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regional adjuvant

Suyi Ooi, Matthew Gutman, Chris Xenos, Ronil Chandra, Catriona McLean
Intracranial epithelioid haemangioendothelioma (EHE) is a rare intermediate grade vascular tumour with heterogeneous clinical and histopathological behaviour. We present the surgical considerations of an exceptionally large skull-based EHE in an 11-year old female who presented to our institution with headaches and a protuberance over the left parietal area. Magnetic resonance imaging (MRI) demonstrated a left sided 10.5 × 6.6 × 11.1 cm extra-axial tumour arising from the parieto-temporaloccipital region which was continuous with the calvarium...
October 19, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Brian Fiani, Syed A Quadri, Mudassir Farooqui, Massimo D'Apuzzo, Robert J Rosser, Blake W Berman, Jerry Noel, Xin S Xin, Behnam Badie, Anirudh Ramachandran, Javed Siddiqi
Brainstem tumors are rare, even rarer is a brainstem tumor containing tissues of an embryologic gynecologic origin. We report a very rare case of presence of a calcified heterogeneously contrast enhancing brainstem mass of Müllerian origin in a patient in a 38 year old female with no female genital tract cancer and past surgical history of ventriculoperitoneal (VP) shunt placement for congenital hydrocephalus. To our knowledge this is the very first and unusual case of a mass of gynecologic origin in the brainstem region especially in the setting of no history of gynecological tumor...
October 15, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Yu-Hsuan Hung, Shih-An Liu, Chen-Chi Wang, Ching-Ping Wang, Rong-San Jiang, Shang-Heng Wu
BACKGROUND: Treatment modality of unknown primary squamous cell carcinoma of the head and neck (SCCHN) remains controversial. OBJECTIVES: To evaluate the treatment outcomes and prognostic factors of unknown primary SCCHN. MATERIALS AND METHODS: Patients with unknown primary SCCHN from April 1995 to March 2013 were recruited retrospectively. RESULTS: Sixty-nine patients were enrolled. The median time of follow-up was 55...
2018: PloS One
Li-Hao Li, Cong-Cong Ma, Hai-Feng Zhang, Ya-Jun Lian
PURPOSE: The purpose of this study was to analyze the clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis. METHODS: The methods utilized in this study were prospective analysis of the clinical manifestations, types of seizures, electroencephalogram (EEG), adjuvant examination, treatment and prognosis of 19 cases of LGI1-antibody encephalitis diagnosed from January 2017 to February 2018 in First Affiliated Hospital of Zhengzhou University, and reviewed related literatures...
October 14, 2018: Epilepsy & Behavior: E&B
Caitlin N Dodd, Maria de Ridder, Wan-Ting Huang, Daniel Weibel, Maria Giner-Soriano, Silvia Perez-Vilar, Javier Diez-Domingo, Lawrence W Svenson, Salahddin M Mahmud, Bruce Carleton, Monika Naus, Jeffrey C Kwong, Brian J Murray, Lisen Arnheim-Dahlstrom, Lars Pedersen, Rosa Morros, Francisco Javier Puertas, Steven Black, Miriam Sturkenboom
BACKGROUND & OBJECTIVES: Vaccine safety signals require investigation, which may be done rapidly at the population level using ecological studies, before embarking on hypothesis-testing studies. Incidence rates were used to assess a signal of narcolepsy following AS03-adjuvanted monovalent pandemic H1N1 (pH1N1) influenza vaccination among children and adolescents in Sweden and Finland in 2010. We explored the utility of ecological data to assess incidence of narcolepsy following exposure to pandemic H1N1 virus or vaccination in 10 sites that used different vaccines, adjuvants, and had varying vaccine coverage...
2018: PloS One
Peter A S Johnstone, David Boulware, Rosa Djajadiningrat, Sarah Ottenhof, Andrea Necchi, Mario Catanzaro, Dingwei Ye, Yao Zhu, Nicola Nicolai, Simon Horenblas, Philippe E Spiess
BACKGROUND: In head and neck cancer, the presence of extranodal extension (ENE) in lymph nodes (LNs) has been shown prospectively to require adding chemotherapy to postoperative radiation therapy (RT). Limited data exist regarding ENE in LNs from primary penile cancer (PeCa). OBJECTIVE: To determine the association of RT and ENE in PeCa. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively analyzed the outcomes of 93 patients with pT1-4 N3 M0 (American Joint Committee on Cancer 7th edition) squamous cell carcinoma of the penis across four international centers...
October 13, 2018: European Urology Focus
Yeon Joo Kim, Su Ssan Kim, Si Yeol Song, Seung-Il Park, Dong Kwan Kim, Yong-Hee Kim, Hyeong Ryul Kim, Eun Kyung Choi
INTRODUCTION: We evaluated the clinical outcome of patients with stage III to IV thymomas (Ts) or stage II to IV thymic carcinomas (TCs) treated with complete thymectomy and local radiation therapy (LRT, targeting the tumor bed and anterior mediastinal areas only) or elective nodal irradiation (ENI, targeting the entire mediastinal and supraclavicular regions). MATERIALS AND METHODS: Data from 47 patients diagnosed with Ts or TCs and treated with surgery and adjuvant RT from May 2002 to May 2015 were analyzed...
September 21, 2018: Clinical Lung Cancer
José Barrera, David A Brake, Christopher Schutta, Damodar Ettyreddy, Barbara J Kamicker, Max V Rasmussen, Carla Bravo de Rueda, Mariceny Zurita, Melia Pisano, William Hurtle, Douglas E Brough, Bryan T Butman, Bruce G Harper, John G Neilan
We investigated the serotype- and topotype versatility of a replication-deficient human adenovirus serotype 5 vectored foot-and-mouth disease (FMD) vaccine platform (AdtFMD). Sixteen AdtFMD recombinant subunit monovalent vaccines targeting twelve distinct FMD virus (FMDV) serotype/topotypes in FMD Regional Pools I-VII were constructed. The AdtA24 serotype conditionally licensed vaccine served as the basis for vaccine design and target dose for cattle clinical trials. Several vaccines contained an additional RGD motif genetic insertion in the adenovector fiber knob, and/or a full-length 2B gene insertion in the FMDV P1 gene cassette...
October 13, 2018: Vaccine
Terence Fu, Christopher J Chin, Wei Xu, Jiahua Che, Shao Hui Huang, Eric Monteiro, Yazeed Alghonaim, Jolie Ringash, Ian J Witterick
OBJECTIVES/HYPOTHESIS: Treatment of non-squamous cell carcinoma sinonasal malignancies (NSCCSMs) typically involves surgery and radiotherapy (RT), but optimal sequencing remains controversial. STUDY DESIGN: Retrospective chart review. METHODS: Patients with NSCCSM treated with combined surgery and RT between 2000 and 2011 were identified. Margin control, overall survival, disease-free survival, local recurrence-free survival, and regional recurrence-free survival were compared between neoadjuvant and adjuvant RT groups...
October 16, 2018: Laryngoscope
Patrick Ifesinachi Emelife, Matthew R Eng, Bethany L Menard, Andrew S Myers, Elyse M Cornett, Richard D Urman, Alan D Kaye
Regional and neuraxial anesthesia can provide a safer perioperative experience, greater satisfaction, reduced opioid consumption, and reduction of pain, while minimizing side effects. Ultrasound technology has aided clinicians in depositing local anesthetic medication in precise proximity to targeted peripheral nerves. There are a plethora of adjuvants that have been utilized to prolong local anesthetic actions and enhance effects in peripheral nerve blocks. This manuscript describes the current state of the use of adjuncts, e...
June 2018: Best Practice & Research. Clinical Anaesthesiology
Barry Ting Sheen Kweh, Chengde Pham, Catriona McLean, Jin Wee Tee
Hemangiopericytomas are rare mesenchymal tumors with propensity to recur locally and metastasize. We report the unique case of a fifty-five-year-old male with recurrence of a previously resected craniocervical hemangiopericytoma presenting with obstructive hydrocephalus secondary to new metastatic cerebellar deposits. Emergent surgical resection of the cerebellar hemangiopericytomas was performed prior to adjuvant radiotherapy. Hemangiopericytomas are rare but important differentials for craniocervical junction lesions...
October 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Masood Umer, Javeria Saeed, Nida Zahid
INTRODUCTION: Aggressive fibromatosis or Desmoid fibromatosis is a benign tumor which originated form mesenchymal tissues of the body. This tumor has strong potential of recurrence and infiltration but it does not metastasize to other organs of the body. This case series is focused to determine the treatment outcomes for pediatric patients of aggressive fibromatosis. METHODOLOGY: It is a retrospective case series conducted on 7 patients presented to section of Orthopedics, department of surgery of our institute in Karachi...
October 4, 2018: International Journal of Surgery Case Reports
Yosuke Inoue, Akio Saiura, Atsushi Oba, Shoji Kawakatsu, Yoshihiro Ono, Takafumi Sato, Yoshihiro Mise, Takeaki Ishizawa, Yu Takahashi, Hiromichi Ito
BACKGROUND: We describe the short- and long-term outcomes for PDAC patients after tailored mesopancreas dissection using supracolic artery-first approach followed by adjuvant therapy. METHODS: This study analyzed 233 consecutive patients who underwent artery-first pancreaticoduodenectomy for PDAC. Dissection extent for the superior mesenteric artery (SMA) was categorized into three levels: level 2 (LV2) including regional lymph nodes, level 3 (LV3) with hemicircumferential nerve plexus dissection, and extended-level 3 (E-LV3) including borderline resectable cases for the SMA...
October 10, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Kavita Singh, Paushali Mukherjee, Ahmad Rushdi Shakri, Ankita Singh, Gaurav Pandey, Meenakshi Bakshi, Geetanjali Uppal, Rajender Jena, Ankita Rawat, Purnima Kumar, Rukmini Bhardwaj, Syed Shams Yazdani, Dhiraj Hans, Shantanu Mehta, Ajay Srinivasan, K Anil, R L Madhusudhan, Jaya Patel, Amit Singh, Rajeshwar Rao, Santosh Gangireddy, Rudrappa Patil, Swarnendu Kaviraj, Sanjay Singh, Darrick Carter, Steve Reed, David C Kaslow, Ashley Birkett, Virander S Chauhan, Chetan E Chitnis
Reticulocyte invasion by Plasmodium vivax requires interaction of the Duffy-binding protein (PvDBP) with host Duffy antigen receptor for chemokines (DARCs). The binding domain of PvDBP maps to a cysteine-rich region referred to as region II (PvDBPII). Blocking this interaction offers a potential path to prevent P. vivax blood-stage growth and P. vivax malaria. This forms the rationale for development of a vaccine based on PvDBPII. Here we report results of a Phase I randomized trial to evaluate the safety and immunogenicity of recombinant PvDBPII formulated with glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE)...
2018: NPJ Vaccines
Neal Van Hoeven, Steven Wiley, Emily Gage, Andrew Fiore-Gartland, Brian Granger, Sean Gray, Christopher Fox, David E Clements, D Elliot Parks, Scott Winram, Dan T Stinchcomb, Steven G Reed, Rhea N Coler
Members of the Flaviviridae family are the leading causes of mosquito-borne viral disease worldwide. While dengue virus is the most prevalent, the recent Zika virus outbreak in the Americas triggered a WHO public health emergency, and yellow fever and West Nile viruses (WNV) continue to cause regional epidemics. Given the sporadic nature of flaviviral epidemics both temporally and geographically, there is an urgent need for vaccines that can rapidly provide effective immunity. Protection from flaviviral infection is correlated with antibodies to the viral envelope (E) protein, which encodes receptor binding and fusion functions...
2018: NPJ Vaccines
Vijay M Ravindra, Yair M Gozal, Cheryl Palmer, William T Couldwell
BACKGROUND: Symptoms that mimic pituitary apoplexy may be encountered with other neoplastic or infectious lesions. CASE DESCRIPTION: This 38-year-old man presented with severe sudden-onset headache and relapsing and remitting vision loss. Radiographic imaging studies demonstrated radiographic features of a hyperdense, hemorrhagic mass in the sellar region. MRI revealed a 4-cm mass abutting the optic chiasm and compressing the pituitary. After 4-week follow-up surveillance MRI demonstrated near-complete resolution of the previously identified planum sphenoidale and suprasellar mass, the patient re-presented 13 months later with recurrent symptoms...
October 4, 2018: World Neurosurgery
Fabien Mignot, Delphine Loirat, Sylvain Dureau, Guillaume Bataillon, Martial Caly, Anne Vincent-Salomon, Frédérique Berger, Alain Fourquet, Jean-Yves Pierga, Youlia M Kirova, Francois-Clement Bidard
BACKGROUND: The disseminated tumor cells (DTC) are collected in the bone marrow and are the witness of micrometastatic spread. We previously reported that DTC could be a predictive factor of the efficacy of regional node irradiation (IMN/SCN: internal mammary nodes & supra-infra clavicular nodes). In this article, we report the long-term results (>10 years) on the impact of DTC status in early-stage breast cancer. METHODS: Patients with localized breast cancer were eligible for this prospective cohort...
October 3, 2018: International Journal of Radiation Oncology, Biology, Physics
Amr Muhammed, Esraa Elnakib, Mahmoud Nady
Dermatofibrosarcoma protuberans is a rare form of soft tissue sarcoma that tends to invade and recur locally. The most common site of this disease is head, neck and extremities; however, the involvement of the breast has been reported. We present a case with a dermatofibrosarcoma of the breast that is composed of low-grade spindle cells which are positive for CD43. She was treated by wide surgical excision followed by adjuvant external beam irradiation at a dose of 60 Gray. After a follow-up of 24 months, no local-regional or distant recurrence was detected...
October 2018: European Journal of Breast Health
Christiane Matuschek, Jan Haussmann, Edwin Bölke, Stephan Gripp, Patrick J Schuler, Bálint Tamaskovics, Peter Arne Gerber, Freddy-Joel Djiepmo-Njanang, Kai Kammers, Christian Plettenberg, Bahar Anooshahr, Klaus Orth, Wilfried Budach
BACKGROUND: Adjuvant radiotherapy in advanced head and neck squamous cell cancer (HNSCC) reduces the risk of local-regional failure and most likely increases the survival rate. Patients at high risk for tumor recurrence may benefit from more aggressive altered fractionation schedules in order to reduce the overall time from surgery to completion of radiotherapy. Here, we reviewed the results of six randomized trials addressing the above hypothesis. METHODS: In the six trials of interest, a total of 988 patients with locally advanced HNSCC were randomly assigned to receive either accelerated or conventionally fractionated adjuvant radiotherapy...
October 4, 2018: Radiation Oncology
Tina J Hieken, John M Kane, Sandra L Wong
PURPOSE AND METHODS: Completion lymph node dissection (CLND) for sentinel lymph node (SLN)-positive melanoma patients has been guideline-concordant standard of care since adoption of lymphatic mapping and SLN biopsy for the management of clinically node-negative melanoma patients more than 20 years ago. However, a trend for omission of CLND has been observed over the past decade, and we now have randomized, controlled clinical trial data to help guide treatment recommendations. Publication of these data prompted an American Society of Clinical Oncology-Society of Surgical Oncology 2018 clinical practice guideline update for these patients...
October 3, 2018: Annals of Surgical Oncology
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