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https://www.readbyqxmd.com/read/30514362/tailored-axillary-surgery-with-or-without-axillary-lymph-node-dissection-followed-by-radiotherapy-in-patients-with-clinically-node-positive-breast-cancer-taxis-study-protocol-for-a-multicenter-randomized-phase-iii-trial
#1
Guido Henke, Michael Knauer, Karin Ribi, Stefanie Hayoz, Marie-Aline Gérard, Thomas Ruhstaller, Daniel R Zwahlen, Simone Muenst, Markus Ackerknecht, Hanne Hawle, Florian Fitzal, Michael Gnant, Zoltan Mátrai, Bettina Ballardini, Andreas Gyr, Christian Kurzeder, Walter P Weber
BACKGROUND: Complete lymph node removal through conventional axillary dissection (ALND) has been standard treatment for breast cancer patients for almost a century. In the 1990s, however, and in parallel with the advent of the sentinel lymph node (SLN) procedure, ALND came under increasing scrutiny due to its association with significant patient morbidity. Several studies have since provided evidence to suggest omission of ALND, often in favor of axillary radiation, in selected clinically node-negative, SLN-positive patients, thus supporting the current trend in clinical practice...
December 4, 2018: Trials
https://www.readbyqxmd.com/read/30514270/racial-differences-in-long-term-adjuvant-endocrine-therapy-adherence-and-mortality-among-medicaid-insured-breast-cancer-patients-in-texas-findings-from-tcr-medicaid-linked-data
#2
Albert J Farias, Wen-Hsing Wu, Xianglin L Du
BACKGROUND: There are racial/ethnic disparities in breast cancer mortality may be attributed to differences in receipt of adjuvant cancer treatment. Our purpose was to determine whether the mortality disparities could be explained by racial/ethnic differences in long-term adherence to adjuvant endocrine therapy (AET). METHODS: We conducted a retrospective cohort study with the Texas Cancer Registry and Medicaid claims-linked dataset of women (20-64 years) diagnosed with local and regional breast cancer who filled a prescription for AET from 2000-2008...
December 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30510337/estimating-the-net-survival-of-patients-with-gastric-cancer-in-iran-in-a-relative-survival-framework
#3
Fatemeh Paknazar, Mahmood Mahmoudi, Kazem Mohammad, Hojjat Zeraati, Mohammad Ali Mansournia, Mahdi Yaseri
Background: Iran is an Eastern Mediterranean region country with the highest rate of gastric cancer. The present study aimed to evaluate the 5-year net survival of patients with gastric cancer in Iran using a relative survival framework. Methods: In a cross-sectional study, using life-table estimation of relative survival, we reported 1- to 5-year relative survival regarding age, sex, disease stage, pathology, and adjuvant therapies via modeling excess mortality...
November 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/30508188/co-operative-groups-in-the-development-of-chemotherapy-for-gastric-cancer
#4
Hiroyuki Arai, Yu Sunakawa, Takako Eguchi Nakajima
In the multimodality treatment strategy for gastric cancer, chemotherapy has an important role in conferring survival benefit. For the last three decades, great progress has been achieved in adjuvant and palliative chemotherapy. Powerful combination regimens using doublet or triplet cytotoxic agents have been developed and new molecular targeted drugs, including trastuzumab and ramucirumab, have been introduced in clinical practice. These advances have resulted from the accumulation of many clinical trials...
December 1, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30506150/patterns-of-failures-after-surgical-resection-in-olfactory-neuroblastoma
#5
Nalee Kim, Chang Geol Lee, Eui Hyun Kim, Chang-Hoon Kim, Ki Chang Keum, Kyu-Sung Lee, Jong Hee Chang, Chang-Ok Suh
INTRODUCTION: Patterns of failure in patients with olfactory neuroblastoma (ONB) according to two surgical approaches, craniofacial resection (CFR) and endoscopic surgery (ENDO), have yet to be analyzed. METHODS: We retrospectively reviewed 28 patients with surgically treated ONB between January 1995 and October 2017. Fourteen (50.0%) patients underwent CFR (9 CFR alone, 5 ENDO-assisted CFR) and 14 (50.0%) underwent ENDO. Nineteen (67.9%) patients underwent post-operative radiotherapy (RT)...
November 30, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/30506131/outcome-and-toxicity-of-intensity-modulated-radiotherapy-with-simultaneous-integrated-boost-in-patients-with-pharyngo-laryngeal-cancer
#6
REVIEW
A Fondevilla Soler, J L López-Guerra, A García Fernández, M A Samaniego Conde, M J Belmonte González, J M Praena-Fernandez, E Rivin Del Campo, M Alcaraz, I Azinovic
PURPOSE: The present work aims at evaluating intensity-modulated radiation therapy with simultaneous integrated boost (IMRT-SIB) in squamous cell carcinomas (SCC) of the larynx and hypopharynx. METHODS/PATIENTS: We performed a single institutional retrospective analysis on 116 pharyngo (29%)-laryngeal (71%) SCC patients (93% male) treated with IMRT-SIB to 66-69.96 Gy in 33 fractions between 2008 and 2016. Those who underwent surgery (54%) received adjuvant radiation of 66 Gy at 2 Gy/fraction to the surgical bed...
November 30, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/30505590/clinical-fate-of-t0n1-esophageal-cancer-results-from-the-national-cancer-database
#7
Caitlin Takahashi, Ravi Shridhar, Jamie Huston, Kenneth Meredith
The long-term survival for patients with locally advanced esophageal cancer (EC) remains poor despite improvements in multi-modality care. Neoadjuvant chemoradiation (NCR) followed by surgical resection remains pivotal in the management of patients with EC. However, the outcome of patients whose primary tumor exhibits a complete response with residual regional nodal disease (T0N1) remains unclear as well as the role for adjuvant therapy.Utilizing the National Cancer Database we identified patients with EC who underwent NCR followed by esophagectomy who had subsequent pathology of T0N1...
October 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30505236/adjuvant-gamma-knife-surgery-and-image-guided-intensity-modulated-radiation-therapy-for-the-treatment-of-sacral-chordomas
#8
Shun Lu, Xinhao Peng, Bingwen Zou, Cheng Zhou, Mei Feng, Jinyi Lang
Aim: The aim of this study was to confirm whether patients with sacral chordoma benefit from adjuvant radiotherapy and to determine the optimal photon radiotherapy module for comprehensive treatment. Background: Chordoma is a rare slow-growing neoplasm arisen from cellular remnants of the notochord. About 50% occur in the sacrococcygeal region. Surgical resection and adjuvant radiation therapy are recommended treatment due to the improving local control rate. Materials and methods: 118 patients treated by surgery and adjuvant radiotherapy from August 2003 to May 2015 were retrospectively analyzed...
January 2019: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/30504393/chemotherapy-in-patients-with-hereditary-angioedema
#9
Cristina Morelli, Vincenzo Formica, Stefania Pellicori, Antonello Menghi, Maria Domenica Guarino, Roberto Perricone, Mario Roselli
BACKGROUND: Hereditary angioedema (HAE) is an autosomal dominant hereditary disorder characterized by episodic swelling of many body regions (especially throat and abdomen), potentially triggered by medication. No data are available for HAE in patients with cancer assigned to standard chemotherapy. The aim of our study was to identify circulating mediators potentially predictive of acute HAE attacks during chemotherapy. PATIENT AND METHODS: Repeated blood testing (approximately every week) for complement system members (C3, C4, CH50, C1 inhibitor, C1-inhibitor functional C1Q), D-dimers and for routine haematochemistry were performed in a 42-year-old male affected by type 2 HAE during standard adjuvant oxaliplatin/fluorouracil-based chemotherapy administered for stage III radically resected rectal cancer...
December 2018: Anticancer Research
https://www.readbyqxmd.com/read/30500852/hiv-1-t-cell-epitopes-targeted-to-rhesus-macaque-cd40-and-dcir-a-comparative-study-of-prototype-dendritic-cell-targeting-therapeutic-vaccine-candidates
#10
Anne-Laure Flamar, Henri Bonnabau, Sandra Zurawski, Christine Lacabaratz, Monica Montes, Laura Richert, Aurelie Wiedemann, Lindsey Galmin, Deborah Weiss, Anthony Cristillo, Lauren Hudacik, Andres Salazar, Cécile Peltekian, Rodolphe Thiebaut, Gerard Zurawski, Yves Levy
HIV-1 infection can be controlled by anti-retroviral drug therapy, but this is a lifetime treatment and the virus remains latent and rapidly rebounds if therapy is stopped. HIV-1-infected individuals under this drug regimen have increased rates of cancers, cardiovascular diseases, and autoimmunity due to compromised immunity. A therapeutic vaccine boosting cellular immunity against HIV-1 is therefore desirable and, possibly combined with other immune modulating agents, could obviate the need for long-term drug therapies...
2018: PloS One
https://www.readbyqxmd.com/read/30499077/national-failure-of-surgical-staging-for-t1b-gallbladder-cancer
#11
Elaine Vo, Steven A Curley, Christy Y Chai, Nader N Massarweh, Hop S Tran Cao
BACKGROUND: Current guidelines recommend radical cholecystectomy with regional lymphadenectomy (RC-RL) for patients with T1b gallbladder cancer (GBC). However, the extent to which these guidelines are followed is unclear. This study aimed to evaluate current surgical practices for T1b GBC and their implications for overall management strategies and associated outcomes. METHODS: This retrospective cohort study investigated patients identified from the National Cancer Data Base (2004-2012) with non-metastatic T1b GBC...
November 29, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30496881/implications-of-image-defined-risk-factors-and-primary-site-response-on-local-control-and-radiation-treatment-delivery-in-the-management-of-high-risk-neuroblastoma-is-there-a-role-for-de-escalation-of-adjuvant-primary-site-radiotherapy
#12
John T Lucas, M Beth McCarville, David A Cooper, Mikhail Doubrovin, Daniel Wakefield, Teresa Santiago, Yimei Li, Xingyu Li, Matthew Krasin, Victor Santana, Wayne Furman, Andrew M Davidoff
BACKGROUND: The predictive value of Image-Defined Risk Factors (IDRFs) developed by the International Neuroblastoma Risk Group (INRG) Task Force as it relates to primary site management is undefined and may aid patient selection for de-escalation of adjuvant radiotherapy to the primary site in high risk neuroblastoma (HRNB). METHODS: Patients (N=76) with HRNB treated on prospective trials at our institution from 1997 to 2014 were eligible for inclusion. IDRFs were defined based on pre-therapy imaging...
November 26, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30488669/chimaeric-rift-valley-fever-virus-like-particle-vaccine-candidate-production-in-nicotiana-benthamiana
#13
Sandiswa Mbewana, Ann E Meyers, Edward P Rybicki
Rift valley fever virus (RVFV) is an emerging mosquito borne virus and haemorrhagic fever agent, which causes abortion storms in farmed small ruminants and potentially causes miscarriages in humans. Although live-attenuated vaccines are available for animals, they can only be used in endemic areas and there are currently no commercially available vaccines for humans. Here we describe the production of chimaeric RVFV virus-like particles transiently expressed in Nicotiana benthamiana by Agrobacterium tumefaciens-mediated gene transfer...
November 28, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/30487695/pancreatic-cancer-a-review-of-clinical-diagnosis-epidemiology-treatment-and-outcomes
#14
REVIEW
Andrew McGuigan, Paul Kelly, Richard C Turkington, Claire Jones, Helen G Coleman, R Stephen McCain
This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients...
November 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30485442/a-novel-prospective-study-assessing-the-combination-of-photodynamic-therapy-and-proton-radiation-therapy-safety-and-outcomes-when-treating-malignant-pleural-mesothelioma
#15
Stephanie R Rice, Yun R Li, Theresa M Busch, Michele M Kim, Sally McNulty, Andrea Dimofte, Timothy C Zhu, Keith A Cengel, Charles B Simone
Malignant pleural mesothelioma remains difficult to treat, with high failure rates despite optimal therapy. We present a novel prospective trial combining proton therapy (PT) and photodynamic therapy (PDT) and the largest-ever mesothelioma PT experience (n=10). PDT photosensitizers included porfimer sodium (2mg/kg; 24hr drug-light interval) or 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) (4mg/m2 ;48hr) with wavelengths of 630nm to 60J/cm2 and 665nm to 15-45J/cm2 , respectively. With a median age of 69 years, patients were predominantly male (90%) with epithelioid histology (100%) and stage III-IV disease (100%)...
November 28, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/30485420/spontaneous-remission-of-residual-post-therapy-plasma-epstein-barr-virus-dna-and-its-prognostic-implication-in-nasopharyngeal-carcinoma-a-large-scale-big-data-intelligence-platform-based-analysis
#16
Yuan Zhang, Ling-Long Tang, Ying-Qin Li, Xu Liu, Qing Liu, Jun Ma
Detectable post-therapy plasma Epstein-Barr virus (EBV) DNA predicts poor survival in non-metastatic nasopharyngeal carcinoma (NPC). However, some patients subsequently experience spontaneous remission of residual EBV DNA during follow-up and it was unclear whether these patients were still at high risk of disease failure. Using the NPC database from an established big-data intelligence platform, 3269 NPC patients who had the plasma EBV DNA load measured at the end of therapy (+ 1 week) were identified. In total, 93...
November 28, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30476666/exophytic-primary-spinal-intramedullary-glioblastoma-a-case-report-and-critical-review-of-literature
#17
Apisara Chanchotisatien, Jie Xiong, Jintai Yu, Shuguang Chu
BACKGROUND: Primary spinal intramedullary glioblastoma is an extremely rare entity; we report the first case of primary spinal intramedullary glioblastoma presenting with exophytic involvement. The prognosis of glioblastoma remains poor due to the aggressive nature of the disease and lack of effective treatment. CASE DESCRIPTION: A 27-year-old Asian female presented to our hospital with a one-month history of dysuria, incomplete bladder emptying, progressive numbness and weakness of both lower limbs, and a one-year history of back pain...
November 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30471626/melanotic-neuroectodermal-tumour-of-infancy-a-report-of-two-cases
#18
Shady A Moussa, Mohamed ElSayed, Soad Mansour, Fahmy A Mobarak
INTRODUCTION: Melanotic neuroectodermal tumour of infancy (MNTI) is a benign tumour of infancy, most commonly affecting the head and neck region. First described in 1918, less than 500 cases have been reported in the literature. MNTI is aggressive in nature & has a high rate of recurrence. PRESENTATION OF CASES: In this retrospective case series, we report two cases of MNTI that presented at our unit; both cases were managed by wide excision and have been followed up uneventfully for over two years...
November 15, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30470126/clear-cell-sarcoma-of-tendons-and-aponeuroses-in-the-right-genitofemoral-line-a-case-report
#19
R Adwan, P Prošvic, J Prošvicová, V Straka, B Herzig
INTRODUCTION: Our case report presents a rare occurrence of clear cell sarcoma in the genitofemoral line region that has not been described to date. CASE REPORT: A 57-year-old male patient with clear-cell sarcoma of tendons and aponeuroses is presented. The patient underwent a radical operation and adjuvant radiotherapy. CONCLUSION: The patient is still alive, in a good health condition, without local recurrence or generalised disease...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/30459364/probing-tumor-microenvironment-in-patients-with-newly-diagnosed-glioblastoma-during-chemoradiation-and-adjuvant-temozolomide-with-functional-mri
#20
K Ina Ly, Bella Vakulenko-Lagun, Kyrre E Emblem, Yangming Ou, Xiao Da, Rebecca A Betensky, Jayashree Kalpathy-Cramer, Dan G Duda, Rakesh K Jain, Andrew S Chi, Scott R Plotkin, Tracy T Batchelor, Gregory Sorensen, Bruce R Rosen, Elizabeth R Gerstner
Functional MRI may identify critical windows of opportunity for drug delivery and distinguish between early treatment responders and non-responders. Using diffusion-weighted, dynamic contrast-enhanced, and dynamic susceptibility contrast MRI, as well as pro-angiogenic and pro-inflammatory blood markers, we prospectively studied the physiologic tumor-related changes in fourteen newly diagnosed glioblastoma patients during standard therapy. 153 MRI scans and blood collection were performed before chemoradiation (baseline), weekly during chemoradiation (week 1-6), monthly before each cycle of adjuvant temozolomide (pre-C1-C6), and after cycle 6...
November 20, 2018: Scientific Reports
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