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Implant sonication

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https://www.readbyqxmd.com/read/30333127/improving-the-diagnosis-of-orthopedic-implant-associated-infections-optimizing-the-use-of-tools-already-in-the-box
#1
Shawn Vasoo
With the increasing number of prosthetic joints replaced annually worldwide, orthopedic implant-associated infections (OIAIs) present a considerable burden. Accurate diagnostics are required to optimize surgical and antimicrobial therapy. Sonication fluid cultures have been shown in multiple studies to improve the microbiologic yield OIAIs, but uptake of sonication has not been widespread in many routine clinical microbiology laboratories. In this issue M. Dudareva and colleagues (J Clin Microbiol 56:e00688-18, 2018, https://doi...
October 17, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/30231861/transcranial-focused-ultrasound-stimulation-of-motor-cortical-areas-in-freely-moving-awake-rats
#2
Wonhye Lee, Phillip Croce, Ryan W Margolin, Amanda Cammalleri, Kyungho Yoon, Seung-Schik Yoo
BACKGROUND: Low-intensity transcranial focused ultrasound (tFUS) has emerged as a new non-invasive modality of brain stimulation with the potential for high spatial selectivity and penetration depth. Anesthesia is typically applied in animal-based tFUS brain stimulation models; however, the type and depth of anesthesia are known to introduce variability in responsiveness to the stimulation. Therefore, the ability to conduct sonication experiments on awake small animals, such as rats, is warranted to avoid confounding effects of anesthesia...
September 19, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/30213920/fabrication-of-a-silver-nanoparticle-coated-collagen-membrane-with-anti-bacterial-and-anti-inflammatory-activities-for-guided-bone-regeneration
#3
Peilin Chen, Zhigang Wu, Alex Leung, Xiaobo Chen, Euphemie Landao-Bassonga, Junjie Gao, Lianzhi Chen, Monica Zheng, Felix Yao, Hong Yang, Lars Lidgren, Brent Allan, Yinong Liu, Tao Wang, Minghao Zheng
Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering...
October 2, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30189620/insonation-of-systemically-delivered-cisplatin-loaded-microbubbles-significantly-attenuates-nephrotoxicity-of-chemotherapy-in-experimental-models-of-head-and-neck-cancer
#4
Hang-Kang Chen, Shu-Mei Zhang, Junn-Liang Chang, Hsin-Chien Chen, Yi-Chun Lin, Cheng-Ping Shih, Huey-Kang Sytwu, Mei-Cho Fang, Yuan-Yung Lin, Chao-Yin Kuo, Ai-Ho Liao, Yueng-Hsiang Chu, Chih-Hung Wang
The use of cisplatin (CDDP), the most common chemotherapy drug for head and neck cancer, is limited by its undesirable side effects, especially nephrotoxicity. We investigated ultrasound microbubbles (USMB) as a tool to increase the local intra-tumoral CDDP level while decreasing systemic CDDP cytotoxicity. We allowed CDDP to interact with human serum albumin and then sonicated the resulting CDDP‒albumin complex to generate CDDP-loaded MBs (CDDP-MBs). We then established a head-and-neck tumor-bearing mouse model by implanting FaDu-fLuc/GFP cells into severe combined immunodeficiency mice and used IVIS® bioluminescence imaging to determine the tumor xenograft formation and size...
September 5, 2018: Cancers
https://www.readbyqxmd.com/read/30152610/identifying-common-pathogens-in-periprosthetic-joint-infection-and-testing-drug-resistance-rate-for-different-antibiotics-a-prospective-single-center-study-in-beijing
#5
Zhang-Lai Li, Yun-Fei Hou, Bao-Qing Zhang, Yi-Fan Chen, Qi Wang, Kai Wang, Zhao-Yu Chen, Xiao-Wei Li, Jian-Hao Lin
OBJECTIVE: The aim of this study is to identify the common microorganisms causing PJI as well as the drug-resistant spectrum for each microorganism, to help orthopaedic surgeons to choose appropriate antibiotics. METHOD: One hundred and sixty patients who suffered from failure of primary or revision total hip or knee arthroplasty for different reasons were prospectively recruited. These patients underwent revision or re-revision total hip or knee arthroplasty in our institution between August 2013 to August 2016...
August 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/30150523/a-facile-flow-casting-production-of-bioactive-glass-coatings-on-porous-titanium-for-bone-tissue-engineering
#6
Haiou Yang, Qijie Zhu, Hongfei Qi, Xianhu Liu, Meixia Ma, Qiang Chen
Additive manufacturing enabled the fabrication of porous titanium (PT) with customized porosity and mechanical properties. However, functionalization of PT surfaces with bioactive coatings is being challenged due to sophisticated geometry and highly porous structure. In this study, a facile flow-casting technique was developed to produce homogeneous 45S5 bioactive glass (BG) coatings on the entire surface of PT. The coating weight as a function of BG concentration in a BG-PVA slurry was investigated to achieve controllable coating yield without blocking macropore structure...
August 27, 2018: Materials
https://www.readbyqxmd.com/read/30137609/sonication-improves-pathogen-detection-in-ventriculoperitoneal-shunt-associated-infections
#7
Vincent Prinz, Simon Bayerl, Nora Renz, Andrej Trampuz, Peter Vajkoczy, Tobias Finger
BACKGROUND: Antimicrobial treatment of ventriculoperitoneal (VP) shunt infections is challenging when the causative pathogen is unknown. OBJECTIVE: To evaluate the value of sonication of explanted shunt-devices to improve the microbiological detection rate. METHODS: All consecutive patients undergoing revision surgery due to suspected VP-shunt infection from January 2015 to February 2017 were evaluated. Intraoperative tissue samples, wound swabs, and cerebrospinal fluid (CSF) were collected for microbiological examination...
August 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/30125299/orthopedic-implant-associated-infections-caused-by-cutibacterium-spp-a-remaining-diagnostic-challenge
#8
Nora Renz, Stasa Mudrovcic, Carsten Perka, Andrej Trampuz
BACKGROUND: The definition criteria and clinical characteristics of implant-associated infection (IAI) caused by Cutibacterium (formerly Propionibacterium) spp. are poorly known. We analyzed microbiologically proven Cutibacterium orthopedic IAI in a prospective cohort. METHODS: Patients with periprosthetic joint infections (PJI) and fixation device-associated infections (FDAI) caused by Cutibacterium spp. were prospectively included. IAI was defined by significant growth of Cutibacterium spp...
2018: PloS One
https://www.readbyqxmd.com/read/30074457/evaluation-of-an-in-vivo-model-for-ventricular-shunt-infection-a-pilot-study-using-a-novel-antimicrobial-loaded-polymer
#9
Rajiv R Iyer, Noah Gorelick, Karen Carroll, Ari M Blitz, Sarah Beck, Caroline M Garrett, Audrey Monroe, Betty Tyler, Sean T Zuckerman, Jeffrey R Capadona, Horst A von Recum, Mark G Luciano
OBJECTIVE Ventricular shunt infection remains an issue leading to high patient morbidity and cost, warranting further investigation. The authors sought to create an animal model of shunt infection that could be used to evaluate possible catheter modifications and innovations. METHODS Three dogs underwent bilateral ventricular catheter implantation and inoculation with methicillin-sensitive Staphylococcus aureus ( S. aureus). In 2 experimental animals, the catheters were modified with a polymer containing chemical "pockets" loaded with vancomycin...
August 3, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30015418/mandibular-ridge-reconstruction-a-review-of-contemporary-methods
#10
REVIEW
Natalia Dorosz, Marzena Dominiak
Reconstruction can be very problematic in the case of mandibular alveolar bone loss, which can also hinder the implant restorative treatment. The aim of the study was to present current views on reconstructing the alveolar part of mandibular bone, which allows the insertion of implants and then the placement of denture. Based on the available literature, the efficacy of various techniques of filling of mandibular bone losses was described and compared. Reconstruction with autogenous bone block graft had been used as a gold standard...
July 17, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30013895/cerclages-after-femoral-osteotomy-are-at-risk-for-bacterial-colonization-during-two-stage-septic-total-hip-arthroplasty-revision
#11
Viktor Janz, Georgi I Wassilew, Carsten F Perka, Michael Müller
Aims: In cases of a two-stage septic total hip arthroplasty (THA) exchange a femoral osteotomy with subsequent cerclage stabilization may be necessary to remove a well-fixed stem. This study aims to investigate the rate of bacterial colonization and risk of infection persistence associated with in situ cerclage hardware in two-stage septic THA exchange. Patients and Methods: Twenty-three patients undergoing two-stage THA exchange between 2011 and 2016 were included in this retrospective cohort study. During the re-implantation procedure synovial fluid, periprosthetic tissue samples and sonicate fluid cultures (SFC) of the cerclage hardware were acquired...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29971110/the-efficacy-of-graphene-foams-for-culturing-mesenchymal-stem-cells-and-their-differentiation-into-dopaminergic-neurons
#12
Nishat Tasnim, Vikram Thakur, Munmun Chattopadhyay, Binata Joddar
The implantation of stem cells in vivo is the ideal approach for the restoration of normal life functions, such as replenishing the decreasing levels of affected dopaminergic (DA) neurons during neurodegenerative disease conditions. However, combining stem cells with biomaterial scaffolds provides a promising strategy for engineering tissues or cellular delivery for directed stem cell differentiation as a means of replacing diseased/damaged tissues. In this study, mouse mesenchymal stem cells (MSCs) were differentiated into DA neurons using sonic hedgehog, fibroblast growth factor, basic fibroblast growth factor, and brain-derived neurotrophic factor, while they were cultured within collagen-coated 3D graphene foams (GF)...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29939183/chemical-reversion-of-conventional-human-pluripotent-stem-cells-to-a-na%C3%A3-ve-like-state-with-improved-multilineage-differentiation-potency
#13
Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Elias T Zambidis
Naïve human pluripotent stem cells (N-hPSC) with improved functionality may have a wide impact in regenerative medicine. The goal of this protocol is to efficiently revert lineage-primed, conventional human pluripotent stem cells (hPSC) maintained on either feeder-free or feeder-dependent conditions to a naïve-like pluripotency with improved functionality. This chemical naïve reversion method employs the classical leukemia inhibitory factor (LIF), GSK3β, and MEK/ERK inhibition cocktail (LIF-2i), supplemented with only a tankyrase inhibitor XAV939 (LIF-3i)...
June 10, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29929699/non-union-after-plate-fixation
#14
A Hamish R W Simpson, S T Jerry Tsang
Approximately a third of patients presenting with long-bone non-union have undergone plate fixation as their primary procedure. In the assessment of a potential fracture non-union it is critical to understand the plating technique that the surgeon was intending to achieve at the primary procedure, i.e. whether it was direct or indirect fracture repair. The distinction between delayed union and non-union is a diagnostic dilemma especially in plated fractures, healing by primary bone repair. The distinction is important as nonunions are not necessarily part of the same spectrum as delayed unions...
June 2018: Injury
https://www.readbyqxmd.com/read/29929513/treatment-of-calvarial-defects-by-resorbable-and-non-resorbable-sonic-activated-polymer-pins-and-mouldable-titanium-mesh-in-two-dogs-a-case-report
#15
Pierre Langer, Cameron Black, Padraig Egan, Noel Fitzpatrick
BACKGROUND: To date, calvarial defects in dogs have traditionally been addressed with different types of implants including bone allograft, polymethylmethacrylate and titanium mesh secured with conventional metallic fixation methods. This report describes the use of an absorbable and non absorbable novel polymer fixation method, Bonewelding® technology, in combination with titanium mesh for the repair of calvarial defects in two dogs. The clinical outcomes and comparative complication using resorbable and non-resorbable thermoplastic pins were compared...
June 22, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29914077/lhx2-mediates-the-fgf-to-shh-regulatory-loop-during-limb-development
#16
Billy A Watson, Jennifer M Feenstra, Jonathan M Van Arsdale, Karndeep S Rai-Bhatti, Diana J H Kim, Ashley S Coggins, Gennaya L Mattison, Stephen Yoo, Eric D Steinman, Charmaine U Pira, Brendan R Gongol, Kerby C Oberg
During limb development, fibroblast growth factors (Fgfs) govern proximal⁻distal outgrowth and patterning. FGFs also synchronize developmental patterning between the proximal⁻distal and anterior⁻posterior axes by maintaining Sonic hedgehog (Shh) expression in cells of the zone of polarizing activity (ZPA) in the distal posterior mesoderm. Shh, in turn, maintains Fgfs in the apical ectodermal ridge (AER) that caps the distal tip of the limb bud. Crosstalk between Fgf and Shh signaling is critical for patterned limb development, but the mechanisms underlying this feedback loop are not well-characterized...
June 15, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29910567/detection-of-biofilm-associated-implant-pathogens-in-cardiac-device-infections-high-sensitivity-of-sonication-fluid-culture-even-in-the-presence-of-antimicrobials
#17
Alessandra Oliva, Maria Teresa Mascellino, Bich Lien Nguyen, Massimiliano De Angelis, Alessia Cipolla, Annalisa Di Berardino, Antonio Ciccaglioni, Claudio Maria Mastroianni, Vincenzo Vullo
Introduction: Sonication showed more sensitivity than traditional culture in the diagnosis of device infections. Aims of the study were to assess the role of sonication in the microbiological diagnosis and management of cardiac device infections (CDIs), to evaluate the sensitivity of sonication in patients on antimicrobial therapy at the time of device removal, and to analyze biofilm formation of the isolated strains. Materials and Methods: A total of 90 devices (31 generators and 59 electrodes) collected from 31 patients with infection underwent sonication before culture...
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29870449/vancomycin-loaded-polymethylmethacrylate-spacers-fail-to-eradicate-periprosthetic-joint-infection-in-a-clinically-representative-mouse-model
#18
Alberto V Carli, Samrath Bhimani, Xu Yang, Karen L de Mesy Bentley, F Patrick Ross, Mathias P G Bostrom
BACKGROUND: Periprosthetic joint infection (PJI) remains a devastating complication following total joint arthroplasty. Current animal models of PJI do not effectively recreate the clinical condition and thus provide limited help in understanding why treatments fail. We developed a mouse model of the first-stage surgery of a 2-stage revision for PJI involving a 3-dimensionally printed Ti-6Al-4V implant and a mouse-sized cement spacer that elutes vancomycin. METHODS: Vancomycin was mixed with polymethylmethacrylate (PMMA) cement and inserted into custom-made mouse-sized spacer molds...
June 6, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29795100/-in-vitro-evaluation-of-two-methods-for-fractured-screw-retrieval-from-dental-implants
#19
A A Kulakov, V A Badalyan, T M Bagirov
The aim of the study was to compare estimated efficiency of fractured dental implant screw removal methods. Twenty screws in implant internal connections were fractured in animal model to test fragment retrieval comparing two methods: using ultrasonic tools (group 1, 10 implants) and special reverse force kit (group 2, 10 implants). Removing screws with ultra-sonic tools proved to be slightly more effective, than using specialized kit. Mean procedure time in group 1 was 4 min more than in group 2. The possibility of screw retrieval correlates with fracture level, as deeper fractured screws were the easiest ones to remove...
2018: Stomatologii︠a︡
https://www.readbyqxmd.com/read/29789958/prosthetic-joint-infections-an-update
#20
REVIEW
C L Abad, A Haleem
PURPOSE OF REVIEW: Prosthetic joint infection (PJI) is a rare but serious complication that is frequently misdiagnosed. We aimed to highlight the nuances of PJI diagnosis and antimicrobial therapies and provide clarity in key areas of management. RECENT FINDINGS: Current research in PJI centers on a potential role for diagnostic biomarkers, molecular techniques, and implant sonication to reduce culture-negativity rates. The optimal duration of antimicrobial therapy remains controversial...
May 22, 2018: Current Infectious Disease Reports
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