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isolation of phytochemicals

Alfred Maroyi
The bark, leaves, and roots of Albizia adianthifolia are highly sought after in tropical Africa as herbal medicines. Therefore, the aim of this study was to review the botany, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia so as to provide baseline data required for evaluating the therapeutic potential of the species. Information on the botanical profile, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia was undertaken using databases such as ScienceDirect, SciFinder, Pubmed, Google Scholar, Medline, SCOPUS, EThOS, ProQuest, OATD, and Open-thesis...
2018: TheScientificWorldJournal
Michael Afolayan, Radhakrishnan Srivedavyasasri, Olayinka T Asekun, Oluwole B Familoni, Abayomi Orishadipe, Fazila Zulfiqar, Mohamed A Ibrahim, Samir A Ross
Piliostigma thonningii (Schumach.) Milne-Redhead. (Leguminosae) is used for various medicinal purposes in African countries. Phytochemical investigation of P. thonningii yielded two compounds newly isolated from natural sources, 2 β -methoxyclovan-9 α -ol ( 1 ), and methyl- ent -3 β -hydroxylabd-8(17)-en-15-oate ( 2 ), along with 14 known compounds ( 3 - 16 ). Compounds 1 and 4 (alepterolic acid) showed potential selectivity towards Trypanosoma brucei brucei with IC50 7.89 and 3.42 μM, respectively. Compound 2 showed activity towards T...
October 2018: Medicinal Chemistry Research
Zahra Ayati, Mohammad Sadegh Amiri, Mahin Ramezani, Elahe Delshad, Amirhossein Sahebkar, Seyed Ahmad Emami
BACKGROUND: The fruit of genus Rosa, known as "rose hip", is frequently used in different traditional medicines. Rose hips have long been used to treat kidney stones, gastroenteric ailments, hypertension and respiratory problems such as bronchitis, cough and cold. AIM: This review focused on the ethnopharmacological uses of rose hip as well as phytochemical and pharmacological aspects. RESULTS: Ethno-medical uses of rose hip have been recorded in many countries since a long time...
October 10, 2018: Current Pharmaceutical Design
Tareq Abu-Izneid, Abdur Rauf, Muhammad Saleem, Nashwa Mansour, Mohamed I S Abdelhady, Munjed M Ibrahim, Seema Patel
Urease inhibition potential of compound (1), guaiane-type sesquiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughput mechanism-based assay. These compounds were isolated from Hypochaeris radicata L., an Asteraceae family member. The pure compounds were screened for their urease and carbonic anhydrase inhibitory activities. The ethyl acetate fractions were subjected to column chromatography, which resulted in the isolation and purification of four compounds (1-4). On evaluation, compounds (1-4) exhibited selective activity against urease enzyme with an IC50 value of 180...
October 15, 2018: Natural Product Research
Muhammad Ibrahim, Shanza Siddique, Kanwal Rehman, Muhammad Husnain, Ajaz Hussain, Muhammad Sajid Hamid Akash, Farooq Azam
The genus Datura comprises wild shrub plants that belong to the Solanaceae family. Naturally, they possess both medicinal and poisonous properties due to the presence of many biologically active phytochemical constituents. Traditionally, Datura had been used for mystic and religious purposes, as a natural drug to treat asthma, pain, gout, boils, abscesses, and wounds, and as psychoactive infusions and fumitories. Different Datura species exhibit diverse ethnopharmacological activities against different diseases, and many ancient and traditional cultures have used various forms of Datura to treat ailments and to prevent many diseases...
2018: Critical Reviews in Eukaryotic Gene Expression
Radha Verma, B S Balaji, Aparna Dixit
Jasminum mesnyi Hance (yellow jasmine, Family Oleaceae) belongs to an important subclass of Jasminum family whose biological significance is under explored. The current study pertains to isolation of various solvent extracts fractions and their anti-bacterial effects on the Gram-positive and Gram-negative bacterial pathogens. Ethanolic extract of J. mesnyi Hance leaves was subjected to further partitioning using different solvents with increasing polarity to get different solvent fractions. Different extracts were analysed for their phytochemical constitutents and were evaluated for their antibacterial activity against a number of diseases causing bacteria...
2018: Bioinformation
Samith Rathnayake, Samantha Weerasinghe
BACKGROUND: Sri Lanka offers a huge diversity of flora with a large proportion of those being endemic to the island. Both the endemic and native plants species serve as a rich bank of phytochemicals. METHOD: In this study, "Sri Lankan Flora" an online web-based information system of phytochemical compounds isolated from the flora of Sri Lanka was proposed. RESULTS: The database contained 3D structures of those compounds, calculated quantitative-structure-activity relationship (QSAR) data and the GROMOS 54a7 force field parameters for each and every compound...
October 10, 2018: Combinatorial Chemistry & High Throughput Screening
Rocío Santiago, Mônica C B Martins, Matheus D Vilaça, Luiz F B de Barros, Tais Nascimento, Nicácio H da Silva, Emerson P S Falcão, María-Estrella Legaz, Carlos Vicente, Eugênia C Pereira
In this work, new biotechnological procedures have been optimized on the basis of immobilization in alginate of bionts isolated from the lichen C. substellata. From these immobilizates, soluble and biologically active phenolics can be obtained. During bionts-immobilization, stictic, norstictic and usnic acids were secreted to the medium. The amount produced of each of them differed depending on the immobilization time, the precursor supplied and the type of biont used. Greater amounts of stictic acid were detected and maintained over time in all bioreactors...
October 7, 2018: Fitoterapia
Sumit Arora, Prakash Itankar
Chenopodium album L., ( C. album ) (family: Chenopodiaceae) is an annual shrub widely grown in Asia, Africa, Europe and North America. It is commonly known as Bathua (in Hindi), pigweed, fat hen or lamb-quarters. The leaves of C. album are applied as a poultice to bug bites, sunstroke, rheumatic joints and as mild laxative. The flavonoids contained in C. album aerial parts were extracted, identified and characterized. Sequential soxhlet extraction was subjected to preliminary phytochemical screening and flavonoid quantification...
October 2018: Journal of Traditional and Complementary Medicine
Huan-You Lin, Tzu-Cheng Chang, Shang-Tzen Chang
In the present review article, the phytochemical, antioxidant and pharmacological studies are congregated and summarized concerning the current knowledge of the phenolic compounds of a traditional medical plant Acacia confusa in Taiwan. This plant is native to Taiwan and South-East Asia. It possesses major pharmacological activities, including antioxidant and radical scavenging activity, hepatoprotective effect, xanthine oxidase inhibition, semicarbazide-sensitive amine oxidase inhibition, angiotensin I converting enzyme inhibition, antihyperuricemic effect and anti-inflammatory activity...
October 2018: Journal of Traditional and Complementary Medicine
Erkin Pekmezci, Cihat Dundar, Murat Turkoglu
Background: Currently while, topical minoxidil and oral finasteride are the only medications approved in androgenetic alopecia (AGA), the cause oriented treatment and immunsupressive treatment are being performed in telogen effluvium (TE) and alopecia areata (AA) respectively. Considering the inflammatory factors in the pathogenesis of these three nonscarring alopecia forms, we have formulated a mixture for topical usage composed of six different herbal extracts (HE) which have already known antiinflammatory and antioxidant features...
April 2018: Medical Archives
Xikang Zheng, Yuemei Chen, Xiaoli Ma, Chen Zhang, Zhengren Xu, Yong Jiang, Pengfei Tu
Phytochemical study on the roots and rhizomes of Notopterygium incisum resulted in the isolation of six new coumarins, notoptetherins A - F (1-6), and 20 known analogues (7-26). Their structures were elucidated on the basis of extensive analyses of NMR and HRMS data, and the absolute configurations of 5 and 6 were established by Mo2 (AcO)4 -induced CD and exciton chirality, respectively. Moreover, a biomimetic synthesis of 6 from 21 was employed to confirm its absolute configuration. In a subsequent activity screening, compounds 12 and 17 exhibited potent inhibition against LPS-induced nitric oxide production in RAW 264...
October 3, 2018: Fitoterapia
Juan Xiong, Li-Jun Wang, Jianchang Qian, Pei-Pei Wang, Xue-Jiao Wang, Guang-Lei Ma, Huaqiang Zeng, Jia Li, Jin-Feng Hu
A preliminary phytochemical investigation on the MeOH extract of the leaves and twigs of the endangered ornamental plant Michelia shiluensis led to the isolation of 16 sesquiterpenoids. The isolated compounds comprised germacrane- (1-4, 13, 14), guaiane- (5-9, 15), amorphane- (10), and eudesmane-type (11, 12, 16) sesquiterpenoids. The new structures (1-12) were elucidated by spectroscopic and computational methods, and their absolute configurations (except for 9) were assigned by single-crystal X-ray diffraction crystallographic data and/or electronic circular dichroism spectra...
October 5, 2018: Journal of Natural Products
Fatemeh Rezaee, Behzad Zolfaghari, Masoud Sadeghi Dinani
Alliums are rich sources of steroidal saponins, flavonoids, and sulphoric compounds of which steroidal saponins have recently received more attention due to their important pharmacological activities. Allium paradoxum L. is a common edible vegetable in north regions of Iran, especially in Mazandaran province, where it is named "Alezi" and considerably used as a raw vegetable, to make dishes, and as a medicinal plant. Phytochemical investigation of chloroform-methanol extract of the plant resulted in the isolation and identification of a dioscin related steroidal saponin, using comprehensive spectroscopic methods including 1D and 2D NMR, its chemical structure was determined as (25R)-spirost-5-en-3b-ol,3-O-α-rhamnopyranosyl-(1→4)-α-rhamnopyranosyl-(1→4)-[a-rhamnopyranosyl-(1→2)]-glucopyranoside...
October 2018: Research in Pharmaceutical Sciences
Seyed Ebrahim Sajjadi, Zeinab Delazari, Mahmoud Aghaei, Mustafa Ghannadian
Phlomis bruguieri (P. bruguieri) is a large genus in the Lamiaceae family, with a wide variety distributed in Euro-Asia, Central Asia, Iran, and China. Phlomis flowers have been used as herbal tea for gastrointestinal disturbances, protection of liver and cardiovascular systems. The aim of this study was to analyse phytochemical of flavonoid constituents in semi polar fraction of P. bruguieri . Methanol extract of plant material (4 kg) yielded 361 g dark green concentrated extract gum. After preliminary fractionation by normal column chromatography on silica gel, Fr...
October 2018: Research in Pharmaceutical Sciences
Lin Ni, Li Li, Yingda Zang, Chuang-Jun Li, Jie Ma, Tiantai Zhang, Dong-Ming Zhang
Phytochemical studies on the leaves of Tripterygium wilfordii led to the isolation of seven new 18(4 → 3)-abeo-abietane lactones, triptergulides E - K (1 - 7). The structure of the new compounds was elucidated on the basis of their spectroscopic analysis, and the absolute configurations of compounds were confirmed by ECD, calculated ECD, and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Some compounds showed moderate inhibitory activities against NO, IL-6, and TNF-α production in LPS RAW 264...
September 24, 2018: Bioorganic Chemistry
Adam Hermawan, Herwandhani Putri
Chemotherapeutic agents are commonly used as neoadjuvant for breast cancer therapy. However, there is evidence of treatment failure for most of patients due to acquired resistance. Cancer stem cells, a small population of cells within tumors, contribute to cancer resistance, tumor relapse, and metastasis. Therefore breast cancer stem cells-targeted therapy is a strategic way of overcoming chemoresistance. Some natural products have been identified to target breast cancer stem cells. This article aims to discuss the current report of preclinical studies of natural products i...
September 25, 2018: International Journal of Biochemistry & Cell Biology
Elakkiya Venugopal, Narmadha Rajeswaran, K Santosh Sahanand, Amitava Bhattacharyya, Selvakumar Rajendran
Wattakaka volubilis, a medicinal plant, is known to exhibit various potential health benefits and has been traditionally used in Ayurveda for various medicinal applications. In the present study, phytochemicals hexadecanoic acid, octadecanoic acid and N,N-Diisopropyl(2,2,3,3,3-pentafluoropropyl)amine isolated from W. volubilis leaf extract were co-electrospun with gelatin nanofibers for meniscus and osteoblast cell attachment and proliferation. The electrospun nanofibers were characterized using suitable techniques such as scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy...
September 25, 2018: Biomedical Materials
Xinhui Wang, Dujuan Wang, Xue Wang, Manana Khutsishvili, Kamilla Tamanyan, George Fayvush, Daniel Atha, Youcai Zhang, Robert P Borris
Phytochemical investigation of Camphorosma lessingii has resulted in the isolation of four previously unreported isoflavones (1: -4: ) and eight known compounds (5: -12: ). Nine of these compounds (1: -6, 8: -10: ) are reported for the first time from members of the family Amaranthaceae. The structures of all isolated compounds were determined by spectroscopic methods, primarily one-dimensional and two-dimensional nuclear magnetic resonance and mass spectrometry. The absolute configuration of 6: was confirmed by circular dichroism...
September 24, 2018: Planta Medica
Abo El-Khair B El-Sayed, Wael M Aboulthana, Amal M El-Feky, Noha E Ibrahim, Mohamed M Seif
Paracetamol is the most commonly used analgesic-antipyretic drugs. Its excess use causes an acute hepatotoxicity. It is well known that the Bacillariophyta alga Amphora coffeaeformis is rich in many photosynthetic pigments with antioxidant activities as well as a series of biologically active substances. The current work has been designed to study the phytochemical composition of different A. coffeaeformis algal extracts to select the most effective one. It was verified that acetone A. coffeaeformis algal extract is rich in various pigments and polyphenolic compounds (β-carotene (9...
September 22, 2018: Molecular Biology Reports
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