keyword
https://read.qxmd.com/read/38429191/impact-of-the-new-definition-of-pulmonary-hypertension-on-the-prevalence-of-primary-graft-dysfunction-in-lung-transplant-recipients
#1
JOURNAL ARTICLE
Víctor M Mora-Cuesta, Amaya Martínez-Meñaca, David Iturbe-Fernández, Sandra Tello-Mena, Sheila Izquierdo-Cuervo, Tamara García-Camarero, Aritz Gil-Ongay, Laura Sánchez-Moreno, Pilar Alonso-Lecue, Sara Naranjo-Gozalo, José M Cifrián-Martínez
BACKGROUND AND AIM: Pulmonary hypertension (PH) secondary to lung disease (Group-3 PH) is the second leading cause of PH. The role of PH as a risk factor for primary graft dysfunction (PGD) following lung transplant (LT) is controversial. OBJECTIVE: To assess the impact that the new definition of PH had on the prevalence of PH in patients with advanced lung disease-candidate for LT, and its association with the occurrence of PGD. METHOD: A retrospective study was performed in all patients undergoing cardiac catheterisation referred for consideration as candidates to LT in a centre between 1 January 2017 and 31 December 2022...
February 29, 2024: Heart, Lung & Circulation
https://read.qxmd.com/read/38331722/passionfruit-genomic-database-pgd-a-comprehensive-resource-for-passionfruit-genomics
#2
JOURNAL ARTICLE
Chaowei Yu, Peng Wang, Shengjie Zhang, Jindian Liu, Yingyin Cheng, Songbai Zhang, Zujian Wu
Passionfruit (Passiflora edulis) is a significant fruit crop in the commercial sector, owing to its high nutritional and medicinal value. The advent of high-throughput genomics sequencing technology has led to the publication of a vast amount of passionfruit omics data, encompassing complete genome sequences and transcriptome data under diverse stress conditions. To facilitate the efficient integration, storage, and analysis of these large-scale datasets, and to enable researchers to effectively utilize these omics data, we developed the first passionfruit genome database (PGD)...
February 8, 2024: BMC Genomics
https://read.qxmd.com/read/37678172/acute-complication-posttransplant-primary-allograft-dysfunction
#3
REVIEW
Darshan H Brahmbhatt, David Blitzer, Filio Billia, Hannah Copeland
PURPOSE OF REVIEW: Heart transplant is the gold standard treatment for patients with end-stage heart failure, improving both quality of life and survival. Despite advances in donor and recipient management, primary graft dysfunction (PGD) remains the most common cause of morbidity and mortality in the early posttransplant period. This review summarizes recent discoveries in the underlying pathophysiology, risk prediction and management of PGD. RECENT FINDINGS: The incidence of PGD appears to be rising and it is not clear whether this is due to better recognition or secular changes in transplant practice...
October 1, 2023: Current Opinion in Organ Transplantation
https://read.qxmd.com/read/37386898/prevalence-of-prolonged-grief-disorder-and-related-clinical-factors-among-turkish-psychiatric-outpatients-during-the-covid-19-pandemic
#4
JOURNAL ARTICLE
Yusuf Ezel Yıldırım
Prolonged grief disorder (PGD), a new diagnosis in some classification systems, has gained prominence due to the high mortality rates observed during the Covid-19 pandemic. Herein, the prevalence of PGD (diagnosed with structured clinical interviews), death-related features, and associated clinical factors were investigated among outpatient psychiatric patients who lost a first-degree relative within the past 12-24 months. PGD was diagnosed in 30/68 patients (44.1%). PGD development did not differ based on cause of death (Covid-19-related vs...
June 30, 2023: Omega
https://read.qxmd.com/read/37256785/development-and-validation-of-a-nomogram-model-to-predict-primary-graft-dysfunction-in-patients-after-lung-transplantation-based-on-the-clinical-factors
#5
JOURNAL ARTICLE
Jianan Qin, Chunxiao Hu, Xiaodong Cao, Jian Gao, Yuan Chen, Meiqiong Yan, Jingyu Chen
BACKGROUND: Primary graft dysfunction (PGD), a significant complication that can affect patients' prognosis and quality of life, develops within 72 h post lung transplantation (LTx). Early detection and prevention of PGD should be given special consideration. The purpose of this study was to create a clinical prediction model to forecast the occurrence of PGD. METHODS: We collected information on 622 LTx patients from Wuxi People's Hospital from 2016 to 2020 and used the data to construct the prediction model...
May 31, 2023: Clinical Transplantation
https://read.qxmd.com/read/36826221/prolonged-grief-disorder-and-symptoms-of-anxiety-and-depression-among-bereaved-family-caregivers-in-the-context-of-palliative-home-care
#6
JOURNAL ARTICLE
Alberto Sardella, Alessandro Musetti, Pasquale Caponnetto, Maria C Quattropani, Vittorio Lenzo
Background : This study aimed to investigate the prevalence and the psychological comorbidity of PGD among bereaved family caregivers of palliative care cancer patients. We also examined the discriminant validity of two simple and reliable tools in correctly categorized individuals with PGD. Methods : A cross-sectional study was conducted with 157 bereaved participants (77.1% females, mean age = 43.50 ± 14.04 years, mean time since the loss = 3.59 years) recruited from three palliative home care services...
February 17, 2023: European journal of investigation in health, psychology and education
https://read.qxmd.com/read/36650643/primary-graft-dysfunction-in-lung-transplantation-a-review-of-mechanisms-and-future-applications
#7
REVIEW
Lourdes Chacon-Alberty, Ramiro Fernandez, Peter Jindra, Madelyn King, Ivan Rosas, Camila Hochman-Mendez, Gabriel Loor
Lung allograft recipients have worse survival than all other solid organ transplant recipients, largely because of primary graft dysfunction (PGD), a major form of acute lung injury affecting a third of lung recipients within the first 72 h after transplant. PGD is the clinical manifestation of ischemia-reperfusion injury and represents the predominate cause of early morbidity and mortality. Despite PGD's impact on lung transplant outcomes, no targeted therapies are currently available; hence, care remains supportive and largely ineffective...
August 1, 2023: Transplantation
https://read.qxmd.com/read/36591820/clinical-diagnostic-performance-of-common-laboratory-indicators-in-primary-glomerulonephritis
#8
JOURNAL ARTICLE
X-H Li, W-Y Yang, J Wang, Y-W Yang, C-M Dai, B Zhang, J-F Feng
OBJECTIVE: Immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) are common types of primary glomerulonephritis (PGD). A lack of specific clinical features makes diagnosis difficult. Kidney function indicators have been used for their diagnosis. However, the diagnostic performance of these indicators is undetermined. The purpose of this paper is to evaluate their diagnostic potential. PATIENTS AND METHODS: 101 patients with PGD were enrolled, including 50 with MN and 51 with IgAN...
December 2022: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/36103583/the-lung-allograft-microbiome-associates-with-pepsin-inflammation-and-primary-graft-dysfunction
#9
JOURNAL ARTICLE
John E McGinniss, Samantha A Whiteside, Rebecca A Deek, Aurea Simon-Soro, Jevon Graham-Wooten, Michelle Oyster, Melanie D Brown, Edward Cantu, Joshua M Diamond, Hongzhe Li, Jason D Christie, Frederic D Bushman, Ronald G Collman
RATIONALE: Primary graft dysfunction (PGD) is the principal cause of early morbidity and mortality after lung transplantation. The lung microbiome has been implicated in later transplantation outcomes but has not been investigated in PGD. OBJECTIVES: To define the peri-transplant bacterial lung microbiome and relationship to host response and PGD. METHODS: Single-center prospective cohort study. Airway lavage samples from donor lungs before organ procurement and recipient allografts immediately post-implantation underwent bacterial 16S rRNA gene sequencing...
September 14, 2022: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/35865996/an-internet-delivered-cognitive-behavioral-therapy-icbt-for-prolonged-grief-disorder-pgd-in-adults-a-multiple-baseline-single-case-experimental-design-study
#10
JOURNAL ARTICLE
Cintia Tur, Daniel Campos, Carlos Suso-Ribera, Evaldas Kazlauskas, Diana Castilla, Irene Zaragoza, Azucena García-Palacios, Soledad Quero
The death of a loved one has physical, psychological, and social consequences. Between 9.8 and 21.5 % of people who lose a loved one develop Prolonged Grief Disorder (PGD). Internet- and computer-based interventions (i.e., Internet-delivered Cognitive-Behavioral Therapy, iCBT) are cost-effective and scalable alternatives that make it possible to reach more people with PGD. The main goal of the present investigation was to examine the effect and feasibility (usability and satisfaction) of an iCBT ( GROw program ) for adults with PGD...
September 2022: Internet Interventions
https://read.qxmd.com/read/35581553/pgd-a-machine-learning-based-photosynthetic-related-gene-detection-approach
#11
JOURNAL ARTICLE
Yunchuan Wang, Xiuru Dai, Daohong Fu, Pinghua Li, Baijuan Du
BACKGROUND: The primary determinant of crop yield is photosynthetic capacity, which is under the control of photosynthesis-related genes. Therefore, the mining of genes involved in photosynthesis is important for the study of photosynthesis. MapMan Mercator 4 is a powerful annotation tool for assigning genes into proper functional categories; however, in maize, the functions of approximately 22.15% (9520) of genes remain unclear and are labeled "not assigned", which may include photosynthesis-related genes that have not yet been identified...
May 17, 2022: BMC Bioinformatics
https://read.qxmd.com/read/35344963/the-network-structure-of-icd-11-disorders-specifically-associated-with-stress-adjustment-disorder-prolonged-grief-disorder-posttraumatic-stress-disorder-and-complex-posttraumatic-stress-disorder
#12
JOURNAL ARTICLE
Thanos Karatzias, Matthias Knefel, Andreas Maercker, Marylene Cloitre, Geoffrey Reed, Richard A Bryant, Menachem Ben-Ezra, Evaldas Kazlauskas, Sally Jowett, Mark Shevlin, Philip Hyland
INTRODUCTION: The ICD-11 includes a new grouping for "disorders specifically associated with stress" that contains revised descriptions of posttraumatic stress disorder (PTSD) and adjustment disorder (AjD) and new diagnoses in the form of complex PTSD (CPTSD) and prolonged grief disorder (PGD). These disorders are similar in that they each require a life event for the diagnosis; however, they have not yet been assessed together for validity within the same sample. We set out to test the distinctiveness of the four main ICD-11 stress disorders using a network analysis approach...
2022: Psychopathology
https://read.qxmd.com/read/35096286/content-overlap-analyses-of-icd-11-and-dsm-5-prolonged-grief-disorder-and-prior-criteria-sets
#13
LETTER
Maarten C Eisma, Antje Janshen, Lonneke I M Lenferink
Background: The International Classification of Diseases eleventh edition (ICD-11) has recently included prolonged grief disorder (PGD), a diagnosis characterized by severe, persistent, and disabling grief. The text revision of the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5-TR) is scheduled to include a similar but distinct diagnosis, also termed PGD. Concerns have been raised that these new diagnoses are qualitatively different from both prior proposed diagnoses for pathological grief and each other, which may affect the generalizability of findings obtained with different criteria sets...
2022: European Journal of Psychotraumatology
https://read.qxmd.com/read/34912501/dsm-5-tr-prolonged-grief-disorder-and-dsm-5-posttraumatic-stress-disorder-are-related-yet-distinct-confirmatory-factor-analyses-in-traumatically-bereaved-people
#14
JOURNAL ARTICLE
L I M Lenferink, M J A van den Munckhof, J de Keijser, P A Boelen
Background: Prolonged grief disorder (PGD) is newly included in the text revision of the DSM-5 (DSM-5-TR). So far, it is unknown if DSM-5-TR PGD is distinguishable from bereavement-related posttraumatic stress disorder (PTSD). Prior research examining the distinctiveness of PTSD and pathological grief focused on non-traumatic loss samples, used outdated conceptualizations of grief disorders, and has provided mixed results. Objective: In a large sample of traumatically bereaved people, we first evaluated the factor structure of PTSD and PGD separately and then evaluated the factor structure when combining PTSD and PGD symptoms to examine the distinctiveness between the two syndromes...
2021: European Journal of Psychotraumatology
https://read.qxmd.com/read/34545210/decision-making-and-experiences-of-preimplantation-genetic-diagnosis-in-inherited-heart-diseases-a-qualitative-study
#15
JOURNAL ARTICLE
Laura Yeates, Kristie McDonald, Charlotte Burns, Christopher Semsarian, Stacy Carter, Jodie Ingles
Preimplantation genetic diagnosis (PGD) ensures a disease-causing variant is not passed to the next generation, including for inherited heart diseases. PGD is known to cause significant emotional burden, but little is known about how parents experience PGD to select against inherited heart disease. We aim to understand how people with inherited heart disease, and their partners, experience and make decisions about PGD. Participants were recruited from a specialised inherited heart disease clinic. Qualitative semi-structured interviews were conducted with adult participants who had considered PGD...
September 21, 2021: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/34230018/internet-delivered-cognitive-behavioral-therapy-icbt-for-adults-with-prolonged-grief-disorder-pgd-a-study-protocol-for-a-randomized-feasibility-trial
#16
JOURNAL ARTICLE
Cintia Tur, Daniel Campos, Rocio Herrero, Sonia Mor, Alba López-Montoyo, Diana Castilla, Soledad Quero
INTRODUCTION: Grief is an emotional reaction to the loss of a loved one with a natural recovery. Approximately 10% of people who lose a loved one develop prolonged grief disorder (PGD). Internet-based and computer-based interventions (ie, internet-delivered cognitive-behavioural therapy, iCBT) are a cost-effective alternative that makes it possible to reach more people with PGD. The main aim of this study is to assess the feasibility of a new iCBT-called GROw-for PGD. As a secondary objective, the potential effectiveness of GROw will be explored...
July 6, 2021: BMJ Open
https://read.qxmd.com/read/34000119/posttraumatic-distress-symptoms-and-their-response-to-treatment-in-adults-with-prolonged-grief-disorder
#17
RANDOMIZED CONTROLLED TRIAL
Peter J Na, Samrachana Adhikari, Kristin L Szuhany, Alan Z Chen, Rebecca R Suzuki, Matteo Malgaroli, Donald J Robinaugh, Eric Bui, Christine Mauro, Natalia A Skritskaya, Barry D Lebowitz, Sidney Zisook, Charles F Reynolds, M Katherine Shear, Naomi M Simon
OBJECTIVE: Posttraumatic stress disorder and prolonged grief disorder (PGD) arise following major life stressors and may share some overlapping symptomatology. This study aimed to examine the presence and response to treatment of posttraumatic stress symptoms (PTSS) in bereaved adults with a primary diagnosis of PGD. METHODS: A randomized controlled trial of 395 adults with PGD (defined as an Inventory of Complicated Grief score ≥ 30 plus confirmation on structured clinical interview) randomly assigned participants to either complicated grief treatment (CGT) with citalopram, CGT plus placebo, citalopram, or placebo between March 2010 and September 2014...
April 20, 2021: Journal of Clinical Psychiatry
https://read.qxmd.com/read/33979631/associations-between-interpersonal-dependency-and-severity-of-prolonged-grief-disorder-symptoms-in-bereaved-surviving-family-members
#18
JOURNAL ARTICLE
Marcin Sekowski, Holly G Prigerson
BACKGROUND: Several studies have shown that interpersonal dependency is a risk factor for prolonged grief disorder (PGD), a disorder that has been recently approved by the American Psychiatric Association Assembly for inclusion in the Diagnostic and Statistical Manual of Mental Disorders-5-Text Revision (DSM-5-TR). Nevertheless, it remains unclear whether this relationship is independent of depression, which may also be related to both loss and interpersonal dependency. Furthermore, anaclitic dependency (maladaptive and immature) compared to relatedness (more adaptive and mature) dependency, and the relationships between these types of dependency and PGD, have not been examined...
April 30, 2021: Comprehensive Psychiatry
https://read.qxmd.com/read/33786716/mental-imagery-in-patients-with-prolonged-grief-disorder-a-comparison-with-matched-bereaved-healthy-controls
#19
JOURNAL ARTICLE
Octavia Harrison, Claudio Wiedenmann, Rita Rosner, Regina Steil
Mental imagery is a transdiagnostic feature that has been increasingly researched in mental disorders in the past years. This study is the first to investigate mental imagery in individuals suffering from Prolonged Grief Disorder (PGD), a new disorder which will be included into the new edition of the International Classification of Diseases and Related Health Problems (ICD-11).Our objective was to find out to what extent patients suffering from PGD differ from healthy, but equally bereaved, controls in terms of mental imagery, and how mental imagery is related to psychopathology...
March 30, 2021: Psychiatric Quarterly
https://read.qxmd.com/read/33449224/double-heterozygosity-for-tp53-and-brca1-mutations-clinical-implications-in-populations-with-founder-mutations
#20
JOURNAL ARTICLE
Hagit Shani, Rinat Bernstein-Molho, Yael Laitman, Iris Netzer, Eitan Friedman
PURPOSE: The co-occurrence or double heterozygosity of pathogenic/likely pathogenic sequence variants (P/LPSVs) in major cancer susceptibility genes has rarely been reported. Such co-occurrence raises the issues of accurate genetic counseling, preferred recommended surveillance scheme, and the use of preimplantation genetic diagnosis (PGD). METHODS: A clinical report of an Ashkenazi Jewish (AJ) family with co occurrence of two PSVs in BRCA1 and TP53 and a literature search...
January 15, 2021: Breast Cancer Research and Treatment
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