keyword
MENU ▼
Read by QxMD icon Read
search

cAMK-II

keyword
https://www.readbyqxmd.com/read/30092488/leptin-regulated-autophagy-plays-a-role-in-long-term-neurobehavioral-injury-after-neonatal-seizures-and-the-regulation-of-zinc-cpla2-and-camk-ii-signaling-in-cerebral-cortex
#1
Li-Li Li, Ya-Chao Li, Dong-Jing Zhao, Mei-Fang Jin, Hong Ni
Metabolic disorders play an important role in the pathogenesis of many neurological diseases. Recent evidence suggests that leptin levels in peripheral blood and brain are lower in patients with epilepsy. Leptin is an energy-regulating hormone that plays a neuroprotective role in neurodegenerative diseases and brain trauma. However, little is known about the effects and molecular mechanisms of leptin treatment on long-term neurobehavioral impairment caused by developmental seizures. The present study evaluated whether chronic leptin treatment protected against neurobehavioral impairments induced by recurrent seizures in newborns treated with flurothyl...
August 3, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/30071829/gene-expression-analysis-indicates-reduced-memory-and-cognitive-functions-in-the-hippocampus-and-increase-in-synaptic-reorganization-in-the-frontal-cortex-3-weeks-after-mdma-administration-in-dark-agouti-rats
#2
Peter Petschner, Viola Tamasi, Csaba Adori, Eszter Kirilly, Romeo D Ando, Laszlo Tothfalusi, Gyorgy Bagdy
BACKGROUND: 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is a widely used entactogenic drug known to impair cognitive functions on the long-run. Both hippocampal and frontal cortical regions have well established roles in behavior, memory formation and other cognitive tasks and damage of these regions is associated with altered behavior and cognitive functions frequently described in otherwise healthy MDMA users. Meanwhile, in post-traumatic stress disorder (PTSD) patients seem to benefit from therapeutic application of the drug, where damage in hippocampal cue extinction may play a role...
August 2, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29997101/-mitochondrial-calcium-overload-in-the-masseter-muscle-of-rats-with-occlusal-interference-ionic-changes-and-regulation-by-calmodulin-kinase-ii
#3
Lin Zeng, Jing Liu
OBJECTIVE: To investigate the changes in mitochondrial calcium and extracellular sodium concentrations in the masseter muscle of rats with occlusal interference and the regulatory mechanism of mitochondrial Ca2+ overload by calmodulin kinase II (CaMK II). METHODS: SD rat models of occlusal interference were established by placing a stainless steel segments (0.8 mm in diameter) to raise the occlusal surface of the upper right first molar. At 3, 7, 14, and 21 days after occlusal interference and at 3 days after removal of occlusal interference, HE staining was used to observe the histomorphological changes of the masseter muscle...
June 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29860638/characterization-of-fibroblasts-from-hypertrophied-right-ventricle-of-pulmonary-hypertensive-rats
#4
Keisuke Imoto, Muneyoshi Okada, Hideyuki Yamawaki
Pulmonary arterial hypertension (PAH), which is characterized by an elevation of pulmonary arterial resistance, leads to a lethal right heart failure. It is an urgent issue to clarify the pathogenesis of PAH-induced right heart failure. The present study aimed to elucidate the characteristics of cardiac fibroblasts (CFs) isolated from hypertrophied right ventricles of monocrotaline (MCT)-induced PAH model rats. CFs were isolated from the right ventricles of MCT-injected rats (MCT-CFs) and saline-injected control rats (CONT-CFs)...
June 2, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29804319/microrna-219-decreases-hippocampal-long-term-potentiation-inhibition-and-hippocampal-neuronal-cell-apoptosis-in-type-2-diabetes-mellitus-mice-by-suppressing-the-nmdar-signaling-pathway
#5
Ling Zhang, Zheng-Wen Chen, Shu-Fen Yang, Muyasi Shaer, Ying Wang, Jun-Jie Dong, Beili Jiapaer
OBJECTIVE: Type 2 diabetes mellitus (T2DM) is a complex polygenic disease that causes hyperglycemia and accounts for 90%-95% of all diabetes mellitus cases. Hence, this study aimed to examine the effects of microRNA-219 (miR-219) on inhibition of long-term potentiation (LTP) and apoptosis of hippocampal neuronal cells in T2DM mice through the N-methyl-d-aspartate receptor (NMDAR) signaling pathway regulation. METHODS: The T2DM mouse models were established, after which LTP in vivo was recorded by means of electrical biology, and the fasting blood glucose of mice was measured...
May 27, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29771437/works-on-heart-how-about-brain-effect-of-hyperkalemia-on-focal-cerebral-ischemia-reperfusion-injury-in-rats
#6
T Qin, N Li, X-F Tan, J-H Zheng, R Tao, M-H Chen
OBJECTIVE: To investigate the effects of hyperkalemia on the brain after I/R in h transient middle cerebral artery occlusion (tMCAO) model. MATERIALS AND METHODS: A total of 120 adult male SD rats were randomly assigned to four groups: (1) hyperkalemia 80 µg/g (HK80) group; (2) hyperkalemia 40 µg/g (HK40) group; (3) normal saline (NS) group; (4) sham (SH) group. The concentration of serum K+ was elevated in HK80 and HK40 groups. The transient middle cerebral artery occlusion (tMCAO) model was used to assess the effect of hyperkalemia on the brain after I/R...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29652442/antioxidant-hydrolyzed-peptides-from-manchurian-walnut-juglans-mandshurica-maxim-attenuate-scopolamine-induced-memory-impairment-in-mice
#7
Dayong Ren, Fanrui Zhao, Chunlei Liu, Ji Wang, Yong Guo, Jingsheng Liu, Weihong Min
BACKGROUND: Walnut protein, which is obtained as a by-product of oil expression, has not been used efficiently. Although walnuts are beneficial for cognitive functioning, the potential of their protein composition in strengthening learning and memory functions remains unknown. In this study, the inhibition of memory impairment by the Manchurian walnut hydrolyzed peptide (MWHP) was evaluated. RESULTS: Small-molecular-weight MWHP (<3 kDa) achieved the optimal antioxidative activity...
April 13, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29395480/melanopsin-and-rhodopsin-mediate-uva-induced-immediate-pigment-darkening-unravelling-the-photosensitive-system-of-the-skin
#8
Leonardo Vinícius Monteiro de Assis, Maria Nathalia Moraes, Keila Karoline Magalhães-Marques, Ana Maria de Lauro Castrucci
The mammalian skin has a photosensitive system comprised by several opsins, including rhodopsin (OPN2) and melanopsin (OPN4). Recently, our group showed that UVA (4.4 kJ/m2 ) leads to immediate pigment darkening (IPD) in murine normal and malignant melanocytes. We show the role of OPN2 and OPN4 as UVA sensors: UVA-induced IPD was fully abolished when OPN4 was pharmacologically inhibited by AA9253 or when OPN2 and OPN4 were knocked down by siRNA in both cell lines. Our data, however, demonstrate that phospholipase C/protein kinase C pathway, a classical OPN4 pathway, is not involved in UVA-induced IPD in either cell line...
April 2018: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29393654/trpv4-stimulation-releases-atp-via-pannexin-channels-in-human-pulmonary-fibroblasts
#9
Mozibur Rahman, Rui Sun, Subhendu Mukherjee, Bernd Nilius, Luke J Janssen
We previously described several ionic conductances in human pulmonary fibroblasts, including one activated by two structurally distinct TRPV4 (transient receptor potential, vanilloid-type, subtype 4)-channel agonists: 4αPDD (4α-phorbol-12,13-didecanoate) and GSK1016790A. However, the TRPV4-activated current exhibited peculiar properties: it developed slowly over many minutes, exhibited reversal potentials that could vary by tens of millivolts even within a given cell, and was not easily reversed by subsequent addition of two distinct TRPV4-selective blockers (RN-1734 and HC-067047)...
July 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29221166/high-salt-induced-hypertension-leads-to-cognitive-defect
#10
Cui-Ping Guo, Zhen Wei, Fang Huang, Min Qin, Xing Li, Yu-Man Wang, Qun Wang, Jian-Zhi Wang, Rong Liu, Bin Zhang, Hong-Lian Li, Xiao-Chuan Wang
Although increasing evidences suggest a relationship between hypertension and brain function for years, it is still unclear whether hypertension constitutes a risk factor for cognitive decline and its underlying mechanism. In the present study, an experimental animal model of hypertension simply by feeding rats with high salt diet was employed. We found that long-term high salt intake caused a marked increase of systolic blood pressure linked to a declined regional cerebral blood flow. Fear conditioning and morris water maze behavioral test revealed that high salt diet induced hippocampal dependent spatial reference memory deficits, while a decreased synaptogenesis without neuronal loss in hippocampus was observed in high salt treated rats...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29216949/-effects-of-n-butylphthalide-on-the-expressions-of-calpain-1-and-camk-ii-in-hippocampus-in-rats-with-acute-severe-carbon-monoxide-poisoning
#11
Qin Li, Xiaoyu Ding, Weikang Bi, Jinglin Wang, Yong Zou
OBJECTIVE: To investigate the effects of N-butylphthalide (NBP) on cognitive function in acute severe carbon monoxide (CO) poisoning rats and its mechanism. METHODS: 120 health Sprague-Dawley (SD) rats were randomly divided into three groups (n = 40): normal control group (NC group), CO poisoning group (CO group) and NBP treatment group (NBP group). The acute severe CO poisoning model was established in a hyperbaric oxygen chamber by intoxicated with 1 000 ×10-6 CO for 40 minutes, followed with 3 000 ×10-6 CO for another 20 minutes, and then received hyperbaric oxygen therapy 1...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29200726/influence-of-flavonoids-on-mechanism-of-modulation-of-insulin-secretion
#12
Juliana Mikaelly Dias Soares, Ana Ediléia Barbosa Pereira Leal, Juliane Cabral Silva, Jackson R G S Almeida, Helinando Pequeno de Oliveira
Background: The development of alternatives for insulin secretion control in vivo or in vitro represents an important aspect to be investigated. In this direction, natural products have been progressively explored with this aim. In particular, flavonoids are potential candidates to act as insulin secretagogue. Objective: To study the influence of flavonoid on overall modulation mechanisms of insulin secretion. Methods: The research was conducted in the following databases and platforms: PubMed, Scopus, ISI Web of Knowledge, SciELO, LILACS, and ScienceDirect, and the MeSH terms used for the search were flavonoids, flavones, islets of Langerhans, and insulin-secreting cells...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137154/two-sulfur-glycoside-compounds-isolated-from-lepidium-apetalum-willd-protect-nrk52e-cells-against-hypertonic-induced-adhesion-and-inflammation-by-suppressing-the-mapk-signaling-pathway-and-raas
#13
Peipei Yuan, Xiaoke Zheng, Meng Li, Yingying Ke, Yang Fu, Qi Zhang, Xiaolan Wang, Weisheng Feng
Lepidium apetalum Willd has been used to reduce edema and promote urination. Cis -desulfoglucotropaeolin ( cis -DG) and trans -desulfoglucotropaeolin ( trans -DG) were isolated from Lepidium apetalum Willd, and caused a significant increase in cell viability in a hypertonic model in NRK52e cells. In the hypertonic model, cis -DG and trans -DG significantly promoted the cell viability of NRK52e cells and inhibited the elevation of Na⁺ in the supernatant, inhibited the renin-angiotensin-aldosterone (RAAS) system, significantly reduced the levels of angiotensin II (Ang II) and aldosterone (ALD), and lowered aquaporin-2 (AQP2) and Na⁺-K⁺ ATP content in renal medulla...
November 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29128805/ursolic-acid-affords-antidepressant-like-effects-in-mice-through-the-activation-of-pka-pkc-camk-ii-and-mek1-2
#14
Ana B Ramos-Hryb, Mauricio P Cunha, Francis L Pazini, Vicente Lieberknecht, Rui D S Prediger, Manuella P Kaster, Ana Lúcia S Rodrigues
BACKGROUND: Ursolic acid has been shown to display antidepressant-like effects in mice through the modulation of monoaminergic systems. In this study, we sought to investigate the involvement of signaling pathways on the antidepressant-like effects of ursolic acid. METHODS: Mice were treated orally with ursolic acid (0.1mg/kg) and, 45min later they received the followings inhibitors by intracerebroventricular route: H-89 (PKA inhibitor, 1μg/mouse), KN-62 (CAMK-II inhibitor, 1μg/mouse), chelerythrine (PKC inhibitor, 1μg/mouse), U0126 (MEK1/2 inhibitor, 5μg/mouse), PD98059 (MEK1/2 inhibitor, 5μg/mouse), wortmannin (PI3K irreversible inhibitor, 0...
December 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29079520/zac1-gpr39-phosphorylating-camk-ii-contributes-to-the-distinct-roles-of-pax3-and-pax7-in-myogenic-progression
#15
Qiumei Yang, Ye Li, Xulong Zhang, Daiwen Chen
Both Pax3 and Pax7 can activate a large panel of genes involved in muscle stem cell function. Despite a significant overlap in their transcriptional network, functional difference between them is observed. After overexpressing Pax3 or Pax7 in C2C12, we find both Zac1 and GPR39 are upregulated by Pax7 but not Pax3. Further studies suggest Zac1 interacts directly with Pax7, which can regulate GPR39 expression by activating Zac1. In addition, the effect of Zac1/GPR39 system on myogenic progression has been illuminated: Zac1/GPR39 can promote myogenic differentiation and produce type-II muscle fibers...
February 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28990082/fluid-shear-stress-induces-osteoblast-differentiation-and-arrests-the-cell-cycle-at-the-g0-phase-via-the-erk1-2-pathway
#16
Liyin Yu, Xingfeng Ma, Junqin Sun, Jie Tong, Liang Shi, Lijun Sun, Jianbao Zhang
Numerous studies have demonstrated that fluid shear stress (FSS) may promote the proliferation and differentiation of osteoblast cells. However, proliferation and differentiation are mutually exclusive processes and are unlikely to be promoted by FSS simultaneously. Cell proliferation and differentiation induced by FSS has rarely been reported. In order to provide an insight into this process, the present study investigated the effects of FSS on osteoblast‑like MC3T3 cells in the G0/G1 phase, the period during which the fate of a cell is determined...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28937250/role-of-exercise-induced-calmodulin-protein-kinase-camk-ii-activation-in-the-regulation-of-omega-6-fatty-acids-and-lipid-metabolism-genes-in-rat-skeletal-muscle
#17
J S Joseph, A O Ayeleso, E Mukwevho
Activation of calmodulin dependent protein kinase (CaMK)II by exercise is beneficial in controlling membrane lipids associated with type 2 diabetes and obesity. Regulation of lipid metabolism is crucial in the improvement of type 2 diabetes and obesity associated symptoms. The role of CaMKII in membrane associated lipid metabolism was the focus of this study. Five to six weeks old male Wistar rats were used in this study. GC×GC-TOFMS technique was used to determine the levels of polyunsaturated fatty acids (linoleic acid, arachidonic acid and 11,14-eicosadienoic acid)...
December 20, 2017: Physiological Research
https://www.readbyqxmd.com/read/28901173/cyclin-d2-is-a-critical-mediator-of-exercise-induced-cardiac-hypertrophy
#18
Stephen W Luckey, Chris D Haines, John P Konhilas, Elizabeth D Luczak, Antke Messmer-Kratzsch, Leslie A Leinwand
A number of signaling pathways underlying pathological cardiac hypertrophy have been identified. However, few studies have probed the functional significance of these signaling pathways in the context of exercise or physiological pathways. Exercise studies were performed on females from six different genetic mouse models that have been shown to exhibit alterations in pathological cardiac adaptation and hypertrophy. These include mice expressing constitutively active glycogen synthase kinase-3β (GSK-3βS9A), an inhibitor of CaMK II (AC3-I), both GSK-3βS9A and AC3-I (GSK-3βS9A/AC3-I), constitutively active Akt (myrAkt), mice deficient in MAPK/ERK kinase kinase-1 (MEKK1-/- ), and mice deficient in cyclin D2 (cyclin D2-/- )...
December 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28872356/vitamin-b6-prevents-isocarbophos-induced-vascular-dementia-in-rats-through-n-methyl-d-aspartate-receptor-signaling
#19
Peng Li, Mo-Li Zhu, Guo-Pin Pan, Jun-Xiu Lu, Fan-Rong Zhao, Xu Jian, Li-Ying Liu, Guang-Rui Wan, Yuan Chen, Song Ping, Shuang-Xi Wang, Chang-Ping Hu
BACKGROUND: We have previously reported that the long-term exposure of organophosphorus induces vascular dementia (VD) in rats. As a coenzyme, vitamin B6 is mainly involved in the regulation of metabolisms. Whether vitamin B6 improves VD remains unknown. METHODS: The model of VD was induced by feeding rats with isocarbophos (0.5 mg/kg per two day, 12 weeks). The blood flow of the posterior cerebral artery (PCA) in rat was assessed by transcranial Doppler (TCD)...
2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28825180/sansoninto-as-evidence-based-remedial-medicine-for-depression-like-behavior
#20
Atsushi Sawamoto, Satoshi Okuyama, Yoshiaki Amakura, Rie Yamada, Morio Yoshimura, Mitsunari Nakajima, Yoshiko Furukawa
In vitro screening methods using cultured Neuro2a cells to examine the activation (phosphorylation) of extracellular signal-regulated kinase (ERK) 1/2 and promotion of neurite outgrowth revealed that the extracts of 5 Kampo (Japanese traditional) formulations have potential as medicines for the treatment of behavioral abnormalities. Since sansoninto (SAT) extract exerted stronger effects than the other candidates tested, we investigated whether its oral administration ameliorates the pathologies of some mouse models of behavioral impairments...
January 2018: Journal of Natural Medicines
keyword
keyword
158182
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"