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https://www.readbyqxmd.com/read/30108165/comprehensive-genomic-profiling-of-patient-matched-head-and-neck-cancer-cells-a-preclinical-pipeline-for-metastatic-and-recurrent-disease
#1
Lluís Nisa, David Barras, Michaela Medová, Daniel M Aebersold, Matúš Medo, Michaela Poliaková, Jonas Koch, Beat Bojaxhiu, Olgun Elicin, Matthias S Dettmer, Paolo Angelino, Roland Giger, Urs Borner, Marco D Caversaccio, Thomas E Carey, Liza Ho, Thomas A McKee, Mauro Delorenzi, Yitzhak Zimmer
Metastases and tumor recurrence have a major prognostic impact in head and neck squamous cell carcinoma (HNSCC); however, cellular models that comprehensively characterize metastatic and recurrent HNSCC are lacking. To this end, we obtained genomic, transcriptomic and copy-number profiles of the UM-SCC cell line panel, encompassing patient-matched metastatic and recurrent cells. UM-SCC cells recapitulate the most prevalent genomic alterations described in HNSCC, featuring common TP53, PI3K, NOTCH, and Hippo pathway mutations...
August 14, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/30105029/-schistosoma-mansoni-sm-ki-1-or-its-c-terminal-fragment-induces-partial-protection-against-s-mansoni-infection-in-mice
#2
Suellen B Morais, Barbara C Figueiredo, Natan R G Assis, Jane Homan, Fábio S Mambelli, Rodrigo M Bicalho, Cláudia Souza, Vicente P Martins, Carina S Pinheiro, Sergio C Oliveira
Current schistosomiasis control strategies are mainly based on chemotherapy, but the development of a vaccine against this parasitic disease would contribute to a long-lasting decrease in disease spectrum and transmission. When it comes to vaccine candidates, several genes encoding Schistosoma mansoni proteins expressed at the mammalian host-parasite interface have been tested. Among the most promising molecules are the proteins present on the tegument and digestive tract of the parasite. In this study, we evaluate the potential of Sm KI-1, the first Kunitz-type protease inhibitor functionally characterized in S...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30103407/the-current-role-of-salvage-surgery-in-recurrent-head-and-neck-squamous-cell-carcinoma
#3
REVIEW
Marc Hamoir, Sandra Schmitz, Carlos Suarez, Primoz Strojan, Kate A Hutcheson, Juan P Rodrigo, William M Mendenhall, Ricard Simo, Nabil F Saba, Anil K D'Cruz, Missak Haigentz, Carol R Bradford, Eric M Genden, Alessandra Rinaldo, Alfio Ferlito
Chemoradiotherapy has emerged as a gold standard in advanced squamous cell carcinoma of the head and neck (SCCHN). Because 50% of advanced stage patients relapse after nonsurgical primary treatment, the role of salvage surgery (SS) is critical because surgery is generally regarded as the best treatment option in patients with recurrent resectable SCCHN. Surgeons are increasingly confronted with considering operation among patients with significant effects of failed non-surgical primary treatment. Wide local excision to achieve clear margins must be balanced with the morbidity of the procedure, the functional consequences of organ mutilation, and the likelihood of success...
August 10, 2018: Cancers
https://www.readbyqxmd.com/read/30103196/intranasal-immunization-of-cocktail-fusion-protein-containing-tir-along-with-%C3%AE-g-active-fragment-of-zot-as-mucosal-adjuvant-confers-enhanced-immunogenicity-and-reduces-e-coli-o157-h7-shedding-in-mice
#4
Aravind Shekar, Shylaja Ramlal, Joseph Kingston Jeyabalaji, Murali Harishchandra Sripathy
Ruminants are the major reservoirs of Escherichia coli O157:H7 and its fecal shedding mainly act as a source of entry of this pathogen into the human food chain. In humans, E. coli O157:H7 infection causes diarrhea, hemorrhagic colitis and hemolytic uremic syndrome. Intimate adherence of E. coli O157:H7 is mediated by Translocated intimin receptor (Tir) to which intimin binds in the host cell. Since E. coli O157:H7 colonizes intestinal epithelium, the mucosal vaccine has a potential to prevent its colonization...
August 10, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30102208/analysis-of-skin-flap-thickness-and-residual-breast-tissue-after-mastectomy
#5
Daniela Gregolin Giannotti, Samir Abdallah Hanna, Giovanni Guido Cerri, Jose Luiz Barbosa Bevilacqua
PURPOSE: Residual breast tissue (RBT) after mastectomy represents an unknown risk for local recurrence or development of a new cancer and affects decisions regarding adjuvant radiation therapy. This study used breast magnetic resonance imaging to evaluate the frequency of RBT and provide average thickness skin flap measurements in patients with total mastectomy, skin-sparing mastectomy, and nipple-sparing mastectomy (NSM) followed by breast reconstruction. METHODS AND MATERIALS: We carried out a retrospective analysis of 7432 consecutive postoperative breast magnetic resonance imaging examinations performed between August 2008 and July 2013, selecting 367 women (mean ± standard deviation age, 46...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30100994/risk-factors-for-loco-regional-recurrence-in-breast-cancer-patients-a-retrospective-study
#6
Tomás Merino, Teresa Ip, Francisco Domínguez, Francisco Acevedo, Lidia Medina, Alejandra Villaroel, Mauricio Camus, Eugenio Vinés, César Sánchez
Background: Although fairly uncommon, loco-regional recurrence in breast cancer (BC) has major consequences for the patient. Several predictors for locoregional have been previously reported from large randomized clinical trials mainly from Europe & North America; data from other geographical areas are somewhat scarce. Here we performed a retrospective review of medical records in a single academic center in Chile, searching for predictors of breast tumor recurrence. Results: Median patient follow up was 61 months, 5 year overall survival (OS) rate was 94...
July 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/30098956/what-factors-are-associated-with-regional-recurrence-after-operative-treatment-of-oral-squamous-cell-carcinoma
#7
Matthias Troeltzsch, Selgai Haidari, Sophie Boser, Markus Troeltzsch, Florian A Probst, Michael Ehrenfeld, Sven Otto
PURPOSE: A considerable proportion of oral squamous cell carcinoma (OSCC) recurrences involve the neck, which has a significant impact on prognosis and is poorly understood. The purpose of this study was to analyze clinical and pathologic characteristics of regional recurrence of OSCC and identify possible risk factors. MATERIALS AND METHODS: A single-center retrospective cohort study was designed to address the study purpose. All patients who were treated surgically for primary OSCC with or without adjuvant therapy between 2010 and 2015 were considered for inclusion with respect to predefined criteria, and demographic, clinical, and pathologic variables were collected...
July 19, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30098782/nomogram-for-preoperative-prediction-of-nodal-extracapsular-extension-or-positive-surgical-margins-in-oropharyngeal-squamous-cell-carcinoma
#8
Mohammad K Hararah, William A Stokes, Bernard L Jones, Ayman Oweida, Ding Ding, Jessica McDermott, Julie Goddard, Sana D Karam
INTRODUCTION: Extracapsular extension (ECE) in regional lymph nodes and positive surgical margins (PSM) are considered high-risk adverse pathologic features in patients with oropharyngeal squamous cell carcinoma (OPSCC) that each constitute an indication for postoperative adjuvant chemoradiation. We identify pre-operative clinical factors that can predict post-operative ECE and/or PSM and create a nomogram to help clinical decision making. METHODS: Adult patients with non-metastatic OPSCC with initial surgical treatment and confirmed HPV status diagnosed between 2010 and 2014 were selected from the National Cancer Database...
August 2018: Oral Oncology
https://www.readbyqxmd.com/read/30095709/the-clinical-features-of-recurrent-endometrial-cancer-in-japan-chemotherapy-instead-of-radiotherapy-as-postoperative-adjuvant-treatment
#9
Haruko Iwase, Seigi Furukawa, Takeshi Hirasawa, Satoshi Asai, Tatsuru Ohara, Shinji Hosonuma, Shinichi Endo, Yuki Tazo, Hidetaka Sato, Toshio Takada, Masahide Arai, Masae Ikeda, Masako Shida, Norihito Yoshioka, Akiko Tozawa-Ono, Nao Suzuki, Mikio Mikami, Takashi Onda
OBJECTIVE: Chemotherapy is a standard adjuvant treatment after primary surgery for endometrial cancer in Japan. We aimed to characterize the clinical features of recurrent endometrial cancer (REC) patients in Japan. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 112 REC patients who were primarily treated at 1 of 3 university hospitals in Japan from 2005 to 2012. We analyzed overall survival since the first recurrence (R-OS) in accordance with several factors...
August 7, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/30095446/pain-control-in-a-pediatric-patient-with-sickle-cell-disease-using-regional-nerve-blocks-for-laparoscopic-cholecystectomy-a-case-report
#10
Aysha Hasan, Autumn D Nanassy, Gregory Disilvio, Teerin Meckmongkol, L Grier Arthur, Pravin A Taneja
The sickle cell patient population continues to provide challenges in pain control. Current therapies include narcotic usage with adjuvant therapies such as anti-inflammatories and nonpharmacological interventions. Poor pain management in the sickle cell patient population, especially postoperatively, can lead to hypoventilation, escalating opioid requirements, poor recovery, and longer hospital stays. This case report addresses a novel addition of ultrasound-guided paravertebral and rectus sheath blocks postinduction of general anesthesia and before surgical incision to assist with the intravenous postoperative pain management regimen after laparoscopic cholecystectomy in a 10-year-old boy with sickle cell disease...
August 7, 2018: A&A practice
https://www.readbyqxmd.com/read/30094592/breast-ultrasound-recommendations-for-information-to-women-and-referring-physicians-by-the-european-society-of-breast-imaging
#11
Andrew Evans, Rubina M Trimboli, Alexandra Athanasiou, Corinne Balleyguier, Pascal A Baltzer, Ulrich Bick, Julia Camps Herrero, Paola Clauser, Catherine Colin, Eleanor Cornford, Eva M Fallenberg, Michael H Fuchsjaeger, Fiona J Gilbert, Thomas H Helbich, Karen Kinkel, Sylvia H Heywang-Köbrunner, Christiane K Kuhl, Ritse M Mann, Laura Martincich, Pietro Panizza, Federica Pediconi, Ruud M Pijnappel, Katja Pinker, Sophia Zackrisson, Gabor Forrai, Francesco Sardanelli
This article summarises the information that should be provided to women and referring physicians about breast ultrasound (US). After explaining the physical principles, technical procedure and safety of US, information is given about its ability to make a correct diagnosis, depending on the setting in which it is applied. The following definite indications for breast US in female subjects are proposed: palpable lump; axillary adenopathy; first diagnostic approach for clinical abnormalities under 40 and in pregnant or lactating women; suspicious abnormalities at mammography or magnetic resonance imaging (MRI); suspicious nipple discharge; recent nipple inversion; skin retraction; breast inflammation; abnormalities in the area of the surgical scar after breast conserving surgery or mastectomy; abnormalities in the presence of breast implants; screening high-risk women, especially when MRI is not performed; loco-regional staging of a known breast cancer, when MRI is not performed; guidance for percutaneous interventions (needle biopsy, pre-surgical localisation, fluid collection drainage); monitoring patients with breast cancer receiving neo-adjuvant therapy, when MRI is not performed...
August 9, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/30094478/electroacupuncture-induces-antihyperalgesic-effect-through-endothelin-b-receptor-in-the-chronic-phase-of-a-mouse-model-of-complex-regional-pain-syndrome-type-i
#12
Leidiane Mazzardo-Martins, Daiana Cristina Salm, Elisa C Winkelmann-Duarte, Júlia Koerich Ferreira, Daniela Dero Lüdtke, Kamilla Pamplona Frech, Luiz Augusto Oliveira Belmonte, Verônica Vargas Horewicz, Anna Paula Piovezan, Francisco José Cidra-Filho, Ari Ojeda Ocampo Moré, Daniel Fernandes Martins
Complex regional pain syndrome (CRPS) is a disorder that involves abnormal inflammation and nerve dysfunction frequently resistant to a broad range of treatments. Peripheral nerve stimulation with electroacupuncture (EA) has been widely used in different clinical conditions to control pain and inflammation; however, the use of EA in the treatment of CRPS is under investigation. In this study, we explore the effects of EA on hyperalgesia and edema induced in an animal model of chronic post-ischemia pain (CPIP model) and the possible involvement of endothelin receptor type B (ETB ) in this effect...
August 10, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/30094161/hippocampal-functional-connectivity-is-related-to-self-reported-cognitive-concerns-in-breast-cancer-patients-undergoing-adjuvant-therapy
#13
Alexandra C Apple, Matthew P Schroeder, Anthony J Ryals, Lynne I Wagner, David Cella, Pei-An Shih, James Reilly, Frank J Penedo, Joel L Voss, Lei Wang
Nearly three out of four survivors experience Cancer-Related Cognitive Impairment (CRCI) for months or years following treatment. Both clinical and animal studies point to the hippocampus as a likely brain region affected in CRCI, however no previous study has investigated the functional connectivity of the hippocampus in CRCI. We compared hippocampal connectivity in cancer survivors and healthy controls and tested the relationship between functional connectivity differences and measures of objective and subjective cognition...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30094043/the-nerve-of-legal-entrapment
#14
Ali S Ahmed, Mark C Flemmer
Chordomas are a rare type of bone tumor that arises from the embryological remnant of the notochord. They originate at any point along the axial spine with the sacrum and the skull based region being the most commonly affected sites. Chordomas are slowly growing, indolent tumors, presenting insidiously, but also carry a high recurrence rate with a tendency to invade contiguous structure making their treatment challenging. The current standard of care for localized chordoma is aggressive cytoreductive surgery followed by high dose adjuvant radiotherapy...
August 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/30088178/gray-matter-density-reduction-associated-with-adjuvant-chemotherapy-in-older-women-with-breast-cancer
#15
Bihong T Chen, Taihao Jin, Sunita K Patel, Ningrong Ye, Can-Lan Sun, Huiyan Ma, Russell C Rockne, James C Root, Andrew J Saykin, Tim A Ahles, Andrei I Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan, Daneng Li, George Somlo, Jessica Vazquez, Abrahm Levi, Heidi Tan, Richard Yang, Vani Katheria, Arti Hurria
PURPOSE: The purpose of this study was to evaluate longitudinal changes in brain gray matter density (GMD) before and after adjuvant chemotherapy in older women with breast cancer. METHODS: We recruited 16 women aged ≥ 60 years with stage I-III breast cancers receiving adjuvant chemotherapy (CT) and 15 age- and sex-matched healthy controls (HC). The CT group underwent brain MRI and the NIH Toolbox for Cognition testing prior to adjuvant chemotherapy (time point 1, TP1) and within 1 month after chemotherapy (time point 2, TP2)...
August 7, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/30081196/fusion-to-tetrahymena-thermophila-granule-lattice-protein-1-confers-solubility-to-sexual-stage-malaria-antigens-in-escherichia-coli
#16
Alka Agrawal, Yelena Bisharyan, Ashot Papoyan, Janna Bednenko, Joanna Cardarelli, Monica Yao, Theodore Clark, Mehmet Berkmen, Na Ke, Paul Colussi
A transmission-blocking vaccine targeting the sexual stages of Plasmodium species could play a key role in eradicating malaria. Multiple studies have identified the P. falciparum proteins Pfs25 and Pfs48/45 as prime targets for transmission-blocking vaccines. Although significant advances have been made in recombinant expression of these antigens, they remain difficult to produce at large scale and lack strong immunogenicity as subunit antigens. We linked a self-assembling protein, granule lattice protein 1 (Grl1p), from the ciliated protozoan, Tetrahymena thermophila, to regions of the ectodomains of either Pfs25 or Pfs48/45...
August 3, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/30074014/extracranial-meningiomas-in-the-head-and-neck-region-a-15-years-experience
#17
D Krasic, M Stojanovic, V Petrovic, Z Pesic
Meningiomas constitute a large group of tumors of the central nervous system, with the prevalence of 18%-20%. Extracranial localization of meningeomas could appear due to their extracranial origin or due to the spreading of intracranial meningeomas. In this paper, we present our 15 years' experience in the diagnosis and treatment of extra- and intracranial meningiomas invading the head-and-neck region. In the period from 2001 to 2016 at our clinic, there were five patients (three men and two women), with meningiomas of extracranial origin or meningiomas of intracranial origin, spreading into the head-and-neck region...
August 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/30057002/experience-of-definitive-chemoradiation-for-oesophageal-cancer-within-a-large-regional-cancer-treatment-centre-improving-outcomes-and-tolerability
#18
V J Lavin, S Mehta, P Sumra, X Wang, L Bhatt, A S Jackson, H Y Sheikh
AIMS: To review delivery of definitive chemoradiation (dCRT) for patients with oesophageal cancer within a large regional cancer centre. To assess toxicity, tolerability and outcomes and compare with published data. MATERIALS AND METHODS: A retrospective review of patients undergoing dCRT between November 2009 and November 2014 was carried out. Data were collected regarding treatment completion, radiotherapy plans, toxicity, failure and death. Kaplan-Meier survival curves with a Log-rank test for significance were used for survival analysis...
July 26, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/30055967/intra-seasonal-antibody-repertoire-analysis-of-a-subject-immunized-with-an-mf59%C3%A2-adjuvanted-pandemic-2009-h1n1-vaccine
#19
Jack Ferdman, Giuseppe Palladino, Hua-Xin Liao, M Anthony Moody, Thomas B Kepler, Giuseppe Del Giudice, Philip R Dormitzer, Stephen C Harrison, Ethan C Settembre, Pirada Suphaphiphat
During the height of the 2009 H1N1 swine-derived influenza pandemic, a clinical trial was conducted in which seven subjects were immunized using a monovalent, MF59®-adjuvanted vaccine, developed from an egg-passaged candidate vaccine virus (CVV), A/California/07/2009 X-181. Whole blood was collected prior to immunization and at 8, 22, and 202 days post-vaccination, and subjects' serological responses were evaluated. Here, we reconstruct and examine the longitudinal, influenza-specific circulating B cell repertoire of one subject in that study...
July 25, 2018: Vaccine
https://www.readbyqxmd.com/read/30050803/magnetic-resonance-imaging-mri-based-radiomics-for-prostate-cancer-radiotherapy
#20
REVIEW
Fei Yang, John C Ford, Nesrin Dogan, Kyle R Padgett, Adrian L Breto, Matthew C Abramowitz, Alan Dal Pra, Alan Pollack, Radka Stoyanova
In radiotherapy (RT) of prostate cancer, dose escalation has been shown to reduce biochemical failure. Dose escalation only to determinate prostate tumor habitats has the potential to improve tumor control with less toxicity than when the entire prostate is dose escalated. Other issues in the treatment of the RT patient include the choice of the RT technique (hypo- or standard fractionation) and the use and length of concurrent/adjuvant androgen deprivation therapy (ADT). Up to 50% of high-risk men demonstrate biochemical failure suggesting that additional strategies for defining and treating patients based on improved risk stratification are required...
June 2018: Translational Andrology and Urology
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