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inflammation influenza

Liyana Ahmad, Serge Mostowy, Vanessa Sancho-Shimizu
Autophagy is a highly conserved intracellular degradation process that targets protein aggregates and damaged organelles. Autophagy is also implicated in numerous viral infections, including human immunodeficiency virus-1 (HIV-1), influenza A (IAV) and herpes simplex virus-1 (HSV-1). Depending on the virus, autophagy can restrict or promote viral replication, and play key roles in modulating inflammation and cell survival. In this review, we consider examples of autophagy-virus interplay, highlighting the protective role of autophagy in human infections...
2018: Frontiers in Cell and Developmental Biology
Patrick Baah Ampomah, Wan Ting Kong, Olga Zharkova, Sonja C J H Chua, R Perumal Samy, Lina H K Lim
Influenza A viruses (IAVs) are important human respiratory pathogens which cause seasonal or periodic endemic infections. IAV can result in severe or fatal clinical complications including pneumonia and respiratory distress syndrome. Treatment of IAV infections is complicated because the virus can evade host immunity through antigenic drifts and antigenic shifts, to establish infections making new treatment options desirable. Annexins (ANXs) are a family of calcium and phospholipid binding proteins with immunomodulatory roles in viral infections, lung injury, and inflammation...
2018: Frontiers in Pharmacology
Chloe C Boyle, Kate R Kuhlman, Larissa N Dooley, Marcie D Haydon, Theodore F Robles, Yuen-Siang Ang, Diego A Pizzagalli, Julienne E Bower
BACKGROUND: Alterations in reward processing are a central feature of depression and may be influenced by inflammation. Indeed, inflammation is associated with deficits in reward-related processes in animal models and with dysregulation in reward-related neural circuitry in humans. However, the downstream behavioral manifestations of such impairments are rarely examined in humans. METHODS: The influenza vaccination was used to elicit a mild inflammatory response in 41 healthy young adults (age range: 18-22, 30 female)...
November 20, 2018: Psychoneuroendocrinology
Sofie M R Starbæk, Louise Brogaard, Harry D Dawson, Allen D Smith, Peter M H Heegaard, Lars E Larsen, Gregers Jungersen, Kerstin Skovgaard
Influenza is a viral respiratory disease having a major impact on public health. Influenza A virus (IAV) usually causes mild transitory disease in humans. However, in specific groups of individuals such as severely obese, the elderly, and individuals with underlying inflammatory conditions, IAV can cause severe illness or death. In this review, relevant small and large animal models for human IAV infection, including the pig, ferret, and mouse, are discussed. The focus is on the pig as a large animal model for human IAV infection as well as on the associated innate immune response...
November 22, 2018: ILAR Journal
Yu-Ching Su, Farshid Jalalvand, John Thegerström, Kristian Riesbeck
Chronic obstructive pulmonary disease (COPD) is a debilitating respiratory disease and one of the leading causes of morbidity and mortality worldwide. It is characterized by persistent respiratory symptoms and airflow limitation due to abnormalities in the lower airway following consistent exposure to noxious particles or gases. Acute exacerbations of COPD (AECOPD) are characterized by increased cough, purulent sputum production, and dyspnea. The AECOPD is mostly associated with infection caused by common cold viruses or bacteria, or co-infections...
2018: Frontiers in Immunology
Seiki Fujiwara, Midori Hoshizaki, Yu Ichida, Dennis Lex, Etsushi Kuroda, Ken J Ishii, Shigeyuki Magi, Mariko Okada, Hiroyuki Takao, Masahiro Gandou, Hirotaka Imai, Ryujiro Hara, Herbert Herzog, Akihiko Yoshimura, Hitoshi Okamura, Josef M Penninger, Arthur S Slutsky, Stefan Uhlig, Keiji Kuba, Yumiko Imai
Crosstalk between the autonomic nervous system and the immune system by means of the sympathetic and parasympathetic pathways is a critical process in host defence. Activation of the sympathetic nervous system results in the release of catecholamines as well as neuropeptide Y (NPY). Here, we investigated whether phagocytes are capable of the de novo production of NPY, as has been described for catecholamines. We show that the synthesis of NPY and its Y1 receptor (Y1R) is increased in phagocytes in lungs following severe influenza virus infection...
November 19, 2018: Nature Microbiology
Ageng Wiyatno, E S Zul Febrianti, Aghnianditya Kresno Dewantari, Khin Saw Myint, Dodi Safari, Nikmah Salamia Idris
Introduction: Myocarditis, inflammation of the heart muscle, can be caused by infections, autoimmune disease or exposure to toxins. The major cause of myocarditis in the paediatric population is viral infection, including coxsackievirus B3, adenovirus, herpesvirus, parvovirus, influenza A and B, and hepatitis. Here, we report the detection of rhinovirus C in a boy with a clinical presentation of myocarditis, suggesting a possible causative role of this virus in this case. Case presentation: A previously well 4...
September 2018: JMM Case Reports
Peiyu Li, Ji Wang, Miao Cao, Qiwen Deng, Shibo Jiang, Mei X Wu, Lu Lu
Skin contains a large number of antigen presenting cells, making intradermal (ID) injection one of the most effective ways for vaccine administration. However, although current adjuvants may cause severe local reactions and inflammations in the skin, no adjuvant has been approved for ID vaccination so far. Here, we report that topical application of all- trans retinoic acid (ATRA), a vitamin A derivative produced in the human body, augmented cutaneous influenza vaccination. The adjuvant effects were evaluated in a murine vaccination/challenge model by using A/California/07/2009 pandemic vaccine (09V) or a seasonal influenza vaccine (SIV)...
2018: Frontiers in Microbiology
Jiayuan Jiao, Jiming Wu, Jiali Wang, Yaping Guo, Le Gao, Honggang Liang, Jian Huang, Jinhui Wang
CONTEXT: Ma Huang Tang (MHT) has been used to treat influenza, fever, bronchial asthma, etc. as a traditional Chinese medication. However, the anti-inflammation mechanism of MHT remains unclear. OBJECTIVE: The study identifies the possible mechanisms of MHT on ovalbumin (OVA)-induced acute bronchial asthma in mice. MATERIALS AND METHODS: First, an asthma-related protein-protein interaction (PPI) network was constructed. And then, the acute bronchial asthma mice models were established by exposing to aerosolized 1% ovalbumin for 30 min/day for 1 week, and the mice were administered 2...
December 2018: Pharmaceutical Biology
Byung-Cheol Lee, Seiko Susuki-Miyata, Chen Yan, Jian-Dong Li
Phosphodiesterase 4B (PDE4B) plays an important role in inflammation. Recently we have reported that roflumilast as a PDE4-selective inhibitor, synergizes with nontypeable Haemophilus influenzae (NTHi) to up-regulate PDE4B expression in vitro and in vivo. Clinical evidence and our previous results suggest that synergistic induction of PDE4B could be counterproductive for suppressing inflammation or may contribute to tolerance to roflumilast. We thus investigated if dexamethasone inhibits the synergistic induction of PDE4B by roflumilast and NTHi as well as inflammation...
November 8, 2018: International Journal of Molecular Sciences
Jennifer L Ather, Oliver Dienz, Jonathan E Boyson, Vikas Anathy, Eyal Amiel, Matthew E Poynter
Serum amyloid A (SAA) proteins are a family of acute phase apolipoproteins implicated to directly modulate innate and adaptive immune responses. However, new studies comparing endogenous SAAs and recombinant forms of these proteins have questioned the function of SAA in inflammation and immunity. We generated SAA3 knockout mice to evaluate the contribution of SAA3 to lung development and immune-mediated lung disease. While SAA3 deficiency does not affect the generation of house dust mite-induced allergic asthma, mice lacking SAA3 develop adult-onset obesity, intrinsic airway hyperresponsiveness, increased inflammatory and fibrotic gene expression in the lung, and elevated levels of lung citrullinated proteins...
November 8, 2018: Scientific Reports
Jef Serré, Carolien Mathyssen, Tom Tanjeko Ajime, Hannelie Korf, Karen Maes, Nele Heulens, Conny Gysemans, Chantal Mathieu, Bart Vanaudenaerde, Wim Janssens, Ghislaine Gayan-Ramirez
Chronic obstructive pulmonary disease (COPD), which is characterized by an excessive inflammatory response of the airways, is often complicated by exacerbations. Vitamin D deficiency has been associated with an increased risk for COPD and may predispose COPD patients to a higher exacerbation rate, particularly during smoking. In the current study, we investigated the effect of vitamin D deficiency and cigarette smoke (CS)-exposure on lung inflammation and bacterial clearance after an acute infection with Nontypeable Haemophilus influenzae (NTHi)...
November 3, 2018: Journal of Steroid Biochemistry and Molecular Biology
Simon P Jochems, Fernando Marcon, Beatriz F Carniel, Mark Holloway, Elena Mitsi, Emma Smith, Jenna F Gritzfeld, Carla Solórzano, Jesús Reiné, Sherin Pojar, Elissavet Nikolaou, Esther L German, Angie Hyder-Wright, Helen Hill, Caz Hales, Wouter A A de Steenhuijsen Piters, Debby Bogaert, Hugh Adler, Seher Zaidi, Victoria Connor, Stephen B Gordon, Jamie Rylance, Helder I Nakaya, Daniela M Ferreira
Colonization of the upper respiratory tract by pneumococcus is important both as a determinant of disease and for transmission into the population. The immunological mechanisms that contain pneumococcus during colonization are well studied in mice but remain unclear in humans. Loss of this control of pneumococcus following infection with influenza virus is associated with secondary bacterial pneumonia. We used a human challenge model with type 6B pneumococcus to show that acquisition of pneumococcus induced early degranulation of resident neutrophils and recruitment of monocytes to the nose...
December 2018: Nature Immunology
Meghan E Rebuli, Adam M Speen, Elizabeth M Martin, Kezia A Addo, Erica A Pawlak, Ellen Glista-Baker, Carole Robinette, Haibo Zhou, Terry L Noah, Ilona Jaspers
RATIONALE: Exposure to particulates from burning biomass is an increasing global health issue. Burning biomass, including wood smoke, is associated with increased lower respiratory infections. OBJECTIVES: To determine whether acute exposure to wood smoke modifies nasal inflammatory responses to influenza. METHODS: Healthy young adults (N=39) were randomized to a 2-hr controlled chamber exposure to wood smoke, where exposure levels were controlled to particulate number, (WSP) (500 μg/cm3), or filtered air (FA), followed by nasal inoculation with a vaccine dose of live attenuated influenza virus (LAIV)...
October 26, 2018: American Journal of Respiratory and Critical Care Medicine
Amit Gaba, Fang Xu, Yao Lu, Hong-Su Park, GuanQun Liu, Yan Zhou
Elimination of infected cells by programmed cell death is a well-recognized host defense mechanism to control the spread of infection. In addition to apoptosis, necroptosis is also one of the mechanisms of cell death that can be activated by viral infection. Activation of necroptosis leads to the phosphorylation of mixed-lineage kinase domain-like protein (MLKL) by receptor interacting protein kinase (RIPK)-3 and results in MLKL oligomerization and membrane translocation, leading to membrane disruption and loss of cellular ion homeostasis...
October 24, 2018: Journal of Virology
Nina Kim, Katie L Lannan, Thomas H Thatcher, Stephen J Pollock, Collynn F Woeller, Richard P Phipps
Vaccination has been the most effective way to prevent or reduce infectious diseases; examples include the eradication of smallpox and attenuation of tetanus and measles. However, there is a large segment of the population that responds poorly to vaccines, in part because they are immunocompromised because of disease, age, or pharmacologic therapy and are unable to generate long-term protection. Specialized proresolving mediators are endogenously produced lipids that have potent proresolving and anti-inflammatory activities...
December 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Yuhang Sun, Jiarui Su, Zixuan Liu, Dandan Liu, Fang Gan, Xingxiang Chen, Kehe Huang
Aflatoxin B1 (AFB1 ), which alters immune responses to mammals, is one of the most common mycotoxins in feeds and food. Swine influenza virus (SIV) is a major pathogen of both animals and humans. However, there have been few studies about the relationship between AFB1 exposure and SIV replication. Here, for the first time, we investigated the involvement of AFB1 in SIV replication in vitro and in vivo and explored the underlying mechanism using multiple cell lines and mouse models. In vitro studies demonstrated that low concentrations of AFB1 (0...
2018: Frontiers in Immunology
Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers the recruitment of mast cell progenitors to the lung. This process starts early after infection and leads to the accumulation of mast cells. Previous studies showed that an adaptive immune response was required to trigger the recruitment of mast cell progenitors to the lung in a mouse model of allergic lung inflammation...
2018: Frontiers in Immunology
Radha Gopal, Benjamin Lee, Kevin J McHugh, Helen E Rich, Krishnaveni Ramanan, Sivanarayana Mandalapu, Michelle E Clay, Philip J Seger, Richard I Enelow, Michelle L Manni, Keven M Robinson, Javier Rangel-Moreno, John F Alcorn
Influenza is a common respiratory virus that infects between 5 and 20% of the US population and results in 30,000 deaths annually. A primary cause of influenza-associated death is secondary bacterial pneumonia. We have previously shown that influenza induces type I interferon (IFN)-mediated inhibition of Type 17 immune responses, resulting in exacerbation of bacterial burden during influenza and Staphylococcus aureus super-infection. In this study, we investigated the role of STAT2 signaling during influenza and influenza-bacterial super-infection in mice...
2018: Frontiers in Immunology
Lara Ravanetti, Annemiek Dijkhuis, Tamara Dekker, Yanaika S Sabogal Pineros, Abilash Ravi, Barbara S Dierdorp, Jonas S Erjefält, Michiko Mori, Stelios Pavlidis, Ian M Adcock, Navin L Rao, René Lutter
BACKGROUND: Influenza virus triggers severe exacerbations of asthma for which no adequate treatment is available. It is known that IL-33 levels correlate with exacerbation severity, but its role in the immune-pathogenesis of exacerbations has remained elusive. OBJECTIVE: We hypothesized that IL-33 is necessary to drive asthma exacerbations. We intervened with the IL-33 cascade and sought to dissect its role, also in synergy with TSLP, in airway inflammation, anti-viral activity and lung function...
October 11, 2018: Journal of Allergy and Clinical Immunology
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