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regional adjunct

M Takanosu, K Okada, Y Kagawa
Plasmacytomas are discrete, B cell-derived, round cell tumours that sometimes are difficult to distinguish from canine cutaneous histiocytomas or T cell lymphosarcomas (lymphomas). Diagnosis of plasmacytomas relies on morphological observations and immunohistochemistry for multiple myeloma oncogene-1 (MUM-1) and cluster of differentiation 3 (CD3). Clonality testing often is used as an adjunct diagnostic tool to examine lymphoproliferative diseases. In this study, the sensitivity of PCR-based clonality analysis of antigen receptor gene rearrangements in canine cutaneous plasmacytomas was determined...
November 2018: Veterinary Journal
Sheryl A Singerling, Laura K Burkemper, Zachary D Sharp
The carbon isotope compositions (δ13 C values) of 23 hard ciders obtainable in the United States were analyzed to detect adjuncts, specifically added C4 sugars (i.e., corn syrup and cane sugar). In contrast, the main ingredient of hard ciders is fruit, mostly apple, juice which is derived from C3 plants. The labeled ingredients of ciders were found to be inconsistent with the carbon isotope ratios. A higher proportion of imported ciders studied had no isotopic evidence of added C4 -based sweetener, while most domestic ciders had elevated δ13 C values, indicative of C4 -based sugar additives...
October 19, 2018: Journal of Agricultural and Food Chemistry
Massimo Rugge, Robert M Genta, Matteo Fassan, Elisa Valentini, Irene Coati, Stefano Guzzinati, Edoardo Savarino, Manuel Zorzi, Fabio Farinati, Peter Malfertheiner
OBJECTIVES: Gastritis OLGA-staging ranks the risk for gastric cancer (GC) in progressive stages (0-IV). This long-term follow-up study quantifies the GC risk associated with each OLGA stage. METHODS: Consecutive patients (7436) underwent esophagogastroscopy (T-0), with mapped gastric biopsies, OLGA staging, and H. pylori status assessment. Patients with neoplastic lesion (invasive or non-invasive) at the index endoscopy (and/or within 12 months) were excluded. All patients were followed-up (T-1) by combining different sources of clinical/pathological information (Regional Registries of: (i) esophagogastroduodenoscopies; (ii) pathology reports; (iii) cancer, (iv) mortality)...
October 17, 2018: American Journal of Gastroenterology
Richi Niida, Bun Yamagata, Hiroshi Matsuda, Akira Niida, Akihiko Uechi, Shinsuke Kito, Masaru Mimura
OBJECTIVES: The present study investigated the usefulness of evaluating the existence of volume reduction in brain regions using voxel-based morphometry (VBM) to dissociate major depressive disorder (MDD) from bipolar disorder (BD). METHODS/DESIGN: This study enrolled 92 individuals with MDD, 32 individuals with BD and 43 healthy controls (HCs). We focused on gray mater volume (GMV) of the subgenual anterior cingulate cortex (sgACC), subcallosal area (SCA), and hippocampus...
October 17, 2018: International Journal of Geriatric Psychiatry
Bismark Sarfo, Zelalem Haile, Selase Deletsu, Eric Akpanja Mensah
Background Tumor necrosis factor and its receptors (sTNFR1 and sTNFR2) have been implicated in many infectious diseases. Identification of the key receptor (sTNFR1 or sTNFR2) which drives the immunopathogenesis of HIV infection is crucial in developing adjunctive therapy for HIV. Objective This study determined the expression levels of sTNFR1 and sTNFR2 in antiretroviral therapy (ART) - experienced and naïve HIV patients. Method: A total of 40 HIV patients comprising 30 with ART and 10 without ART were enrolled from the Pantang Hospital located in the Greater Accra Region of Ghana for data and blood collection...
October 16, 2018: Infectious Disorders Drug Targets
Lindsay Reardon, William J Scheels, Adam J Singer, Robert F Reardon
BACKGROUND: Speckle tracking echocardiography (STE) is a novel technology that measures regional wall-motion abnormalities that may speed diagnosis and intervention of acute coronary occlusion in Emergency Department (ED) patients with non-ST elevation ACS (NSTE-ACS). STE provides an objective measurement of myocardial strain that is superior to visual assessment of wall motion when performed as part of a point-of-care (POC) echocardiogram. We determined the feasibility and preliminary accuracy of POC STE operated by emergency providers when compared to comprehensive echocardiography or final diagnosis of ACS...
September 4, 2018: American Journal of Emergency Medicine
Patrick Ifesinachi Emelife, Matthew R Eng, Bethany L Menard, Andrew S Myers, Elyse M Cornett, Richard D Urman, Alan D Kaye
Regional and neuraxial anesthesia can provide a safer perioperative experience, greater satisfaction, reduced opioid consumption, and reduction of pain, while minimizing side effects. Ultrasound technology has aided clinicians in depositing local anesthetic medication in precise proximity to targeted peripheral nerves. There are a plethora of adjuvants that have been utilized to prolong local anesthetic actions and enhance effects in peripheral nerve blocks. This manuscript describes the current state of the use of adjuncts, e...
June 2018: Best Practice & Research. Clinical Anaesthesiology
Andrea Gabusi, Davide Bartolomeo Gissi, Achille Tarsitano, Sofia Asioli, Claudio Marchetti, Lucio Montebugnoli, Maria Pia Foschini, Luca Morandi
PURPOSE: Improvements in sequencing technologies have shown that genetic differences among neoplastic cells can reflect clonal expansion. Intratumor heterogeneity (ITH) has been suggested to explain differences in prognosis and treatment response, indicating that personalized medicine is the goal of the future. This study evaluated ITH in 5 patients with recurrent metastatic oral squamous cell carcinoma (OSCC) and tracked the evolution from non-neoplastic tissue to neoplastic events developing after primary tumor formation...
September 20, 2018: Journal of Oral and Maxillofacial Surgery
Barry Ting Sheen Kweh, Chengde Pham, Catriona McLean, Jin Wee Tee
Hemangiopericytomas are rare mesenchymal tumors with propensity to recur locally and metastasize. We report the unique case of a fifty-five-year-old male with recurrence of a previously resected craniocervical hemangiopericytoma presenting with obstructive hydrocephalus secondary to new metastatic cerebellar deposits. Emergent surgical resection of the cerebellar hemangiopericytomas was performed prior to adjuvant radiotherapy. Hemangiopericytomas are rare but important differentials for craniocervical junction lesions...
October 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Talha Ahmed Qureshi, Shabbir Akhtar, Mariam Abid
Occurrence of inflammatory pseudotumour in head and neck region or nose and paranasal sinuses is rare. However, when they do occur, they could be quite aggressive. Etiologically, they are believed to be reactive than neoplastic, and calcification may suggest end-stage. Their clinical presentation and radiologic features may resemble a malignancy. Grossly, they are not encapsulated, but multilobulated and can be circumscribed or infiltrative. Histologically, they constitute of bland spindle cells with scant cytoplasm and occasional mitotic figures...
October 2018: JPMA. the Journal of the Pakistan Medical Association
Flavia Squeglia, Alessia Ruggiero, Rita Berisio
The scenario of chemical reactions prompted by the infection by Mycobacterium tuberculosis is huge. The infection generates a localized inflammatory response, with the recruitment of neutrophils, monocytes, and T-lymphocytes. Consequences of this immune reaction can be the eradication or containment of the infection, but these events can be deleterious to the host inasmuch as lung tissue can be destroyed. Indeed, a hallmark of tuberculosis (TB) is the formation of lung cavities, which increase disease development and transmission, as they are sites of high mycobacterial burden...
October 11, 2018: Biochemical Journal
Luis Augusto da Silva, Danilo Luiz Flumignan, Aristeu Gomes Tininis, Helena Redigolo Pezza, Leonardo Pezza
1 H NMR spectroscopy combined with chemometrics was employed to discriminate lager beer samples from two different classes, according to their style and information provided on the label. Partial replacement of barley malt by adjuncts is a common practice adopted by large breweries, which can lead to a decrease in diastatic power, requiring the use of exogenous enzymes. For this reason, small variations in the spectral profile can occur in the carbohydrates region. Many studies have focused on differentiating beers according to type and brewing process...
January 30, 2019: Food Chemistry
Julie Kieffer, Florence Le Duff, Henri Montaudié, Christine Chiaverini, Jean-Philippe Lacour, Thierry Passeron
Importance: Hailey-Hailey disease (HHD) is a rare, autosomal-dominant acantholytic dermatosis characterized clinically by development of recurrent blisters and erosions in friction areas. Despite progression in our understanding of the molecular genetics of HHD, therapy remains suboptimal and there is no known cure. Objective: To determine whether the novel phosphodiesterase-4 inhibitor apremilast is effective in the treatment of HHD. Design, Setting, and Participants: Clinical case series of 4 patients with severe, treatment-resistant HHD at an outpatient clinic in the Department of Dermatology of Nice University Hospital, Nice, France...
October 10, 2018: JAMA Dermatology
Marcus Yu Bin Pai, Thais Tavares Terranova, Marcel Simis, Felipe Fregni, Linamara Rizzo Battistella
Neurologic disorders such as stroke and cerebral palsy are leading causes of long-term disability and can lead to severe incapacity and restriction of daily activities due to lower and upper limb impairments. Intensive physical and occupational therapy are still considered main treatments, but new adjunct therapies to standard rehabilitation that may optimize functional outcomes are being studied. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that polarizes underlying brain regions through the application of weak direct currents through electrodes on the scalp, modulating cortical excitability...
September 23, 2018: Journal of Visualized Experiments: JoVE
Ban C H Tsui, Ahtziri Fonseca, Farrukh Munshey, Grant McFadyen, Thomas J Caruso
STUDY OBJECTIVE: The erector spinae plane block (ESPB) was first described in 2016 as a regional block for thoracic neuropathic pain. Given its short history, there are a paucity of controlled clinical trials, yet an abundance of case reports. The primary aim of this review is to examine pooled clinical data from published literature to gain an understanding of ESPB characteristics. DESIGN: A PubMed search was conducted to identify all ESPB related publications...
October 3, 2018: Journal of Clinical Anesthesia
Manish Khandelwal, Varun Kumar Saini, Sandeep Kothari, Gaurav Sharma
Context: Airway management is a crucial skill and area of concern for the anesthesiologist. Awake fiber-optic intubation (AFOI) remains the gold standard in managing difficult airway. Anaesthetizing the airway along with psychological assurance is the mainstay for Preparation of AFOI. Different topical and regional techniques have been developed to subdue reflexes and facilitate AFOI. Aim: This randomized controlled study was performed to evaluate the effectiveness of using lignocaine nebulization in addition to specific airway blocks for AFOI...
July 2018: Anesthesia, Essays and Researches
Adeel Ilyas, Colin Przybylowski, Ching-Jen Chen, Dale Ding, Paul M Foreman, Thomas J Buell, Davis G Taylor, M Yashar Kalani, Min S Park
Neoadjuvant endovascular embolization of skull base meningiomas may facilitate surgical resection, thereby potentially decreasing operative morbidity. However, due to variation in the reported efficacy and complication rates, the utility of embolization remains incompletely defined. The aim of this systematic review is to assess the outcomes of preoperative embolization for skull base meningiomas. A literature review was performed to identify studies reporting outcomes of patients with skull base meningiomas who underwent preoperative embolization...
September 29, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Bruno R Nascimento, Luisa C Caldeira Brant, Bárbara C A Marino, Luiz Guilherme Passaglia, Antonio Luiz P Ribeiro
Ischaemic heart disease is the leading cause of death worldwide, with an increasing trend from 6.1 million deaths in 1990 to 9.5 million in 2016, markedly driven by rates observed in low/middle-income countries (LMIC). Improvements in myocardial infarction (MI) care are crucial for reducing premature mortality. We aimed to evaluate the main challenges for adequate MI care in LMIC, and possible strategies to overcome these existing barriers.Reperfusion is the cornerstone of MI treatment, but worldwide around 30% of patients are not reperfused, with even lower rates in LMIC...
September 29, 2018: Heart: Official Journal of the British Cardiac Society
Pallavi Dham, Neeraj Gupta, Jacob Alexander, Warwick Black, Tarek Rajji, Elaine Skinner
BACKGROUND: Evaluation of telepsychiatry (via videoconference) for older adults is mostly focussed on nursing homes or inpatients. We evaluated the role of a community based program for older adults in rural and remote regions of South Australia. METHOD: The utilization pattern was studied using retrospective chart review of telepsychiatry assessments over 24 months (2010-2011). Satisfaction was evaluated through prospective post-consultation feedback (using a 5-point Likert scale), from patients, community based clinicians and psychiatrist participating in consecutive assessments from April-November 2012...
September 27, 2018: BMC Psychiatry
Bendix Labeit, Hannah Mueller, Paul Muhle, Inga Claus, Tobias Warnecke, Rainer Dziewas, Sonja Suntrup-Krueger
BACKGROUND: For the early detection of post-stroke dysphagia (PSD), valid screening parameters are crucial as part of a step-wise diagnostic procedure. This study examines the role of the National Institute of Health Stroke Scale (NIH-SS) as a potential low-threshold screening parameter. METHODS: During a ten-year period, 687 newly admitted patients at University Hospital Muenster were included in a retrospective analysis, if they had ischemic or haemorrhagic stroke confirmed by neuroimaging and had received NIH-SS scoring and endoscopic swallowing evaluation upon admission...
September 25, 2018: Cerebrovascular Diseases
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