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Implant sonication

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https://www.readbyqxmd.com/read/30074457/evaluation-of-an-in-vivo-model-for-ventricular-shunt-infection-a-pilot-study-using-a-novel-antimicrobial-loaded-polymer
#1
Rajiv R Iyer, Noah Gorelick, Karen Carroll, Ari M Blitz, Sarah Beck, Caroline M Garrett, Audrey Monroe, Betty Tyler, Sean T Zuckerman, Jeffrey R Capadona, Horst A von Recum, Mark G Luciano
OBJECTIVE Ventricular shunt infection remains an issue leading to high patient morbidity and cost, warranting further investigation. The authors sought to create an animal model of shunt infection that could be used to evaluate possible catheter modifications and innovations. METHODS Three dogs underwent bilateral ventricular catheter implantation and inoculation with methicillin-sensitive Staphylococcus aureus ( S. aureus). In 2 experimental animals, the catheters were modified with a polymer containing chemical "pockets" loaded with vancomycin...
August 3, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30015418/mandibular-ridge-reconstruction-a-review-of-contemporary-methods
#2
REVIEW
Natalia Dorosz, Marzena Dominiak
Reconstruction can be very problematic in the case of mandibular alveolar bone loss, which can also hinder the implant restorative treatment. The aim of the study was to present current views on reconstructing the alveolar part of mandibular bone, which allows the insertion of implants and then the placement of denture. Based on the available literature, the efficacy of various techniques of filling of mandibular bone losses was described and compared. Reconstruction with autogenous bone block graft had been used as a gold standard...
July 17, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30013895/cerclages-after-femoral-osteotomy-are-at-risk-for-bacterial-colonization-during-two-stage-septic-total-hip-arthroplasty-revision
#3
Viktor Janz, Georgi I Wassilew, Carsten F Perka, Michael Müller
Aims: In cases of a two-stage septic total hip arthroplasty (THA) exchange a femoral osteotomy with subsequent cerclage stabilization may be necessary to remove a well-fixed stem. This study aims to investigate the rate of bacterial colonization and risk of infection persistence associated with in situ cerclage hardware in two-stage septic THA exchange. Patients and Methods: Twenty-three patients undergoing two-stage THA exchange between 2011 and 2016 were included in this retrospective cohort study. During the re-implantation procedure synovial fluid, periprosthetic tissue samples and sonicate fluid cultures (SFC) of the cerclage hardware were acquired...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29971110/the-efficacy-of-graphene-foams-for-culturing-mesenchymal-stem-cells-and-their-differentiation-into-dopaminergic-neurons
#4
Nishat Tasnim, Vikram Thakur, Munmun Chattopadhyay, Binata Joddar
The implantation of stem cells in vivo is the ideal approach for the restoration of normal life functions, such as replenishing the decreasing levels of affected dopaminergic (DA) neurons during neurodegenerative disease conditions. However, combining stem cells with biomaterial scaffolds provides a promising strategy for engineering tissues or cellular delivery for directed stem cell differentiation as a means of replacing diseased/damaged tissues. In this study, mouse mesenchymal stem cells (MSCs) were differentiated into DA neurons using sonic hedgehog, fibroblast growth factor, basic fibroblast growth factor, and brain-derived neurotrophic factor, while they were cultured within collagen-coated 3D graphene foams (GF)...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29939183/chemical-reversion-of-conventional-human-pluripotent-stem-cells-to-a-na%C3%A3-ve-like-state-with-improved-multilineage-differentiation-potency
#5
Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Elias T Zambidis
Naïve human pluripotent stem cells (N-hPSC) with improved functionality may have a wide impact in regenerative medicine. The goal of this protocol is to efficiently revert lineage-primed, conventional human pluripotent stem cells (hPSC) maintained on either feeder-free or feeder-dependent conditions to a naïve-like pluripotency with improved functionality. This chemical naïve reversion method employs the classical leukemia inhibitory factor (LIF), GSK3β, and MEK/ERK inhibition cocktail (LIF-2i), supplemented with only a tankyrase inhibitor XAV939 (LIF-3i)...
June 10, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29929699/non-union-after-plate-fixation
#6
A Hamish R W Simpson, S T Jerry Tsang
Approximately a third of patients presenting with long-bone non-union have undergone plate fixation as their primary procedure. In the assessment of a potential fracture non-union it is critical to understand the plating technique that the surgeon was intending to achieve at the primary procedure, i.e. whether it was direct or indirect fracture repair. The distinction between delayed union and non-union is a diagnostic dilemma especially in plated fractures, healing by primary bone repair. The distinction is important as nonunions are not necessarily part of the same spectrum as delayed unions...
June 2018: Injury
https://www.readbyqxmd.com/read/29929513/treatment-of-calvarial-defects-by-resorbable-and-non-resorbable-sonic-activated-polymer-pins-and-mouldable-titanium-mesh-in-two-dogs-a-case-report
#7
Pierre Langer, Cameron Black, Padraig Egan, Noel Fitzpatrick
BACKGROUND: To date, calvarial defects in dogs have traditionally been addressed with different types of implants including bone allograft, polymethylmethacrylate and titanium mesh secured with conventional metallic fixation methods. This report describes the use of an absorbable and non absorbable novel polymer fixation method, Bonewelding® technology, in combination with titanium mesh for the repair of calvarial defects in two dogs. The clinical outcomes and comparative complication using resorbable and non-resorbable thermoplastic pins were compared...
June 22, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29914077/lhx2-mediates-the-fgf-to-shh-regulatory-loop-during-limb-development
#8
Billy A Watson, Jennifer M Feenstra, Jonathan M Van Arsdale, Karndeep S Rai-Bhatti, Diana J H Kim, Ashley S Coggins, Gennaya L Mattison, Stephen Yoo, Eric D Steinman, Charmaine U Pira, Brendan R Gongol, Kerby C Oberg
During limb development, fibroblast growth factors (Fgfs) govern proximal⁻distal outgrowth and patterning. FGFs also synchronize developmental patterning between the proximal⁻distal and anterior⁻posterior axes by maintaining Sonic hedgehog (Shh) expression in cells of the zone of polarizing activity (ZPA) in the distal posterior mesoderm. Shh, in turn, maintains Fgfs in the apical ectodermal ridge (AER) that caps the distal tip of the limb bud. Crosstalk between Fgf and Shh signaling is critical for patterned limb development, but the mechanisms underlying this feedback loop are not well-characterized...
June 15, 2018: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29910567/detection-of-biofilm-associated-implant-pathogens-in-cardiac-device-infections-high-sensitivity-of-sonication-fluid-culture-even-in-the-presence-of-antimicrobials
#9
Alessandra Oliva, Maria Teresa Mascellino, Bich Lien Nguyen, Massimiliano De Angelis, Alessia Cipolla, Annalisa Di Berardino, Antonio Ciccaglioni, Claudio Maria Mastroianni, Vincenzo Vullo
Introduction: Sonication showed more sensitivity than traditional culture in the diagnosis of device infections. Aims of the study were to assess the role of sonication in the microbiological diagnosis and management of cardiac device infections (CDIs), to evaluate the sensitivity of sonication in patients on antimicrobial therapy at the time of device removal, and to analyze biofilm formation of the isolated strains. Materials and Methods: A total of 90 devices (31 generators and 59 electrodes) collected from 31 patients with infection underwent sonication before culture...
April 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29870449/vancomycin-loaded-polymethylmethacrylate-spacers-fail-to-eradicate-periprosthetic-joint-infection-in-a-clinically-representative-mouse-model
#10
Alberto V Carli, Samrath Bhimani, Xu Yang, Karen L de Mesy Bentley, F Patrick Ross, Mathias P G Bostrom
BACKGROUND: Periprosthetic joint infection (PJI) remains a devastating complication following total joint arthroplasty. Current animal models of PJI do not effectively recreate the clinical condition and thus provide limited help in understanding why treatments fail. We developed a mouse model of the first-stage surgery of a 2-stage revision for PJI involving a 3-dimensionally printed Ti-6Al-4V implant and a mouse-sized cement spacer that elutes vancomycin. METHODS: Vancomycin was mixed with polymethylmethacrylate (PMMA) cement and inserted into custom-made mouse-sized spacer molds...
June 6, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29795100/-in-vitro-evaluation-of-two-methods-for-fractured-screw-retrieval-from-dental-implants
#11
A A Kulakov, V A Badalyan, T M Bagirov
The aim of the study was to compare estimated efficiency of fractured dental implant screw removal methods. Twenty screws in implant internal connections were fractured in animal model to test fragment retrieval comparing two methods: using ultrasonic tools (group 1, 10 implants) and special reverse force kit (group 2, 10 implants). Removing screws with ultra-sonic tools proved to be slightly more effective, than using specialized kit. Mean procedure time in group 1 was 4 min more than in group 2. The possibility of screw retrieval correlates with fracture level, as deeper fractured screws were the easiest ones to remove...
2018: Stomatologii︠a︡
https://www.readbyqxmd.com/read/29789958/prosthetic-joint-infections-an-update
#12
REVIEW
C L Abad, A Haleem
PURPOSE OF REVIEW: Prosthetic joint infection (PJI) is a rare but serious complication that is frequently misdiagnosed. We aimed to highlight the nuances of PJI diagnosis and antimicrobial therapies and provide clarity in key areas of management. RECENT FINDINGS: Current research in PJI centers on a potential role for diagnostic biomarkers, molecular techniques, and implant sonication to reduce culture-negativity rates. The optimal duration of antimicrobial therapy remains controversial...
May 22, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29744925/microcalorimetric-detection-of-staphylococcal-biofilm-growth-on-various-prosthetic-biomaterials-after-exposure-to-daptomycin
#13
Christen Ravn, Inês S Ferreira, Elena Maiolo, Søren Overgaard, Andrej Trampuz
Primary aim of this in vitro study was to test the efficacy of daptomycin to eradicate staphylococcal biofilms on various orthopedic implant materials. Secondary aim was to quantitatively estimate the formation of staphylococcal biofilm. We tested six clinically important biomaterials: Cobalt chrome, pure titanium, grid-blasted titanium, porous plasma-coated titanium with/without hydroxyapatite, and polyethylene. Biofilms of S. aureus and S. epidermidis were formed on the samples and thereafter exposed to daptomycin...
May 10, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29720250/efficient-induction-of-functional-ameloblasts-from-human-keratinocyte-stem-cells
#14
Xuefeng Hu, Jyh-Wei Lee, Xi Zheng, Junhua Zhang, Xin Lin, Yingnan Song, Bingmei Wang, Xiaoxiao Hu, Hao-Hueng Chang, Yiping Chen, Chun-Pin Lin, Yanding Zhang
BACKGROUND: Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme that possesses odontogenic potential, the induction rate is relatively low. In addition, whether the regenerated enamel retains a running pattern of prism identical to and acquires mechanical properties comparable with human enamel indeed warrants further study. METHODS: Cultured human keratinocyte stem cells (hKSCs) were treated with fibroblast growth factor 8 (FGF8) and Sonic hedgehog (SHH) for 18 h or 36 h prior to being recombined with E13...
May 2, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29609540/cost-benefit-analysis-of-antibiofilm-microbiological-techniques-for-peri-prosthetic-joint-infection-diagnosis
#15
Carlo L Romanò, Maria Teresa Trentinaglia, Elena De Vecchi, Nicola Logoluso, David A George, Ilaria Morelli, Lorenzo Drago
BACKGROUND: Implant-related infections, including those of peri-prosthetic joint (PJIs), osteosynthesis and other biomaterials, are biofilm-related. Pathogen identification is considered the diagnostic benchmark; however, the presence of bacterial biofilms makes pathogen detection with traditional microbiological techniques only partially effective. To improve microbiological diagnostic accuracy, some biofilm debonding techniques have been recently proposed. Aim of this health economics assessment study was to evaluate their economic impact on hospital costs...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29607715/hedgehog-signaling-contributes-to-bone-cancer-pain-by-regulating-sensory-neuron-excitability-in-rats
#16
Su Liu, You Lv, Xin-Xin Wan, Zhi-Jing Song, Yue-Peng Liu, Shuai Miao, Guang-Lei Wang, Gong-Jian Liu
Treating bone cancer pain continues to be a clinical challenge and underlying mechanisms of bone cancer pain remain elusive. Here, we reported that sonic hedgehog signaling plays a critical role in the development of bone cancer pain. Tibia bone cavity tumor cell implantation produces bone cancer-related mechanical allodynia, thermal hyperalgesia, and spontaneous and movement-evoked pain behaviors. Production and persistence of these pain behaviors are well correlated with tumor cell implantation-induced up-regulation and activation of sonic hedgehog signaling in primary sensory neurons and spinal cord...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29588854/experimental-study-of-beam-distortion-due-to-fiducial-markers-during-salvage-hifu-in-the-prostate
#17
Marina Bakaric, Eleanor Martin, Panayiotis S Georgiou, Benjamin T Cox, Heather Payne, Bradley E Treeby
Background: Prostate cancer is frequently treated using external beam radiation therapy (EBRT). Prior to therapy, the prostate is commonly implanted with a small number of permanent fiducial markers used to monitor the position of the prostate during therapy. In the case of local cancer recurrence, high-intensity focused ultrasound (HIFU) provides a non-invasive salvage treatment option. However, the impact of the fiducial markers on HIFU treatment has not been thoroughly studied to date...
2018: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/29554102/the-effect-of-storage-delay-and-storage-temperature-on-orthopaedic-surgical-samples-contaminated-by-staphylococcus-epidermidis
#18
Maïté Van Cauter, Olivier Cornu, Jean-Cyr Yombi, Hector Rodriguez-Villalobos, Ludovic Kaminski
BACKGROUND: Prosthetic Joint Infection (PJI) is a rare but devastating complications with high morbitity and mortality. The identification of the causal microorganism remains crucial and determines therapeutic strategies and success. Microbiology cultures remain the common method to diagnose PJI. Unfortunately, 14% of intra-articular punctures remain negative after culture. The microorganisms are best detected by inoculation of microbiology samples in blood culture bottles (Bactec), or after sonication of the implant and polymerase chain reaction (PCR)...
2018: PloS One
https://www.readbyqxmd.com/read/29486892/value-of-pcr-in-sonication-fluid-for-the-diagnosis-of-orthopedic-hardware-associated-infections-has-the-molecular-era-arrived
#19
Nora Renz, Sabrina Cabric, Christian Morgenstern, Michael A Schuetz, Andrej Trampuz
INTRODUCTION: Bone healing disturbance following fracture fixation represents a continuing challenge. We evaluated a novel fully automated polymerase chain reaction (PCR) assay using sonication fluid from retrieved orthopedic hardware to diagnose infection. PATIENTS AND METHODS: In this prospective diagnostic cohort study, explanted orthopedic hardware materials from consecutive patients were investigated by sonication and the resulting sonication fluid was analyzed by culture (standard procedure) and multiplex PCR (investigational procedure)...
April 2018: Injury
https://www.readbyqxmd.com/read/29389758/is-treatment-with-dithiothreitol-more-effective-than-sonication-for-the-diagnosis-of-prosthetic-joint-infection
#20
Andrea Sambri, Matteo Cadossi, Sandro Giannini, Giovanni Pignatti, Maurilio Marcacci, Maria Pia Neri, Alessandra Maso, Elisa Storni, Simonetta Gamberini, Susanna Naldi, Arianna Torri, Silvia Zannoli, Martina Tassinari, Michela Fantini, Giuseppe Bianchi, Davide Donati, Vittorio Sambri
BACKGROUND: Prosthetic joint infection (PJI) is among the most-severe complications of a total joint arthroplasty. Identification of the causal organism is of paramount importance for successful treatment, and sonication of implants may aid in this identification. Dithiothreitol (DTT) treatment has been proposed as an alternative to sonication to improve diagnosis, reduce costs, and improve reliability of the procedure, but its efficacy remains poorly characterized. QUESTIONS/PURPOSES: (1) Are DTT and sonication more sensitive and/or more specific than standard cultures of tissue samples for the diagnosis of PJI? (2) Which test (DTT or sonication) is more sensitive when the clinician does not suspect infection before surgery? (3) Which test (DTT or sonication) is more sensitive when the clinician suspects infection before surgery? METHODS: Two hundred thirty-two patients undergoing revision of a knee or hip arthroplasty were prospectively evaluated in this randomized study...
January 2018: Clinical Orthopaedics and related Research
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