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occult malignancy

Andrew J Sinnamon, Jason K C Tong, Elizabeth A Bailey, Caitlin Brown, Latesha Colbert, Shannon Murray, Benjamin M Jackson, Robert E Roses
BACKGROUND AND OBJECTIVES: Venous thromboembolism (VTE) remains a major cause of perioperative morbidity and mortality despite implementation of prophylaxis guidelines. We sought to identify risk factors for occult deep venous thrombosis (DVT) following abdominal surgery for cancer and measure the clinical impact of a prospectively implemented standardized postoperative DVT screening protocol. METHODS: Patients undergoing abdominal surgery for malignant indication were screened with early postoperative lower extremity duplex to identify DVT...
August 16, 2018: Journal of Surgical Oncology
Marta D'Alonzo, Silvia Pecchio, Paola Campisi, Giovanni De Rosa, Valentina Elisabetta Bounous, Andrea Villasco, Paolo Balocco, Nicoletta Biglia
INTRODUCTION: The oncological safety of nipple-areolar complex (NAC) preservation is a concern in the mastectomies performed for cancer indication. The detection of tumor cells during the intraoperative frozen section examination (IE) of sub-areolar/nipple tissue (SAT) leads to the removal of NAC, but frequently the final histology of the nipple is negative for malignancy. This study aims to evaluate the accuracy of SAT examination in predicting occult NAC involvement in case of Nipple-Sparing Mastectomy (NSM)...
August 2, 2018: European Journal of Surgical Oncology
Linqi Zhang, Qiao He, Ming Jiang, Bing Zhang, Xi Zhong, Rusen Zhang
Insufficiency fractures (IFs) are a type of stress fracture caused by the effects of normal or physiological stresses on abnormally weakened bone. Frequently, these fractures are occult, and a portion of these fractures is misdiagnosed as bone metastases on a whole-body bone scan (WBS). The aim of this study was to evaluate a potential benefit of single-photon emission computed tomography/computed tomography (SPECT/CT) with metabolic and morphological imaging to diagnose IF in patients with cervical cancer after radiotherapy...
August 7, 2018: International Journal of Gynecological Cancer
Ivan Ignjatovic, Dragoslav Basic, Milan Potic, Ljubomir Dinic, Aleksandar Skakic
INTRODUCTION: Distal urogenital fistulas (DUF) are usually iatrogenic and are uncommon in Europe. They occur in the urethra or near the bladder neck, and can be caused by vaginal hysterectomy, para-urethral cyst surgery, or erosion of the bladder or urethra from tension-free slings or meshes. The psychological and physical health consequences of DUF are devastating because most patients consider themselves "healthy" before surgery. Incontinence can appear after successful DUF closure due to previously occult incontinence or urethral incompetence...
August 1, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Masooma Aqeel, Nevin Uysal-Biggs, Timothy S Fenske, Nagarjun Rao
Introduction . Mantle cell lymphoma (MCL) comprises approximately 3% to 10% of all non-Hodgkin lymphomas. Although there is an increased risk for secondary malignancies after treatment among non-Hodgkin lymphomas survivors, a synchronous diagnosis of primary lung cancer arising in conjunction with lymphoma at the same site has rarely been reported. We report an unusual case of primary lung adenocarcinoma with coexistent MCL within the same lung lesion. Case Presentation . A 55-year-old female with newly diagnosed stage IV-B MCL was referred for workup of a right upper lobe cavitary lesion detected during lymphoma staging...
January 2018: Journal of Investigative Medicine High Impact Case Reports
Mara Mantiero, Giovanni Faggioni, Alice Menichetti, Matteo Fassan, Valentina Guarneri, Pierfranco Conte
Gastric linitis plastica is a diffuse involvement of the stomach walls by neoplastic cells. It represents about 3-19% of primitive gastric adenocarcinomas, but it can also be the manifestation of a metastatic disease. Breast cancer is the most frequent malignancy in women, and the metastatic spread to the stomach occurs in less than 10% of the cases. We present an unusual case of gastric linitis plastica and peritoneal carcinomatosis as manifestations of an occult breast cancer in a 53-year-old woman. Imaging and endoscopic evaluation were not able to discriminate a primary from a secondary gastric lesion...
2018: Case Reports in Oncological Medicine
Megan E Speer, Beatriz E Adrada, Elsa M Arribas, Kenneth R Hess, Lavinia P Middleton, Gary J Whitman
OBJECTIVE: To describe the clinical, imaging, and histopathologic findings of intracystic papillary carcinoma (IPC) of the breast. MATERIALS AND METHODS: Following institutional review board approval, a database at a single institution was searched to identify cases of patients who received a diagnosis of IPC from 1999-2013 and who had undergone preoperative imaging with mammography, sonography, or MRI. The clinical, mammographic, sonographic, and MRI features of IPC were compared and analyzed using the BI-RADS mammography, ultrasound, and MRI lexicons...
May 22, 2018: Current Problems in Diagnostic Radiology
Sayf Al-Katib, Gurpriya Gupta, Andrea Brudvik, Stacy Ries, Jillian Krauss, Michael Farah
While it is well accepted that CT is not an optimal imaging study to evaluate the breasts, findings on chest CT may be the first indication of an occult malignancy. The nonspecific appearance of breast findings and the lack of consensus guidelines for managing incidental breast findings may dissuade radiologists from thoroughly evaluating the breasts on CT. We review commonly encountered breast findings on CT and present an algorithm for managing incidentally detected breast findings.
July 24, 2018: Clinical Imaging
Jeong Suk Jeon, Eun Jeong Choi, Hyun Ju Lim
Malignancy is an independent risk factor of venous thromboembolism, although it is difficult to determine whether occult cancer is the cause of unprovoked VTE. About 25% of patients with VTE remain idiopathic. Here, the authors report the case of a 63-year-old woman with a history of unprovoked VTE some 10 months previously who presented with recurrent cough and dyspnea of 6 months duration and was finally diagnosed to have multiple myeloma.
January 2018: JNMA; Journal of the Nepal Medical Association
Chih-Hao Chao, Hsin-Yi Wang, Chia-Hung Kao
Venous thromboembolism (VTE) may be the first presentation of malignancy. Up to 10% of patients of unprovoked VTE would be diagnosed with occult cancer within 1 year. Cancer patients with concomitant VTE would have worse outcome. In screen occult cancer in VTE patients, while limited screening strategy (through history, physical examination, basic laboratory test and chest X-ray) and extensive screening strategy (limited screening + CT scan of abdomen/pelvis or 18F-FDG PET/CT) shared similar ability in detecting early-stage cancer and improving morbidity/mortality of cancer patient, the extensive screening strategy could diagnose occult cancer earlier...
July 27, 2018: Polish Archives of Internal Medicine
Helena Barton, David Shatti, Charlotte Anne Jones, Mathuri Sakthithasan, Will W Loughborough
The premise of medical screening is to identify clinically occult disease, facilitating intervention at an early stage with the intention of improving prognosis. Identifying solid organ malignancy before nodal or distal metastases have occurred unanimously offers the best chance of successful radical treatment, thus there is clearly a potential significant mortality benefit for successful oncological screening programmes. However, the negative consequences of screening have to be considered, particularly the impact of intervening in asymptomatic populations...
June 2018: Quantitative Imaging in Medicine and Surgery
Ibrahim Alali, Lilianne Haj Hassan, Ghadeer Mardini, Nermeen Hijazi, Lama Hadid, Younes Kabalan
Hirsutism is a common endocrine complaint affecting about 10 percent of women. It may be caused by multiple etiologies including adrenal and ovarian disorders. Usually, it is a result of a benign entity such as PCOs and idiopathic hirsutism. However, sometimes especially when it is severe and rapid in progression an androgen-secreting tumor should be excluded. Sertoli-Leydig cell tumors constitute fewer than 0.5 percent of ovarian tumors and it may be benign or malignant. In this article, we present two cases of hyperandrogenism caused by occult ovarian Leydig cell tumors...
2018: Case Reports in Endocrinology
Anirudh V Nair, M Meera, Bindhu M Rajamma, Soumya Anirudh, P K Nazer, P V Ramachandran
Objectives: (1) To assess the statistical correlation between the tumor thickness (TT) by ultrasonography (USG) and microscopic measurement in cases of early oral tongue squamous cell carcinoma (OTSCC). (2) To assess the predictive capacity of TT by ultrasound in detecting nodal metastasis. Materials and Methods: Prospective analysis was performed in 24 patients for a period of 2 years from 2012 to 2013. Nodal status and TT measurement was done preoperatively by neck and intraoral USG respectively in cases of early (pT1 & T2, clinically N0) OTSCC...
April 2018: Indian Journal of Radiology & Imaging
Fawad Rast, Konstantinos Parperis, Surabhi Amar, Mohammed Al-Charakh
The immunodeficiency virus infection is known to increase the risk of malignancies, including lymphomas. We report a case of a 51-year-old male with a history of human immunodeficiency virus (HIV) infection, well-controlled on antiretroviral treatment, who presented with polyarthritis and hypercalcemia due to an elevated parathyroid-hormone-related peptide. Computer tomography (CT) revealed diffuse lymphadenopathy and a lymph node biopsy revealed large B-cell lymphoma. He was treated and responded well to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy regimen...
May 21, 2018: Curēus
Jarrod D Predina, Andrew D Newton, Christopher Corbett, Leilei Xia, Michael Shin, Lydia Frenzel Sulfyok, Olugbenga T Okusanya, Keith A Cengel, Andrew Haas, Leslie Litzky, John C Kucharczuk, Sunil Singhal
BACKGROUND: Macroscopic complete resection can provide a select group of malignant pleural mesothelioma (MPM) patients improved survival. During resection, differentiating residual tumor from inflammation or scar can be challenging. In this trial we evaluate near-infrared (NIR) intraoperative imaging using TumorGlow® technology to improve detection of macroscopic residual disease. METHODS: Twenty subjects were enrolled in an open-label clinical trial of NIR intraoperative imaging with TumorGlow® imaging (NCT02280954)...
July 17, 2018: Annals of Thoracic Surgery
Mohamad A Mouchli, Sarah E Kerr, Lewis Roberts
Calcified liver lesions are caused by a wide variety of factors. The most common lesions are inflammatory liver lesions followed by benign and malignant neoplasms. Hemangioma, one of the most common benign hepatic neoplasm in adults, often contains calcifications, in up to 20% of cases secondary to fibrosis and thrombosis of blood vessels. These calcifications are typically large, coarse, and located in the center of the lesions. Liver metastases, the most common malignant lesions found in the noncirrhotic liver, may contain areas of calcification...
May 2018: Case Reports in Oncology
Gil Bornstein, Nadav Furie, Nimrod Perel, Ilan Ben-Zvi, Chagai Grossman
It is well established that some rheumatic syndromes (RS) are associated with several hematological malignancies. We aimed to describe the clinical course of patients with hematological malignancies mimicking RS. We studied a series of four patients presenting with apparent RS who were eventually diagnosed with hematological malignancies, and reviewed the relevant literature. Our series consisted of 4 patients, with a mean age of 62.8 ± 20.3 years, who presented to our rheumatology unit between December 2012 and March 2018...
July 18, 2018: Rheumatology International
Deepti M Reddi, Kathryn P Scherpelz, Angelica Lerma, Jabi Shriki, Jeffrey Virgin
Hernia sacs are a common anatomic pathology specimen, which rarely contain malignancy. We present a case of rapidly growing pancreatic adenocarcinoma, which initially presented as metastasis to an umbilical hernia sac. The patient was a 55-year-old male with a two-year history of umbilical hernia. Two months prior to herniorrhaphy, the hernia became painful and the patient experienced nausea and weight loss. The gross examination did not reveal distinct lesions. Microscopically, the hernia sac was diffusely infiltrated by moderately differentiated adenocarcinoma, which was positive for CK7 and pancytokeratin and negative for TTF-1, CK20, PSA, and CDX2...
2018: Case Reports in Pathology
Biji Babu, Bhawna Dev, T Mohanapriya, C N Sai Shalini
Mammary Paget disease is an uncommon malignancy of the breast that presents with ulceration or eczema of the nipple and is almost always associated with an underlying breast carcinoma. This disease is most commonly seen in the fifth and sixth decades of life and is almost always unilateral. The diagnosis of mammary Paget disease is generally based on clinical findings, confirmed by histopathologic examination. Mammographic and ultrasonographic findings may be nonspecific for malignancy, with 50% of cases showing negative findings...
June 2018: Radiology Case Reports
Adriana M Pedraza, Andrew J Stephenson
PURPOSE OF REVIEW: Testicular germ cell tumour (TGCT) is a common malignancy among young men. There is controversy regarding the best approach for patients with clinical stage I disease due to rates of relapse with active surveillance in contrast to overtreatment with adjuvant therapy. The aim of this review is to describe the role of prognostic factors in this setting. RECENT FINDINGS: Molecular prognostic factors have been described as a possible future aid to clinical and histologic features in the approach of patients with clinical stage I germ cell tumours...
September 2018: Current Opinion in Urology
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