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Hamid Reza Mozaffari, Elisa Zavattaro, Abas Abdolahnejad, Pia Lopez-Jornet, Neda Omidpanah, Roohollah Sharifi, Masoud Sadeghi, Mohammad Shooriabi, Mohsen Safaei
Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the Newcastle⁻Ottawa Quality Assessment Scale (NOS) questionnaire...
December 3, 2018: Medicina
Victor M Rivera
Multiple sclerosis (MS) has become a common neurological disorder involving populations previously considered to be infrequently affected. Genetic dissemination from high- to low-risk groups is a determining influence interacting with environmental and epigenetic factors, mostly unidentified. Disease modifying therapies (DMT) are effective in treating relapsing MS in variable degrees; one agent is approved for primary progressive disease, and several are in development. In the era of high-efficacy medications, complex molecules, and monoclonal antibodies (MAB), including anti-VLA4 (natalizumab), anti-CD52 (alemtuzumab), and anti-CD20 (ocrelizumab), obtaining NEDA (no evidence of disease activity) becomes an elusive accomplishment in areas of the world where access to MS therapies and care are generally limited...
November 30, 2018: Biomedicines
Mojtaba Mikaniki, Neda Babaee, Ebrahim Mikaniki, Mohammad Reza Hasanjani Roushan, Ali Bijani
Background: Behcet's syndrome is a disease with different aspects in its clinical manifestations. The purpose of this study was to evaluate the simultaneous presence of oral mucosal and ophthalmologic lesions in patients with Behcet's syndrome. Methods: From April 2012 to December 2014, 50 cases of Behcet's syndrome who referred to the Departments of Ophtalmology, Oral Diseases and Infectious Diseases of Babol University Medical Sciences were entered into the study...
2018: Caspian Journal of Internal Medicine
Jelena Jović, Aneta Buntić, Neda Radovanović, Bojan Petrović, Ljiljana Mojović
The aim of this research is to isolate and identify fungi with high lignin-degrading abilities that are autochthonous to southern Serbian region. Two novel fungal isolates identified as Trametes hirsuta F13 and Stereum gausapatum F28 were selected to assess their ligninolytic enzyme activities and the efficiency of lignin removal from beech wood sawdust. Obtained results show that both isolates are good sources of industrially valuable enzymes with a potential for application in various biotechnological and industrial processes...
September 2018: Food Technology and Biotechnology
Jessica L F Teh, Phil F Cheng, Timothy J Purwin, Neda Nikbakht, Prem Patel, Inna Chervoneva, Adam Ertel, Paolo M Fortina, Ines Kleiber, Kim HooKim, Michael A Davies, Lawrence N Kwong, Mitch P Levesque, Reinhard Dummer, Andrew E Aplin
No abstract text is available yet for this article.
December 2018: Cancer Discovery
Kazem Darvish Bastami, Mahmoud Reza Neyestani, Neda Molamohyedin, Elnaz Shafeian, Sara Haghparast, Imam Ali Shirzadi, Mehrnaz Baniamam
We investigated the bioavailability, mobility, and origin of heavy metals present in sediments from the Anzali Wetland. Chemical speciation of the metals was performed according to the Tessier method. Results indicated that Cd and As showed the highest level of bioavailability, whereas Cr showed the lowest level. Cr, Co, and V were shown to have a terrestrial origin. The metal As was mostly found in the reducible fraction (F3), whereas other metals were highest in the residual phase. The levels of Co present in the oxidizable fraction (F4); Pb and Cd present in the carbonate fraction (F2); and the other metals present in the exchangeable fraction (F1) were found to be the lowest...
November 2018: Marine Pollution Bulletin
Mohammad Mehdi Movahedi, Alireza Mehdizadeh, Fereshteh Koosha, Neda Eslahi, Vahid Pirhajati Mahabadi, Habib Ghaznavi, Ali Shakeri-Zadeh
In this article, we report a targeted cancer treatment strategy using nano-photo-thermal therapy (NPTT) and radiotherapy (RT) methods. Gold nanorods (AuNRs) without and with folic acid (FA) conjugation were firstly synthesized and then characterized. Cytotoxicity of various methods; NPTT (nanoparticles; 808 nm laser; 2 W/cm2 ) or RT (6 MV X-ray; 2 Gy) or combination of NPTT and RT; was separately investigated on KB nasopharyngeal carcinoma cells. The effects of different treatments were studies using MTT assay, inductively coupled plasma-mass spectrometry (ICP-MS) and transmission electron microscopy (TEM)...
December 2018: Photodiagnosis and Photodynamic Therapy
Neda Eslahi, Ali Shakeri-Zadeh, Khadijeh Ashtari, Vahid Pirhajati-Mahabadi, Tahereh Tohidi Moghadam, Ronak Shabani, Kamran Kamrava, Zahra Madjd, Chad Maki, Hamid Reza Asgari, Morteza Koruji
Objective: The purpose of this study was to evaluate in vitro cytotoxicity of gold nanorods (GNRs) on the viability of spermatogonial cells (SSCs) and mouse acute lymphoblastic leukemia cells (EL4s). Materials and Methods: In this experimental study, SSCs were isolated from the neonate mice, following enzymatic digestion and differential plating. GNRs were synthesized, then modified by silica and finally conjugated with folic acid to form F-Si-GNRs. Different doses of F-Si-GNRs (25, 50, 75, 100, 125 and 140 μM) were used on SSCs and EL4s...
April 2019: Cell Journal
Lynn J Gillespie, Robert John Soreng, Evren Cabi, Neda Amiri
Eremopoa is a small genus of annual grasses distributed from Egypt to western China. Phylogenetic analyses of plastid and nuclear ribosomal DNA show that Eremopoa species, together with the monotypic genus Lindbergella and a single species of Poa ( P.speluncarum ), are nested within the genus Poa , in a clade that we accept as Poasubg.Pseudopoa. Here we accept seven species, four subspecies and four varieties in Poasubg.Pseudopoa. Five new combinations are made: Poaattalica, P.diaphora var. alpina, P.diaphora var...
2018: PhytoKeys
Peter Kochunov, Brian Donohue, Braxton D Mitchell, Habib Ganjgahi, Bhim Adhikari, Meghann Ryan, Sarah E Medland, Neda Jahanshad, Paul M Thompson, John Blangero, Els Fieremans, Dmitry S Novikov, Daniel Marcus, David C Van Essen, David C Glahn, L Elliot Hong, Thomas E Nichols
Imaging genetic analyses quantify genetic control over quantitative measurements of brain structure and function using coefficients of relationship (CR) that code the degree of shared genetics between subjects. CR can be inferred through self-reported relatedness or calculated empirically using genome-wide SNP scans. We hypothesized that empirical CR provides a more accurate assessment of shared genetics than self-reported relatedness. We tested this in 1,046 participants of the Human Connectome Project (HCP) (480 M/566 F) recruited from the Missouri twin registry...
November 29, 2018: Human Brain Mapping
Neda Yaghoubi, Masoud Youssefi, Seyed Isaac Hashemy, Houshang Rafat Panah, Barat Ali Mashkani, Farnaz Zahedi Avval
BACKGROUND: The thioredoxin (Trx) system is a reducing complex, consisting of Trx, Trx Reductase (TrxR), and NADPH, that scavenges reactive oxygen species (ROS). The system is a natural protective mechanism to prevent apoptosis and progression of oxidative stress-related diseases. The present study was conducted to explore possible changes in TrxR activity and gene expression as a response to the oxidative stress during HTLV-1 infection. MATERIAL AND METHODS: Blood samples were collected from 40 HTLV-1-infected patients and 40 age- and sex-matched healthy controls...
November 29, 2018: Journal of Medical Virology
Mahsa Hatami, Mina Abdolahi, Neda Soveyd, Mahmoud Djalali, Mansoureh Togha, Niyaz Mohammadzadeh Honarvar
OBJECTIVE: Neuroinflammatory disease is a general term used to denote the progressive loss of neuronal function or structure. Many neuroinflammatory diseases, including Alzheimer's, Parkinson's, and multiple sclerosis (MS), occur due to neuroinflammation. Neuroinflammation increases nuclear factor-κB (NF-κB) levels, cyclooxygenase-2 enzymes and inducible nitric oxide synthase, resulting in the release of inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)...
November 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Neda Nejati Moharrami, Erlend Bjørkøy Tande, Liv Ryan, Terje Espevik, Victor Boyartchuk
ROR family of nuclear receptor transcription factors forms nodes connecting metabolic and inflammatory signaling pathways. The RORα members of the family have intrinsic transcriptional activity and they are involved in both activation and repression of a wide range of genes. The role of RORα in control of inflammation has been extensively studied using animal models but its function in human cells is not as well understood. To address this shortcoming, we analyzed how RORα is shaping the inflammatory state of human macrophages...
2018: PloS One
Yifei Zhang, Megan J Armstrong, Neda M Bassir Kazeruni, Henry Hess
Recent experimental studies have measured a 30-80% increase of the diffusion coefficient when various enzymes, including aldolase, are catalytically active. This observation has been supported by several theoretical explanations, but other theoretical studies argue against the possibility of enhanced diffusion, and two of them ascribe the experimental observations to potential artifacts arising in fluorescence correlation spectroscopy (FCS) measurements. Here, we utilized dynamic light scattering (DLS) to measure the diffusion coefficient of aldolase in the absence and presence of its substrate...
November 28, 2018: Nano Letters
Robyn N Parks, Christopher J Kim, Zain A Al-Safi, Abigail A Armstrong, Temeka Zore, Neda A Moatamed
Chronic endometritis is characterized by plasma cell (PC) infiltration of endometrial stroma. Identification of PCs can be challenging by routine hematoxylin and eosin (H&E) stain due to the low numbers of PCs or to their being obscured by other cells in the stroma. CD138 is widely used as an ancillary immunohistochemistry stain to identify PCs; however, it has a high background reaction. In this study, multiple myeloma 1 (MUM1) transcription factor is introduced as an alternative PC marker in endometrial tissues...
November 28, 2018: International Journal of Surgical Pathology
Mohammad Rafi Bazrafshan, Mehdi Noroozi, Hesam Ghisvand, Alireza Noroozi, Neda Alibeigi, Mohammad Abbasi, Peter Higgs, Bahram Armoon
BACKGROUND: Global estimates suggest there are 15.6 million people who inject drugs (PWID) of whom 17.8% are living with HIV.Few studies have characterized newly-onset injectors with long-term injectors and its association with injecting risk behaviors. OBJECTIVES: We examined the relationship between length of injection and risk behaviors among people who inject drugs (PWID) in Tehran, Iran. METHODS: A cross-sectional study was conducted among PWID, from March to August 2016 in Tehran, Iran...
November 26, 2018: Substance Use & Misuse
Gemma Montalban, Sandra Bonache, Alejandro Moles-Fernández, Alexandra Gisbert-Beamud, Anna Tenés, Vanessa Bach, Estela Carrasco, Adrià López-Fernández, Neda Stjepanovic, Judith Balmaña, Orland Diez, Sara Gutiérrez-Enríquez
BACKGROUND: Genetic analysis of BRCA1 and BRCA2 for the diagnosis of hereditary breast and ovarian cancer (HBOC) is commonly restricted to coding regions and exon-intron boundaries. Although germline pathogenic variants in these regions explain about ~20% of HBOC cases, there is still an important fraction that remains undiagnosed. We have screened BRCA1/2 deep intronic regions to identify potential spliceogenic variants that could explain part of the missing HBOC susceptibility. METHODS: We analysed BRCA1/2 deep intronic regions by targeted gene sequencing in 192 high-risk HBOC families testing negative for BRCA1/2 during conventional analysis...
November 24, 2018: Journal of Medical Genetics
Emanuele D'Amico, Aurora Zanghì, Clara Grazia Chisari, Salvatore Lo Fermo, Simona Toscano, Sebastiano Arena, Francesco Patti, Mario Zappia
BACKGROUND: Rituximab (RTX), a monoclonal antibody targeting the CD20+ B lymphocytes, deserves major attention as therapeutic option in the treatment of demyelinating disorders of the central nervous system (DDCNS). We reported our clinical experience with the use of RTX in terms of efficacy and safety in persons suffering from DDCNS. METHODS: An Italian single-center observational analysis of patients who underwent RTX treatment between 2011 and 2017 was performed at MS center of Catania, Italy...
October 3, 2018: Multiple Sclerosis and related Disorders
Neda Mostafaee, Hossein Negahban, Mohammad Jafar Shaterzadeh Yazdi, Shahin Goharpey, Mohammad Mehravar, Nahid Pirayeh
PURPOSE: To evaluate the responsiveness and determine the minimal clinically important changes (MCICs), anchored by the patient response to a 7-point global rating scale, for Knee Injury and Osteoarthritis Outcome Score (KOOS), and Tegner activity scale in athletes undergoing physiotherapy treatment after anterior cruciate ligament reconstruction (ACL-R). METHODS: Fifty-four patients undergoing physiotherapy completed the Persian versions of KOOS and Tegner scales at weeks 6 and 10 post ACL-R...
November 23, 2018: Physiotherapy Theory and Practice
Mohaddeseh Shahabi Nejad, Neda Seyedi, Hassan Sheibani, Soheila Behzadi
A new magnetically recoverable silica-based nickel(II) nanocatalyst was synthesized by a simple cost-effective procedure, which was characterized by TEM, SEM, XRD, VSM analysis, and FT-IR spectrophotometry. The catalytic activity of the prepared Ni(II) nanocatalyst was tested in two complementary reactions: C-N Chan-Lam cross-coupling of phenylboronic acid with aryl amines and C-C Suzuki-Miyaura cross-coupling reaction of phenylboronic acid with aryl halides. The catalyst was easily recovered by magnetic separation and reused for five times...
November 22, 2018: Molecular Diversity
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