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Antonio Pea, Jun Yu, Luigi Marchionni, Michael Noe, Claudio Luchini, Alessandra Pulvirenti, Roeland F de Wilde, Lodewijk A Brosens, Neda Rezaee, Ammar Javed, Stefano Gobbo, Paolo Regi, Roberto Salvia, Claudio Bassi, Jin He, Matthew J Weiss, John L Cameron, G Johan A Offerhaus, Ralph H Hruban, Rita T Lawlor, Aldo Scarpa, Christopher M Heaphy, Laura D Wood, Christopher L Wolfgang
OBJECTIVE: The aim of this study was to investigate the key molecular alterations in small primary pancreatic neuroendocrine tumors (PanNETs) associated with the development of liver metastases. BACKGROUND: Well-differentiated PanNETs with small size are typically indolent; however, a limited subset metastasize to the liver. METHODS: A total of 87 small primary PanNETs (<3 cm), including 32 metastatic cases and 55 nonmetastatic cases after a 5-year follow-up, were immunolabeled for DAXX/ATRX and analyzed for alternative lengthening of telomeres (ALT) by Fluorescence In Situ Hybridization...
October 17, 2018: Annals of Surgery
Andrew S Fischer, Neda Black, Brandon McNally, Joshua Wisell
No abstract text is available yet for this article.
November 2018: American Journal of Dermatopathology
Dana DiRenzo, Monica Crespo-Bosque, Neda Gould, Patrick Finan, Julie Nanavati, Clifton O Bingham
PURPOSE OF REVIEW: To determine the efficacy of mindfulness-based interventions (MBIs) on clinical and patient-reported outcomes in rheumatoid arthritis (RA). RECENT FINDINGS: We identified randomized clinical trials from inception through April 2018 from MEDLINE, PsycINFO, EMBASE, CINAHL, Web of Science, the Cochrane Library, and hand searches. After screening 338 references, we included five trials with one post-hoc analysis that evaluated MBIs and collectively included 399 participants...
October 18, 2018: Current Rheumatology Reports
Parvin Abbasi, Neda Kianipour, Gülcan Demir Özdenk, Arash Ziapour
The present data article aimed to investigate the leisure time among students at Kermanshah University of Medical Sciences and its relationship with health-related quality of life. In this descriptive and correlational data article, the statistical population consisted of 420 students at faculties of Health, Paramedics, Nursing and Midwifery in Kermanshah University of Medical Sciences who were selected through multi-stage cluster sampling. For data collection, the demographic questions, 36-item short form survey (SF-36) and a researcher-made leisure time questionnaire were utilized...
December 2018: Data in Brief
Dennis Ruder, Vassiliki Papadimitrakopoulou, Kazuhiko Shien, Carmen Behrens, Neda Kalhor, Huiqin Chen, Li Shen, J Jack Lee, Waun Ki Hong, Ximing Tang, Luc Girard, John D Minna, Lixia Diao, Jing Wang, Barbara Mino, Pamela Villalobos, Jaime Rodriguez-Canales, Nana E Hanson, James Sun, Vincent Miller, Joel Greenbowe, Garrett Frampton, Roy S Herbst, Veera Baladandayuthapani, Ignacio I Wistuba, Julie G Izzo
Despite a therapeutic paradigm shift into targeted-driven medicinal approaches, resistance to therapy remains a hallmark of lung cancer, driven by biological and molecular diversity. Using genomic and expression data from advanced non-small cell lung cancer (NSCLC) patients enrolled in the BATTLE-2 clinical trial, we identified RICTOR alterations in a subset of lung adenocarcinomas and found RICTOR expression to carry worse overall survival. RICTOR-altered cohort was significantly enriched in KRAS/MAPK axis mutations, suggesting a co-oncogenic driver role in these molecular settings...
September 21, 2018: Oncotarget
Scott Mackey, Nicholas Allgaier, Bader Chaarani, Philip Spechler, Catherine Orr, Janice Bunn, Nicholas B Allen, Nelly Alia-Klein, Albert Batalla, Sara Blaine, Samantha Brooks, Elisabeth Caparelli, Yann Ying Chye, Janna Cousijn, Alain Dagher, Sylvane Desrivieres, Sarah Feldstein-Ewing, John J Foxe, Rita Z Goldstein, Anna E Goudriaan, Mary M Heitzeg, Robert Hester, Kent Hutchison, Ozlem Korucuoglu, Chiang-Shan R Li, Edythe London, Valentina Lorenzetti, Maartje Luijten, Rocio Martin-Santos, April May, Reza Momenan, Angelica Morales, Martin P Paulus, Godfrey Pearlson, Marc-Etienne Rousseau, Betty Jo Salmeron, Renée Schluter, Lianne Schmaal, Gunter Schumann, Zsuzsika Sjoerds, Dan J Stein, Elliot A Stein, Rajita Sinha, Nadia Solowij, Susan Tapert, Anne Uhlmann, Dick Veltman, Ruth van Holst, Sarah Whittle, Margaret J Wright, Murat Yücel, Sheng Zhang, Deborah Yurgelun-Todd, Derrek P Hibar, Neda Jahanshad, Alan Evans, Paul M Thompson, David C Glahn, Patricia Conrod, Hugh Garavan
OBJECTIVE: Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondependent control subjects, the brain regions exhibiting lower volume have not been consistent across studies. In addition, it is not clear whether a common set of regions are involved in substance dependence regardless of the substance used or whether some brain volume effects are substance specific. Resolution of these issues may contribute to the identification of clinically relevant imaging biomarkers...
October 19, 2018: American Journal of Psychiatry
Katharina Huttenlochner, Neda Davoudi, Christin Schlegel, Martin Bohley, Christine Müller-Renno, Jan C Aurich, Roland Ulber, Christiane Ziegler
Bacteria in flowing media are exposed to shear forces exerted by the fluid. Before a biofilm can be formed, the bacteria have to attach to a solid surface and have to resist these shear forces. Here, the authors determined dislodgement forces of single Paracoccus seriniphilus bacteria by means of lateral force microscopy. The first measurement set was performed on very flat glass and titanium (both as very hydrophilic samples with water contact angles below 20°) as well as highly oriented pyrolytic graphite (HOPG) and steel surfaces (both as more hydrophobic surfaces in the context of biological interaction with water contact angles above 50°)...
October 18, 2018: Biointerphases
Nicholas Petronella, Jennifer Ronholm, Menka Suresh, Jennifer Harlow, Oksana Mykytczuk, Nathalie Corneau, Sabah Bidawid, Neda Nasheri
BACKGROUND: Human norovirus is the leading cause of viral gastroenteritis globally, and the GII.4 has been the most predominant genotype for decades. This genotype has numerous variants that have caused repeated epidemics worldwide. However, the molecular evolutionary signatures among the GII.4 variants have not been elucidated throughout the viral genome. METHOD: A metagenomic, next-generation sequencing method, based on Illumina RNA-Seq, was applied to determine norovirus sequences from clinical samples...
October 17, 2018: BMC Infectious Diseases
Katharina Kern, Stephan M G Schäfer, Jennifer Cohnen, Sandra Pierre, Tabea Osthues, Neda Tarighi, Stefan Hohmann, Nerea Ferreiros, Bernhard Brüne, Andreas Weigert, Gerd Geisslinger, Marco Sisignano, Klaus Scholich
Macrophages are highly versatile cells, which acquire, depending on their microenvironment, pro- (M1-like), or antiinflammatory (M2-like) phenotypes. Here, we studied the role of the G-protein coupled receptor G2A (GPR132), in chemotactic migration and polarization of macrophages, using the zymosan-model of acute inflammation. G2A-deficient mice showed a reduced zymosan-induced thermal hyperalgesia, which was reversed after macrophage depletion. Fittingly, the number of M1-like macrophages was reduced in the inflamed tissue in G2A-deficient mice...
2018: Frontiers in Immunology
Neda Martinović, Helena Abramovič, Nataša Poklar Ulrih
The efficiencies of sinapic acid and its derivatives syringic acid, syringaldehyde, three sinapoyl esters (ethyl, propyl, butyl sinapates), 4-vinylsyringol and sinapine were investigated for prevention of lipid peroxidation in correlation with their interactions with model lipid membrane systems. Significant antioxidant activities of propyl and butyl sinapates were seen by fluorimetric assay in phosphatidylcholine liposomes as model membrane using C11-BODIPY581/591 lipophilic fluorescent probe. The sinapic acid esters also had the highest impact on membrane structural properties, as observed by differential scanning calorimetry and fluorescence polarisation measurements...
October 13, 2018: Biochimica et biophysica acta. Biomembranes
Farshid Kompani, Ehsan Valavi, Parisa Amuri, Neda Mohtasham
OBJECTIVE: Considering the predictive role of the relatively low urinary citrate for stone formation, especially in hypercalciuric patients, this study is aimed at comparing urine calcium to citrate (Ca/Cit) ratio in 3 groups of children, including patients with idiopathic hypercalciuria with and without renal stone as well as the healthy children. METHODS: This study was carried out on 96 children (2 to 12 years old) referred to a pediatric nephrology clinic in the city of Ahvaz, Southwest Iran...
October 12, 2018: Journal of Renal Nutrition
Maneesh K Misra, Danillo G Augusto, Gonzalo Montero Martin, Neda Nemat-Gorgani, Jürgen Sauter, Jan A Hofmann, James A Traherne, Betsy González-Quezada, Clara Gorodezky, Will P Bultitude, Wesley Marin, Cynthia Vierra-Green, Kirsten M Anderson, Antonio Balas, Jose L Caro-Oleas, Elisa Cisneros, Francesco Colucci, Ravi Dandekar, Sally M Elfishawi, Marcelo A Fernández-Viña, Merhan Fouda, Rafael González-Fernández, Arend Große, Maria J Herrero-Mata, Sam Q Hollenbach, Steven G E Marsh, Alex Mentzer, Derek Middleton, Ashley Moffett, Miguel A Moreno-Hidalgo, Ghada I Mossallam, Annettee Nakimuli, Jorge R Oksenberg, Stephen J Oppenheimer, Peter Parham, Maria-Luiza Petzl-Erler, Dolores Planelles, Florentino Sánchez-García, Francisco Sánchez-Gordo, Alexander H Schmidt, John Trowsdale, Luciana B Vargas, Jose L Vicario, Carlos Vilches, Paul J Norman, Jill A Hollenbach
The goals of the KIR component of the 17th International HLA and Immunogenetics Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at allelic resolution, and to survey the nature and extent of KIR allelic diversity across human populations. To represent worldwide diversity, we analyzed 1269 individuals from ten populations, focusing on the most polymorphic KIR genes, which express receptors having three immunoglobulin (Ig)-like domains (KIR3DL1/S1, KIR3DL2 and KIR3DL3). We identified 13 novel alleles of KIR3DL1/S1, 13 of KIR3DL2 and 18 of KIR3DL3...
October 12, 2018: Human Immunology
Di Lin, Neda Baktash, Shaif-Ul Alam, David J Richardson
We report the generation of high average output power, high peak power, and high pulse energy radially polarized picosecond pulses from a compact gain-switched laser-diode-seeded Yb-doped fiber master oscillator power amplifier (MOPA) system. A q-plate was employed as a mode converter prior to the final power amplifier to efficiently convert the linearly polarized Gaussian-shaped beam into a donut-shaped radially polarized beam. The desired vector beam was efficiently amplified yielding ∼110  ps pulses with a maximum output pulse energy of ∼30...
October 15, 2018: Optics Letters
Neda Asadi, Robabeh Memarian, Zohreh Vanaki
BACKGROUND: The performance of nurses, which is rooted in personal motivation, determines the quality of care. Therefore, it is important that nurses are motivated to provide high-quality care. PURPOSE: The purpose of this study was to explore the factors that affect caring motivation from the perspectives of nurses in Iran. METHODS: This was a qualitative study. Seventeen nurses were interviewed using a semistructured, in-depth interview method...
October 12, 2018: Journal of Nursing Research: JNR
Neda Motamedi Rad, Meysam Rezaeishahmirzadi, Sepideh Shakeri, Mohamad Reza Abbaszadegan, Mohammad Shekari
Background: Helicobacter pylori are the main cause of chronic inflammation and peptic ulcer. We aimed to determine if IL-1B+ 3954 and IL-1RN polymorphisms are associated with the risk of chronic gastritis and peptic ulcer in Iranian population. Methods: In this case-control study, from 198 individuals enrolled by Mohammadi Hospital, Bandar Abbas, southern Iran from 2012 to 2014 and who showed the symptoms of chronic gastritis and 84 with peptic ulcer participated in the case group, two biopsies were taken from the body, antrum, or ulcer edge of each patient...
September 2018: Iranian Journal of Public Health
Hadi Hassankhani, Amin Soheili, Samad S Vahdati, Farough A Mozaffari, Justin F Fraser, Neda Gilani
STUDY OBJECTIVE: We evaluate the extent and nature of treatment delays and the contributing factors influencing them for patients with acute ischemic stroke, as well as main barriers to stroke care in an Iranian emergency department (ED). METHODS: A retrospective chart review was conducted on 394 patients with acute ischemic stroke who were referred to the ED of a tertiary academic medical center in northwest Iran from March 21 to June 21, 2017. The steps of this review process included instrument development, medical records retrieval, data extraction, and data verification...
October 11, 2018: Annals of Emergency Medicine
Mohsen Emadedin, Narges Labibzadeh, Maede Ghorbani Liastani, Aliasghar Karimi, Neda Jaroughi, Tina Bolurieh, Seyyedeh-Esmat Hosseini, Hossein Baharvand, Nasser Aghdami
BACKGROUND: The intra-articular implantation of mesenchymal stromal cells (MSCs) as a treatment for knee osteoarthritis (OA) is an emerging new therapy. In this study, patients with knee OA received intra-articular implantations of autologous bone marrow-derived MSCs. We sought to assess the safety and efficacy of this implantation. MATERIALS AND METHODS: This was a phase 1/2 single-center, triple-blind, randomized controlled trial (RCT) with a placebo control. The subjects consisted of patients with knee OA randomly assigned to either an intra-articular implantation of MSCs (40 × 106 cells) or 5mL normal saline (placebo)...
October 11, 2018: Cytotherapy
Bagher Farhood, Keywan Mortezaee, Nasser Hashemi Goradel, Neda Khanlarkhani, Ensieh Salehi, Maryam Shabani Nashtaei, Masoud Najafi, Amirhossein Sahebkar
Cancer is the second cause of death worldwide. Chemotherapy and radiotherapy are the most common modalities for the treatment of cancer. Experimental studies have shown that inflammation plays a central role in tumor resistance and the incidence of several side effects following both chemotherapy and radiotherapy. Inflammation resulting from radiotherapy and chemotherapy is responsible for adverse events such as dermatitis, mucositis, pneumonitis, fibrosis, and bone marrow toxicity. Chronic inflammation may also lead to the development of second cancer during years after treatment...
October 14, 2018: Journal of Cellular Physiology
Marta Massanella, Christina Yek, Steven M Lada, Masato Nakazawa, Neda Shefa, Karissa Huang, Douglas D Richman
BACKGROUND: Improved assays are critical to better characterize the HIV reservoir and to reliably evaluate candidate intervention strategies. Here we describe different methods to quantify the HIV reservoir. METHODS: We developed an optimized quantitative viral outgrowth assay (QVOA) to quantify the frequency of cells harboring replication-competent HIV, which is simpler and more sensitive than classical QVOAs. We also developed new inducible RNA assays that concomitantly measure the frequency of cell-associated [ca-] (gag and tat-rev) and cell-free [cf-] HIV RNA after three days of anti-CD3/CD28 stimulation...
October 2018: EBioMedicine
Neda Orakifar, Mohammad Jafar Shaterzadeh-Yazdi, Reza Salehi, Mohammad Mehravar, Neda Namnik
OBJECTIVE: To investigate impairment in the activity pattern of some muscles involved in sit to stand (STD) and stand to sit (STS) among two low back pain (LBP) subgroups of the Movement System Impairment (MSI) model. DESIGN: Case-control study SETTING: A university medical center PARTICIPANTS: Fifteen healthy women and twenty-two women with chronic LBP in two subgroups (fifteen into the lumbar extension rotation (LER) and seven into lumbar flexion rotation (LFR)) voluntarily participated in this study...
October 10, 2018: Archives of Physical Medicine and Rehabilitation
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