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Nicole L Sullivan, Morgan A Reuter-Monslow, Janet Sei, Eberhard Durr, Carl W Davis, Cathy Chang, Megan McCausland, Andreas Wieland, David Krah, Nadine Rouphael, Aneesh K Mehta, Mark J Mulligan, Bali Pulendran, Rafi Ahmed, Kalpit A Vora
Herpes zoster (HZ/shingles) is the clinical manifestation of varicella zoster virus (VZV) reactivation. HZ typically develops as people age due to decreased cell-mediated immunity. However, the importance of antibodies for immunity against HZ prevention remains to be understood. The goal of this study was to examine the breadth and functionality of VZV-specific antibodies after vaccination with a live attenuated HZ vaccine (Zostavax). Direct enumeration of VZV-specific antibody secreting cells (ASC) via ELISPOT showed that Zostavax can induce both IgG and IgA ASCs seven days after vaccination, but not IgM ASCs...
May 9, 2018: Journal of Virology
Haeyoung Kim, Young Seok Kim, Ji Hyeon Joo, Keun-Yong Eom, Won Park, Jin Hee Kim, Jong Hoon Lee, Yeon Sil Kim, Seok Ho Lee, Kijung Ahn, Yong Bae Kim, Me-Yeon Lee, Sei Kyung Chang
PURPOSE: We conducted this study to evaluate the outcomes of external-beam radiotherapy tumor boost (EBRT-B) in cervical cancer patients who could not receive intracavitary brachytherapy. METHODS: A total of 11 hospitals provided the data of patients who received EBRT-B during the period from January 2005 through October 2012. RESULTS: A total of 75 patients were included. The median radiotherapy dose was 46 Gy (range, 40-54 Gy) for whole pelvis and 24 Gy (range, 9-35 Gy) for EBRT-B...
February 2018: International Journal of Gynecological Cancer
Yuzhang Li, Yanbin Li, Allen Pei, Kai Yan, Yongming Sun, Chun-Lan Wu, Lydia-Marie Joubert, Richard Chin, Ai Leen Koh, Yi Yu, John Perrino, Benjamin Butz, Steven Chu, Yi Cui
Whereas standard transmission electron microscopy studies are unable to preserve the native state of chemically reactive and beam-sensitive battery materials after operation, such materials remain pristine at cryogenic conditions. It is then possible to atomically resolve individual lithium metal atoms and their interface with the solid electrolyte interphase (SEI). We observe that dendrites in carbonate-based electrolytes grow along the <111> (preferred), <110>, or <211> directions as faceted, single-crystalline nanowires...
October 27, 2017: Science
Takafumi Shimogawa, Takato Morioka, Tetsuro Sayama, Tomoaki Akiyama, Sei Haga, Toshiyuki Amano, Yoshihiko Furuta, Kei Murao, Shuji Arakawa, Iwao Takeshita
BACKGROUND: Cerebrospinal fluid hypovolemia (CSFH) is sometimes associated with chronic subdural hematomas (CSHs). Affected patients often develop enlargement and recurrence of the CSH, even if appropriate treatments such as epidural blood patch (EBP) and/or burr-hole surgery for the CSH are performed. This situation may lead to subclinical coagulopathy, including low coagulation factor XIII (CFXIII) activity. We retrospectively analyzed whether CFXIII activity was involved in the development of CSHs and post-treatment exacerbation of CSHs in patients with CSFH...
2017: Surgical Neurology International
Masato Miyoshi, Sei Kakinuma, Yoko Tanabe, Koji Ishii, Tian-Cheng Li, Takaji Wakita, Yukio Tsuura, Hideki Watanabe, Yasuhiro Asahina, Mamoru Watanabe, Takaaki Ikeda
Recent case reports have shown that hepatitis E virus (HEV) infection can cause chronic hepatitis in immunosuppressed or immunocompromised patients. A 37-year-old woman suffered from prolonged elevation of aminotransferases after chemotherapy for Burkitt's lymphoma and was diagnosed with chronic hepatitis E due to a transfusion during chemotherapy. After an 8-month administration of ribavirin, complete HEV clearance was not achieved, likely due to prolonged hypogammaglobulinemia. This case indicates that HEV infection should be ruled out during liver dysfunction in immunosuppressed or immunocompromised patients and suggests that an alternative therapeutic strategy for such patients will be needed...
2016: Internal Medicine
Sowmya Nagaraj, Shylaja Ramlal, Joseph Kingston, Harsh Vardhan Batra
Staphylococcal food poisoning (SFP) is a major foodborne illness caused by staphylococcal enterotoxins (SEs). It is a well known fact that foodborne outbreak investigations are solely characterized by commercially available immunoassay kits. However, these assays encompass only few enterotoxins such as SEA-SEE which are renowned as "classical" enterotoxins and unable to detect any other novel enterotoxins even though their involvement is predicted. In this context, the present study involved development of a sandwich ELISA immunoassay for the specific detection of "non-classical" enterotoxin G (SEG)...
November 21, 2016: International Journal of Food Microbiology
Rebecca Mercieca-Bebber, Michael Friedlander, Peey-Sei Kok, Melanie Calvert, Derek Kyte, Martin Stockler, Madeleine T King
PURPOSE: Patient-reported outcomes (PROs) provide the patient's perspective of the impact of treatment. Evidence suggests that PRO content of randomised controlled trials (RCTs) protocols is generally sub-optimal. This study aimed to describe and evaluate the PRO-specific content of ovarian cancer RCT protocols. METHODS: Published, phase III, ovarian cancer RCTs with PRO endpoints were identified following a systematic search of Medline and Cochrane databases (Jan 2000 to Feb 2016)...
October 2016: Quality of Life Research
Fumitaka Mito, Tsuguo Nishijima, Shigeru Sakurai, Tetsuya Kizawa, Keisuke Hosokawa, Susumu Takahashi, Akira Suwabe, Hiroshi Akasaka, Sei-ichiro Kobayashi
INTRODUCTION: The 2011 Great East Japan Earthquake caused major disruptions in the provision of health care, including that for patients with sleep-disordered breathing (SDB) using a nasal continuous positive airway pressure (nCPAP) device. This study investigated the ability of SDB patients to continue using the nCPAP device in the weeks immediately following the earthquake, whether inability to use the nCPAP device led to symptom relapse, and measures that should be taken to prevent disruptions in nCPAP therapy during future disasters...
December 2013: Prehospital and Disaster Medicine
Kanna Nagamatsu, Asaomi Kuwae, Tadashi Konaka, Shigenori Nagai, Sei Yoshida, Masahiro Eguchi, Mineo Watanabe, Hitomi Mimuro, Shigeo Koyasu, Akio Abe
The inflammatory response is one of several host alert mechanisms that recruit neutrophils from the circulation to the area of infection. We demonstrate that Bordetella, a bacterial pathogen, exploits an antiinflammatory cytokine, interleukin-10 (IL-10), to evade the host immune system. We identified a Bordetella effector, BopN, that is translocated into the host cell via the type III secretion system, where it induces enhanced production of IL-10. Interestingly, the BopN effector translocates itself into the nucleus and is involved in the down-regulation of mitogen-activated protein kinases...
December 21, 2009: Journal of Experimental Medicine
Eunsong Lee, Mohammad Musharraf Bhuiyan, Hiroyuki Watanabe, Kohji Matsuoka, Yoshihiro Fujise, Hajime Ishikawa, Yutaka Fukui
In this study, we examined the feasibility of using subzonal cell injection with electrofusion for interspecies somatic cell nuclear transfer (iSCNT) to produce sei whale embryos and to improve their developmental capacity by investigating the effect of osmolarity and macromolecules in the culture medium on the in vitro developmental capacity. Hybrid embryos produced by the electrofusion of fetal whale fibroblasts with enucleated porcine oocytes were cultured in modified porcine zygote medium-3 to examine the effects of osmolarity and fetal serum on their in vitro developmental capacity...
December 2009: Journal of Veterinary Science
Toshikazu Shimane, Tomoaki Mori, Tomohiro Ono, Tetsuya Monden, Ayako Furuya, Sei Kobayashi, Takeyuki Sanbe, Harumi Suzaki
Palliative treatments are applied for older adult cases that are not indicated for either surgery or potential chemotherapy, as well as in cases with unresectable primary lesions, distant metastases, and serious complications among head and neck cancer cases. There is no established treatment for such cases, and therefore treatment has to be selected on a case-by-case basis. Two cases showing sustained QOL after long administration of S-1 are presented in this paper. The first is an 84-year-old male patient with cancer of the hypopharynx (T3N2aM1, stage IVc)...
July 2009: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Toshi A Furukawa, Junwen Chen, Norio Watanabe, Yumi Nakano, Tetsuji Ietsugu, Sei Ogawa, Tadashi Funayama, Yumiko Noda
Safety behavior (SB) and self-focused attention (SFA) have been posited as important maintenance factors in the cognitive model of social anxiety disorder (SAD). The present study reports the results of experiments to drop SB and SFA among clinically diagnosed patients with SAD employing their own idiosyncratic anxiety-provoking situations. The ratings for observable anxiety, belief in feared outcome and overall performance were better for role plays without SB and SFA than for role plays with them. The degree of drop in SFA predicted drop in observable anxiety and belief in feared outcome...
June 2009: Journal of Behavior Therapy and Experimental Psychiatry
Satoshi Sunaga, Atsushi Yoshimori, Daisuke Shiokawa, Sei-ichi Tanuma
DNase gamma, a member of the DNase I family, has been suggested to cause DNA fragmentation during apoptosis. We recently identified 4-(4,6-dichloro-[1,3,5]-triazine-2-ylamino)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid (DR396) as a novel specific inhibitor for human DNase gamma [Sunaga, S.; Kobayashi, T.; Yoshimori, A.; Shiokawa, D.; Tanuma, S. Biochem. Biophys. Res. Commun.2004, 325, 1292]. However, the binding mode (coordinate) of DR396 to DNase gamma has not yet been defined. Here, we examined the molecular basis for the inhibitory activity of DR396 to DNase gamma by structure-based computational docking studies...
June 15, 2006: Bioorganic & Medicinal Chemistry
Sang Wook Bai, Bo Sung Yoon, Ja Young Kwon, Jong Seung Shin, Sei Kwang Kim, Ki Hyun Park
The objective of this study was to evaluate characteristics, satisfaction degree, and problems of patients using a pessary for pelvic organ prolapse. A total of 104 patients who had been fitted with a pessary and available for follow-up for pelvic organ prolapse management were enrolled. The patients answered questions on general characteristics, indications for pessary use, complications from pessary use, satisfaction degree, and frequency of removal. The results indicated that 76 (73.0%) patients had at least more than one medical illness and 86 (82...
May 2005: International Urogynecology Journal and Pelvic Floor Dysfunction
Kerry S Campbell, Sei-ichi Yusa, Akiko Kikuchi-Maki, Tracey L Catina
NKp44 (NCR2) is a member of the natural cytotoxicity receptor (NCR) family that is expressed on activated human NK cells. We dissected structural attributes of NKp44 to determine their contributions to receptor function. Our results demonstrate that surface expression and NK cell activation by NKp44 is mediated through noncovalent association with the immunoreceptor tyrosine-based activation motif-containing protein, DAP12. Physical linkage to DAP12 requires lysine-183 in the NKp44 transmembrane domain. Intriguingly, the cytoplasmic domain of NKp44 also contains a sequence that matches the immunoreceptor tyrosine-based inhibitory motif (ITIM) consensus...
January 15, 2004: Journal of Immunology: Official Journal of the American Association of Immunologists
Dong Hoon Shin, Jin-Soo Kim, Bum Sun Kwon, Kun-Sei Lee, Jong Wan Kim, Myung Ho Kim, Sa Sun Cho, Wang Jae Lee
Caveolin-3, a protein that is correlated with caveolae, is found in muscle cells, especially during their differentiation. Although the distribution of caveolin-3 has been studied in cases such as adult and late embryonic mammalians, the expression of caveolin-3 has not been clearly defined during chicken development. In this study, we detected intense caveolin-3 immunoreactivity (IR) as early as embryonic day 4 (E4), most of the signals were localized within the neural tube and myotome. While IRs in the brain occurred in radial glia at E6, these intensities were reduced to an almost undetectable level at E8...
March 14, 2003: Brain Research. Developmental Brain Research
C A Sei, G L Hand, S F Murray, C C Glembotski
Cardiac myocytes store the 126-amino acid precursor of atrial natriuretic factor (pro-ANF), yet the mature, bioactive 28-amino acid peptide, ANF-(99-126), and the resulting N-terminal product, ANF-(1-98), are the forms of the hormone that are released by the heart and found in the circulation. Although previous studies have shown that the maturation of ANF takes place in the heart, it is not known whether it occurs in or on the myocyte concurrently with secretion, or whether cleavage takes place postsecretionally on either the myocyte surface or the surface of a nonmuscle cardiac cell...
March 1992: Molecular Endocrinology
W C Chumlea, S Guo
In an anthropometric nutritional assessment, elderly individuals are frequently unable to assume the positions needed for many measurements. This is especially true for stature, which is affected by mobility and skeletal deformities, and as a result measurements may be unreliable and inaccurate. An alternative is to use a surrogate value of stature. We developed predictive equations using data from elderly subjects in Cycle I of the National Health Examination Survey (NHES). The developed equations were cross-validated using two separate independent and more contemporary samples of elderly White men and women...
November 1992: Journal of Gerontology
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