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isolation of phytochemicals

Luiz Francisco Wemmenson Gonçalves Moura, João Xavier da Silva Neto, Tiago Deiveson Pereira Lopes, Stephen Rathinaraj Benjamin, Fernando César Rodrigues Brito, Francisco Ernani Alves Magalhães, Eridan Orlando Pereira Tramontina Florean, Daniele de Oliveira Bezerra de Sousa, Maria Izabel Florindo Guedes
The application of medicinal plants are the most important biotechnological alternative in the treatment of numerous diseases, especially in developing countries, such as Brazil. Among them, we specified some specimens of the genus Cnidoscolus used as phytotherapies, with healing properties, analgesic, anti-inflammatory, antibiotic and diuretic, anticancer, among others. Such effects are possibly associated with the presence of terpenoids, alkaloids, coumarins, flavonoids phenolic compounds, among others. Thus, the objective of this work was to evaluate in the literature the studies on the phytochemical, ethnopharmacological and biotechnological applications of this genus, from 1998 to 2017...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Qinghao Jin, Xinyi Hu, Yanping Deng, Jinjun Hou, Min Lei, Hongjian Ji, Jing Zhou, Hua Qu, Wanying Wu, Dean Guo
By investigating of the roots of Salvia miltiorrhiza , which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides ( 1 ⁻ 4 ) that were previously undescribed, along with eight known ones ( 5 ⁻ 12 ). Their structure characteristics were assessed by HR-ESIMS, CD, NMR (¹H, 13 C, HSQC, HMBC) data analyses. These four newly isolated compounds ( 1 ⁻ 4 ), as well as the other eight compounds ( 5 ⁻ 12 ), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells...
December 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Guanhua Liu, Jianyu Fu
BACKGROUND: Three species of wintersweets: Chimonanthus salicifolius S. Y. Hu, Chimonanthus zhejiangensis M. C. Liu and Chimonanthus grammalus M. C. Liu are widely distributed in China. The three wintersweets belonging to the genus of Chimonanthus that can synthesize abundant terpenoids that are beneficial to human health. Their buds and leaves are traditional Chinese herb applied by the 'She' ethnic minority in southeast of China. Squalene is a multi-functional and ubiquitous triterpene in plants, which is biosynthesized by squalene synthase (SQS) using farnesyl diphosphate (FPP) as the substrate...
December 11, 2018: Botanical Studies (Taipei, Taiwan)
Hai-Xia Zhan, Juan Li, Han-Li Ruan, Peng Zhang, Hui-Fang Pi
Ilex cornuta (I. cornuta) is a traditional Chinese medicine (TCM) that has been used in clinical practice for hundreds of years. In order to provide more information about the chemical basis of its pharmacological effects, phytochemical investigation on the roots of I. cornuta was conducted in this study. The roots of the plant were firstly extracted with 95% EtOH, and then the crude was partitioned with petroleum ether, EtOAc and n-butyl alcohol. Different chromatographies were employed to isolate the crude step by step and the crude was further purified by semipreparative high performance liquid chromatography (HPLC)...
December 2018: Current medical science
Aamir Mushtaq, Rukhsana Anwar, Mobasher Ahmad
The objective of the current project was to explore the pharmacotherapeutic role of Lavandula stoechas (L) for the management of dementia. Dementia is considered a global challenge of current century seeking special attention of pharmacologists to explore its best remedies. Methanolic extract of aerial parts of L. stoechas was tested for phytochemical analysis along with free radical scavenging activity. Behavioral studies were performed on scopolamine induced amnesic mice by using elevated plus maze (EPM), light and dark test and hole board paradigms...
2018: Frontiers in Pharmacology
Liqing Deng, Wei Zong, Xueying Tao, Shuang Liu, Zhiying Feng, Yuping Lin, Zhihua Liao, Min Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Plants of Epilobium angustifolium are popular in China to treatment of traumatic injury, subduing inflammation and menstrual disorders. In European, the preparations or extracts containing E. angustifolium are popular to treat prostate diseases. Recent research suggested that E. angustifolium showed therapeutic effects in early stage of BPH, inflammation of urethra and prostate, as well as micturition problems. And the related researches were focus on aqueous extract and its main constituent of oenothein B...
December 5, 2018: Journal of Ethnopharmacology
Gui-Lian Liu, Wei Xu, Xin-Juan Liu, Xue-Long Yan, Jie Chen
Phytochemical investigation on the leaves of Rabdosia serra led to the isolation of two new abietane diterpenoids, raserranes A (1) and B (2), and four known phenylpropanoids (3-6). Their structures were determined by spectroscopic data. Compound 1 represented the rare examples of abietane diterpenoids featuring a 16-methoxycarbonyl group.
December 10, 2018: Journal of Asian Natural Products Research
Lei Huang, Tong Peng, Yu Li, Yunyun He, Li Wang, Shiyan Zhang, Yiran Sun, Fang Chen, Lin Tang
Phytochemical investigation on the ethyl acetate extract of Idesia polycarpa Maxim. Leaves led to the isolation of four phenolic glycoside isomers (1-4). Compound 2 appeared to be new reported phenolic glycoside, while compound 1 was the first time isolated from the titled species. Their structures were established by IR, UV, HRESI-MS and 1D and 2D NMR spectroscopies analysis and comparison of spectral data with previously reported data. The compounds 3 and 4 showed stronger activity of scavenging the DPPH free radical than the other two compounds, while the compounds 1 and 2 showed a significant activity of scavenging the ABTS free radical...
December 9, 2018: Natural Product Research
Tong Shen, Han Qian, Yong-Dong Wang, Hai-Bei Li, Wei-Dong Xie
Phytochemical investigation of the roots of Leontopodium longifolium, led to the isolation of a novel norsesquiterpene, named as longifolactone (1), along with three known diterpenes. The structures of these compounds were elucidated by analysis of HR-ESI-MS, UV, IR and 1D and 2D NMR spectroscopic data. The absolute configuration of the new compound was determined by electronic circular dichroism (ECD) using both experimental and calculated ECD spectra. Furthermore, their anti-inflammatory effects were evaluated in LPS-activated RAW264...
December 9, 2018: Natural Product Research
Roberta Saltarelli, Francesco Palma, Anna Maria Gioacchini, Cinzia Calcabrini, Umberto Mancini, Roberta De Bellis, Vilberto Stocchi, Lucia Potenza
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Curtis) P. Karst. (also known as Linghzhi and Reishi) is the most appreciated and revered medicinal mushroom across many Asian countries, but its properties have also attracted interest in Western countries. Indeed, in the West, it is now commercially available as a dietary supplement in preparations mainly made from spores, fruiting bodies and mycelia. It is employed in both nutraceutical and pharmacological formulations either for its immuno-modulating anti-inflammatory properties or as an effective adjuvant therapy in the treatment of several chronic diseases as well as in cancer treatment...
December 1, 2018: Journal of Ethnopharmacology
Sameh Soliman, Alshaimaa M Hamoda, Abdel-Nasser A El-Shorbagi, Ali A El-Keblawy
ETHNOPHARMACOLOGICAL RELEVANCE: Several natural products derived from plant sources are developed to remarkable medicines based on their traditional uses. Ziziphus, a worldwide known plant, is proven for potential cytotoxic activity. However, the plant growing at the unique hot environmental climate of UAE was never investigated. Different phytochemicals may be produced from the same plant genotype at different climates leading to variable pharmacological activities. AIM OF THE STUDY: The study was conducted in order to investigate phytochemicals in the UAE native Z...
November 30, 2018: Journal of Ethnopharmacology
Takashi Uchikura, Hidemi Sugiwaki, Morio Yoshimura, Hiromi Mitsuhashi, Hiroyuki Fuchino, Nobuo Kawahara, Takashi Hakamatsuka, Yoshiaki Amakura
Polygala Root (the root of Polygala tenuifolia WILLDENOW; Japanese name "Onji"), a well-known crude drug, traditionally used as an expectorant and sedative, has been attracting increased interest in recent years owing to its newly found pharmacological effect related to neuroprotection. However, there is no specific method for identifying and estimating the quality of this crude drug in the Japanese Pharmacopoeia, 17th edition. Therefore, in order to develop a TLC-based simple and convenient identification method using characteristic chemical marker(s) for the drug and its extract products, UV-sensitive constituents of Polygala Root were first investigated...
2018: Chemical & Pharmaceutical Bulletin
Ben-Mei Zhang, Zhi-Bin Wang, Ping Xin, Qiu-Hong Wang, He Bu, Hai-Xue Kuang
The genus Ephedra of the Ephedraceae family contains more than 60 species of nonflowering seed plants distributed throughout Asia, America, Europe, and North Africa. These Ephedra species have medicinal, ecological, and economic value. This review aims to summarize the chemical constituents and pharmacological activities of the Ephedra species to unveil opportunities for future research. Comprehensive information on the Ephedra species was collected by electronic search (e.g., GoogleScholar, Pubmed, SciFinder, and Web of Science) and phytochemical books...
November 2018: Chinese Journal of Natural Medicines
Zhaoyu Shi, Lijun An, Xueyuan Yang, Yaru Xi, Chenyue Zhang, Yuan Shuo, Jie Zhang, Da-Qing Jin, Yasushi Ohizumi, Dongho Lee, Jing Xu, Yuanqiang Guo
Recent studies have revealed that there is a close relationship between neuroinflammation and Alzheimer's disease (AD) and compounds with anti-neuroinflammatory effects are potentially useful for the treatment of AD. A phytochemical investigation to obtain new neuroinflammatory inhibitors resulted in the isolation of four new and three known limonoids from Swietenia mahagoni. The structures of these limonoids were established by NMR, MS, and electronic circular dichroism (ECD) data analysis. Compounds 1-3 feature complicated polycyclic caged structures of limonoid orthoester and represent new examples of phragmalin-type limonoids...
November 19, 2018: Bioorganic Chemistry
Yun-Hyeok Choi, Chun Whan Choi, Seong Hyun Hong, Se Kyu Park, Joa Sub Oh, Dongho Lee, Seong Su Hong
Coix lachryma-jobi L. var. ma-yuen has been a source of food and traditional folk medicine in some parts of Asia for thousands of years; however, the roots of this plant have not been phytochemically investigated. Herein, we report the isolation of a new benzoxazinoid glycoside, coixlachryside B (1), along with ten known compounds (2-11), from the roots of C. lachryma-jobi var. ma-yuen using a variety of chromatographic methods. Among the known compounds, the absolute configuration of compound 4 was determined...
December 3, 2018: Journal of Asian Natural Products Research
Ashish Kumar, Vijai K Agnihotri
Phytochemical investigation of the Jurinea macrocephala roots afforded six compounds namely β-sitosterol (1), lupenone (2), physcion (3), ptiloepoxide (4), 20, 21α-epoxytaraxastan-3β-ol (5) and chlorogenic acid (6). All the compounds were isolated for the first time in roots. The structures of the compounds were established by analysis of their spectroscopic (1 H and 13 C NMR) and spectrometric (MS) data, as well as by comparison of these with those reported in the literature. Metabolic profiling of chloroform and ethyl acetate fractions were also accomplished using NMR...
November 30, 2018: Natural Product Research
Alessandro Venditti, Claudio Frezza, Flaminia Vincenti, Antonia Brodella, Fabio Sciubba, Camilla Montesano, Marco Franceschin, Manuel Sergi, Sebastiano Foddai, Maria Enrica Di Cocco, Roberta Curini, Maurizio Delfini, Armandodoriano Bianco, Mauro Serafini
An undescribed labdane-like diterpene with a rare spiro-β-lactone function was identified from the ethanol extract of the male cones of the coniferous tree Wollemia nobilis. This spirolabdadienolide (IUPAC name: syn-ent-8(17),13-labdadien-19,18-olid-15-oic acid methyl ester; trivial name: wollemolide), was isolated by means of traditional and high performance chromatography techniques and structurally elucidated through NMR and MS. In addition, six further known metabolites were evidenced in the extract. Wollemolide, which may be considered an additional chemotaxonomic marker, and 4'-O-methyl-scutellarein, a simple flavonoid, had not been isolated in our previous phytochemical study on the same plant organ...
November 24, 2018: Phytochemistry
Suhyun Kim, Eun-Rhan Woo, Dong Gun Lee
Isoquercitrin (ISO), one of phytochemical isolated from aerial parts of Aster yomena, has been reported to have antifungal activity. However, the synergistic effect and the mechanism of ISO in combination with conventional antifungal agents are poorly understood. Therefore, synergistic antifungal effect between ISO and conventional antifungal agents was investigated. ISO at non-antifungal concentration interacts synergistically with amphotericin B (AMB) and fluconazole (FLC), but the combination with flucytosine (5-FC) showed no interaction...
November 27, 2018: IUBMB Life
Taewoong Rho, Soo-Jung Choi, Hyun Woo Kil, Jaeyoung Ko, Kee Dong Yoon
INTRODUCTION: Camellia japonica L. (Theaceae) is an evergreen shrub, which is cultivated as a popular ornamental tree in Korea, China, and Japan and its seeds have been used as a source of cooking oil, in cosmetics and as a traditional medicine. Intensive phytochemical works have revealed that oleanane-type saponins are the characteristic compounds of the seeds of C. japonica. OBJECTIVE: The purpose of the present study is to isolate and determine oleanane-type saponins from C...
November 26, 2018: Phytochemical Analysis: PCA
Zefeng Zhao, Xirui He, Wei Han, Xufei Chen, Peiliang Liu, Xue Zhao, Xing Wang, Lixin Zhang, Shaoping Wu, Xiaohui Zheng
ETHNOPHARMACOLOGICAL RELEVANCE: The dried fruit of Tetradium ruticarpum is frequently utilized as a common traditional medicine in China, Japan and Korea. It has been widely used for the treatment of various diseases such as headache, menorrhalgia, dermatophytosis, celialgia, emesis and aphtha and so on. AIM OF THIS REVIEW: Despite the wide biological activities of Tetradium plants, there is no current review summarizing medicinal properties of the genus of plants; thus, this review aims to systematically summarize studies on botanical characteristics, traditional uses, phytochemical ingredients, quality control, pharmacokinetics, pharmacological activities and toxicity of Tetradium species to demonstrate their therapeutic capacity...
November 22, 2018: Journal of Ethnopharmacology
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