Jessica G Santana, Alexandra Petukhova-Greenstein, Moritz Gross, Fahmeed Hyder, Vasily Pekurovsky, Luzie A Gottwald, Annemarie Boustani, John J Walsh, Ahmet S Kucukkaya, Rohil Malpani, David C Madoff, S Nahum Goldberg, Muneeb Ahmed, Nikhil Joshi, Daniel Coman, Julius Chapiro
OBJECTIVES: To establish molecular magnetic resonance imaging (MRI) instruments for in vivo characterization of the immune response to hepatic radiofrequency ablation (RFA) using cell-specific immunoprobes. MATERIALS AND METHODS: 72 C57BL/6 wild type mice underwent a standardized hepatic RFA (70 °C for 5 minutes) to generate a coagulation area measuring 6-7mm in diameter. CD68+ macrophage periablational infiltration was characterized with immunohistochemistry (IHC) 24h, 72h, 7d, and 14d post-ablation (n = 24)...
November 21, 2022: Journal of Vascular and Interventional Radiology: JVIR