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https://www.readbyqxmd.com/read/30321517/intratumoral-heterogeneity-in-recurrent-metastatic-squamous-cell-carcinoma-of-the-oral-cavity-new-perspectives-afforded-by-multiregion-dna-sequencing-and-mtdna-analysis
#1
Andrea Gabusi, Davide Bartolomeo Gissi, Achille Tarsitano, Sofia Asioli, Claudio Marchetti, Lucio Montebugnoli, Maria Pia Foschini, Luca Morandi
PURPOSE: Improvements in sequencing technologies have shown that genetic differences among neoplastic cells can reflect clonal expansion. Intratumor heterogeneity (ITH) has been suggested to explain differences in prognosis and treatment response, indicating that personalized medicine is the goal of the future. This study evaluated ITH in 5 patients with recurrent metastatic oral squamous cell carcinoma (OSCC) and tracked the evolution from non-neoplastic tissue to neoplastic events developing after primary tumor formation...
September 20, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30318074/metastatic-craniocervical-hemangiopericytoma-presenting-with-hydrocephalus-and-papilledema-case-review
#2
Barry Ting Sheen Kweh, Chengde Pham, Catriona McLean, Jin Wee Tee
Hemangiopericytomas are rare mesenchymal tumors with propensity to recur locally and metastasize. We report the unique case of a fifty-five-year-old male with recurrence of a previously resected craniocervical hemangiopericytoma presenting with obstructive hydrocephalus secondary to new metastatic cerebellar deposits. Emergent surgical resection of the cerebellar hemangiopericytomas was performed prior to adjuvant radiotherapy. Hemangiopericytomas are rare but important differentials for craniocervical junction lesions...
October 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30317354/calcifying-fibrous-pseudotumour-of-maxilla-a-rare-entity-mimicking-malignancy-a-case-report
#3
Talha Ahmed Qureshi, Shabbir Akhtar, Mariam Abid
Occurrence of inflammatory pseudotumour in head and neck region or nose and paranasal sinuses is rare. However, when they do occur, they could be quite aggressive. Etiologically, they are believed to be reactive than neoplastic, and calcification may suggest end-stage. Their clinical presentation and radiologic features may resemble a malignancy. Grossly, they are not encapsulated, but multilobulated and can be circumscribed or infiltrative. Histologically, they constitute of bland spindle cells with scant cytoplasm and occasional mitotic figures...
October 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30315001/collagen-degradation-in-tuberculosis-pathogenesis-the-biochemical-consequences-of-hosting-an-undesired-guest
#4
REVIEW
Flavia Squeglia, Alessia Ruggiero, Rita Berisio
The scenario of chemical reactions prompted by the infection by Mycobacterium tuberculosis is huge. The infection generates a localized inflammatory response, with the recruitment of neutrophils, monocytes, and T-lymphocytes. Consequences of this immune reaction can be the eradication or containment of the infection, but these events can be deleterious to the host inasmuch as lung tissue can be destroyed. Indeed, a hallmark of tuberculosis (TB) is the formation of lung cavities, which increase disease development and transmission, as they are sites of high mycobacterial burden...
October 11, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/30309572/discrimination-of-brazilian-lager-beer-by-1-h-nmr-spectroscopy-combined-with-chemometrics
#5
Luis Augusto da Silva, Danilo Luiz Flumignan, Aristeu Gomes Tininis, Helena Redigolo Pezza, Leonardo Pezza
1 H NMR spectroscopy combined with chemometrics was employed to discriminate lager beer samples from two different classes, according to their style and information provided on the label. Partial replacement of barley malt by adjuncts is a common practice adopted by large breweries, which can lead to a decrease in diastatic power, requiring the use of exogenous enzymes. For this reason, small variations in the spectral profile can occur in the carbohydrates region. Many studies have focused on differentiating beers according to type and brewing process...
January 30, 2019: Food Chemistry
https://www.readbyqxmd.com/read/30304341/treatment-of-severe-hailey-hailey-disease-with-apremilast
#6
Julie Kieffer, Florence Le Duff, Henri Montaudié, Christine Chiaverini, Jean-Philippe Lacour, Thierry Passeron
Importance: Hailey-Hailey disease (HHD) is a rare, autosomal-dominant acantholytic dermatosis characterized clinically by development of recurrent blisters and erosions in friction areas. Despite progression in our understanding of the molecular genetics of HHD, therapy remains suboptimal and there is no known cure. Objective: To determine whether the novel phosphodiesterase-4 inhibitor apremilast is effective in the treatment of HHD. Design, Setting, and Participants: Clinical case series of 4 patients with severe, treatment-resistant HHD at an outpatient clinic in the Department of Dermatology of Nice University Hospital, Nice, France...
October 10, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30295660/the-combined-use-of-transcranial-direct-current-stimulation-and-robotic-therapy-for-the-upper-limb
#7
Marcus Yu Bin Pai, Thais Tavares Terranova, Marcel Simis, Felipe Fregni, Linamara Rizzo Battistella
Neurologic disorders such as stroke and cerebral palsy are leading causes of long-term disability and can lead to severe incapacity and restriction of daily activities due to lower and upper limb impairments. Intensive physical and occupational therapy are still considered main treatments, but new adjunct therapies to standard rehabilitation that may optimize functional outcomes are being studied. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that polarizes underlying brain regions through the application of weak direct currents through electrodes on the scalp, modulating cortical excitability...
September 23, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30292068/the-erector-spinae-plane-esp-block-a-pooled-review-of-242-cases
#8
REVIEW
Ban C H Tsui, Ahtziri Fonseca, Farrukh Munshey, Grant McFadyen, Thomas J Caruso
STUDY OBJECTIVE: The erector spinae plane block (ESPB) was first described in 2016 as a regional block for thoracic neuropathic pain. Given its short history, there are a paucity of controlled clinical trials, yet an abundance of case reports. The primary aim of this review is to examine pooled clinical data from published literature to gain an understanding of ESPB characteristics. DESIGN: A PubMed search was conducted to identify all ESPB related publications...
October 3, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/30283186/role-of-lignocaine-nebulization-as-an-adjunct-to-airway-blocks-for-awake-fiber-optic-intubation-a-comparative-study
#9
Manish Khandelwal, Varun Kumar Saini, Sandeep Kothari, Gaurav Sharma
Context: Airway management is a crucial skill and area of concern for the anesthesiologist. Awake fiber-optic intubation (AFOI) remains the gold standard in managing difficult airway. Anaesthetizing the airway along with psychological assurance is the mainstay for Preparation of AFOI. Different topical and regional techniques have been developed to subdue reflexes and facilitate AFOI. Aim: This randomized controlled study was performed to evaluate the effectiveness of using lignocaine nebulization in addition to specific airway blocks for AFOI...
July 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/30279120/preoperative-embolization-of-skull-base-meningiomas-a-systematic-review
#10
REVIEW
Adeel Ilyas, Colin Przybylowski, Ching-Jen Chen, Dale Ding, Paul M Foreman, Thomas J Buell, Davis G Taylor, M Yashar Kalani, Min S Park
Neoadjuvant endovascular embolization of skull base meningiomas may facilitate surgical resection, thereby potentially decreasing operative morbidity. However, due to variation in the reported efficacy and complication rates, the utility of embolization remains incompletely defined. The aim of this systematic review is to assess the outcomes of preoperative embolization for skull base meningiomas. A literature review was performed to identify studies reporting outcomes of patients with skull base meningiomas who underwent preoperative embolization...
September 29, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30269080/implementing-myocardial-infarction-systems-of-care-in-low-middle-income-countries
#11
REVIEW
Bruno R Nascimento, Luisa C Caldeira Brant, Bárbara C A Marino, Luiz Guilherme Passaglia, Antonio Luiz P Ribeiro
Ischaemic heart disease is the leading cause of death worldwide, with an increasing trend from 6.1 million deaths in 1990 to 9.5 million in 2016, markedly driven by rates observed in low/middle-income countries (LMIC). Improvements in myocardial infarction (MI) care are crucial for reducing premature mortality. We aimed to evaluate the main challenges for adequate MI care in LMIC, and possible strategies to overcome these existing barriers.Reperfusion is the cornerstone of MI treatment, but worldwide around 30% of patients are not reperfused, with even lower rates in LMIC...
September 29, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30261845/community-based-telepsychiatry-service-for-older-adults-residing-in-a-rural-and-remote-region-utilization-pattern-and-satisfaction-among-stakeholders
#12
Pallavi Dham, Neeraj Gupta, Jacob Alexander, Warwick Black, Tarek Rajji, Elaine Skinner
BACKGROUND: Evaluation of telepsychiatry (via videoconference) for older adults is mostly focussed on nursing homes or inpatients. We evaluated the role of a community based program for older adults in rural and remote regions of South Australia. METHOD: The utilization pattern was studied using retrospective chart review of telepsychiatry assessments over 24 months (2010-2011). Satisfaction was evaluated through prospective post-consultation feedback (using a 5-point Likert scale), from patients, community based clinicians and psychiatrist participating in consecutive assessments from April-November 2012...
September 27, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/30253410/predicting-dysphagia-with-national-institute-of-health-stroke-scale-distinction-between-infra-and-supratentorial-region-is-essential
#13
Bendix Labeit, Hannah Mueller, Paul Muhle, Inga Claus, Tobias Warnecke, Rainer Dziewas, Sonja Suntrup-Krueger
BACKGROUND: For the early detection of post-stroke dysphagia (PSD), valid screening parameters are crucial as part of a step-wise diagnostic procedure. This study examines the role of the National Institute of Health Stroke Scale (NIH-SS) as a potential low-threshold screening parameter. METHODS: During a ten-year period, 687 newly admitted patients at University Hospital Muenster were included in a retrospective analysis, if they had ischemic or haemorrhagic stroke confirmed by neuroimaging and had received NIH-SS scoring and endoscopic swallowing evaluation upon admission...
September 25, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/30250466/treating-influenza-infection-from-now-and-into-the-future
#14
REVIEW
Sophia Davidson
Influenza viruses (IVs) are a continual threat to global health. The high mutation rate of the IV genome makes this virus incredibly successful, genetic drift allows for annual epidemics which result in thousands of deaths and millions of hospitalizations. Moreover, the emergence of new strains through genetic shift (e.g., swine-origin influenza A) can cause devastating global outbreaks of infection. Neuraminidase inhibitors (NAIs) are currently used to treat IV infection and act directly on viral proteins to halt IV spread...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30249578/digital-health-in-melanoma-posttreatment-care-in-rural-and-remote-australia-systematic-review
#15
REVIEW
Audrey Rollin, Brad Ridout, Andrew Campbell
BACKGROUND: The melanoma incidence and mortality rates in rural and remote communities are exponentially higher than in urban areas. Digital health could be used to close the urban/rural gap for melanoma and improve access to posttreatment and support care services. OBJECTIVE: The aim of this review was to understand how digital health is currently used for melanoma posttreatment care and determine the benefits for Australian rural and remote areas. METHODS: A systematic search of PubMed, Medline, PsycINFO, and Scopus was conducted in March 2018...
September 24, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/30248938/low-dose-naltrexone-ldn-review-of-therapeutic-utilization
#16
REVIEW
Karlo Toljan, Bruce Vrooman
Naltrexone and naloxone are classical opioid antagonists. In substantially lower than standard doses, they exert different pharmacodynamics. Low-dose naltrexone (LDN), considered in a daily dose of 1 to 5 mg, has been shown to reduce glial inflammatory response by modulating Toll-like receptor 4 signaling in addition to systemically upregulating endogenous opioid signaling by transient opioid-receptor blockade. Clinical reports of LDN have demonstrated possible benefits in diseases such as fibromyalgia, Crohn's disease, multiple sclerosis, complex-regional pain syndrome, Hailey-Hailey disease, and cancer...
September 21, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/30236544/high-grade-myoepithelial-carcinoma-can-show-histologically-undifferentiated-anaplastic-features
#17
Yingting Mok, Abbas Agaimy, Shi Wang, Chik Hong Kuick, Kenneth Tou-En Chang, Fredrik Petersson
High grade malignant tumors with a poorly-/un-differentiated morphology pose significant diagnostic challenges. Increasingly, the use of adjunct immunohistochemical and molecular tests to characterize and delineate the histopathologic phenotype of these tumors has become necessary, particularly in head and neck tumors. Recently, several entities with a poorly-/un-differentiated light microscopic morphology have been defined based on specific immunohistochemical and genetic characteristics. We herein describe two cases of high-grade myoepithelial carcinoma, one occurring in the submandibular gland and the other occurring in the left nasal cavity, both showing undifferentiated histological and anaplastic cytomorphological features...
September 11, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/30219054/a-pilot-study-on-adjunctive-use-of-parametric-colour-coded-digital-subtraction-angiography-in-endovascular-interventions-of-haemodialysis-access
#18
Ru Yu Tan, Tze Tec Chong, Fu Chieh Tsai, Suh Chien Pang, Kian Guan Lee, Apoorva Gogna, Alicia Huiying Ong, Chieh Suai Tan
BACKGROUND: Two-dimensional digital subtraction angiography (DSA) is the gold standard for angiographic evaluation of dysfunctional haemodialysis access. We aim to investigate the utility of parametric colour coded DSA in providing hemodynamic analysis during haemodialysis access interventions. METHODS: We retrospectively studied 20 patients who underwent access intervention and applied parametric colour-coding on selected DSA acquisitions before and after percutaneous transluminal angioplasty (PTA)...
September 15, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/30215934/hyperhidrosis-management-options
#19
John R McConaghy, Daniel Fosselman
Hyperhidrosis is excessive sweating that affects patients' quality of life, resulting in social and work impairment and emotional distress. Primary hyperhidrosis is bilaterally symmetric, focal, excessive sweating of the axillae, palms, soles, or craniofacial region not caused by other underlying conditions. Secondary hyperhidrosis may be focal or generalized, and is caused by an underlying medical condition or medication use. The Hyperhidrosis Disease Severity Scale is a validated survey used to grade the tolerability of sweating and its impact on quality of life...
June 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/30215460/the-analgesic-efficiency-of-transversus-abdominis-plane-tap-block-after-caesarean-delivery
#20
Anna Kupiec, Jacek Zwierzchowski, Joanna Kowal-Janicka, Waldemar Goździk, Tomasz Fuchs, Michał Pomorski, Mariusz Zimmer, Andrzej Kübler
OBJECTIVES: The ultrasound-guided transversus abdominis plane (TAP) block is a supporting method of pain relief after different types of surgical and gynecological procedures. The aim of the present study was to evaluate the analgesic effects of the TAP-block in patients undergoing caesarean section. MATERIAL AND METHODS: 88 women undergoing elective caesarean section under spinal anaesthesia were prospectively randomized into two groups. In the first group, an ultrasound-guided bilateral TAP block was performed using 40 mL 0...
2018: Ginekologia Polska
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