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https://www.readbyqxmd.com/read/30276674/absence-of-potential-gadolinium-toxicity-symptoms-following-22-897-gadoteric-acid-dotarem%C3%A2-examinations-including-3-209-performed-on-renally-insufficient-individuals
#1
Laura K Young, Shona Z Matthew, J Graeme Houston
OBJECTIVES: Recent safety concerns regarding gadolinium-based contrast agents (GdCAs) concluded with the suspension of some agents from the European market, yet a clinical consequence remains unknown. We used electronic health records to investigate the incidence of potential toxicity to gadoteric acid (Dotarem®) within our local population, including those with renal insufficiency (RI). METHODS: Data for patients who underwent contrast-enhanced MRI were identified, stratified by renal function at time of scan and retrospectively followed using routinely collected health data...
October 1, 2018: European Radiology
https://www.readbyqxmd.com/read/30209850/effects-of-gadodiamide-and-gadoteric-acid-on-rat-kidneys-a-comparative-study
#2
Fatma Beyazal Celiker, Levent Tumkaya, Tolga Mercantepe, Mehmet Beyazal, Arzu Turan, Hatice Beyazal Polat, Zehra Topal Suzan, Mehmet Fatih Inecikli, Kerimali Akyildiz, Adnan Yilmaz
BACKGROUND: Gadolinium-based contrast agents are complex chelates to provide contrast in NRI. However, recent studies have highlighted the deposition of free Gd+3 ion in various tissues. PURPOSE: To evaluate the histopathological and immunohistochemical changes on rat kidney tissue following both macrocyclic (gadoteric acid) and linear (gadodiamide) agents under the hypothesis that gadolinium-based contrast agents (GBCA) lead to toxic, free Gd+3 accumulation in tissues...
September 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/30046901/half-dose-versus-full-dose-macrocyclic-gadolinium-at-3-t-magnetic-resonance-imaging-in-paediatric-bone-and-soft-tissue-disease
#3
Giovanna Stefania Colafati, Enrica Rossi, Chiara Carducci, Simone Piga, Ioan Paul Voicu, Angela Mastronuzzi, Paolo Tomà
BACKGROUND: Given the recent concerns about gadolinium-based contrast agent safety, dose reduction strategies are being investigated. OBJECTIVE: To compare half-dose and standard full-dose gadoterate meglumine at 3-tesla (T) MRI in paediatric bone and soft-tissue diseases. MATERIALS AND METHODS: We prospectively enrolled 45 children (age range 2.7 months to 17.5 years, median age 8.7 years, 49 total anatomical segments) with bone and soft-tissue diseases (neoplastic, inflammatory/infectious, ischaemic and vascular) imaged at 3-T MRI...
July 25, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/30044884/cerebral-blood-perfusion-deficits-using-dynamic-susceptibility-contrast-mri-with-gadolinium-chelates-in-rats-with-post-ischemic-reperfusion-without-significant-dynamic-contrast-enhanced-mri-derived-vessel-permeabilities-a-cautionary-note
#4
Seokha Jin, MungSoo Kang, HyungJoon Cho
In this study, we quantified perfusion deficits using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with an extravasating contrast agent (CA). We also investigated the efficacy of leakage compensation from CA pre-load in brains from post-ischemic rat models without significant dynamic contrast-enhanced MRI (DCE-MRI)-derived vessel wall permeability. DSC measurements were obtained using fast (0.3 s) echo-planar imaging in both normal rats and rats with transient middle carotid artery occlusion (MCAO) (1-h MCAO, 24-h reperfusion) after successive administrations of gadoterate meglumine (Dotarem) and intravascular superparamagnetic iron oxide nanoparticles (SPION)...
2018: PloS One
https://www.readbyqxmd.com/read/30033962/-influence-of-different-contrast-agent-concentrations-and-injection-protocols-on-dynamic-contrast-enhanced-mri-of-prostate-equimolar-comparison-of-1-0m-gadobutrol-and-0-5m-gadolinium-chelates
#5
Yuya Makino, Satoru Akimoto, Hirobumi Hoshino
The purpose of this study was to evaluate the enhancement profile of 1.0M gadobutrol (high concentration: HC) in comparison to 0.5M gadopentetate dimeglumine and gadoterate meglumine (low concentration: LC) in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of prostate. In total, 48 patients who were diagnosed with prostate cancer by radiologist were included. Each patient was examined after intravenous injection of 0.1 mmol/kg body weight contrast agent with flow rate of 1.5 (HC) or 3.0 mL/s (LC)...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29997463/prostate-cancer-detection-with-multiparametric-mri-a-comparison-of-1-m-concentration-gadobutrol-with-0-5-m-concentration-gadolinium-based-contrast-agents
#6
Takeshi Hara, Takeshi Ogata, Hiroko Wada, Takayuki Yabuki, Susumu Kanazawa
Introduction: Gadobutrol (Gd-DO3A-butrol) (Gadovist®) is a macrocyclic gadolinium-based contrast agent for magnetic resonance imaging (MRI) formulated at 1.0 mmol Gd/ml. Gadobutrol's higher concentration compared to other contrast agents (0.5 mmol Gd/ml) is associated with higher T1 relaxivity. We examined whether gadobutrol increases the accuracy of prostate cancer detection using dynamic contrast-enhanced MRI. Materials and Methods: Multiparametric MRI was performed in 379 patients: 94 patients received 1 M gadobutrol while 285 randomly received equivalent doses of 0...
June 2018: Current Urology
https://www.readbyqxmd.com/read/29985204/multimodal-imaging-study-of-gadolinium-presence-in-rat-cerebellum-differences-between-gd-chelates-presence-in-the-virchow-robin-space-association-with-lipofuscin-and-hypotheses-about-distribution-pathway
#7
Marlène Rasschaert, Josef A Schroeder, Ting-Di Wu, Sergio Marco, Andréa Emerit, Heiko Siegmund, Claudia Fischer, Nathalie Fretellier, Jean-Marc Idée, Claire Corot, Christoph Brochhausen, Jean-Luc Guerquin-Kern
PURPOSE: The aim of this study was to investigate, based on in-depth multimodal imaging, the presence of Gd deposits, their ultrastructure, location, and co-location with endogenous elements, in the cerebellum, after repeated administrations of gadolinium-based contrast agents (GBCAs). METHODS: Rats sensitized by subtotal nephrectomy received 20 daily intravenous injections of 0.6 mmol Gd/kg for 5 weeks of commercial forms of either gadoterate, gadobenate or gadodiamide, or saline (n = 2/group)...
September 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29786486/one-year-retention-of-gadolinium-in-the-brain-comparison-of-gadodiamide-and-gadoterate-meglumine-in-a-rodent-model
#8
COMPARATIVE STUDY
Philippe Robert, Stefanie Fingerhut, Cécile Factor, Véronique Vives, Justine Letien, Michael Sperling, Marlène Rasschaert, Robin Santus, Sébastien Ballet, Jean-Marc Idée, Claire Corot, Uwe Karst
Purpose To compare the long-term brain elimination kinetics and gadolinium species in healthy rats after repeated injections of the contrast agents gadodiamide (a linear contrast agent) or gadoterate (a macrocyclic contrast agent). Materials and Methods Nine-week-old rats received five doses of 2.4 mmol gadolinium per kilogram of body weight over 5 weeks and were followed for 12 months with T1-weighted MRI (n = 140 rats, corresponding to seven time points, two contrast agents, and 10 rats per group). Animals were sacrificed at 1 week, 1 month, and 2, 3, 4, 5, and 12 months after the last injection...
August 2018: Radiology
https://www.readbyqxmd.com/read/29737953/gadolinium-distribution-in-cerebrospinal-fluid-after-administration-of-a-gadolinium-based-mr-contrast-agent-in-humans
#9
Florian Berger, Rahel A Kubik-Huch, Tilo Niemann, Hans Ruedi Schmid, Michael Poetzsch, Johannes M Froehlich, Jürg H Beer, Michael J Thali, Thomas Kraemer
Purpose To evaluate whether gadolinium penetrates human cerebrospinal fluid (CSF) after MR imaging (MRI) with a gadolinium-based contrast agent (GBCA). Materials and Methods For this retrospective study, the authors analyzed 60 CSF samples from 57 patients (median age, 50 years; range, 3-92 years) who underwent one contrast material-enhanced MRI examination with gadoterate meglumine within 60 days of CSF extraction between January and December 2016. CSF samples from patients who underwent MRI without contrast material administration (n = 22) or those who underwent contrast-enhanced MRI at least 1 year before extraction (n = 2) were analyzed and used as control samples...
September 2018: Radiology
https://www.readbyqxmd.com/read/29727401/signal-changes-in-the-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-magnetic-resonance-images-after-intrathecal-administration-of-macrocyclic-gadolinium-contrast-agent
#10
Kerem Ozturk, Omer Fatih Nas, Esra Soylu, Bahattin Hakyemez
OBJECTIVES: The aim of this study was to evaluate signal changes in the dentate nucleus and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images (T1 WI) in a cohort of patients who have received intrathecal macrocyclic ionic gadolinium-based contrast agent (GBCA) gadoterate meglumine. MATERIALS AND METHODS: A group of 20 patients (male/female ratio, 8:12; mean age, 39.5 ± 15.5 years) who had not received intravenous GBCA but had received an intrathecal macrocyclic ionic GBCA (plus baseline and an additional final magnetic resonance imaging [MRI] for reference) from 2012 to 2017 were retrospectively included in this institutional review board-approved study...
September 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29713214/single-dose-gadoterate-meglumine-for-3t-late-gadolinium-enhancement-mri-for-the-assessment-of-chronic-myocardial-infarction-intra-individual-comparison-with-conventional-double-dose-1-5t-mri
#11
Jiyeon Lim, Eun-Ah Park, Yong Sub Song, Whal Lee
Objective: To intra-individually compare 3T magnetic resonance (MR) images obtained with one dose gadoterate meglumine to 1.5T MR using conventional double dose for assessment of chronic myocardial infarction. Materials and Methods: Sixteen patients diagnosed with chronic myocardial infarctions were examined on single-dose 3T MR within two weeks after undergoing double-dose 1.5T MR. Representative short-axis images were acquired at three points after administration of gadoterate meglumine...
May 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29700836/the-effect-of-gadolinium-based-contrast-agents-on-rat-testis
#12
F Beyazal Celiker, L Tumkaya, T Mercantepe, G Turan, A Yılmaz, M Beyazal, A Turan, M F Inecikli, M Kösem
Previous studies have reported that repeated administrations of linear gadolinium-based contrast agents lead to their accumulation in the brain and other tissues in individuals with normal renal functions. The purpose of this prospective animal study was to investigate the effect of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCAs) on rat testis tissue and to compare these molecules in terms of tissue damage. Thirty-two male Sprague-Dawley rats were kept without drugs for 5 weeks after administration of 0...
April 26, 2018: Andrologia
https://www.readbyqxmd.com/read/29680674/multifunctional-hybrid-nanoconstruct-of-zerovalent-iron-and-carbon-dots-for-magnetic-resonance-angiography-and-optical-imaging-an-in-vivo-study
#13
N Nimi, Ariya Saraswathy, Shaiju S Nazeer, Nimmi Francis, Sachin J Shenoy, Ramapurath S Jayasree
In magnetic resonance imaging (MRI), gadolinium (Gd) complexes are very often used as contrast agents to enhance the signal from soft tissue deformities and vascular anomalies, to improve the accuracy of diagnosis. The safety concern of using Gd complexes in renally compromised patients pose limitations on its application. To overcome this scenario, we introduce a nontoxic zerovalent iron based nanoparticle as a novel contrast agent for MR angiography and a hybrid version of the same to serve as a dual function contrast agent for targeted liver imaging...
July 2018: Biomaterials
https://www.readbyqxmd.com/read/29607566/effects-of-gadolinium-based-mri-contrast-agents-on-liver-tissue
#14
Tolga Mercantepe, Levent Tümkaya, Fatma Beyazal Çeliker, Zehra Topal Suzan, Seda Çinar, Kerimali Akyildiz, Filiz Mercantepe, Adnan Yilmaz
BACKGROUND: MRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium-based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models. PURPOSE: To compare the effects on liver tissue of gadolinium-based MRI contrast agents in the light of biochemical and histopathological evaluation. STUDY TYPE: Institutional Review Board (IRB)-approved controlled longitudinal study...
April 1, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29605866/effects-of-gadolinium-based-contrast-agents-on-submandibular-gland-tissue-in-rats
#15
Fatma Beyazal Celiker, Levent Tumkaya, Adnan Yilmaz, Zerrin Ozergin Coskun, Metin Celiker, Fatih Oghan, Tolga Mercantepe, Suat Terzi, Engin Dursun
AIM: The aim of this prospective animal study is to investigate the influence of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCA) on submandibular gland tissue (SGT) of the rats. MATERIAL AND METHOD: Twenty-four Sprague Dawley female rats were included the study. Group 1 was determined as a control group (n = 6). Group 2 was determined as saline group (n = 6). Group 3 was determined as Omniscan group (n = 6) and received only intraperitoneal (IP) 0...
June 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29583046/quantitative-analysis-of-brain-perfusion-parameters-in-dogs-with-idiopathic-epilepsy-by-use-of-magnetic-resonance-imaging
#16
Antje Hartmann, Clea von Klopmann, Ines E Lautenschläger, Volkher B Scholz, Martin J Schmidt
OBJECTIVE To quantitatively analyze brain perfusion parameters in dogs with idiopathic epilepsy (IE) by use of MRI and to compare those findings with brain perfusion parameters for healthy dogs. ANIMALS 12 client-owned dogs with IE. PROCEDURES For each dog, standard MRI and perfusion-weighted imaging (before and after injection of gadoteric acid contrast medium) sequences of the brain were obtained during the interictal period by means of the same protocol used in a comparable study of healthy dogs. Time of contrast medium arrival, time to peak contrast enhancement, mean contrast transit time, and cerebral blood flow were calculated for the caudate nucleus, thalamus, piriform lobe, hippocampus, semioval center, and temporal cerebral cortex...
April 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29559210/anaphylaxis-after-first-exposure-to-gadoterate-meglumine-a-case-report-and-literature-review
#17
Leonardo Bianchi, Katharina Hansel, Rossella Marietti, Marta Tramontana, Luca Stingeni
No abstract text is available yet for this article.
March 17, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29398574/comparison-of-enhancement-of-the-vestibular-perilymph-between-gadoterate-meglumine-and-gadobutrol-at-3-tesla-in-meniere-s-disease
#18
M Eliezer, G Poillon, A Gillibert, J Horion, Y Cruypeninck, E Gerardin, N Magne, A Attyé
PURPOSE: To compare the degree of enhancement of the perilymph between two macrocyclic gadolinium-based contrast agents (gadobutrol and gadoterate meglumine) in patients with Meniere's disease at 3-T magnetic resonance imaging (MRI). MATERIALS AND METHODS: The MRI examinations of 20 patients with Meniere's disease obtained 4hours after a single intravenous dose of macrocyclic gadolinium-based contrast agents were retrospectively compared. Ten patients (median age: 58...
May 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29371404/concurrent-respiratory-motion-correction-of-abdominal-pet-and-dynamic-contrast-enhanced-mri-using-a-compressed-sensing-approach
#19
Niccolo Fuin, Onofrio A Catalano, Michele Scipioni, Lisanne P W Canjels, David Izquierdo-Garcia, Stefano Pedemonte, Ciprian Catana
We present an approach for concurrent reconstruction of respiratory motion-compensated abdominal dynamic contrast-enhanced (DCE)-MRI and PET data in an integrated PET/MR scanner. The MR and PET reconstructions share the same motion vector fields derived from radial MR data; the approach is robust to changes in respiratory pattern and does not increase the total acquisition time. Methods: PET and DCE-MRI data of 12 oncologic patients were simultaneously acquired for 6 min on an integrated PET/MR system after administration of 18 F-FDG and gadoterate meglumine...
September 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29337841/frequency-and-severity-of-acute-allergic-like-reactions-to-intravenously-administered-gadolinium-based-contrast-media-in-children
#20
Monica M Forbes-Amrhein, Jonathan R Dillman, Andrew T Trout, Bernadette L Koch, Julie M Dickerson, Richard M Giordano, Alexander J Towbin
OBJECTIVES: The purpose of this study is to determine the frequency and severity of acute allergic-like reactions to gadolinium-based contrast media (GBCM) in children before, during, and after the transition from gadopentetate dimeglumine to gadoterate meglumine as our primary clinical GBCM. MATERIALS AND METHODS: Institutional review board approval was obtained for this Health Insurance Portability and Accountability Act-compliant retrospective investigation. Allergic-like reactions to GBCM in pediatric patients were retrospectively assessed from January 2009 to January 2017, which included a departmental change of GBCM from gadopentetate dimeglumine to gadoterate meglumine...
May 2018: Investigative Radiology
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