design a comprehensive evaluation system to assess the safety, efficacy, authenticity according to label claim and pharmaceutical quality, of herbal slimming products in between 2015 and 2017...
December 5, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/30517918/cervical-artery-dissection-in-patients-of-african-ancestry
#9
Ilana E Green, Shareena A Rahman, Debra L Owens, Michèle M Sale, Lillian J Currie, Keith L Keene, Bradford B Worrall, Andrew M Southerland
BACKGROUND AND PURPOSE: The majority of published data in cervical artery dissection (CeAD), a common cause of stroke in young adults, derive from populations of European ancestry (EA), including a recent genome-wide study identifying an association with the rs9349379 polymorphism of the PHACTR1 gene. Little is known about CeAD in individuals of African ancestry (AA) despite robust epidemiological data showing increased risk of stroke at younger ages. We hypothesize that AA patients with CeAD have different epidemiology and clinical profiles compared to those of EA, and a different genetic architecture related to rs9349379 of the PHACTR1 gene...
December 5, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/30517908/cortical-excitability-affects-mood-state-in-patients-with-idiopathic-generalized-epilepsies-iges
#10
Lauren B Bolden, Joseph C Griffis, Rodolphe Nenert, Jane B Allendorfer, Jerzy P Szaflarski
Previously, we demonstrated an association between cortical hyperexcitability and mood disturbance in healthy adults. Studies have documented hyperexcitability in patients with idiopathic generalized epilepsies (IGEs; long-interval intracortical inhibition [LICI]) and high prevalence of mood comorbidities. This study aimed to investigate the influences of cortical excitability and seizure control on mood state in patients with IGEs. Single and paired-pulse transcranial magnetic stimulation (TMS) was applied to 30 patients with IGEs (16 controlled IGEs [cIGEs], 14 with treatment-resistant IGEs [trIGEs]), and 22 healthy controls (HCs) to assess cortical excitability with LICI...
December 2, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30517880/antigenic-relationship-among-zoonotic-flaviviruses-from-italy
#11
Alessio Lorusso, Valeria Marini, Annapia Di Gennaro, Gaetano Federico Ronchi, Claudia Casaccia, Grazia Carelli, Giuseppe Passantino, Nicola D'Alterio, Vincenzo D'Innocenzo, Giovanni Savini, Federica Monaco, Daniel L Horton
Here we report studies of the antigenic relationships of West Nile virus (WNV) and Usutu virus (USUV), two zoonotic flaviviruses from Italy, together with a Japanese encephalitis virus (JEV) strain and compared them with their genetic relationships using the immunodominant viral E protein. Thirty-nine isolates and reference strains were inactivated and used to immunize rabbits to produce hyper immune sera. Serum samples were tested by neutralization against all isolates and results visualized by generating antigenic map...
December 2, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/30517863/hdac3-regulates-the-transition-to-the-homeostatic-myelinating-schwann-cell-state
#12
Laura H Rosenberg, Anne-Laure Cattin, Xavier Fontana, Elizabeth Harford-Wright, Jemima J Burden, Ian J White, Jacob G Smith, Ilaria Napoli, Victor Quereda, Cristina Policarpi, Jamie Freeman, Robin Ketteler, Antonella Riccio, Alison C Lloyd
The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates the myelin sheath. Once formed, the mSC transitions to a stable homeostatic state, with loss of this stability associated with neuropathies. The histone deacetylases histone deacetylase 1 (HDAC1) and HDAC2 are required for the myelination transcriptional program. Here, we show a distinct role for HDAC3, in that, while dispensable for the formation of mSCs, it is essential for the stability of the myelin sheath once formed-with loss resulting in progressive severe neuropathy in adulthood...
December 4, 2018: Cell Reports
https://www.readbyqxmd.com/read/30517806/nuclear-charge-radii-of-229-th-from-isotope-and-isomer-shifts
#13
M S Safronova, S G Porsev, M G Kozlov, J Thielking, M V Okhapkin, P Głowacki, D M Meier, E Peik
The isotope ^{229}Th is unique in that it possesses an isomeric state of only a few electron volts above the ground state, suitable for nuclear laser excitation. An optical clock based on this transition is expected to be a very sensitive probe for variations of fundamental constants, but the nuclear properties of both states have to be determined precisely to derive the actual sensitivity. We carry out isotope shift calculations in Th^{+} and Th^{2+} including the specific mass shift, using a combination of configuration interaction and all-order linearized coupled-cluster methods and estimate the uncertainty of this approach...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517716/severe-gastrointestinal-disease-in-very-early-systemic-sclerosis-is-associated-with-early-mortality
#14
Nicolas Richard, Marie Hudson, Mianbo Wang, Geneviève Gyger, Susanna Proudman, Wendy Stevens, Mandana Nikpour, Murray Baron
Objectives: To examine the incidence, predictors and outcomes associated with severe gastrointestinal (GI) disease in a large inception SSc cohort. Methods: SSc subjects with <2 years of disease duration were identified from two multicentre cohorts. Severe GI disease was defined as: malabsorption, hyperalimentation, pseudo-obstruction and/or ⩾10% weight loss in association with the use of antibiotics for bacterial overgrowth or oesophageal stricture. Kaplan-Meier, multivariate logistic regression and Cox proportional hazard analyses were performed to determine the cumulative incidence rate, independent clinical correlates and mortality rate associated with severe GI disease...
December 4, 2018: Rheumatology
https://www.readbyqxmd.com/read/30517707/transient-receptor-potential-ion-channels-mediate-adherens-junctions-dysfunction-in-a-toluene-diisocyanate-induced-murine-asthma-model
#15
Lihong Yao, Shuyu Chen, Haixiong Tang, Peikai Huang, Shushan Wei, Zhenyu Liang, Ailin Tao, Qingling Zhang, Rongchang Chen
Disruption of epithelial cell-cell junctions is essential for the initiation and perpetuation of airway inflammation in asthma. We've previously reported compromised epithelial barrier integrity in a toluene diisocyanate (TDI)-induced occupational asthma model. This study is aimed to explore the role of transient receptor potential vanilloid 4 (TRPV4) and transient receptor potential ankyrin 1 (TRPA1) in the dysfunction of adherens junctions in TDI-induced asthma. Mice were sensitized and challenged with TDI for a chemical-induced asthma model...
December 4, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/30517688/errors-in-estimating-usual-sodium-intake-by-the-kawasaki-formula-alter-its-relationship-with-mortality-implications-for-public-health
#16
Feng J He, Norm R C Campbell, Yuan Ma, Graham A MacGregor, Mary E Cogswell, Nancy R Cook
Background: Several cohort studies with inaccurate estimates of sodium reported a J-shaped relationship with mortality. We compared various estimated sodium intakes with that measured by the gold-standard method of multiple non-consecutive 24-h urine collections and assessed their relationship with mortality. Methods: We analysed the Trials of Hypertension Prevention follow-up data. Sodium intake was assessed in four ways: (i) average measured (gold standard): mean of three to seven 24-h urinary sodium measurements during the trial periods; (ii) average estimated: mean of three to seven estimated 24-h urinary sodium excretions from sodium concentration of 24-h urine using the Kawasaki formula; (iii) first measured: 24-h urinary sodium measured at the beginning of each trial; (iv) first estimated: 24-h urinary sodium estimated from sodium concentration of the first 24-h urine using the Kawasaki formula...
December 1, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/30517631/the-course-of-neuropsychiatric-symptoms-in-patients-with-dementia-in-primary-care
#17
Petra Borsje, Peter L B J Lucassen, Hans Bor, Roland B Wetzels, Anne Margriet Pot, Raymond T C M Koopmans
Background: During the course of dementia, most people develop some type of neuropsychiatric symptoms (NPS), which result in lower quality of life, high caregiver burden, psychotropic drug use and a major risk of institutionalization. Studies on NPS in people with dementia have been mainly conducted in clinical centres or psychiatric services. Objectives: To investigate the course of NPS in people with dementia in primary care. Methods: Analysis of (cumulative) prevalence and incidence, persistence and resolution based on data collected during an assessment at home of a prospective naturalistic cohort study in primary care in a sample of 117 people with dementia and their informal caregivers...
December 4, 2018: Family Practice
https://www.readbyqxmd.com/read/30517621/unlocking-the-potential-of-value-based-health-care-by-defining-global-standard-sets-of-outcome-measures-that-matter-to-patients-with-cardiovascular-diseases
#18
William H Seligman, Matthew Salt, Alethse De la Torre Rosas, Zofia Das-Gupta
As health systems around the world increasingly look to record and improve the value of care that they provide to patients, being able to measure the outcomes that matter most to patients is vital. Clinicians today gather more data than ever before, but what is measured often has little relationship to the results of care that matter most to patients. Through its working groups of global experts in particular diseases, the International Consortium for Health Outcomes Measurement (ICHOM) aims to define minimum Standard Sets of outcomes, along with case-mix factors to support risk-adjustment and meaningful comparison...
December 4, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/30517607/comparing-pulmonary-hypertension-severity-between-rat-strains-suggests-right-ventricle-nk-cells-are-protective
#19
Claudia Mickael, Michael H Lee, Sue Gu, Brian B Graham
No abstract text is available yet for this article.
December 4, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/30517599/the-association-between-the-montreal-cognitive-assessment-and-functional-activity-questionnaire-in-the-systolic-blood-pressure-intervention-trial-sprint
#20
Carolyn H Still, Nicholas M Pajewski, Gordon J Chelune, Stephen R Rapp, Kaycee M Sink, Virginia G Wadley, Jeff D Williamson, Alan J Lerner
Objective: To examine the association of global cognitive function assessed via the Montreal Cognitive Assessment (MoCA) and deficiencies in instrumental activities of daily living (IADL) on the Functional Activity Questionnaire (FAQ) in hypertensive older adults in the Systolic Blood Pressure Intervention Trial (SPRINT). Methods: In cross-sectional analysis, 9,296 SPRINT participants completed the MoCA at baseline. The FAQ was obtained from 2,705 informants for SPRINT participants scoring <21 or <22 on the MoCA, depending on education...
December 5, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
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