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isolation of phytochemicals

Xinxin Zhang, Guanqun Zhan, Ming Jin, Hui Zhang, Jun Dang, Yan Zhang, Zengjun Guo, Yoichiro Ito
BACKGROUND: Radix Gentianae Macrophyllae, commonly known as Qinjiao (in Chinese), is dried roots of medicinal plants that belong to Gentianaceae family and Gentiana genus. It has medically been used for the treatment of various diseases such as arthritis, stroke, facial paralysis, and scapulohumeral periarthritis in China since ancient times. PURPOSE: The aim of this paper is to provide a comprehensive and constructive overview of Qinjiao mainly containing Gentiana macrophylla Pall...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Maria Carla Marcotullio, Massimo Curini, Judith X Becerra
The genus Bursera belongs to the family Burseraceae and has been used in traditional Mexican medicine for treating various pathophysiological disorders. The most representative phytochemicals isolated from this genus are terpenoids and lignans. Lignans are phenolic metabolites known for their antioxidant, apoptotic, anti-cancer, anti-inflammatory, anti-bacterial, anti-viral, anti-fungal, and anti-protozoal properties. Though the genus includes more than 100 species, we have attempted to summarize the biological activities of the 34 lignans isolated from selected Mexican Bursera plants...
August 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yingjiao Wang, Dandan Wang, Jianhua Zhang, Dan Liu, Zihao Wang, Dali Meng
The phytochemical study on Corydalis tomentella Franch, a traditional Chinese medicinal plant in Tibet, China, led to the isolation of six previously undescribed isoquinolines, including two rarely reported N-benzyl ones, and twenty-one known ones firstly obtained from this plant. Their planar structures were elucidated by 1D, 2D NMR experiments and high resolution mass spectrometry, and the absolute configurations were determined by NOE experiments, electronic circular dichroism, and specific rotation. Seven isoquinolines exhibited stronger hepatoprotective activities than that of positive control in D-galactosamine induced L02 cells damage model, which could be served as the leading compounds for further investigations...
August 3, 2018: Phytochemistry
Wen-Wen Peng, Li-Xia Zheng, Chang-Jiu Ji, Xu-Gen Shi, Zhong-Hua Xiong, Xin-Chen Shangguan
The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines...
July 2018: Chinese Journal of Natural Medicines
Jiwon Baek, Tae Kyoung Lee, Jae-Hyoung Song, Eunyong Choi, Hyun-Jeong Ko, Sanghyun Lee, Sang Un Choi, Seong Lee, Sang-Woo Yoo, Seon-Hee Kim, Ki Hyun Kim
Lespedeza cuneata (Fabaceae), known as Chinese bushclover, has been used in traditional medicines for the treatment of diseases including diabetes, hematuria, and insomnia. As part of a continuing search for bioactive constituents from Korean medicinal plant sources, phytochemical analysis of the aerial portion of L. cuneata led to the isolation of two new lignan glycosides ( 1 , 2 ) along with three known lignan glycosides ( 3 ⁻ 7 ) and nine known flavonoid glycosides ( 8 ⁻ 14 ). Numerous analysis techniques, including 1D and 2D NMR spectroscopy, CD spectroscopy, HR-MS, and chemical reactions, were utilized for structural elucidation of the new compounds ( 1 , 2 )...
August 1, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Marcos Marçal Ferreira Queiroz, Aymeric Monteillier, Sarah Berndt, Laurence Marcourt, Eryvelton de Souza Franco, Gilles Carpentier, Samad Nejad Ebrahimi, Muriel Cuendet, Vanderlan da Silva Bolzani, Maria Bernadete Souza Maia, Emerson Ferreira Queiroz, Jean-Luc Wolfender
The ethyl acetate extract of the aerial parts of Chresta martii showed significant in vitro NF-κB inhibition. Bioactivity-guided isolation was undertaken using HPLC microfractionation to localize the active compounds. Different zones of the HPLC chromatogram were linked to NF-κB inhibition. In parallel to this HPLC-based activity profiling, HPLC-PDA-ESI-MS and UHPLC-TOF-HRMS were used for the early identification of some of the compounds present in the extract and to get a complete phytochemical overview...
August 1, 2018: Journal of Natural Products
N W Sit, Y S Chan, S C Lai, L N Lim, G T Looi, P L Tay, Y T Tee, Y Y Woon, K S Khoo, H C Ong
OBJECTIVES: This study was conducted to evaluate the antidermatophytic activity of 48 extracts obtained from medicinal plants (Cibotium barometz, Melastoma malabathricum, Meuhlenbeckia platyclada, Rhapis excelsa, Syzygium myrtifolium, Vernonia amygdalina) and marine algae (Caulerpa sertularioides, Kappaphycus alvarezii) against Trichophyton rubrum and Trichophyton interdigitale (ATCC reference strains), and the cytotoxicity using African monkey kidney epithelial (Vero) cells. Active plant extracts were screened for the presence of phytochemicals and tested against clinical isolates of Trichophyton tonsurans...
July 27, 2018: Journal de Mycologie Médicale
Wei-Yang Zhang, Yang Yu, Lu-Lu Yan, Chong Li, Jing-Yan Han, Zi-Fei Qin, Yi Dai, Zhi-Hong Yao, Hua Zhou, Xin-Sheng Yao
BACKGROUD: Finding effective compounds of TCMs has always been the basis for achieving marker-based quality control which is currently most widely used quality control strategy. Gualou Xiebai Decoction (GLXB), a classical TCM formula, is recorded and proven as a therapy for curing coronary heart disease but the effective constituents are unidentified and the substantial basis of the therapeutic effects is not clear. PURPOSE: The present research is an investigation on the chemistry of this formula aiming at finding and precisely identifying effective compounds...
April 18, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Hanan Y Aati, Ali A El-Gamal, Oliver Kayser, Atallah F Ahmed
Extensive phytochemical analysis of different root fractions of Jatropha pelargoniifolia Courb. (Euphorbiaceae) has resulted in the isolation and identification of 22 secondary metabolites. 6-hydroxy-8-methoxycoumarin-7- O -β-d-glycopyranoside ( 15 ) and 2-hydroxymethyl N -methyltryptamine ( 18 ) were isolated and identified as new compounds along with the known diterpenoid ( 1 , 3 , 4 , and 7 ), triterpenoid ( 2 and 6 ), flavonoid ( 5 , 11 , 13 , 14 , and 16 ), coumarinolignan ( 8 ⁻ 10 ), coumarin ( 15 ), pyrimidine ( 12 ), indole ( 17 , 18 ), and tyramine-derived molecules ( 19 ⁻ 22 )...
July 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Sabrin Ragab Mohamed-Ibrahim, Gamal Abdallah Mohamed, Maan Talaat Abdullah Khayat, Mohamed Fathalla Zayed, Amal Abd-Elmoneim Soliman El-Kholy
Phytochemical investigation of the methanolic extract of Cyperus rotundus L. (Cyperaceae) rhizomes afforded a new norterpenoid with an unprecedented carbon skeleton, namely cyperalin A (1) and sugetriol triacetate (2). Their structures were identified by using advanced spectroscopic technique such as UV, IR, 1D (1H and 13C), 2D (1H-1HCOSY, HSQC, HMBC, and NOESY) NMR, and HRESIMS as well as comparison with literature data. The isolated compounds were evaluated for their anti-inflammatory activity. Compound 1 displayed the highest inhibitory activity of PGE2, COX-2, and LOX-5 with IC50s 0...
July 2018: Pakistan Journal of Pharmaceutical Sciences
Gabrielle Macedo Pereira, Letícia Gondim Lambert Moreira, Themístocles da Silva Negreiros Neto, Wamberto Alristenio Moreira de Almeida, Jailma Almeida-Lima, Hugo Alexandre Oliveira Rocha, Euzébio Guimarães Barbosa, José Angelo S Zuanazzi, Mauro Vieira de Almeida, Richard Michael Grazul, Armando Navarro-Vázquez, Fernando Hallwass, Leandro de Santis Ferreira, Matheus de Freitas Fernandes-Pedrosa, Raquel Brandt Giordani
Stem bark, root bark, and leaf extracts of Erythroxylum pungens were subjected to phytochemical analysis. N,N-dimethyltryptamine (DMT) was isolated and characterized from E. pungens roots. This unprecedented result is remarkable since no indole alkaloid has been previously reported from Erythroxylaceae so far. Eleven known tropane alkaloids were identified by their mass spectra and 3-(2-methylbutyryloxy)tropan-6,7-diol as well as 3-(2-methylbutyryloxy)nortropan-6,7-diol were isolated and characterized based on mass spectrometry, 1 H, 13 C, COSY, and NOESY NMR analysis...
July 25, 2018: Phytochemistry
M S T Diallo, M S Traore, M A Balde, A K Camara, E S Baldé, S Traore, K Oulare, T S Diallo, S Laurent, R N Muller, E Tuenter, L Pieters, A M Balde
ETHNOPHARMACOLOGICAL RELEVANCE: Hypertension is an important public health challenge in low- and middle-income countries, and in many African countries including Guinea medicinal plants are still widely used for its treatment. MATERIALS AND METHODS: The objective of this study was to determine the prevalence of hypertension in two Guinean urban districts (Pounthioun and Dowsare), to describe its management and to collect information on traditional herbal remedies...
July 26, 2018: Journal of Ethnopharmacology
Aya N Talaat, Sherif S Ebada, Rola M Labib, Ahmed Esmat, Fadia S Youssef, Abdel Nasser B Singab
ETHNOPHARMACOLOGICAL RELEVANCE: Araucaria bidwillii Hook., the bunya pine, is an evergreen plant belonging to family Araucariaceae. Traditionally, its leaves and oleoresins have been used as herbal remedies to alleviate pain and inflammation. Based upon the frequent adverse effects accompanying synthetic anti-inflammatory drugs, this study will assess the anti-inflammatory activity of both the total methanol extract and the polyphenolic-rich fraction of A. bidwillii leaves. METHODS AND MATERIALS: The anti-inflammatory activity was assessed in vitro using phytohaemagglutinin-stimulated human peripheral blood mononuclear cells (PBMCs)...
July 24, 2018: Journal of Ethnopharmacology
M Johanna Bapela, Heino Heyman, Francois Senejoux, J J Marion Meyer
ETHNOPHARMACOLOGICAL RELEVANCE: The Vha-Venda people living in rural areas of Limpopo Province of South Africa regularly use traditional plant-based medicines to treat malaria. In our earlier publication, twenty indigenous plant species used to treat malaria or its symptoms by Vha-Venda people were evaluated for antiplasmodial activity. The main objective of the current study was to assess the robustness of NMR-based metabolomics in discriminating classes of secondary compounds that are responsible for the observed antimalarial activity and the isolation of antiplasmodial compounds...
July 23, 2018: Journal of Ethnopharmacology
Xiao-Xia Liang, Lin-Xi Kong, Wen-Bo Fei, Min He
In the present investigation, we carried a phytochemical study of an ethanol-soluble extract from the root barks of Aspidistra typica Baill., a traditional food and herb medicine, leading to the isolation of four different kinds of compounds, including one benzene substituted coumarin, two organic phosphonic compounds, and one xanthone. The novel benzene substituted coumarin typicacoumarin A (1) was a new type of coumarin, and the two new organic phosphonic compounds, typicalphosphine A (2) and typicalphosphine B (3) were isolated for the first time, and their structures were elucidated by spectral techniques, viz...
June 2018: Chinese Journal of Natural Medicines
Anchalee Prasansuklab, Atsadang Theerasri, Matthew Payne, Alison T Ung, Tewin Tencomnao
BACKGROUND: Streblus asper is a well-known plant native to Southeast Asia. Different parts of the plant have been traditionally used for various medicinal purposes. However, there is very little scientific evidence reporting its therapeutic benefits for potential treatment of Alzheimer's disease (AD). The study aimed to evaluate antibacterial, antioxidant, acetylcholinesterase (AChE) inhibition, and neuroprotective properties of S. asper leaf extracts with the primary objective of enhancing therapeutic applications and facilitating activity-guided isolation of the active chemical constituents...
July 24, 2018: BMC Complementary and Alternative Medicine
Rodolfo Abarca-Vargas, Vera L Petricevich
This review discusses the current knowledge of the phytochemistry and in vitro and in vivo evaluations carried out using the extracts and, where appropriate, the main active components isolated from the genus Bougainvillea . Out of 18 species, most phytochemical, pharmacological, and toxicological studies focused on four species with different cultivars and one hybrid. Some plants are used for the treatment of various health disorders. Numerous phytochemical investigations of plants in this genus confirm the presence of aliphatic hydrocarbons, fatty acids, fatty alcohols, volatile compounds, phenolic compounds, peltogynoids, flavonoids, phytosterols, terpenes, carbohydrates, and betalains...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Ihsan Khan, Saira Tabassum, Tofeequr Rehman, Muhammad Ikram, Ihsanul Haq, Muhammad Zia
Fragaria × ananassa leaves extracts prepared in different solvents were subject for antioxidative, cytotoxicity, protein kinase inhibition and antibacterial activities. The extracts showed varying activities depending upon solvent used for extraction. Combined effect of methanol and ethyl acetate showed maximum antioxidant and reducing power potential (207.65±6μg AAE/mg and 88.58±20μg AAE/mg, respectively). Maximum DPPH (2,2-diphenyl-1-picryl hydrazyl) free radical scavenging activity was calculated by when methanol: chloroform and acetate fractions were used (87...
July 2018: Pakistan Journal of Pharmaceutical Sciences
Shahida Rehman, Saiqa Andleeb, Abdul Rehman Niazi, Shaukat Ali
Infectious diseases caused by etiological agents are still a major threat to public health. Their impact is particularly large in developing countries due to relative unavailability of medicine and the emergence of widespread drug resistance. In the current research, trace metals were detected in lichens species through inductively coupled plasma atomic emission spectroscopy. The antimicrobial potency of Pseudevernia furfruracea, Physcia species, Dermatocarpon vellerum and Parmellia species (lichens) extracts have been investigated against three local clinical bacterial isolates i...
July 2018: Pakistan Journal of Pharmaceutical Sciences
Bingzhao Du, Feng Zhao, Hexin'ge Zhang, Xiao Feng, Jianyong Xing, Zhengzhou Han, Zengping Gao, Pengfei Tu, Xingyun Chai
Encouraged by the in vivo anti-inflammatory effect of aqueous extract of Ilex asprella stems, a further phytochemical investigation on I. asprella stems oriented by the in vitro NO production inhibition in RAW264.7 cells was conducted, which led to the isolation of eight new phenolic constituents, namely asprenols A-H (1-8), together with 12 known ones (9-20). The structures of the new compounds were established by extensive spectroscopic data analyses of HR-ESI-MS, IR, UV, and 1D and 2D NMR, and the absolute configurations were determined by comparison of experimental and calculated ECD analyses...
July 19, 2018: Fitoterapia
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