Rachel A Ross, Angela Kim, Priyanka Das, Yan Li, Yong Kee Choi, Andy T Thompson, Ella Douglas, Siva Subramanian, Kat Ramos, Kathryn Callahan, Vadim Y Bolshakov, Kerry J Ressler
BACKGROUND: Melanocortin 4 receptor (MC4R) activity in the hypothalamus is crucial for regulation of metabolism and food intake. The peptide ligands for the MC4R are associated with feeding, energy expenditure, and also with complex behaviors that orchestrate energy intake and expenditure, but the downstream neuroanatomical and neurochemical targets associated with these behaviors are elusive. In addition to strong expression in the hypothalamus, the MC4R is highly expressed in the medial prefrontal cortex, a region involved in executive function and decision-making...
June 25, 2023: Physiology & Behavior