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"BiPap" OR "BPap" OR "Bilevel Positive Airway Pressure" OR "Bi-Level Positive Airway Pressure" OR "IPAP" OR "EPAP"

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https://www.readbyqxmd.com/read/30092901/case-report-of-pediatric-channelopathies-with-unc80-and-kcnj11-mutations-having-abnormal-respiratory-control-treated-with-positive-airway-pressure-therapy
#1
Hanna Hong, Rory Kamerman-Kretzmer, Roberta Kato, Tena Rosser, Michele VanHirtum-Das, Sally L Davidson Ward
There have been no published reports of central respiratory control abnormalities in pediatric patients with UNC80 or KCNJ11 mutations which cause neurologic channelopathies. We describe an 8-year-old male with a pathogenic UNC80 mutation, intellectual disability, hypotonia and epilepsy with severe central sleep apnea (213.5 events/h) on polysomnography (PSG). We also describe a 20-month-old female with a KCNJ11 mutation, neonatal diabetes and developmental delay who had severe central sleep apnea (131.1 events/h)...
August 6, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/30077407/bisphenol-ap-is-anti-estrogenic-and-may-cause-adverse-effects-at-low-doses-relevant-to-human-exposure
#2
Xuan Xiao, Junyu Li, Tong Yu, Lei Zhou, Xiaolin Fan, Han Xiao, Yue Wang, Lei Yang, Junhui Lv, Xiaojing Jia, Zhaobin Zhang
A recent increase in the use of bisphenol A (BPA) alternatives to manufacture plastics has led to safety concerns. Here, we evaluated the estrogenic and anti-estrogenic activities of bisphenol AP (BPAP), a poorly studied BPA alternative, using in vitro, in vivo and in silico tools. BPAP exhibited weak estrogenicity but strong anti-estrogenicity (IC50  = 2.35 μM) in a GeneBLAzer™ β-lactamase reporter gene assay. BPAP, when administered alone or in combination with E2 (50 μg kg-1 bw d-1 ) for 3 d, significantly decreased the uterine weights of post-weaning CD-1 mice at doses of 10 mg kg-1 bw d-1 and higher...
July 24, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/30050497/associative-increases-in-amyotrophic-lateral-sclerosis-survival-duration-with-non-invasive-ventilation-initiation-and-usage-protocols
#3
Nishad Khamankar, Grant Coan, Barry Weaver, Cassie S Mitchell
Objective: It is hypothesized earlier non-invasive (NIV) ventilation benefits Amyotrophic Lateral Sclerosis (ALS) patients. NIV typically consists of the removable bi-level positive airway pressure (Bi-PAP) for adjunctive respiratory support and/or the cough assist intervention for secretion clearance. Historical international standards and current USA insurance standards often delay NIV until percent predicted forced vital capacity (FVC %predict) is <50. We identify the optimal point for Bi-PAP initiation and the synergistic benefit of daily Bi-PAP and cough assist on associative increases in survival duration...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29942881/treating-acute-hypertensive-cardiogenic-pulmonary-edema-with-high-dose-nitroglycerin
#4
Yi-Ting Hsieh, Tai-Ying Lee, Jui-Shih Kao, Hsin-Lin Hsu, Chee-Fah Chong
Acute pulmonary edema due to sympathetic surge and increased peripheral vascular resistance often present to the emergency department (ED) with markedly elevated blood pressure, severe dyspnea, and desaturation. This condition is known as "SCAPE" (sympathetic crashing acute pulmonary edema). We present three SCAPE patients who were successfully treated with high-dose nitroglycerin (NTG) and bilevel positive airway pressure (BiPAP) ventilation. All three patients presented with respiratory failure on arrival but rapidly improved after treatment and did not require endotracheal intubation or admission to the intensive care unit (ICU)...
March 2018: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29889001/the-mean-airway-pressure-may-be-the-answer
#5
Luis Perez-Baena, Martí Pons-Òdena
No abstract text is available yet for this article.
July 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29798125/-relationship-of-symptoms-with-sleep-stage-abnormalities-in-obstructive-sleep-apnea-hypopnea-syndrome
#6
H J Liu, N Zhao, A F Zhang
Objective: To study the relationship between symptoms and sleep staging in OSAHS patients. Method: A cross-sectional study. Adult subjects who attended a sleep laboratory for diagnostic polysomnography for a period of 1 month were recruited consecutively.OSAHS was diagnosed using American Academy of Sleep Medicine criteria.Subjects filled a questionnaire for symptoms prior to polysomnography. Result: Thirty subjects, of whom 83.3% were obese, met diagnostic criteria, with males constituting 46.7% and females constituting 53%...
November 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29782417/prevalence-and-analysis-of-medical-device-related-pressure-injuries-results-from-the-international-pressure-ulcer-prevalence-survey
#7
Susan A Kayser, Catherine A VanGilder, Elizabeth A Ayello, Charlie Lachenbruch
OBJECTIVE: To examine the prevalence and characteristics of medical device-related pressure injuries (MDR PIs) in a large, generalizable database. METHODS: This study is a retrospective analysis of the 2016 International Pressure Ulcer Prevalence data. Data were limited to US and Canadian facilities. Facilities included acute care, long-term care, rehabilitation, long-term acute care hospitals, and hospice. Analysis included 102,865 adult patients; 99,876 had complete data and were the focus of the analysis and are reported in the results below...
June 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29742667/total-laparoscopic-hysterectomy-under-regional-anesthesia
#8
Nash S Moawad, Estefania Santamaria Flores, Linda Le-Wendling, Martina T Sumner, F Kayser Enneking
BACKGROUND: Laparoscopic hysterectomies comprise a large proportion of all hysterectomies in the United States. Procedures completed under regional anesthesia pose a number of benefits to patients, but laparoscopic hysterectomies traditionally have been performed under general anesthesia. We describe a case of total laparoscopic hysterectomy under epidural anesthesia with the patient fully awake. CASE: A 51-year-old woman with abnormal uterine bleeding underwent an uncomplicated total laparoscopic hysterectomy, bilateral salpingectomy, and excision of endometriosis...
June 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29734991/violent-parasomnia-with-recurrent-biting-and-surgical-interventions-case-report-and-differential-diagnosis
#9
Nilam Danish, Imran S Khawaja, Carlos H Schenck
A case is reported of recurrent, injurious self-biting during sleep, requiring surgical interventions, in a 55-year-old obese man with a 20-year history of violent complex parasomnia, with greatly increased frequency and severity of episodes induced by work stress during the preceding 3 years. After clinical evaluation and overnight, hospital-based video-polysomnography, the cause of the chronic injurious parasomnia was deemed to be a non-rapid eye movement (NREM) sleep parasomnia comorbid with severe obstructive sleep apnea...
May 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29724743/efficacy-of-bilevel-positive-airway-pressure-and-continuous-positive-airway-pressure-therapy-in-patients-with-obesity-hypoventilation-syndrome-protocol-for-systematic-review-and-meta-analysis
#10
Lili Guan, Weiliang Wu, Yating Huo, Xiaoying Li, Bingpeng Guo, Yuqiong Yang, Jiawen Xu, Fangfang Jiang, Luqian Zhou, Rongchang Chen
INTRODUCTION: Obesity hypoventilation syndrome (OHS) is a major respiratory complication caused by severe obesity, being associated with significant morbidity, negative impacts on quality of life and reduced survival if not treated appropriately. Positive airway pressure therapy is the first-line treatment for OHS although the optimal modality remains unclear. The goal of this study is to identify the efficacy of home bilevel positive airway pressure therapy by comparison to continuous positive airway pressure therapy and determine the best strategy for patients with OHS...
May 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29701428/anaesthetic-management-in-a-duchennne-muscle-dystrophy-patient-for-treatment-of-recurrent-pneumothorax
#11
Sara Mota, Liuba Germanova, Joana Cortesão, Teresa Paiva
INTRODUCTION: Duchenne muscular dystrophy (DMD) is an x linked recessive disorder. Long term prognosis is ominous, with development of respiratory distress and cardiomyopathy in advanced stage of the disease and expected death in the teens-to-mid 20s due to respiratory or cardiac failure. Peri-operative management of this patients is challenging due to difficult airway anatomy (macroglossia, limited neck and mandibular mobility). Additionally, they are at risk of developing malignant hyperthermia, rhabdomyolysis and hyperkalemic cardiac arrest when exposed to halogenated inhalational anaesthetics and depolarizing muscle relaxants...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29694504/influence-of-expiratory-positive-airway-pressure-on-cardiac-autonomic-modulation-at-rest-and-in-submaximal-exercise-in-copd-patients
#12
RANDOMIZED CONTROLLED TRIAL
C da L Goulart, E A San Martin, K M K Mansour, P B Schneiders, A L G da Silva
The aim of this study was to evaluate the effect of expiratory positive airway pressure (EPAP) on heart rate variability (HRV) indices at rest and during 6-min walk test (6MWT) in chronic obstructive pulmonary disease (COPD) patients. Fifteen moderate to severe COPD patients were randomized and evaluated with and without (Non-EPAP) a 5 cmH2O EPAP device. Respiratory rate (RR) was collected at rest (5 min), during the 6MWT (5 min), and at recovery (5 min). Indices of HRV were computed in the time domain, in the frequency domain, and nonlinear analysis...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29678407/determination-of-nine-bisphenols-in-sewage-and-sludge-using-dummy-molecularly-imprinted-solid-phase-extraction-coupled-with-liquid-chromatography-tandem-mass-spectrometry
#13
Xiaoli Sun, Junyu Peng, Muhua Wang, Jincheng Wang, Chunlan Tang, Luoxing Yang, Hua Lei, Fang Li, Xueli Wang, Jiping Chen
This paper describes the determination of bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF), bisphenol E (BPE), bisphenol B (BPB), bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol Z (BPZ) and tetrabromobisphenol A (TBBPA) in sewage and sludge samples. A highly class-selective dummy molecularly imprinted polymer was used for solid phase extraction (SPE) and clean-up of the samples. Bisphenols was quantified by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The developed method had acceptable recoveries (43...
June 1, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29628437/chronic-respiratory-failure-in-patients-with-chronic-obstructive-pulmonary-disease-under-home-noninvasive-ventilation-real-life-study
#14
V Durão, M Grafino, P Pamplona
BACKGROUND: Home noninvasive ventilation (NIV) has been increasingly used in stable chronic obstructive pulmonary disease (COPD) with chronic hypercapnic respiratory failure (CHRF). However its effectiveness remains debatable. AIM: To describe a follow-up of COPD patients under home NIV. METHODS: Retrospective descriptive study based on a prospective 3-year database that included COPD patients under home NIV between August 2011 and July 2014...
April 5, 2018: Pulmonology
https://www.readbyqxmd.com/read/29551475/first-line-treatment-using-high-flow-nasal-cannula-for-children-with-severe-bronchiolitis-applicability-and-risk-factors-for-failure
#15
C Guillot, C Le Reun, H Behal, J Labreuche, M Recher, A Duhamel, S Leteurtre
BACKGROUND: Viral bronchiolitis is the leading cause of hospitalization in children during the first 12 months of life. There is evidence to support the use of noninvasive ventilation in bronchiolitis. A recent respiratory management of bronchiolitis is the use of high-flow nasal cannula (HFNC) therapy. The primary objective of this study was to evaluate the use of HFNC as the first-line treatment for children with severe bronchiolitis and the secondary objective was to identify factors for HFNC therapy failure...
April 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29550053/early-initiation-of-inhaled-corticosteroids-does-not-decrease-acute-chest-syndrome-morbidity-in-pediatric-patients-with-sickle-cell-disease
#16
Alexis Leonard, Nihal Godiwala, Nicole Herrera, Robert McCarter, Matthew Sharron, Emily Riehm Meier
Acute chest syndrome (ACS) is a leading cause of mortality in patients with sickle cell disease (SCD). Systemic corticosteroids decrease ACS severity, but the risk of readmission for vaso-occlusive crises (VOC) has limited their use. The efficacy of inhaled corticosteroids (ICS) as a safer alternative is currently unknown. An observational, historic cohort study compared patients with SCD with ACS who received ICS at admission (ICS) to those who did not (non-ICS). Outcome measures included rates of transfusion, oxygen requirement, BiPAP initiation, PICU transfer, intubation, readmission, hospital cost, and length of stay...
July 2018: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/29549655/activated-protein-c-has-no-effect-on-pulmonary-capillary-endothelial-function-in-septic-patients-with-acute-respiratory-distress-syndrome-association-of-endothelial-dysfunction-with-mortality
#17
Katerina Kaziani, Alice G Vassiliou, Anastasia Kotanidou, Chariclea Athanasiou, Ioanna Korovesi, Konstantinos Glynos, Stylianos E Orfanos
INTRODUCTION: Pulmonary capillary endothelium-bound (PCEB) angiotensin-converting enzyme (ACE) activity is a direct and quantifiable index of pulmonary endothelial function that decreases early in acute respiratory distress syndrome (ARDS) and correlates with its severity. Endothelial dysfunction is a major pathophysiology that underlies sepsis-related ARDS. Recombinant human activated protein C (rhAPC), now withdrawn from the market, has been used in the recent past as an endothelial-protective treatment in patients with septic organ dysfunction...
March 2018: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29544721/dexmedetomidine-high-flow-nasal-oxygen-and-sugammadex-reversal-of-rocuronium-overcoming-anaesthetic-challenges-in-a-parturient-with-congenital-muscular-dystrophy-presenting-for-caesarean-section
#18
M Creaney, R M Moriarty, M Milner, C Murphy
Congenital muscular dystrophies are characterised by progressive skeletal muscle weakness from birth or early infancy. Maternal respiratory compromise, joint contractures and presence of spinal instrumentation or fusion are some of the anaesthetic challenges that may be encountered in the obstetric setting. The choice of anaesthetic technique for surgical delivery needs to be considered on an individual basis. Multidisciplinary involvement is paramount to optimise peripartum care and outcomes. In this case report, we present the use of dexmedetomidine, humidified high-flow nasal oxygen, rocuronium and sugammadex in the anaesthetic management of a wheelchair-bound, non-invasive bilevel positive airway pressure ventilation-dependent parturient with congenital muscular dystrophy, who was presenting for caesarean section...
May 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29543311/unusual-case-of-central-alveolar-hypoventilation
#19
Hadil Ak AlOtair, Abdulaziz H Alzeer, Mohammed A Abdou, Shaden O Qasrawi
Central alveolar hypoventilation is rarely encountered. This case report describes a young woman who was recently diagnosed with hypertension and ischemic heart disease. She presented to the emergency room with hypercapnic respiratory failure, for which she was mechanically ventilated. This was preceded by an acute upper respiratory tract infection. She was initially suspected to have Guillain-Barré syndrome, but further investigations ruled out neuromuscular or autoimmune disorders. Sleep-related hypoventilation was suspected after she experienced recurrent apneas at night that resulted in re-intubation...
March 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29515212/positive-airway-pressure-therapy-for-sleep-disordered-breathing-confers-short-term-benefits-to-patients-with-spinal-cord-injury-despite-widely-ranging-patterns-of-use
#20
Jeanette P Brown, Kristy A Bauman, Armando Kurili, Gianna M Rodriguez, Anthony E Chiodo, Robert G Sitrin, Helena M Schotland
STUDY DESIGN: Prospective, cohort study. OBJECTIVES: To evaluate the effectiveness of bi-level positive airway pressure (PAP) therapy and the patterns of use for sleep-disordered breathing (SDB) in individuals with spinal cord injury (SCI). SETTING: Academic tertiary care center, USA. METHODS: Overall, 91 adults with C1-T6 SCI for ≥3 months were recruited and 74 remained in the study to be evaluated for SDB and follow-up...
March 7, 2018: Spinal Cord
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